{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:57:23Z","timestamp":1790575043136,"version":"4.1.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Progressive supranuclear palsy (PSP) causes progressive speech impairment. Digital speech analysis can objectively and remotely quantify measures like intelligibility, typically judged subjectively by experts during clinical visits. The objective of this study is to validate digital intelligibility measurement in PSP via BioDigit Speech (BioSensics LLC, United States).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-nine PSP patients performed standardized passage-reading scored by BioDigit Speech and three experts (18\u202f+\u202fyears of experience); expert mean score (EMS) served as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Digital intelligibility showed high correlation and agreement with EMS (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f0.90, ICC\u202f=\u202f0.84 in native speakers), while systematically scoring below EMS. Moreover, the digital measure discriminated PSP clinical severity as well as or better than EMS, particularly for PSP-QoL-11 with a steeper standardized response. Correlations of digital measure with the clinical scales were moderate (up to \u22120.51), significant (\n                      <jats:italic>p<\/jats:italic>\n                      -values &amp;lt;0.02) and consistently higher than the ones of EMS. Raters appeared to use top-down information to recover underlying messages, resulting in saturated scores near 1.0 and low-to-moderate inter-rater agreement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collected remotely with minimal burden, digital speech measures like intelligibility may serve as objective, sensitive outcomes for communication-focused interventions and PSP trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1961535","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:45:37Z","timestamp":1790574337000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Analytical validation of digital measure of intelligibility in progressive supranuclear palsy"],"prefix":"10.3389","volume":"20","author":[{"given":"\u0130lkay","family":"Y\u0131ld\u0131z Potter","sequence":"first","affiliation":[{"name":"BioSensics LLC","place":["Newton, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Kinker","family":"Mishra","sequence":"additional","affiliation":[{"name":"BioSensics LLC","place":["Newton, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejas","family":"Pawar","sequence":"additional","affiliation":[{"name":"BioSensics LLC","place":["Newton, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje S.","family":"Mefferd","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center","place":["Nashville, TN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"de Riesthal","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center","place":["Nashville, TN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mili","family":"Kuruvilla-Dugdale","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders, University of Iowa","place":["Iowa City, IA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Wills","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Pantelyat","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine","place":["Baltimore, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Vaziri","sequence":"additional","affiliation":[{"name":"BioSensics LLC","place":["Newton, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2303.00747","article-title":"WhisperX: time-accurate speech transcription of long-form audio","author":"Bain","year":"2023","journal-title":"arXi"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1044\/2021_JSLHR-21-00306","article-title":"From speech acoustics to communicative participation in dysarthria: toward a causal framework","volume":"65","author":"Borrie","year":"2022","journal-title":"J. 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