{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:27:32Z","timestamp":1776324452141,"version":"3.50.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Integr. Neurosci."],"DOI":"10.3389\/fnint.2019.00048","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T04:37:37Z","timestamp":1568954257000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Moxibustion Reduces Inflammatory Response in the Hippocampus of a Chronic Exercise-Induced Fatigue Rat"],"prefix":"10.3389","volume":"13","author":[{"given":"Tian-ge","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Shui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-yu","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-mei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-song","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1515\/CCLM.2008.050","article-title":"Strenuous exercise activates growth factors and chemokines over-expression in human serum of top-level triathlon athletes during a competitive season.","volume":"46","author":"Banfi","year":"2008","journal-title":"Clin. Chem. Lab. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.bbi.2005.03.012","article-title":"Recovery of running performance following muscle-damaging exercise: relationship to brain IL-1beta.","volume":"19","author":"Carmichael","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"R1344","DOI":"10.1152\/ajpregu.00141.2006","article-title":"Role of brain IL-1beta on fatigue after exercise-induced muscle damage.","volume":"291","author":"Carmichael","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.bbi.2009.12.011","article-title":"Role of brain macrophages on IL-1beta and fatigue following eccentric exercise-induced muscle damage.","volume":"24","author":"Carmichael","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1123\/ijsnem.2018-0288","article-title":"Exercise-induced illness and inflammation: can immunonutrition and iron help?","volume":"29","author":"Castell","year":"2019","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1038\/sj.npp.1301065","article-title":"Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension test.","volume":"31","author":"Crowley","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cyto.2019.04.006","article-title":"Exercise-induced anti-inflammatory effects in overweight\/obese women with polycystic ovary syndrome.","volume":"120","author":"Dantas","year":"2019","journal-title":"Cytokine"},{"key":"B9","first-page":"45","article-title":"Effect of acupuncture and moxibustion interventions on ethological changes and 5-HT\/5-HIAA levels in prefrontal cortex in depression rats.","volume":"41","author":"Ding","year":"2016","journal-title":"Acupuncture Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"373","DOI":"10.2165\/00007256-20636050-00001","article-title":"Trauma-induced systemic inflammatory response versus exercise-induced immunomodulatory effects.","volume":"36","author":"Fehrenbach","year":"2006","journal-title":"Sports Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1152\/physrev.2001.81.4.1725","article-title":"Spinal and supraspinal factors in human muscle fatigue.","volume":"81","author":"Gandevia","year":"2001","journal-title":"Physiol. Rev."},{"key":"B12","first-page":"247","article-title":"Regulating effect of moxibustion pretreatment on Th1\/Th2 imbalance of athletes during course of heavy load training.","volume":"31","author":"Gao","year":"2011","journal-title":"Chin. Acup. Moxib."},{"key":"B13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11010-008-9752-2","article-title":"Influence of gender and oral contraceptives intake on innate and inflammatory response. Role of neuroendocrine factors.","volume":"313","author":"Giraldo","year":"2008","journal-title":"Mol. Cell Biochem."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793","article-title":"Interleukins and exercise.","volume":"15","author":"Gleeson","year":"2000","journal-title":"J. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ejphar.2009.03.076","article-title":"Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-likebehavior via reducing cyclooxygenase-2 expression in rat brain.","volume":"612","author":"Guo","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1248\/bpb.29.2106","article-title":"Effects of astaxanthin supplementation on exercise-induced fatigue in mice.","volume":"29","author":"Ikeuchi","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s11011-019-00410-7","article-title":"The effects of exercise on hippocampal inflammatory cytokine levels, brain oxidative stress markers and memory impairments induced by lipopolysaccharide in rats.","volume":"34","author":"Jahangiri","year":"2019","journal-title":"Metab. Brain Dis"},{"key":"B18","first-page":"119","article-title":"The open window of susceptibility to infection after acute exercise in healthy young male elite athletes.","volume":"16","author":"Kakanis","year":"2010","journal-title":"Exerc. Immunol. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.11675\/j.issn.0253-4304.2017.10.25","article-title":"Clinical efficacy of moxibustion at Qihai and Guanyuan acupoints for treatment of chronic fatigue syndromes and its influence on immune function of rats.","volume":"39","author":"Lin","year":"2017","journal-title":"Guangxi Med. J."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1080\/16546628.2017.1333390","article-title":"Protective effects of tea polyphenols on exhaustive exercise-induced fatigue, inflammation and tissue damage.","volume":"61","author":"Liu","year":"2017","journal-title":"Food Nutr. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1055\/s-0032-1301890","article-title":"Moxibustion attenuates inflammatory response to chronic exhaustive exercise in rats.","volume":"33","author":"Lu","year":"2012","journal-title":"Int. J. Sports Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"166","DOI":"10.19379\/j.cnki.issn.1005-0256.2019.02.065","article-title":"Clinical study on the effect of moxibustion on exercise fatigue recovery\u2014take orienteering team of Jinzhong College as an example.","volume":"27","author":"Ma","year":"2019","journal-title":"Bull. Sport Sci. Technol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/15438620802689757","article-title":"Impact of training on changes in perceived stress and cytokine production.","volume":"17","author":"Main","year":"2009","journal-title":"Res. Sports Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1152\/jappl.2000.89.4.1499","article-title":"Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells.","volume":"89","author":"Moldoveanu","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0259-2","article-title":"Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses.","volume":"13","author":"Morris","year":"2015","journal-title":"BMC Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"945","DOI":"10.2967\/jnumed.113.131045","article-title":"Neuroinflammation in patients with chronic fatigue syndrome\/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET Study.","volume":"55","author":"Nakatomi","year":"2014","journal-title":"J. Nucl. Med."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2015.00027","article-title":"Post-Exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle cytokine mRNA expression.","volume":"9","author":"Nieman","year":"2015","journal-title":"Front. Nutr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.neuroscience","article-title":"Excessive eccentric exercise leads to transitory hypothalamic inflammation, which may contribute to the low body weight gain and food intake in overtrained mice.","volume":"311","author":"Pereira","year":"2015","journal-title":"Neuroscience"},{"key":"B29","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1177\/1099800408329409","article-title":"Long-term exercise training selectively alters serum cytokines involved in fever.","volume":"10","author":"Rowsey","year":"2009","journal-title":"Biol. Res. Nurs."},{"key":"B30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cyto.2017.10.001","article-title":"T-cells and their cytokine production: the anti-inflammatory and immunosuppressive effects of strenuous exercise.","volume":"104","author":"Shaw","year":"2018","journal-title":"Cytokine"},{"key":"B31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00005768-200002000-00011","article-title":"Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress?","volume":"32","author":"Smith","year":"2000","journal-title":"Med. Sci. Sports Exerc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1519\/00124278-200402000-00028","article-title":"Tissue trauma: the underlying cause of overtraining syndrome?","volume":"18","author":"Smith","year":"2004","journal-title":"J. Strength Cond. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"193","DOI":"10.13297\/j.cnki.issn1005-0000.2014.03.001","article-title":"Exercise-induced fatigue may reduce learning and memory function through neuroinflammation mediated by microglia activation in hippocampus.","volume":"29","author":"Sun","year":"2014","journal-title":"J. Tianjin Univ. Sport"},{"key":"B34","first-page":"6","article-title":"Systemic inflammatory response to exhaustive exercise. Cytokine kinetics.","volume":"8","author":"Suzuki","year":"2002","journal-title":"Exerc. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1007\/s40279-014-0232-4","article-title":"A neuroinflammatory model for acute fatigue during exercise.","volume":"44","author":"Vargas","year":"2014","journal-title":"Sports Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.jaci.2015.10.035","article-title":"Physical exercise modulates the homeostasis of human regulatory T cells.","volume":"137","author":"Weinhold","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.13703\/j.0255-2930.2018.11.014","article-title":"Effects of moxibustion at different time points on foot swelling, serum level of TNF-\u03b1 and circadian rhythm in rats with rheumatoid arthritis.","volume":"38","author":"Wu","year":"2018","journal-title":"Chin. Acup. Moxib."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.13935\/j.cnki.sjzx.141125","article-title":"Observation of the clinical efficacy on 41 cases of chronic fatigue syndrome treated with moxibustio at back-shu points of five zang organs.","volume":"9","author":"Xiao","year":"2014","journal-title":"World J. Integr. Tradit. Western Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"169","DOI":"10.13702\/j.1000-0607.2014.02.015","article-title":"Progress of researches on prevention and treatment of sports fatigue with moxibustion therapy.","volume":"39","author":"Xu","year":"2014","journal-title":"Acupuncture Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"224","DOI":"10.13702\/j.1000-0607.2015.03.010","article-title":"Protective effect of preventative moxibustion on myocardial cells in mice experiencing moderate-intensity and exhausted exercise.","volume":"40","author":"Zhang","year":"2015","journal-title":"Acupuncture Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"28","DOI":"10.16040\/j.cnki.cn15-1101.2013.26.043","article-title":"Clinical observation of moxibustion on zusanli intervention of exercise-induced fatigue.","volume":"32","author":"Zhang","year":"2013","journal-title":"Nei Mongol J. Tradit. Chin. Med."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3405146","article-title":"Effect of Herb-Partitioned moxibustion on autophagy and immune-associated gene expression profiles in a rat model of Crohn\u2019s Disease.","volume":"7","author":"Zhao","year":"2019","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B43","first-page":"46","article-title":"Effect of routine moxibustion on sports fatigue recovery.","volume":"18","author":"Zhao","year":"2017","journal-title":"J. Shanxi Coll. Tradit. Chin. Med."}],"container-title":["Frontiers in Integrative Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnint.2019.00048\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T04:37:45Z","timestamp":1568954265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnint.2019.00048\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":43,"alternative-id":["10.3389\/fnint.2019.00048"],"URL":"https:\/\/doi.org\/10.3389\/fnint.2019.00048","relation":{},"ISSN":["1662-5145"],"issn-type":[{"value":"1662-5145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"article-number":"48"}}