{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:33:16Z","timestamp":1786116796030,"version":"build-2736575974"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Integr. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hemispheric asymmetries are a core organizational principle of the vertebrate brain, but they are still not fully integrated into the study of preclinical models of neurological disease. Although many rodent models naturally include lateralization through unilateral interventions, hemispheric differences are not consistently examined or systematically reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted following PRISMA guidelines, combining evidence from 48 studies on hemispheric asymmetries in rodent models of neurological conditions, including mild traumatic brain injury, epilepsy, stroke, Alzheimer\u2019s, and Parkinson\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across these models, disease processes cause strong lateralized effects on behavior, neurochemistry, and regional metabolism. In epilepsy models specifically, hemispheric asymmetries depend on the model: early seizure spread and network excitability can be lateralized, while other paradigms show more symmetric responses, emphasizing the role of baseline circuit asymmetries and genetic background. Similar lateralized effects are seen in stroke and Parkinson\u2019s models, reflecting clinical phenomena such as lesion-side-dependent outcomes and unilateral symptom onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Models focusing on intrinsic hemispheric asymmetry or interhemispheric\/bilateral response highlight existing differential sensitivity to experimental manipulations that may predispose the system to asymmetric outcomes. Nonetheless, variability and dynamic shifts in hemispheric organization are rarely taken into account. Incorporating hemispheric analysis systematically into experimental design and data interpretation could enhance the sensitivity, clarity, and clinical relevance of rodent models of neurological disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnint.2026.1843068","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:35:46Z","timestamp":1786019746000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemispheric asymmetries in rodent models of neurological diseases: a systematic review"],"prefix":"10.3389","volume":"20","author":[{"given":"Maximilian","family":"Schuessler","sequence":"first","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, Neuroradiology and Nuclear Medicine, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum","place":["Bochum, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annakarina","family":"Mundorf","sequence":"additional","affiliation":[{"name":"Institute for Systems Medicine, Department of Human Medicine, MSH Medical School Hamburg","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"107460","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107460","article-title":"Factors associated with the laterality of Cardio-Embolic stroke.","volume":"32","author":"Abdelnaby","year":"2023","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"8232","DOI":"10.1038\/s41467-025-63564-2","article-title":"Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer\u2019s Disease.","volume":"16","author":"Anij\u00e4rv","year":"2025","journal-title":"Nat. Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.bbr.2010.02.015","article-title":"Lateralized and sex-dependent behavioral and morphological effects of unilateral neonatal cerebral hypoxia-ischemia in the rat.","volume":"210","author":"Arteni","year":"2010","journal-title":"Behav. Brain Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"fcab068","DOI":"10.1093\/braincomms\/fcab068","article-title":"Increased facial asymmetry in focal epilepsies associated with unilateral lesions.","volume":"3","author":"Balestrini","year":"2021","journal-title":"Brain Commun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/nbm.705","article-title":"MR angiographic investigation of transient focal cerebral ischemia in rat.","volume":"14","author":"Besselmann","year":"2001","journal-title":"NMR Biomed."},{"key":"B6","doi-asserted-by":"publisher","first-page":"117707","DOI":"10.1016\/j.neuroimage.2020.117707","article-title":"Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice.","volume":"230","author":"Biechele","year":"2021","journal-title":"NeuroImage"},{"key":"B7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/ana.410140207","article-title":"Regional blood-to-tissue transport in ethylnitrosourea-induced brain tumors.","volume":"14","author":"Blasberg","year":"1983","journal-title":"Ann. Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cortex.2021.09.007","article-title":"Reclassifying stroke lesion anatomy.","volume":"145","author":"Bonkhoff","year":"2021","journal-title":"Cortex"},{"key":"B9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s11055-008-9082-6","article-title":"Asymmetry in dopamine levels in the nucleus accumbens and motor preference in rats.","volume":"38","author":"Budilin","year":"2008","journal-title":"Neurosci. Behav. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0031-9384(89)90189-3","article-title":"Absence of a hemispheric difference in seizure sensitivity and kindling rate in the rat brain.","volume":"45","author":"Cain","year":"1989","journal-title":"Physiol. Behav."},{"key":"B11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/s0006-8993(99)01268-8","article-title":"Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson\u2019s model rats.","volume":"828","author":"Carlson","year":"1999","journal-title":"Brain Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1113\/JP279793","article-title":"Inter-hemispheric inhibition sculpts the output of neural circuits by co-opting the two cerebral hemispheres.","volume":"598","author":"Carson","year":"2020","journal-title":"J. Physiol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3791\/59310","article-title":"Evaluation of hemisphere lateralization with bilateral local field potential recording in secondary motor cortex of mice.","author":"Chen","year":"2019","journal-title":"J. Vis. Exp. JoVE"},{"key":"B14","doi-asserted-by":"publisher","first-page":"113221","DOI":"10.1016\/j.expneurol.2020.113221","article-title":"Unilateral accumbal dopamine depletion affects decision-making in a side-specific manner.","volume":"327","author":"Cunha","year":"2020","journal-title":"Exp. Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/s0006-8993(02)02747-6","article-title":"A 6-hydroxydopamine lesion of the mesostriatal dopamine system decreases the expression of corticotropin releasing hormone and neurotensin mRNAs in the amygdala and bed nucleus of the stria terminalis.","volume":"945","author":"Day","year":"2002","journal-title":"Brain Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1089\/neu.2014.3686","article-title":"A novel preclinical model of moderate primary blast-induced traumatic brain injury.","volume":"32","author":"Divani","year":"2015","journal-title":"J. Neurotrauma"},{"key":"B17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2020.11.013","article-title":"Characterizing the protracted neurobiological and neuroanatomical effects of paraquat in a murine model of Parkinson\u2019s disease.","volume":"100","author":"Dwyer","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e82376","DOI":"10.7554\/eLife.82376","article-title":"Sex, strain, and lateral differences in brain cytoarchitecture across a large mouse population.","volume":"12","author":"Elkind","year":"2023","journal-title":"eLife"},{"key":"B19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.nbd.2008.09.007","article-title":"Combined effects of prenatal inhibition of vasculogenesis and neurogenesis on rat brain development.","volume":"32","author":"Fan","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1007\/s12035-014-8936-x","article-title":"Stronger dopamine D1 receptor-mediated neurotransmission in dyskinesia.","volume":"52","author":"Farr\u00e9","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1002\/mds.28682","article-title":"Asymmetric dopamine transporter loss affects cognitive and motor progression in Parkinson\u2019s disease.","volume":"36","author":"Fiorenzato","year":"2021","journal-title":"Mov. Disord."},{"key":"B22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0920-1211(94)90076-0","article-title":"Persistent increases in dopamine D2 receptor mRNA expression in basal ganglia following kindling.","volume":"17","author":"Gelbard","year":"1994","journal-title":"Epilepsy Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41583-022-00584-7","article-title":"Linking interindividual variability in brain structure to behaviour.","volume":"23","author":"Genon","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11065-022-09575-y","article-title":"Variability in hemispheric functional segregation phenotypes: a review and general mechanistic model.","volume":"34","author":"Gerrits","year":"2024","journal-title":"Neuropsychol. Rev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1089\/neu.2006.23.950","article-title":"N-methyl-D-aspartate receptor subunit changes after traumatic injury to the developing brain.","volume":"23","author":"Giza","year":"2006","journal-title":"J. Neurotrauma."},{"key":"B26","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1089\/08977150260190401","article-title":"Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticity.","volume":"19","author":"Griesbach","year":"2002","journal-title":"J. Neurotrauma."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1152\/physrev.00006.2019","article-title":"Brain lateralization: a comparative perspective.","volume":"100","author":"G\u00fcnt\u00fcrk\u00fcn","year":"2020","journal-title":"Physiol. Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/s0006-8993(98)00874-9","article-title":"Methamphetamine induces fos expression in the striatum and the substantia nigra pars reticulata in a rat model of Parkinson\u2019s disease.","volume":"809","author":"Ishida","year":"","journal-title":"Brain Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S0168-0102(98)00015-7","article-title":"Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers.","volume":"30","author":"Ishida","year":"","journal-title":"Neurosci. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1357650X.2024.2341459","article-title":"Measuring paw preferences in dogs, cats and rats: design requirements and innovations in methodology.","volume":"29","author":"Isparta","year":"2024","journal-title":"Laterality"},{"key":"B31","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/s0166-4328(99)00068-6","article-title":"Akinesia and postural abnormality after unilateral dopamine depletion.","volume":"104","author":"Johnson","year":"1999","journal-title":"Behav. Brain Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0006-8993(83)91254-4","article-title":"Recovery of function and basal ganglia [14C]2-deoxyglucose uptake after nigrostriatal injury.","volume":"259","author":"Kozlowski","year":"1983","journal-title":"Brain Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"774247","DOI":"10.3389\/fneur.2021.774247","article-title":"Stroke lateralization in large hemisphere infarctions: characteristics, stroke-related complications, and outcomes.","volume":"12","author":"Li","year":"2021","journal-title":"Front. Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/jcbfm.1984.56","article-title":"Decreased cortical glucose utilization after ibotenate lesion of the rat ventromedial globus pallidus.","volume":"4","author":"London","year":"1984","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"B35","doi-asserted-by":"publisher","first-page":"103416","DOI":"10.1016\/j.nicl.2023.103416","article-title":"The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer\u2019s disease.","volume":"38","author":"Lu","year":"2023","journal-title":"NeuroImage Clin."},{"key":"B36","doi-asserted-by":"publisher","first-page":"fcab211","DOI":"10.1093\/braincomms\/fcab211","article-title":"The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases.","volume":"3","author":"Lubben","year":"2021","journal-title":"Brain Commun."},{"key":"B37","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.neubiorev.2021.05.011","article-title":"Paw preferences in mice and rats: meta-analysis.","volume":"127","author":"Manns","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.pbiomolbio.2010.10.005","article-title":"Distinct temporal patterns of electrical stimulation influence neural recruitment during PTZ infusion: an fMRI study.","volume":"105","author":"Mesquita","year":"2011","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fncel.2018.00023","article-title":"Immunosignals of oligodendrocyte markers and myelin-associated proteins are critically affected after experimental stroke in wild-type and Alzheimer modeling mice of different ages.","volume":"12","author":"Michalski","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1085989","DOI":"10.3389\/fnagi.2022.1085989","article-title":"Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer\u2019s disease.","volume":"14","author":"Morrissey","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"102658","DOI":"10.1016\/j.cpr.2025.102658","article-title":"Substance use disorder and altered hemispheric asymmetries: a systematic review.","volume":"122","author":"Mundorf","year":"","journal-title":"Clin. Psychol. Rev."},{"key":"B42","doi-asserted-by":"publisher","first-page":"106345","DOI":"10.1016\/j.neubiorev.2025.106345","article-title":"Dementia and handedness: meta-analyses.","volume":"177","author":"Mundorf","year":"","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1007\/s00406-024-01888-8","article-title":"Hemispheric asymmetries in borderline personality disorder: a systematic review.","volume":"275","author":"Mundorf","year":"2024","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B44","doi-asserted-by":"crossref","DOI":"10.4324\/9781003082507","volume-title":"The Clinical Neuroscience of Lateralization.","author":"Mundorf","year":"2021"},{"key":"B45","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s44220-025-00405-7","article-title":"Addressing the oversight of hemispheric differences in psychiatry research.","volume":"3","author":"Mundorf","year":"","journal-title":"Nat. Ment. Health"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e70249","DOI":"10.1111\/ejn.70249","article-title":"Looking at both sides: integrating data from both hemispheres is crucial in rodent neuroscience.","volume":"62","author":"Mundorf","year":"","journal-title":"Eur. J. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"6072","DOI":"10.1038\/s41380-025-03319-z","article-title":"Low-intensity transcranial focused ultrasound neuromodulation of the amygdala: Is left always right?","volume":"30","author":"Mundorf","year":"","journal-title":"Mol. Psychiatry"},{"key":"B48","doi-asserted-by":"crossref","unstructured":"Exploring Hemispheric Vulnerability in Crossed Cerebellar Diaschisis: A Systematic Review and Meta-Analysis.\n          \n          e1724985\n          \n            \n              Mundorf\n              A.\n            \n            \n              Stratmann\n              C.\n            \n            \n              Adzaho\n              R.\n            \n            \n              Sch\u00fa\u00dfler\n              M.\n            \n            \n              Peterburs\n              J.\n            \n          \n          Behavioural neurology\n          2026\n          2026","DOI":"10.1155\/bn\/1724985"},{"key":"B49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fnsys.2016.00019","article-title":"Facilitating mitochondrial calcium uptake improves activation-induced cerebral blood flow and behavior after mTBI.","volume":"10","author":"Murugan","year":"2016","journal-title":"Front. Syst. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1528-1157.1979.tb04817.x","article-title":"Hemispheric asymmetry of pentamethylenetetrazol-induced wave-spike discharges and motor imbalance in rats.","volume":"20","author":"Myslobodsky","year":"1979","journal-title":"Epilepsia"},{"key":"B51","doi-asserted-by":"publisher","first-page":"114657","DOI":"10.1016\/j.bbr.2023.114657","article-title":"Lateralization of the hippocampus: a review of molecular, functional, and physiological properties in health and disease.","volume":"454","author":"Nemati","year":"2023","journal-title":"Behav. Brain Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3109\/00207459209000554","article-title":"Hemispheric asymmetry in the effects of substantia nigra lesioning on lymphocyte reactivity in mice.","volume":"64","author":"Neveu","year":"1992","journal-title":"Int. J. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3938523","DOI":"10.1155\/2016\/3938523","article-title":"Comparison of neuroprotective effect of bevacizumab and sildenafil following induction of stroke in a mouse model.","volume":"2016","author":"Novitzky","year":"2016","journal-title":"BioMed. Res. Int."},{"key":"B54","volume-title":"The Lateralized Brain: The Neuroscience and Evolution of Hemispheric Asymmetries.","author":"Ocklenburg","year":"2024"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3389\/fpsyg.2014.01143","article-title":"Lateralization and cognitive systems.","volume":"5","author":"Ocklenburg","year":"2014","journal-title":"Front. Psychol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e2204881119","DOI":"10.1073\/pnas.2204881119","article-title":"Symmetry and asymmetry in biological structures.","volume":"119","author":"Ocklenburg","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41582-024-00974-8","article-title":"Clinical implications of brain asymmetries.","volume":"20","author":"Ocklenburg","year":"2024","journal-title":"Nat. Rev. Neurol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"102283","DOI":"10.1016\/j.pneurobio.2022.102283","article-title":"Hemispheric asymmetries in the amygdala: a comparative primer.","volume":"214","author":"Ocklenburg","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.celrep.2018.01.085","article-title":"A\u00df Facilitates LTD at schaffer collateral synapses preferentially in the left hippocampus.","volume":"22","author":"O\u2019Riordan","year":"2018","journal-title":"Cell Rep."},{"key":"B60","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1037\/bul0000471","article-title":"Handedness in mental and neurodevelopmental disorders: a systematic review and second-order meta-analysis.","volume":"151","author":"Packheiser","year":"2025","journal-title":"Psychol. Bull."},{"key":"B61","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"B62","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1097\/FBP.0000000000000483","article-title":"Functional lateralization in the prefrontal cortex of dopaminergic modulation of memory consolidation.","volume":"30","author":"Papp","year":"2019","journal-title":"Behav. Pharmacol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"imag_a_00437","DOI":"10.1162\/imag_a_00437","article-title":"Evidence for a compensatory relationship between left- and right-lateralized brain networks.","volume":"3","author":"Peterson","year":"2025","journal-title":"Imaging Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1111\/epi.18509","article-title":"Asymmetry of generalized discharges in idiopathic generalized epilepsy in adults.","volume":"66","author":"Pizarro","year":"2025","journal-title":"Epilepsia"},{"key":"B65","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41380-024-02687-2","article-title":"The universe is asymmetric, the mouse brain too.","volume":"30","author":"Rivera-Olvera","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"B66","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0006-8993(80)90557-0","article-title":"The differential effect of right versus left hemispheric cerebral infarction on catecholamines and behavior in the rat.","volume":"188","author":"Robinson","year":"1980","journal-title":"Brain Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/s41467-021-21057-y","article-title":"Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer\u2019s disease.","volume":"12","author":"Roe","year":"2021","journal-title":"Nat. Commun."},{"key":"B68","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/s0006-8993(97)00475-7","article-title":"Hemispheric asymmetries in spontaneous firing characteristics of substantia nigra pars reticulata neurons following a unilateral 6-hydroxydopamine lesion of the rat nigrostriatal pathway.","volume":"761","author":"Rohlfs","year":"1997","journal-title":"Brain Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"CNC101","DOI":"10.2217\/cnc-2022-0003","article-title":"Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury.","volume":"8","author":"Ross","year":"2023","journal-title":"Concussion"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.2967\/jnumed.120.242750","article-title":"Asymmetry of fibrillar plaque burden in amyloid mouse models.","volume":"61","author":"Sacher","year":"2020","journal-title":"J. Nucl. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.neuroscience.2014.12.074","article-title":"Sexual dimorphism and brain lateralization impact behavioral and histological outcomes following hypoxia\u2013ischemia in P3 and P7 rats.","volume":"290","author":"Sanches","year":"2015","journal-title":"Neuroscience"},{"key":"B72","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.neuroscience.2013.01.066","article-title":"Early hypoxia-ischemia causes hemisphere and sex-dependent cognitive impairment and histological damage.","volume":"237","author":"Sanches","year":"","journal-title":"Neuroscience"},{"key":"B73","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.brainres.2013.02.040","article-title":"Are the consequences of neonatal hypoxia-ischemia dependent on animals\u2019 sex and brain lateralization?","volume":"1507","author":"Sanches","year":"","journal-title":"Brain Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1089\/neu.1990.7.207","article-title":"Early polymorphonuclear leukocyte accumulation correlates with the development of posttraumatic cerebral edema in rats.","volume":"7","author":"Schoettle","year":"1990","journal-title":"J. Neurotrauma."},{"key":"B75","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neulet.2017.05.032","article-title":"Investigation of left and right lateral fluid percussion injury in C57BL6\/J mice: in vivo functional consequences.","volume":"653","author":"Schurman","year":"2017","journal-title":"Neurosci. Lett."},{"key":"B76","doi-asserted-by":"publisher","first-page":"121017","DOI":"10.1016\/j.neuroimage.2025.121017","article-title":"Left-right brain-wide asymmetry of neuroanatomy in the mouse brain.","volume":"307","author":"Silberfeld","year":"2025","journal-title":"NeuroImage"},{"key":"B77","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijpsycho.2020.11.001","article-title":"A conceptual critique of brain lateralization models in emotional face perception: toward a hemispheric functional-equivalence (HFE) model.","volume":"160","author":"Stankovi\u0107","year":"2021","journal-title":"Int. J. Psychophysiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1080\/23279095.2021.1907392","article-title":"Laterality in Parkinson\u2019s disease: a neuropsychological review.","volume":"30","author":"Steinbach","year":"2021","journal-title":"Appl. Neuropsychol. Adult"},{"key":"B79","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.pnpbp.2014.05.002","article-title":"Mesocortical dopamine depletion and anxiety-related behavior in the rat: sex and hemisphere differences.","volume":"54","author":"Sullivan","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B80","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/0006-8993(94)91223-8","article-title":"Asymmetrical orientation to edges of an openfield: modulation by striatal dopamine and relationship to motor asymmetries in the rat.","volume":"637","author":"Sullivan","year":"1994","journal-title":"Brain Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.brainres.2006.10.032","article-title":"Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice.","volume":"1130","author":"Tashlykov","year":"2007","journal-title":"Brain Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.brainresbull.2016.03.021","article-title":"Comparative power spectrum analysis of EEG activity in spontaneously hypertensive and Wistar rats in kainate model of temporal model of epilepsy.","volume":"124","author":"Tchekalarova","year":"2016","journal-title":"Brain Res. Bull."},{"key":"B83","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1089\/neu.2019.6487","article-title":"White matter asymmetry: a reflection of pathology in traumatic brain injury.","volume":"37","author":"Vakhtin","year":"2020","journal-title":"J. Neurotrauma."},{"key":"B84","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cortex.2019.11.018","article-title":"A function for the bicameral mind.","volume":"124","author":"Vallortigara","year":"2020","journal-title":"Cortex J. Devoted Study Nerv. Syst. Behav."},{"key":"B85","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/mds.24007","article-title":"Handedness correlates with the dominant Parkinson side: a systematic review and meta-analysis.","volume":"27","author":"van der Hoorn","year":"2012","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"B86","doi-asserted-by":"publisher","first-page":"5154","DOI":"10.3390\/jcm13175154","article-title":"Symptom persistence relates to volume and asymmetry of the limbic system after mild traumatic brain injury.","volume":"13","author":"Vanier","year":"2024","journal-title":"J. Clin. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neuroscience.2012.03.060","article-title":"Lateral asymmetry of early seizure manifestations in experimental generalized epilepsy.","volume":"213","author":"Vinogradova","year":"2012","journal-title":"Neuroscience"},{"key":"B88","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s11055-011-9500-z","article-title":"Post-stroke neurological impairments in rats with functional asymmetry of the cerebral hemispheres.","volume":"41","author":"Volkov","year":"2011","journal-title":"Neurosci. Behav. Physiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1093\/brain\/aww243","article-title":"Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala.","volume":"139","author":"Wachinger","year":"2016","journal-title":"Brain J. Neurol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s12011-012-9546-y","article-title":"The effects of zinc treatment on the blood\u2013brain barrier permeability and brain element levels during convulsions.","volume":"151","author":"Yorulmaz","year":"2013","journal-title":"Biol. Trace Elem. Res"},{"key":"B91","doi-asserted-by":"publisher","first-page":"39280","DOI":"10.1038\/s41598-025-23098-5","article-title":"Impact of gliomas in different brain hemispheres on anxiety and the prognosis of neurosurgical patients.","volume":"15","author":"Zhao","year":"2025","journal-title":"Sci. Rep."},{"key":"B92","doi-asserted-by":"publisher","first-page":"e2484","DOI":"10.1002\/brb3.2484","article-title":"Interhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy.","volume":"12","author":"Zhao","year":"2022","journal-title":"Brain Behav."},{"key":"B93","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/00008506-198906000-00004","article-title":"EEG changes during carotid occlusion and hypotension in the rat: the effects of nitrous oxide.","volume":"1","author":"Zhou","year":"1989","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"5004","DOI":"10.1007\/s00415-023-11849-1","article-title":"Study of the relationship between onset lateralization and hemispheric white matter asymmetry in Parkinson\u2019s disease.","volume":"270","author":"Zhu","year":"2023","journal-title":"J. Neurol."}],"container-title":["Frontiers in Integrative Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnint.2026.1843068\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:35:48Z","timestamp":1786019748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnint.2026.1843068\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":94,"alternative-id":["10.3389\/fnint.2026.1843068"],"URL":"https:\/\/doi.org\/10.3389\/fnint.2026.1843068","relation":{},"ISSN":["1662-5145"],"issn-type":[{"value":"1662-5145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"article-number":"1843068"}}