{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:21:31Z","timestamp":1771521691919,"version":"3.50.1"},"reference-count":54,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2014.00060","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T09:53:50Z","timestamp":1403862830000},"source":"Crossref","is-referenced-by-count":10,"title":["PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform"],"prefix":"10.3389","volume":"7","author":[{"given":"Anuradha","family":"Dhingra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanti R.","family":"Tummala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arkady","family":"Lyubarsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noga","family":"Vardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0896-6273(94)90160-0","article-title":"Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors","volume":"12","author":"Ahmad","year":"1994","journal-title":"Neuron"},{"key":"B2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1152\/physrev.1995.75.4.725","article-title":"Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms","volume":"75","author":"Beavo","year":"1995","journal-title":"Physiol. Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1017\/S0952523803202078","article-title":"Activation of the cGMP\/nitric oxide signal transduction system by nicotine in the retina","volume":"20","author":"Blute","year":"2003","journal-title":"Vis. Neurosci"},{"key":"B4","first-page":"295","article-title":"Analysis of ERG a-wave amplification and kinetics in terms of the G-protein cascade of phototransduction","volume":"35","author":"Breton","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1113\/jphysiol.2003.052738","article-title":"Ganglion cell contributions to the rat full-field electroretinogram","volume":"555","author":"Bui","year":"2004","journal-title":"J. Physiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1017\/S0952523899162175","article-title":"Light and electron microscopical analysis of nitric oxide synthase-like immunoreactive neurons in the rat retina","volume":"16","author":"Chun","year":"1999","journal-title":"Vis. Neurosci"},{"key":"B7","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1523\/JNEUROSCI.15-05-03571.1995","article-title":"L-glutamate-induced responses and cGMP-activated channels in three subtypes of retinal bipolar cells dissociated from the cat","volume":"15","author":"de la Villa","year":"1995","journal-title":"J. Neurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1002\/cne.21807","article-title":"Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse","volume":"510","author":"Dhingra","year":"2008","journal-title":"J. Comp. Neurol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1136\/bjo.2006.100628","article-title":"Selective blockade of phosphodiesterase types 2, 5 and 9 results in cyclic 3\u00e2\u20ac\u00b25\u00e2\u20ac\u00b2 guanosine monophosphate accumulation in retinal pigment epithelium cells","volume":"91","author":"Diederen","year":"2007","journal-title":"Br. J. Ophthalmol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/cne.21206","article-title":"Distribution of soluble guanylyl cyclase in rat retina","volume":"502","author":"Ding","year":"2007","journal-title":"J. Comp. Neurol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/S0042-6989(99)00203-5","article-title":"Contribution to the kinetics and amplitude of the electroretinogram b-wave by third-order retinal neurons in the rabbit retina","volume":"40","author":"Dong","year":"2000","journal-title":"Vision Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/S0042-6989(02)00032-9","article-title":"GABAc feedback pathway modulates the amplitude and kinetics of ERG b-wave in a mammalian retina in vivo","volume":"42","author":"Dong","year":"2002","journal-title":"Vision Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1017\/S0952523810000209","article-title":"Multiple pathways of inhibition shape bipolar cell responses in the retina","volume":"28","author":"Eggers","year":"2011","journal-title":"Vis. Neurosci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1152\/jn.00872.2012","article-title":"Inhibition to retinal rod bipolar cells is regulated by light levels","volume":"110","author":"Eggers","year":"2013","journal-title":"J. Neurophysiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1016\/j.visres.2005.07.033","article-title":"Imaging of nitric oxide in the retina","volume":"45","author":"Eldred","year":"2005","journal-title":"Vision Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"15559","DOI":"10.1074\/jbc.273.25.15559","article-title":"Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase","volume":"273","author":"Fisher","year":"1998","journal-title":"J. Biol. Chem"},{"key":"B17","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1017\/S0952523898155141","article-title":"Nitric oxide modulates cGMP levels in neurons of the inner and outer retina in opposite ways","volume":"15","author":"Gotzes","year":"1998","journal-title":"Vis. Neurosci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/361076a0","article-title":"Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin","volume":"361","author":"Hsu","year":"1993","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1523\/JNEUROSCI.18-21-08936.1998","article-title":"The major cell populations of the mouse retina","volume":"18","author":"Jeon","year":"1998","journal-title":"J. Neurosci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/BFb0033670","article-title":"Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)","volume":"135","author":"Juilfs","year":"1999","journal-title":"Rev. Physiol. Biochem. Pharmacol"},{"key":"B21","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.1523\/JNEUROSCI.16-21-06807.1996","article-title":"Amino acid signatures in the primate retina","volume":"16","author":"Kalloniatis","year":"1996","journal-title":"J. Neurosci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1073\/pnas.0912730107","article-title":"TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade","volume":"107","author":"Koike","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B23","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0166-2236(92)90079-N","article-title":"G-protein cascades: gain and kinetics","volume":"15","author":"Lamb","year":"1992","journal-title":"Trends Neurosci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10633-005-2629-8","article-title":"The decline of the photopic negative response (PhNR) in the rat after optic nerve transection","volume":"111","author":"Li","year":"2005","journal-title":"Doc. Ophthalmol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1111\/j.1440-1681.1997.tb02101.x","article-title":"Protein phosphorylation events in exocytosis and endocytosis","volume":"24","author":"Liu","year":"1997","journal-title":"Clin. Exp. Pharmacol. Physiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1016\/j.visres.2004.09.019","article-title":"From candelas to photoisomerizations in the mouse eye by rhodopsin bleaching in situ and the light-rearing dependence of the major components of the mouse ERG","volume":"44","author":"Lyubarsky","year":"2004","journal-title":"Vision Res"},{"key":"B28","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1523\/JNEUROSCI.20-06-02209.2000","article-title":"Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses","volume":"20","author":"Lyubarsky","year":"2000","journal-title":"J. Neurosci"},{"key":"B29","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1523\/JNEUROSCI.19-01-00442.1999","article-title":"UV- and midwave-sensitive cone-driven retinal responses of the mouse: a possible phenotype for coexpression of cone photopigments","volume":"19","author":"Lyubarsky","year":"1999","journal-title":"J. Neurosci"},{"key":"B26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1523\/JNEUROSCI.16-02-00563.1996","article-title":"Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings","volume":"16","author":"Lyubarsky","year":"1996","journal-title":"J. Neurosci"},{"key":"B30","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1523\/JNEUROSCI.15-07-05106.1995","article-title":"Pattern recognition of amino acid signatures in retinal neurons","volume":"15","author":"Marc","year":"1995","journal-title":"J. Neurosci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0920-9964(08)70122-1","article-title":"PDE9A-mediated regulation of cGMP: impact on synaptic plasticity","volume":"102","author":"Menniti","year":"2008","journal-title":"Schizophr. Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/377734a0","article-title":"Differential properties of two gap junctional pathways made by AII amacrine cells","volume":"377","author":"Mills","year":"1995","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.exer.2009.02.009","article-title":"Retinal pathway origins of the pattern ERG of the mouse","volume":"89","author":"Miura","year":"2009","journal-title":"Exp. Eye Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1113\/jphysiol.2008.150755","article-title":"Contribution of voltage-gated sodium channels to the b-wave of the mammalian flash electroretinogram","volume":"586","author":"Mojumder","year":"2008","journal-title":"J. Physiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1152\/jn.00838.2007","article-title":"Inhibitory feedback shapes bipolar cell responses in the rabbit retina","volume":"98","author":"Molnar","year":"2007","journal-title":"J. Neurophysiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"19174","DOI":"10.1073\/pnas.0908711106","article-title":"TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells","volume":"106","author":"Morgans","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B37","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1523\/JNEUROSCI.19-08-02938.1999","article-title":"The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells","volume":"19","author":"Nawy","year":"1999","journal-title":"J. Neurosci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/346269a0","article-title":"Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells","volume":"346","author":"Nawy","year":"1990","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1523\/JNEUROSCI.5267-09.2010","article-title":"Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors","volume":"30","author":"Ng","year":"2010","journal-title":"J. Neurosci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1146\/annurev.pa.36.040196.002155","article-title":"Cyclic nucleotide phosphordiesterases and vascular smooth muscle","volume":"36","author":"Polson","year":"1996","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/cne.902330406","article-title":"A combined Golgi and autoradiographic study of (3 H)glycine-accumulating amacrine cells in the cat retina","volume":"233","author":"Pourcho","year":"1985","journal-title":"J. Comp. Neurol"},{"key":"B42","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1523\/JNEUROSCI.07-04-01189.1987","article-title":"Visualization of endogenous glycine in cat retina: an immunocytochemical study with Fab fragments","volume":"7","author":"Pourcho","year":"1987","journal-title":"J. Neurosci"},{"key":"B43","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1017\/S0952523805225129","article-title":"Pharmacological studies of the mouse cone electroretinogram","volume":"22","author":"Sharma","year":"2005","journal-title":"Vis. Neurosci"},{"key":"B44","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1098\/rspb.1990.0109","article-title":"Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein","volume":"242","author":"Shiells","year":"1990","journal-title":"Proc. Biol. Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1098\/rspb.1992.0004","article-title":"Properties of the cGMP-activated channel of retinal on-bipolar cells","volume":"247","author":"Shiells","year":"1992","journal-title":"Proc. Biol. Sci"},{"key":"B46","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1113\/jphysiol.2002.019752","article-title":"Potentiation of \u00e2\u20ac\u02dcon\u00e2\u20ac\u2122 bipolar cell flash responses by dim background light and cGMP in dogfish retinal slices","volume":"542","author":"Shiells","year":"2002","journal-title":"J. Physiol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.exer.2008.03.008","article-title":"Postreceptoral contributions to the light-adapted ERG of mice lacking b-waves","volume":"86","author":"Shirato","year":"2008","journal-title":"Exp. Eye Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/nn.2370","article-title":"Genetic address book for retinal cell types","volume":"12","author":"Siegert","year":"2009","journal-title":"Nat. Neurosci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"6621","DOI":"10.1523\/JNEUROSCI.1474-04.2004","article-title":"cGMP-dependent kinase regulates response sensitivity of the mouse on bipolar cell","volume":"24","author":"Snellman","year":"2004","journal-title":"J. Neurosci"},{"key":"B50","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1385\/1-59259-839-0:075","article-title":"Localization of cyclic guanosine 3\u00e2\u20ac\u00b2,5\u00e2\u20ac\u00b2-monophosphate-hydrolyzing phosphodiesterase type 9 in rat brain by nonradioactive in situ hydridization","volume":"307","author":"van Staveren","year":"2005","journal-title":"Methods Mol. Biol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/cne.903510305","article-title":"Specific cell types in cat retina express different forms of glutamic acid decarboxylase","volume":"351","author":"Vardi","year":"1995","journal-title":"J. Comp. Neurol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1017\/S0952523803203084","article-title":"Pharmacological analysis of the rat cone electroretinogram","volume":"20","author":"Xu","year":"2003","journal-title":"Vis. Neurosci"},{"key":"B53","first-page":"9","article-title":"Phototransduction mechanism in retinal rods and cones","volume":"35","author":"Yau","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1017\/S0952523805226123","article-title":"Gycine and GABA interact to regulate the nitric oxide\/cGMP signaling pathway in the turtle retina","volume":"22","author":"Yu","year":"2005","journal-title":"Vis. Neurosci"}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:03:22Z","timestamp":1565568202000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2014.00060\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,27]]},"references-count":54,"URL":"https:\/\/doi.org\/10.3389\/fnmol.2014.00060","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,27]]}}}