{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:35:37Z","timestamp":1791876937117,"version":"4.3.4"},"reference-count":84,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS096332"],"award-info":[{"award-number":["NS096332"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2016.00061","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T03:19:32Z","timestamp":1469503172000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Analysis of Amyloid Precursor Protein Function in Drosophila melanogaster"],"prefix":"10.3389","volume":"9","author":[{"given":"Marl\u00e8ne","family":"Cassar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Kretzschmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1155\/2009\/365637","article-title":"Classification of nonenzymatic homologues of protein kinases","volume":"2009","author":"Anamika","year":"2009","journal-title":"Comp. Funct. Genomics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1002\/ana.410300509","article-title":"Expression patterns of beta-amyloid precursor protein (beta-APP) in neural and nonneural human tissues from Alzheimer\u2019s disease and control subjects","volume":"30","author":"Arai","year":"1991","journal-title":"Ann. Neurol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/s0006-291x(05)81412-3","article-title":"Trophic effect of \u03b2-amyloid precursor protein on cerebral cortical neurons in culture","volume":"181","author":"Araki","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5943","DOI":"10.1523\/JNEUROSCI.1144-05.2005","article-title":"Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11\/Mint","volume":"25","author":"Ashley","year":"2005","journal-title":"J. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"D786","DOI":"10.1093\/nar\/gkv1046","article-title":"FlyBase: establishing a gene group resource for Drosophila melanogaster","volume":"44","author":"Attrill","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1073\/pnas.58.3.1112","article-title":"Behavioral mutants of Drosophila isolated by countercurrent distribution","volume":"58","author":"Benzer","year":"1967","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.nbd.2015.02.012","article-title":"Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila","volume":"77","author":"Blake","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"16181","DOI":"10.1523\/JNEUROSCI.0228-12.2012","article-title":"\u03b2-secretase cleavage of the fly amyloid precursor protein is required for glial survival","volume":"32","author":"Bolkan","year":"2012","journal-title":"J. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.3233\/JAD-142802","article-title":"Drosophila models of Alzheimer\u2019s disease: advances, limits and perspectives","volume":"45","author":"Bouleau","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"24601","DOI":"10.1074\/jbc.m402248200","article-title":"Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation","volume":"279","author":"Cao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.nbd.2008.10.014","article-title":"Neurotoxic effects induced by the Drosophila amyloid-\u03b2 peptide suggest a conserved toxic function","volume":"33","author":"Carmine-Simmen","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"17117","DOI":"10.1073\/pnas.0904397106","article-title":"Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for down syndrome","volume":"106","author":"Chang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B11","doi-asserted-by":"publisher","first-page":"15794","DOI":"10.1073\/pnas.2536696100","article-title":"The Drosophila homolog of down\u2019s syndrome critical region 1 gene regulates learning: implications for mental retardation","volume":"100","author":"Chang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e89847","DOI":"10.1371\/journal.pone.0089847","article-title":"Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKgamma mutant Loechrig","volume":"9","author":"Cook","year":"2014","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e44440","DOI":"10.1371\/journal.pone.0044440","article-title":"Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration","volume":"7","author":"Cook","year":"2012","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0012-1606(89)80040-5","article-title":"Development of the enteric nervous system in the moth. II. Stereotyped cell migration precedes the differentiation of embryonic neurons","volume":"131","author":"Copenhaver","year":"1989","journal-title":"Dev. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/s0197-0186(99)00125-4","article-title":"What the evolution of the amyloid protein precursor supergene family tells us about its function","volume":"36","author":"Coulson","year":"2000","journal-title":"Neurochem. Int."},{"key":"B16","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1042\/BST0380988","article-title":"Insights from Drosophila models of Alzheimer\u2019s disease","volume":"38","author":"Cowan","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"B17","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.tips.2016.01.005","article-title":"APP receptor? To be or not to be","volume":"37","author":"Deyts","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1093\/hmg\/9.11.1681","article-title":"DSCR1, overexpressed in down syndrome, is an inhibitor of calcineurin-mediated signaling pathways","volume":"9","author":"Fuentes","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"B118","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/379074a0","article-title":"Activation of K+ channels and suppression of neuronal activity by secreted \u03b2-amyloid-precursor protein","volume":"379","author":"Furukawa","year":"1996","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","first-page":"10501","DOI":"10.1073\/pnas.92.23.10501","article-title":"Fasciclin II controls proneural gene expression in Drosophila","volume":"92","author":"Garc\u00eda-Alonso","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B101","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/s0006-291x(84)80190-4","article-title":"Alzheimer\u2019s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B103","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1126\/science.3810169","article-title":"Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer\u2019s disease","volume":"235","author":"Goldgaber","year":"1987","journal-title":"Science"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/exnr.1994.1107","article-title":"Secreted forms of \u03b2-amyloid precursor protein protect hippocampal neurons against amyloid \u03b2-peptide-induced oxidative injury","volume":"128","author":"Goodman","year":"1994","journal-title":"Exp. Neurol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/s0074-7742(08)60542-5","article-title":"Assembly and maturation of the Drosophila larval neuromuscular junction","volume":"43","author":"Gramates","year":"1999","journal-title":"Int. Rev. Neurobiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"8575","DOI":"10.1523\/JNEUROSCI.5749-12.2013","article-title":"X11\/Mint genes control polarized localization of axonal membrane proteins in vivo","volume":"33","author":"Gross","year":"2013","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/s0896-6273(01)00496-2","article-title":"Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila","volume":"32","author":"Gunawardena","year":"2001","journal-title":"Neuron"},{"key":"B22","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1515\/revneuro-2015-0017","article-title":"Traumatic brain injury: a risk factor for neurodegenerative diseases","volume":"27","author":"Gupta","year":"2016","journal-title":"Rev. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.conb.2013.02.018","article-title":"Circadian timekeeping and output mechanisms in animals","volume":"23","author":"Hardin","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1046\/j.1471-4159.2002.00911.x","article-title":"Expression and characterization of the Drosophila X11-like\/Mint protein during neural development","volume":"81","author":"Hase","year":"2002","journal-title":"J. Neurochem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nrn1074","article-title":"Mushroom body memoir: from maps to models","volume":"4","author":"Heisenberg","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e55810","DOI":"10.1371\/journal.pone.0055810","article-title":"Neurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding protein","volume":"8","author":"Hopkins","year":"2013","journal-title":"PLoS One"},{"key":"B26","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3233\/JAD-2011-102115","article-title":"The impact of a novel apolipoprotein E and amyloid-beta protein precursor-interacting protein on the production of amyloid-beta","volume":"26","author":"Hopkins","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1083\/jcb.200304014","article-title":"Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex","volume":"161","author":"Hu","year":"2003","journal-title":"J. Cell Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00429-009-0234-4","article-title":"Transgenic Drosophila models of Alzheimer\u2019s disease and tauopathies","volume":"214","author":"Iijima-Ando","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1002\/dvdy.23879","article-title":"Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap\/Cin85 ortholog","volume":"241","author":"Johnson","year":"2012","journal-title":"Dev. Dyn."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7535","DOI":"10.1523\/JNEUROSCI.3739-12.2013","article-title":"Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer\u2019s disease model","volume":"33","author":"Johnson","year":"2013","journal-title":"J. Neurosci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/325733a0","article-title":"The precursor of Alzheimer\u2019s disease amyloid A4 protein resembles a cell-surface receptor","volume":"325","author":"Kang","year":"1987","journal-title":"Nature"},{"key":"B117","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/s0968-0004(98)01340-1","article-title":"Dealing with energy demand: the AMP-activated protein kinase","volume":"24","author":"Kemp","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ydbio.2004.01.032","article-title":"A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity","volume":"269","author":"Lai","year":"2004","journal-title":"Dev. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1038\/sj.emboj.7600757","article-title":"Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain","volume":"24","author":"Leyssen","year":"2005","journal-title":"EMBO J."},{"key":"B112","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/neu.20048","article-title":"Specific functions of Drosophila amyloid precursor-like protein in the development of nervous system and nonneural tissues","volume":"61","author":"Li","year":"2004","journal-title":"J. Neurobiol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/0306-4522(94)00555-j","article-title":"Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor\/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein","volume":"65","author":"Lorent","year":"1995","journal-title":"Neuroscience"},{"key":"B33","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1523\/JNEUROSCI.10-12-03849.1990","article-title":"Identification, secretion and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor","volume":"10","author":"Luo","year":"1990","journal-title":"J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0896-6273(92)90024-8","article-title":"Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene","volume":"9","author":"Luo","year":"1992","journal-title":"Neuron"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1126\/science.1089610","article-title":"Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling","volume":"302","author":"Lyuksyutova","year":"2003","journal-title":"Science"},{"key":"B109","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1242\/dev.110.1.185","article-title":"The Drosophila transcript encoded by the beta-amyloid protein precursor-like gene is restricted to the nervous system","volume":"110","author":"Martin-Morris","year":"1990","journal-title":"Development"},{"key":"B102","doi-asserted-by":"publisher","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B121","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0896-6273(93)90315-i","article-title":"Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein","volume":"10","author":"Mattson","year":"1993","journal-title":"Neuron"},{"key":"B35","first-page":"1363","article-title":"The development of the optic lobe","volume-title":"The Development of Drosophila Melanogaster","author":"Meinertzhagen","year":"1993"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1038\/sj.emboj.7600413","article-title":"Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila","volume":"23","author":"Merdes","year":"2004","journal-title":"EMBO J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1391","DOI":"10.1038\/cddis.2014.352","article-title":"Holo-APP and G-protein-mediated signaling are required for sAPPalpha-induced activation of the Akt survival pathway","volume":"5","author":"Milosch","year":"2014","journal-title":"Cell Death Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.tibs.2009.11.004","article-title":"Alzheimer\u2019s disease: insights from Drosophila melanogaster models","volume":"35","author":"Moloney","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1242\/jcs.114785","article-title":"\u03b2 amyloid protein precursor-like (Appl) is a Ras1\/MAPK-regulated gene required for axonal targeting in Drosophila photoreceptor neurons","volume":"126","author":"Mora","year":"2013","journal-title":"J. Cell Sci."},{"key":"B123","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/j.1471-4159.2005.03595.x","article-title":"Sialylation enhances the secretion of neurotoxic amyloid-\u03b2 peptides","volume":"96","author":"Nakagawa","year":"2006","journal-title":"J. Neurochem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dev.068668","article-title":"Wnt\/PCP proteins regulate stereotyped axon branch extension in Drosophila","volume":"139","author":"Ng","year":"2012","journal-title":"Development"},{"key":"B124","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/nature07767","article-title":"APP binds DR6 to trigger axon pruning and neuron death via distinct caspases","volume":"457","author":"Nikolaev","year":"2009","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1534\/genetics.112.144667","article-title":"Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep","volume":"192","author":"Pirooznia","year":"2012","journal-title":"Genetics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s00221-011-2860-3","article-title":"Analysis of amyloid precursor protein function in Drosophila melanogaster","volume":"217","author":"Poeck","year":"2012","journal-title":"Exp. Brain Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1750-1326-8-35","article-title":"Drosophila melanogaster as a model organism for Alzheimer\u2019s disease","volume":"8","author":"Pr\u00fc\u00dfing","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"B44","doi-asserted-by":"publisher","first-page":"10165","DOI":"10.1523\/jneurosci.1146-13.2013","article-title":"Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration","volume":"33","author":"Ramaker","year":"2013","journal-title":"J. Neurosci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1073\/pnas.84.12.4190","article-title":"Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides","volume":"84","author":"Robakis","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1073\/pnas.86.7.2478","article-title":"A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor","volume":"86","author":"Rosen","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1006\/nbdi.1994.0003","article-title":"APP gene family: unique age-associated changes in splicing of Alzheimer\u2019s \u03b2A4-amyloid protein precursor","volume":"1","author":"Sandbrink","year":"1994a","journal-title":"Neurobiol. Dis."},{"key":"B47","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/S0021-9258(17)42286-1","article-title":"\u03b2 A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons","volume":"269","author":"Sandbrink","year":"1994b","journal-title":"J. Biol. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1003792","DOI":"10.1371\/journal.pgen.1003792","article-title":"Nebula\/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3\u03b2 signaling","volume":"9","author":"Shaw","year":"2013","journal-title":"PLoS Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0006-8993(99)02113-7","article-title":"Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model","volume":"853","author":"Shi","year":"2000","journal-title":"Brain Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.devcel.2012.04.021","article-title":"Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated notch and APP-like cleavages","volume":"23","author":"Singh","year":"2012","journal-title":"Dev. Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e1001562","DOI":"10.1371\/journal.pbio.1001562","article-title":"The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling","volume":"11","author":"Soldano","year":"2013","journal-title":"PLoS Biol."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004466","article-title":"Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening","author":"Sone","year":"2009","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1128\/MCB.00030-10","article-title":"In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity","volume":"30","author":"Stempfle","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ydbio.2005.09.029","article-title":"The insect homologue of the amyloid precursor protein interacts with the heterotrimeric G protein go alpha in an identified population of migratory neurons","volume":"288","author":"Swanson","year":"2005","journal-title":"Dev. Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/0006-291x(89)92760-5","article-title":"Tissue-specific expression of three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer\u2019s disease brain","volume":"165","author":"Tanaka","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.1471-4159.2006.04215.x","article-title":"Novel modulators of amyloid-beta precursor protein processing","volume":"100","author":"Tang","year":"2007","journal-title":"J. Neurochem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1126\/science.2949367","article-title":"Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus","volume":"235","author":"Tanzi","year":"1987","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/s0960-9822(99)80215-2","article-title":"Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport","volume":"9","author":"Torroja","year":"1999","journal-title":"Curr. Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"6367","DOI":"10.1093\/emboj\/cdf636","article-title":"The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and Appl processing","volume":"21","author":"Tsch\u00e4pe","year":"2002","journal-title":"EMBO J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0301-0082(03)00089-3","article-title":"Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory","volume":"70","author":"Turner","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.pharep.2016.01.006","article-title":"Brain ischemia with Alzheimer phenotype dysregulates Alzheimer\u2019s disease-related proteins","volume":"68","author":"U\u0142amek-Kozio\u0142","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.1242\/jcs.01323","article-title":"The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor","volume":"117","author":"von Rotz","year":"2004","journal-title":"J. Cell Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.nbd.2011.12.047","article-title":"Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration","volume":"46","author":"Wentzell","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B60","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.nbd.2010.03.007","article-title":"Alzheimer\u2019s disease and tauopathy studies in flies and worms","volume":"40","author":"Wentzell","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/ana.410170310","article-title":"Occurrence of neuropathological changes and dementia of Alzheimer\u2019s disease in down\u2019s syndrome","volume":"17","author":"Wisniewski","year":"1985","journal-title":"Ann. Neurol."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T19:49:11Z","timestamp":1656877751000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fnmol.2016.00061\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,26]]},"references-count":84,"URL":"https:\/\/doi.org\/10.3389\/fnmol.2016.00061","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,26]]}}}