{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:00:50Z","timestamp":1791406850477,"version":"4.3.3"},"reference-count":101,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_155952\/1"],"award-info":[{"award-number":["310030_155952\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2016.00150","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T22:59:15Z","timestamp":1482274755000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":92,"title":["Prenatal Valproate Exposure Differentially Affects Parvalbumin-Expressing Neurons and Related Circuits in the Cortex and Striatum of Mice"],"prefix":"10.3389","volume":"9","author":[{"given":"Emanuel","family":"Lauber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Filice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Schwaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/BF00191452","article-title":"Postnatal development of parvalbumin and calbindin D28K immunoreactivities in the cerebral cortex of the rat.","volume":"188","author":"Alcantara","year":"1993","journal-title":"Anat. Embryol."},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","author":"American Psychiatric Association","year":"2013","journal-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-5."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1017\/S1461145712001216","article-title":"Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism.","volume":"16","author":"Banerjee","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"13222","DOI":"10.1073\/pnas.192233099","article-title":"Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks.","volume":"99","author":"Bartos","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1212\/WNL.0b013e31827dec42","article-title":"HCN channels: function and clinical implications.","volume":"80","author":"Benarroch","year":"2013","journal-title":"Neurology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00441-014-1806-z","article-title":"Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia.","volume":"357","author":"Berridge","year":"2014","journal-title":"Cell Tissue Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1152\/physrev.00029.2008","article-title":"Hyperpolarization-activated cation channels: from genes to function.","volume":"89","author":"Biel","year":"2009","journal-title":"Physiol. Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/jnnp-2012-304270","article-title":"The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs.","volume":"84","author":"Bromley","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","article-title":"Mechanisms of gamma oscillations.","volume":"35","author":"Buzsaki","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s00424-014-1549-4","article-title":"Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsy.","volume":"467","author":"Cain","year":"2015","journal-title":"Pflugers Arch."},{"key":"B11","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/0306-4522(90)90091-H","article-title":"Calbindin D-28k and parvalbumin in the rat nervous system.","volume":"35","author":"Celio","year":"1990","journal-title":"Neuroscience"},{"key":"B12","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/293300a0","article-title":"Calcium-binding protein parvalbumin as a neuronal marker.","volume":"293","author":"Celio","year":"1981","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.biopsych.2007.09.008","article-title":"Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome.","volume":"63","author":"Centonze","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"9598","DOI":"10.1523\/JNEUROSCI.1851-04.2004","article-title":"Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period.","volume":"24","author":"Chattopadhyaya","year":"2004","journal-title":"J. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1002\/dneu.22172","article-title":"An augmented dopamine system function is present prior to puberty in the methylazoxymethanol acetate rodent model of schizophrenia.","volume":"74","author":"Chen","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1523\/JNEUROSCI.3771-09.2010","article-title":"Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.","volume":"30","author":"Chen","year":"2010","journal-title":"J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"19878","DOI":"10.1073\/pnas.0609440103","article-title":"Impairments in frontal cortical gamma synchrony and cognitive control in schizophrenia.","volume":"103","author":"Cho","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B18","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.1523\/JNEUROSCI.19-21-09332.1999","article-title":"K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons.","volume":"19","author":"Chow","year":"1999","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA"},{"key":"B20","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1523\/JNEUROSCI.3748-04.2005","article-title":"Developmental changes in parvalbumin regulate presynaptic Ca2+ signaling.","volume":"25","author":"Collin","year":"2005","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.brainres.2010.09.101","article-title":"Brain growth across the life span in autism: age-specific changes in anatomical pathology.","volume":"1380","author":"Courchesne","year":"2011","journal-title":"Brain Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nm.4071","article-title":"Advancing the understanding of autism disease mechanisms through genetics.","volume":"22","author":"de la Torre-Ubieta","year":"2016","journal-title":"Nat. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0169-328X(95)00056-X","article-title":"Developmental expression of parvalbumin mRNA in the cerebral cortex and hippocampus of the rat.","volume":"32","author":"de Lecea","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"68","key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2011.00068","article-title":"Prenatal VPA exposure and changes in sensory processing by the superior colliculus.","volume":"5","author":"Dendrinos","year":"2011","journal-title":"Front. Integr. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"12956","DOI":"10.1523\/JNEUROSCI.2890-08.2008","article-title":"Postnatal differentiation of basket cells from slow to fast signaling devices.","volume":"28","author":"Doischer","year":"2008","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1124\/mol.104.009308","article-title":"Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure.","volume":"67","author":"Eickholt","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/mp.2014.98","article-title":"Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.","volume":"20","author":"Ellegood","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.reprotox.2016.04.024","article-title":"Genetic and non-genetic animal models for autism spectrum disorders (ASD).","volume":"64","author":"Ergaz","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"B29","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1152\/jn.1999.82.5.2476","article-title":"Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons.","volume":"82","author":"Erisir","year":"1999","journal-title":"J. Neurophysiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5570","DOI":"10.1523\/JNEUROSCI.0747-08.2008","article-title":"Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo.","volume":"28","author":"Espinosa","year":"2008","journal-title":"J. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1002\/aur.193","article-title":"Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder.","volume":"4","author":"Estes","year":"2011","journal-title":"Autism Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1038\/nn1568","article-title":"Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h).","volume":"8","author":"Fan","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"10","key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-016-0192-8","article-title":"Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism.","volume":"9","author":"Filice","year":"2016","journal-title":"Mol. Brain"},{"issue":"27","key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00027","article-title":"Striatal circuits as a common node for autism pathophysiology.","volume":"10","author":"Fuccillo","year":"2016","journal-title":"Front. Neurosci."},{"issue":"e43904","key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043904","article-title":"Selective expression of KCNS3 potassium channel alpha-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex.","volume":"7","author":"Georgiev","year":"2012","journal-title":"PLoS ONE"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.neuropharm.2012.07.028","article-title":"Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3beta\/beta-catenin pathway.","volume":"63","author":"Go","year":"2012","journal-title":"Neuropharmacology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s11689-009-9023-x","article-title":"Common circuit defect of excitatory-inhibitory balance in mouse models of autism.","volume":"1","author":"Gogolla","year":"2009","journal-title":"J. Neurodev. Disord."},{"key":"B38","doi-asserted-by":"crossref","DOI":"10.5772\/54824","article-title":"\u201cValproic acid in autism spectrum disorder: from an environmental risk factor to a reliable animal model,\u201d in","volume":"Vol. I","author":"Gottfried","year":"2013","journal-title":"Recent Advances in Autism Spectrum Disorders"},{"key":"B39","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.neuroscience.2008.07.035","article-title":"Visual experience regulates Kv3.1b and Kv3.2 expression in developing rat visual cortex.","volume":"158","author":"Grabert","year":"2009","journal-title":"Neuroscience"},{"key":"B40","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1699-0463.1988.tb00954.x","article-title":"Some new, simple and efficient stereological methods and their use in pathological research and diagnosis.","volume":"96","author":"Gundersen","year":"1988","journal-title":"APMIS"},{"key":"B41","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1046\/j.1365-2818.1999.00457.x","article-title":"The efficiency of systematic sampling in stereology\u2013reconsidered.","volume":"193","author":"Gundersen","year":"1999","journal-title":"J. Micros."},{"key":"B42","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1517\/17425250902911455","article-title":"A review of valproate in psychiatric practice.","volume":"5","author":"Haddad","year":"2009","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1097\/00001756-199210000-00012","article-title":"Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons.","volume":"3","author":"Hartig","year":"1992","journal-title":"Neuroreport"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw021","article-title":"The number of parvalbumin-expressing interneurons is decreased in the medial prefrontal cortex in autism.","author":"Hashemi","year":"2016","journal-title":"Cerebral cortex"},{"key":"B45","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/S0006-8993(00)02173-9","article-title":"Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice.","volume":"864","author":"Haunso","year":"2000","journal-title":"Brain Res."},{"key":"B46","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1152\/jn.1999.82.3.1512","article-title":"Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus.","volume":"82","author":"Hernandez-Pineda","year":"1999","journal-title":"J. Neurophysiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"10979","DOI":"10.1523\/JNEUROSCI.1531-09.2009","article-title":"Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis.","volume":"29","author":"Huang","year":"2009","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/S0092-8674(00)81509-3","article-title":"BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex.","volume":"98","author":"Huang","year":"1999","journal-title":"Cell"},{"issue":"27400","key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/srep27400","article-title":"Distinct defects in synaptic differentiation of neocortical neurons in response to prenatal valproate exposure.","volume":"6","author":"Iijima","year":"2016","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1152\/jn.1999.82.4.1855","article-title":"Increased gamma- and decreased delta-oscillations in a mouse deficient for a potassium channel expressed in fast-spiking interneurons.","volume":"82","author":"Joho","year":"1999","journal-title":"J. Neurophysiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tins.2003.10.010","article-title":"Interneuron diversity series: fast in, fast out\u2013temporal and spatial signal processing in hippocampal interneurons.","volume":"27","author":"Jonas","year":"2004","journal-title":"Trends Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/nature13248","article-title":"Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.","volume":"511","author":"Karayannis","year":"2014","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1017\/S1461145711001714","article-title":"Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid.","volume":"16","author":"Kataoka","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"255","key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00255","article-title":"Altered onset response dynamics in somatosensory processing in autism spectrum disorder.","volume":"10","author":"Khan","year":"2016","journal-title":"Front. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s00213-013-3403-3","article-title":"Neurobiology of autism gene products: towards pathogenesis and drug targets.","volume":"231","author":"Kleijer","year":"2014","journal-title":"Psychopharmacology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1113\/jphysiol.2006.110486","article-title":"Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.","volume":"575","author":"Kuisle","year":"2006","journal-title":"J. Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.biopsych.2006.09.040","article-title":"Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism.","volume":"62","author":"Langen","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B58","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1523\/JNEUROSCI.23-06-02058.2003","article-title":"Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons.","volume":"23","author":"Lien","year":"2003","journal-title":"J. Neurosci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/nn962","article-title":"Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites.","volume":"5","author":"Lorincz","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0301-0082(98)00075-6","article-title":"Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action.","volume":"58","author":"Loscher","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.brainres.2011.05.013","article-title":"Malformation of the superior olivary complex in an animal model of autism.","volume":"1398","author":"Lukose","year":"2011","journal-title":"Brain Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"285","DOI":"10.5607\/en.2015.24.4.285","article-title":"Exploring the validity of valproic acid animal model of autism.","volume":"24","author":"Mabunga","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1365-2990.2008.00970.x","article-title":"Microcalcification after excitotoxicity is enhanced in transgenic mice expressing parvalbumin in all neurones, may commence in neuronal mitochondria and undergoes structural modifications over time.","volume":"35","author":"Maetzler","year":"2009","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"224","key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00224","article-title":"The intense world theory \u2013 a unifying theory of the neurobiology of autism.","volume":"4","author":"Markram","year":"2010","journal-title":"Front. Hum. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/sj.npp.1301453","article-title":"Abnormal fear conditioning and amygdala processing in an animal model of autism.","volume":"33","author":"Markram","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"970","key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00970","article-title":"Neurobiological foundations of multisensory integration in people with autism spectrum disorders: the role of the medial prefrontal cortex.","volume":"8","author":"Martinez-Sanchis","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"B68","doi-asserted-by":"crossref","first-page":"7055","DOI":"10.1523\/JNEUROSCI.22-16-07055.2002","article-title":"In vivo labeling of parvalbumin-positive interneurons and analysis of electrical coupling in identified neurons.","volume":"22","author":"Meyer","year":"2002","journal-title":"J. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1515\/BC.1999.121","article-title":"Differential distribution of four hyperpolarization-activated cation channels in mouse brain.","volume":"380","author":"Moosmang","year":"1999","journal-title":"Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.brainres.2004.01.062","article-title":"Characterisation of hyperpolarization-activated currents (I(h)) in the medial septum\/diagonal band complex in the mouse.","volume":"1006","author":"Morris","year":"2004","journal-title":"Brain Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"7040","DOI":"10.1523\/JNEUROSCI.0105-09.2009","article-title":"Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons.","volume":"29","author":"Okaty","year":"2009","journal-title":"J. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.1113\/jphysiol.2012.250795","article-title":"Parvalbumin tunes spike-timing and efferent short-term plasticity in striatal fast spiking interneurons.","volume":"591","author":"Orduz","year":"2013","journal-title":"J. Physiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus?","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"B74","author":"Paxinos","year":"2001","journal-title":"The Mouse Brain in Stereotaxis Coordinates"},{"key":"B75","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nature09965","article-title":"Shank3 mutant mice display autistic-like behaviours and striatal dysfunction.","volume":"472","author":"Peca","year":"2011","journal-title":"Nature"},{"key":"B76","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cell.2011.08.040","article-title":"Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits.","volume":"147","author":"Penagarikano","year":"2011","journal-title":"Cell"},{"key":"B77","doi-asserted-by":"publisher","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B78","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1152\/jn.00556.2001","article-title":"Resilient RTN fast spiking in Kv3.1 null mice suggests redundancy in the action potential repolarization mechanism.","volume":"87","author":"Porcello","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1742-4658.2005.05046.x","article-title":"Parvalbumin deficiency in fast-twitch muscles leads to increased \u2018slow-twitch type\u2019 mitochondria, but does not affect the expression of fiber specific proteins.","volume":"273","author":"Racay","year":"2006","journal-title":"FEBS J."},{"key":"B80","doi-asserted-by":"publisher","first-page":"13501","DOI":"10.1073\/pnas.0704391104","article-title":"Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid.","volume":"104","author":"Rinaldi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"B81","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.04.004.2008","article-title":"Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic acid animal model of autism.","volume":"2","author":"Rinaldi","year":"2008","journal-title":"Front. Neural Circuits"},{"key":"B82","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2247::AID-CNE83.0.CO;2-2","article-title":"Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei.","volume":"370","author":"Rodier","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ntt.2013.01.004","article-title":"In utero exposure to valproic acid and autism\u2013a current review of clinical and animal studies.","volume":"36","author":"Roullet","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1034\/j.1601-183X.2003.00037.x","article-title":"Model of autism: increased ratio of excitation\/inhibition in key neural systems.","volume":"2","author":"Rubenstein","year":"2003","journal-title":"Genes Brain Behav."},{"key":"B85","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00213-007-0795-y","article-title":"Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism.","volume":"193","author":"Schneider","year":"2007","journal-title":"Psychopharmacology"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.bbagen.2011.11.008","article-title":"The use of transgenic mouse models to reveal the functions of Ca2+ buffer proteins in excitable cells.","volume":"1820","author":"Schwaller","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B87","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.neuron.2004.10.011","article-title":"Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons.","volume":"44","author":"Shah","year":"2004","journal-title":"Neuron"},{"key":"B88","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nature07991","article-title":"Parvalbumin neurons and gamma rhythms enhance cortical circuit performance.","volume":"459","author":"Sohal","year":"2009","journal-title":"Nature"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1056\/NEJMoa1307491","article-title":"Patches of disorganization in the neocortex of children with autism.","volume":"370","author":"Stoner","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev-neuro-060909-153238","article-title":"Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement.","volume":"34","author":"Turrigiano","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.biopsych.2007.05.023","article-title":"What do disturbances in neural synchrony tell us about autism?","volume":"62","author":"Uhlhaas","year":"2007","journal-title":"Biol. psychiatry"},{"key":"B92","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.eplepsyres.2007.11.005","article-title":"Increased oxidative stress in epileptic children treated with valproic acid.","volume":"78","author":"Verrotti","year":"2008","journal-title":"Epilepsy Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.yebeh.2008.10.011","article-title":"The behavioral consequences of exposure to antiepileptic drugs in utero.","volume":"14","author":"Vinten","year":"2009","journal-title":"Epilepsy Behav."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1152\/jn.00576.2002","article-title":"Parvalbumin-deficiency facilitates repetitive IPSCs and gamma oscillations in the hippocampus.","volume":"89","author":"Vreugdenhil","year":"2003","journal-title":"J. Neurophysiol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"13097","DOI":"10.1523\/JNEUROSCI.1341-11.2011","article-title":"Synaptic and intrinsic balancing during postnatal development in rat pups exposed to valproic acid in utero.","volume":"31","author":"Walcott","year":"2011","journal-title":"J. Neurosci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/(SICI)1096-9861(19960617)370:111::AID-CNE23.3.CO;2-A","article-title":"Estimation of the number of somatostatin neurons in the striatum: an in situ hybridization study using the optical fractionator method.","volume":"370","author":"West","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/ar.1092310411","article-title":"Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator.","volume":"231","author":"West","year":"1991","journal-title":"Anat. Rec."},{"issue":"e525","key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.19","article-title":"Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities.","volume":"5","author":"Wohr","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"B99","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.matbio.2013.04.001","article-title":"Experience-dependent development of perineuronal nets and chondroitin sulfate proteoglycan receptors in mouse visual cortex.","volume":"32","author":"Ye","year":"2013","journal-title":"Matrix Biol."},{"issue":"aaf2669","key":"B100","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2669","article-title":"Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.","volume":"352","author":"Yi","year":"2016","journal-title":"Science"},{"issue":"609","key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00609","article-title":"Altered neural connectivity in excitatory and inhibitory cortical circuits in autism.","volume":"7","author":"Zikopoulos","year":"2013","journal-title":"Front. Hum. Neurosci."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2016.00150\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T15:56:21Z","timestamp":1568649381000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2016.00150\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":101,"URL":"https:\/\/doi.org\/10.3389\/fnmol.2016.00150","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}