{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:20:24Z","timestamp":1790965224815,"version":"4.1.0"},"reference-count":43,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2016.00152","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T12:31:37Z","timestamp":1482323497000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model"],"prefix":"10.3389","volume":"9","author":[{"given":"Junjie","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ikenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jneuroim.2013.06.012","article-title":"Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model","volume":"262","author":"Acs","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1172\/JCI0213462","article-title":"Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis","volume":"109","author":"Adkison","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.4049\/jimmunol.180.5.3535","article-title":"Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection","volume":"180","author":"Akk","year":"2008","journal-title":"J. Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s12640-013-9380-9","article-title":"Cuprizone [bis(cyclohexylidenehydrazide)] is selectively toxic for mature oligodendrocytes","volume":"24","author":"B\u00e9nardais","year":"2013","journal-title":"Neurotox. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.yexcr.2004.03.048","article-title":"Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting","volume":"297","author":"Cappello","year":"2004","journal-title":"Exp. Cell Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"w13042","DOI":"10.4414\/smw.2010.13042","article-title":"Cathepsins and their involvement in immune responses","volume":"140","author":"Conus","year":"2010","journal-title":"Swiss Med. Wkly."},{"key":"B7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.brainres.2010.07.016","article-title":"Inflammatory responses in aggregating rat brain cell cultures subjected to different demyelinating conditions","volume":"1353","author":"Defaux","year":"2010","journal-title":"Brain Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e52566","DOI":"10.1371\/journal.pone.0052566","article-title":"Adenosine A2A receptor deficiency up-regulates cystatin F expression in white matter lesions induced by chronic cerebral hypoperfusion","volume":"7","author":"Duan","year":"2012","journal-title":"PLoS ONE"},{"key":"B9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1742-2094-9-96","article-title":"Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide -induced neuroinflammation","volume":"9","author":"Fan","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"4578","DOI":"10.1167\/iovs.08-1887","article-title":"Expression of CXCL8, CXCR1, and CXCR2 in neurons and glial cells of the human and rabbit retina","volume":"49","author":"Goczalik","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000058723","article-title":"Monocyte chemoattractant protein-1","volume":"72","author":"Gu","year":"1999","journal-title":"Chem. Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/sj.emboj.7601979","article-title":"Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis","volume":"27","author":"Hamilton","year":"2008","journal-title":"EMBO J."},{"key":"B13","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1182\/blood.V96.6.2206","article-title":"Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression","volume":"96","author":"Hashimoto","year":"2000","journal-title":"Blood"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1002\/art.21192","article-title":"Dipeptidyl peptidase I regulates the development of collagen-induced arthritis","volume":"52","author":"Hu","year":"2005","journal-title":"Arthritis Rheum."},{"key":"B15","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1084\/jem.20141656","article-title":"Inefficient clearance of myelin debris by microglia impairs remyelinating processes","volume":"212","author":"Lampron","year":"2015","journal-title":"J. Exp. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1111\/j.1742-4658.2005.04594.x","article-title":"Inhibitory properties of cystatin F and its localization in U937 promonocyte cells","volume":"272","author":"Langerholc","year":"2005","journal-title":"FEBS J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1750-3639.2007.00064.x","article-title":"The immunopathology of multiple sclerosis: an overview","volume":"17","author":"Lassmann","year":"2007","journal-title":"Brain Pathol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/jnc.13242","article-title":"Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage","volume":"135","author":"Liu","year":"2015","journal-title":"J. Neurochem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nn.2491","article-title":"CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis","volume":"13","author":"Liu","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"841","DOI":"10.4049\/jimmunol.1403063","article-title":"Preferential recruitment of neutrophils into the cerebellum and brainstem contributes to the atypical experimental autoimmune encephalomyelitis phenotype","volume":"195","author":"Liu","year":"2015","journal-title":"J. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1017\/S1740925X06000056","article-title":"An animal model for late onset chronic demyelinaion disease caused by failed terminal differentiation of oligodendrocyte","volume":"2","author":"Ma","year":"2006","journal-title":"Neuron Glia Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/jnr.22567","article-title":"Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination","volume":"89","author":"Ma","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s11064-006-9183-y","article-title":"Induced expression of cathepsins and cystatin C in a murine model of demyelination","volume":"32","author":"Ma","year":"2007","journal-title":"Neurochem. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.7150\/jca.5044","article-title":"Cystatins in immune system","volume":"4","author":"Magister","year":"2013","journal-title":"J. Cancer"},{"key":"B26","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1046\/j.0305-1846.2001.00301.x","article-title":"Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre","volume":"27","author":"Mason","year":"2001","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.4049\/jimmunol.167.5.2964","article-title":"Absence of macrophage-inflammatory protein-1\u03b1 delays central nervous system demyelination in the presence of an intact blood-brain barrier","volume":"167","author":"McMahon","year":"2001","journal-title":"J. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1006\/geno.2000.6237","article-title":"Genomic construct and mapping of the gene for CMAP (leukocystatin\/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3)","volume":"67","author":"Morita","year":"2000","journal-title":"Genomics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1073\/pnas.0606091104","article-title":"Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms","volume":"104","author":"Pagano","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B30","doi-asserted-by":"publisher","first-page":"616","DOI":"10.3389\/fimmu.2014.00616","article-title":"Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells","volume":"5","author":"Peri\u0161i\u0107 Nanut","year":"2014","journal-title":"Front. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"8627","DOI":"10.1073\/pnas.96.15.8627","article-title":"Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo","volume":"96","author":"Pham","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1164\/rccm.200607-1051OC","article-title":"Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?","volume":"176","author":"Pottier","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1210\/en.2012-1415","article-title":"Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue","volume":"154","author":"Rouault","year":"2013","journal-title":"Endocrinology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cellimm.2006.03.003","article-title":"Theiler's virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains","volume":"239","author":"Rubio","year":"2006","journal-title":"Cell. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"591","DOI":"10.2217\/14796678.3.6.591","article-title":"Role of cathepsin C in elastase-induced mouse abdominal aortic aneurysms","volume":"3","author":"Shi","year":"2007","journal-title":"Future Cardiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00401-013-1082-0","article-title":"Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons","volume":"125","author":"Singh","year":"2013","journal-title":"Acta Neuropathol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1179\/016164110X12816242542535","article-title":"Degenerative and inflammatory markers in the cerebrospinal fluid of multiple sclerosis patients with relapsing-remitting course of disease and after clinical isolated syndrome","volume":"33","author":"Sladkova","year":"2011","journal-title":"Neurol Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.biopsych.2009.12.020","article-title":"Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system","volume":"67","author":"Tanaka","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jcpa.2012.05.004","article-title":"Late stage cathepsin C, CXCL13 and Ki-67 overexpression correlate with regional neuropathology in a BSE transgenic murine model","volume":"148","author":"Vidal","year":"2013","journal-title":"J. Comp. Pathol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/1098-1136(200011)32:2<155::AID-GLIA50>3.0.CO;2-4","article-title":"Production of macrophage inflammatory protein-2following hypoxia\/reoxygenation in glial cells","volume":"32","author":"Wang","year":"2000","journal-title":"Glia"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e110024","DOI":"10.1371\/journal.pone.0110024","article-title":"Interleukin-1\u03b2 induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS ONE"},{"key":"B42","doi-asserted-by":"publisher","first-page":"18551","DOI":"10.1074\/jbc.M100223200","article-title":"Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice","volume":"276","author":"Wolters","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1111\/j.1471-4159.1991.tb06367.x","article-title":"Monoclonal antibodies against myelin proteolipid protein: identification and characterization of two major determinants","volume":"57","author":"Yamamura","year":"1991","journal-title":"J. Neurochem."}],"updated-by":[{"DOI":"10.3389\/fnmol.2018.00115","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000}}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2016.00152\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T04:26:37Z","timestamp":1601267197000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2016.00152\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":43,"alternative-id":["10.3389\/fnmol.2016.00152"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2016.00152","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fnmol.2018.00115","asserted-by":"object"}]},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]},"article-number":"152"}}