{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:37:51Z","timestamp":1791959871808,"version":"4.3.4"},"reference-count":223,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2017.00127","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T04:34:52Z","timestamp":1493872492000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["MotomiRs: miRNAs in Motor Neuron Function and Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Zachary C. E.","family":"Hawley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Danae","family":"Campos-Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Cristian A.","family":"Droppelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"10337","DOI":"10.1073\/pnas.1104928108","article-title":"Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits","volume":"108","author":"Akten","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.cell.2015.08.011","article-title":"HNRNPA2B1 Is a mediator of m6A-dependent nuclear RNA processing events","volume":"162","author":"Alarc\u00f3n","year":"2015","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1126\/science.1187058","article-title":"Target RNA-directed trimming and tailing of small silencing RNAs","volume":"328","author":"Ameres","year":"2010","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1126\/science.aad2509","article-title":"Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure","volume":"350","author":"Amin","year":"2015","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/s0896-6273(01)80026-x","article-title":"Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity","volume":"23","author":"Arber","year":"1999","journal-title":"Neuron"},{"key":"B6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuron.2004.12.036","article-title":"Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo","volume":"45","author":"Arlotta","year":"2005","journal-title":"Neuron"},{"key":"B7","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.ydbio.2010.06.003","article-title":"Spatiotemporally restricted regulation of generic motor neuron programs by miR-196-mediated repression of Hoxb8","volume":"344","author":"Asli","year":"2010","journal-title":"Dev. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1101\/gad.1705308","article-title":"Mouse ES cells express endogenous shRNAs, siRNAs and other Microprocessor-independent, Dicer-dependent small RNAs","volume":"22","author":"Babiarz","year":"2008","journal-title":"Genes Dev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cub.2011.01.067","article-title":"Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells","volume":"21","author":"Baccarini","year":"2011","journal-title":"Curr. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.1038\/onc.2012.490","article-title":"TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs","volume":"32","author":"Ballarino","year":"2013","journal-title":"Oncogene"},{"key":"B11","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.neuron.2006.10.028","article-title":"Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies","volume":"52","author":"Barbee","year":"2006","journal-title":"Neuron"},{"key":"B12","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00018-015-2093-x","article-title":"microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases","volume":"73","author":"Basak","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1038\/sj.onc.1208560","article-title":"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair","volume":"24","author":"Beer","year":"2005","journal-title":"Oncogene"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1101\/gad.1424106","article-title":"mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes","volume":"20","author":"Behm-Ansmant","year":"2006","journal-title":"Genes Dev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.ydbio.2007.02.012","article-title":"The on\/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord","volume":"305","author":"Bel-Vialar","year":"2007","journal-title":"Dev. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s12017-016-8396-8","article-title":"Identification of miRNAs as potential biomarkers in cerebrospinal fluid from amyotrophic lateral sclerosis patients","volume":"18","author":"Benigni","year":"2016","journal-title":"Neuromolecular Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/nrg3079","article-title":"Evolution of microRNA diversity and regulation in animals","volume":"12","author":"Berezikov","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.molcel.2007.09.028","article-title":"Mammalian mirtron genes","volume":"28","author":"Berezikov","year":"2007","journal-title":"Mol. Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.nbd.2015.10.002","article-title":"Prospects for mTOR-mediated functional repair after central nervous system trauma","volume":"85","author":"Berry","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/stem.2233","article-title":"MiR-375 is essential for human spinal motor neuron development and may be involved in motor neuron degeneration","volume":"34","author":"Bhinge","year":"2016","journal-title":"Stem Cells"},{"key":"B21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/bf02780547","article-title":"Changes in cytoskeletal protein synthesis following axon injury and during axon regeneration","volume":"6","author":"Bisby","year":"1992","journal-title":"Mol. Neurobiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1261\/rna.5167604","article-title":"Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs","volume":"10","author":"Bohnsack","year":"2004","journal-title":"RNA"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/nsmb1167","article-title":"RNA polymerase III transcribes human microRNAs","volume":"13","author":"Borchert","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"12200","DOI":"10.1038\/ncomms12200","article-title":"Target-dependent biogenesis of cognate microRNAs in human cells","volume":"7","author":"Bose","year":"2016","journal-title":"Nat. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/nrn2150","article-title":"Dendritic mRNA: transport, translation and function","volume":"8","author":"Bramham","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.molcel.2011.09.007","article-title":"GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets","volume":"44","author":"Braun","year":"2011","journal-title":"Mol. Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/s0092-8674(00)80853-3","article-title":"A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube","volume":"101","author":"Briscoe","year":"2000","journal-title":"Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrn2670","article-title":"Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?","volume":"10","author":"Burghes","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1172\/JCI62636","article-title":"Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS","volume":"122","author":"Butovsky","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1261\/rna.7135204","article-title":"Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs","volume":"10","author":"Cai","year":"2004","journal-title":"RNA"},{"key":"B31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1756-6606-6-26","article-title":"Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels","volume":"6","author":"Campos-Melo","year":"2013","journal-title":"Mol. Brain"},{"key":"B32","doi-asserted-by":"publisher","first-page":"15592","DOI":"10.3390\/ijms150915592","article-title":"Comprehensive luciferase-based reporter gene assay reveals previously masked up-regulatory effects of miRNAs","volume":"15","author":"Campos-Melo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B33","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1242\/jcs.109.10.2493","article-title":"Neurofilament triplet protein interactions: evidence for the preferred formation of NF-L-containing dimers and a putative function for the end domains","volume":"109","author":"Carpenter","year":"1996","journal-title":"J. Cell Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"21655","DOI":"10.1073\/pnas.0912384106","article-title":"CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs","volume":"106","author":"Castanotto","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e331","DOI":"10.1038\/mtna.2016.47","article-title":"Altered levels of microRNA-9, -206, and -132 in spinal muscular atrophy and their response to antisense oligonucleotide therapy","volume":"5","author":"Catapano","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B36","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.molcel.2011.07.025","article-title":"A primate herpesvirus uses the integrator complex to generate viral microRNAs","volume":"43","author":"Cazalla","year":"2011","journal-title":"Mol. Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/jnr.490390203","article-title":"Axonal transport of type III intermediate filament protein peripherin in intact and regenerating motor axons of the rat sciatic nerve","volume":"39","author":"Chadan","year":"1994","journal-title":"J. Neurosci. Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.neuroscience.2013.10.027","article-title":"MiR- 7\u20131 potentiated estrogen receptor agonists for functional neuroprotection in VSC4.1 motoneurons","volume":"256","author":"Chakrabarti","year":"2014","journal-title":"Neuroscience"},{"key":"B39","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nature12119","article-title":"A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway","volume":"497","author":"Chang","year":"2013","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fnins.2012.00069","article-title":"Apoptosis of limb innervating motor neurons and erosion of motor pool identity upon lineage specific dicer inactivation","volume":"6","author":"Chen","year":"2012","journal-title":"Front. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nature03868","article-title":"TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing","volume":"436","author":"Chendrimada","year":"2005","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1126\/science.1190809","article-title":"A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity","volume":"328","author":"Cifuentes","year":"2010","journal-title":"Science"},{"key":"B43","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/nn.3082","article-title":"microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons","volume":"15","author":"Dajas-Bailador","year":"2012","journal-title":"Nat. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.celrep.2012.10.023","article-title":"Specific miRNA stabilization by Gld2-catalyzed monoadenylation","volume":"2","author":"D\u2019Ambrogio","year":"2012","journal-title":"Cell Rep."},{"key":"B45","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1478-811x-7-18","article-title":"Regulation of microRNA biogenesis: a miRiad of mechanisms","volume":"7","author":"Davis","year":"2009","journal-title":"Cell Commun. Signal."},{"key":"B46","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/jb\/mvq096","article-title":"Mechanisms of control of microRNA biogenesis","volume":"148","author":"Davis-Dusenbery","year":"2010","journal-title":"J. Biochem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1242\/dev.097410","article-title":"How to make spinal motor neurons","volume":"141","author":"Davis-Dusenbery","year":"2014","journal-title":"Development"},{"key":"B48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jns.2016.06.046","article-title":"MicroRNAs-424 and 206 are potential prognostic markers in spinal onset amyotrophic lateral sclerosis","volume":"368","author":"de Andrade","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature03049","article-title":"Processing of primary microRNAs by the Microprocessor complex","volume":"432","author":"Denli","year":"2004","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3389\/fncel.2015.00463","article-title":"Muscle expression of SOD1G93A modulates microrna and mRNA transcription pattern associated with the myelination process in the spinal cord of transgenic mice","volume":"9","author":"Dobrowolny","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3109\/21678421.2014.881377","article-title":"RNA metabolism in ALS: when normal processes become pathological","volume":"15","author":"Droppelmann","year":"2014","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1093\/hmg\/ddm062","article-title":"Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA","volume":"16","author":"Duan","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1523\/jneurosci.3902-04.2005","article-title":"Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere","volume":"25","author":"Dum","year":"2005","journal-title":"J. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.molcel.2014.08.028","article-title":"mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues","volume":"56","author":"Eichhorn","year":"2014","journal-title":"Mol. Cell"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.15252\/embj.201490493","article-title":"Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS","volume":"34","author":"Emde","year":"2015","journal-title":"EMBO J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.molcel.2008.10.017","article-title":"A human snoRNA with microRNA-like functions","volume":"32","author":"Ender","year":"2008","journal-title":"Mol. Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/nsmb.2149","article-title":"miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4\u2013NOT","volume":"18","author":"Fabian","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/dneu.22111","article-title":"Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons","volume":"74","author":"Fallini","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1523\/JNEUROSCI.3631-10.2011","article-title":"The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons","volume":"31","author":"Fallini","year":"2011","journal-title":"J. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"13694","DOI":"10.1038\/ncomms13694","article-title":"TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments","volume":"7","author":"Fareh","year":"2016","journal-title":"Nat. Commun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/978-3-642-60905-3_25","article-title":"Glial cell extracellular matrix: boundaries for axon growth in development and regeneration","volume":"290","author":"Fitch","year":"1997","journal-title":"Cell Tissue Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"14879","DOI":"10.1073\/pnas.0803230105","article-title":"A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence","volume":"105","author":"Forman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B64","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1523\/JNEUROSCI.23-04-01416.2003","article-title":"Rho kinase inhibition enhances axonal regeneration in the injured CNS","volume":"23","author":"Fournier","year":"2003","journal-title":"J. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2660.e15","DOI":"10.1016\/j.neurobiolaging.2015.06.003","article-title":"Serum microRNAs in sporadic amyotrophic lateral sclerosis","volume":"36","author":"Freischmidt","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B66","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/bf02740621","article-title":"The cellular and molecular basis of peripheral nerve regeneration","volume":"14","author":"Fu","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.molcel.2014.09.005","article-title":"MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans","volume":"56","author":"Fukao","year":"2014","journal-title":"Mol. Cell"},{"key":"B68","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.molcel.2014.09.004","article-title":"MicroRNAs block assembly of eIF4F translation initiation complex in Drosophila","volume":"56","author":"Fukaya","year":"2014","journal-title":"Mol. Cell"},{"key":"B69","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1083\/jcb.123.2.455","article-title":"Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve","volume":"123","author":"Funakoshi","year":"1993","journal-title":"J. Cell Biol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1111\/j.1460-9568.1996.tb01284.x","article-title":"BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo","volume":"8","author":"Giehl","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/s0896-6273(00)80612-1","article-title":"Specifying motor neurons and their connections","volume":"21","author":"Goulding","year":"1998","journal-title":"Neuron"},{"key":"B72","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature03120","article-title":"The Microprocessor complex mediates the genesis of microRNAs","volume":"432","author":"Gregory","year":"2004","journal-title":"Nature"},{"key":"B73","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.yexcr.2004.03.022","article-title":"The SMN complex","volume":"296","author":"Gubitz","year":"2004","journal-title":"Exp. Cell Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","first-page":"30342","DOI":"10.1074\/jbc.M115.691857","article-title":"miR-346 Up-regulates argonaute 2 (AGO2) protein expression to augment the activity of other microRNAs (miRNAs) and contributes to cervical cancer cell malignancy","volume":"290","author":"Guo","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nrn2254","article-title":"Patterning and axon guidance of cranial motor neurons","volume":"8","author":"Guthrie","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/sj.embor.7400509","article-title":"TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing","volume":"6","author":"Haase","year":"2005","journal-title":"EMBO Rep."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/nsmb.1676","article-title":"Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells","volume":"16","author":"Hagan","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1101\/gad.1262504","article-title":"The Drosha-DGCR8 complex in primary microRNA processing","volume":"18","author":"Han","year":"2004","journal-title":"Genes Dev."},{"key":"B81","doi-asserted-by":"publisher","first-page":"13111","DOI":"10.1073\/pnas.1006151107","article-title":"miRNA malfunction causes spinal motor neuron disease","volume":"107","author":"Haramati","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B82","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.cell.2013.03.043","article-title":"Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding","volume":"153","author":"Helwak","year":"2013","journal-title":"Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"e1000238","DOI":"10.1371\/journal.pbio.1000238","article-title":"Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA","volume":"7","author":"Hendrickson","year":"2009","journal-title":"PLoS Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cell.2012.09.022","article-title":"Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs","volume":"151","author":"Heo","year":"2012","journal-title":"Cell"},{"key":"B85","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.molcel.2008.09.014","article-title":"Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA","volume":"32","author":"Heo","year":"2008","journal-title":"Mol. Cell"},{"key":"B86","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.cell.2009.08.002","article-title":"TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation","volume":"138","author":"Heo","year":"2009","journal-title":"Cell"},{"key":"B87","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.tcb.2013.08.007","article-title":"Releasing the brake: restoring fast axonal transport in neurodegenerative disorders","volume":"23","author":"Hinckelmann","year":"2013","journal-title":"Trends Cell Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.neuron.2010.09.039","article-title":"Molecular motors in neurons: transport mechanisms and roles in brain function, development and disease","volume":"68","author":"Hirokawa","year":"2010","journal-title":"Neuron"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1093\/nar\/gkr934","article-title":"Upregulation of Cyclin B1 by miRNA and its implications in cancer","volume":"40","author":"Huang","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/hmg\/ddq500","article-title":"HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects","volume":"20","author":"Hubers","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s13311-011-0072-y","article-title":"C3 peptide promotes axonal regeneration and functional motor recovery after peripheral nerve injury","volume":"9","author":"Huelsenbeck","year":"2012","journal-title":"Neurotherapeutics"},{"key":"B92","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1126\/science.1062961","article-title":"A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA","volume":"293","author":"Hutv\u00e1gner","year":"2001","journal-title":"Science"},{"key":"B93","doi-asserted-by":"publisher","first-page":"e85653","DOI":"10.1371\/journal.pone.0085653","article-title":"Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis","volume":"9","author":"Ishtiaq","year":"2014","journal-title":"PLoS One"},{"key":"B94","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1155\/np.1994.103","article-title":"Long-term effects of axotomy on \u03b2-tubulin and NF gene expression in rat DRG neurons","volume":"5","author":"Jiang","year":"1994","journal-title":"J. Neural Transplant. Plast."},{"key":"B95","doi-asserted-by":"publisher","first-page":"3298","DOI":"10.1093\/nar\/gkt1265","article-title":"Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing","volume":"42","author":"Kamenska","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1101\/gad.1761509","article-title":"Selective stabilization of mammalian microRNAs by 3\u2032 adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2","volume":"23","author":"Katoh","year":"2009","journal-title":"Genes Dev."},{"key":"B97","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0896-6273(02)00643-8","article-title":"Drosophila liprin-\u03b1 and the receptor phosphatase Dlar control synapse morphogenesis","volume":"34","author":"Kaufmann","year":"2002","journal-title":"Neuron"},{"key":"B98","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1073\/pnas.1112427109","article-title":"TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes","volume":"109","author":"Kawahara","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B99","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.tibs.2010.03.009","article-title":"Making RISC","volume":"35","author":"Kawamata","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1101\/gad.927801","article-title":"Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans","volume":"15","author":"Ketting","year":"2001","journal-title":"Genes Dev."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.15252\/embj.201590931","article-title":"TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms","volume":"34","author":"Kim","year":"2015","journal-title":"EMBO J."},{"key":"B103","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/cdd.2013.144","article-title":"A multifunctional protein EWS regulates the expression of Drosha and microRNAs","volume":"21","author":"Kim","year":"2014","journal-title":"Cell Death Differ."},{"key":"B104","doi-asserted-by":"publisher","first-page":"E1881","DOI":"10.1073\/pnas.1602532113","article-title":"Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis","volume":"113","author":"Kim","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B102","doi-asserted-by":"publisher","first-page":"e47454","DOI":"10.1371\/journal.pone.0047454","article-title":"Common genetic variants in miR-1206 (8q24.2) and miR-612 (11q13.3) affect biogenesis of mature miRNA forms","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1111\/j.1460-9568.1996.tb01588.x","article-title":"Increased expression of BDNF and trkB mRNA in rat facial motoneurons after axotomy","volume":"8","author":"Kobayashi","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"B106","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1523\/JNEUROSCI.17-24-09583.1997","article-title":"BDNF and NT-4\/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and T\u03b11-tubulin mRNA expression and promote axonal regeneration","volume":"17","author":"Kobayashi","year":"1997","journal-title":"J. Neurosci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"a008045","DOI":"10.1101\/cshperspect.a008045","article-title":"Wnt signaling in neuromuscular junction development","volume":"4","author":"Koles","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0361-9230(93)90280-o","article-title":"Immature corticospinal neurons respond to axotomy with changes in tubulin gene expression","volume":"30","author":"Kost","year":"1993","journal-title":"Brain Res. Bull."},{"key":"B109","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1093\/hmg\/ddt261","article-title":"Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice","volume":"22","author":"Koval","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B110","doi-asserted-by":"publisher","first-page":"6318","DOI":"10.1093\/hmg\/ddu350","article-title":"SMN regulates axonal local translation via miR-183\/mTOR pathway","volume":"23","author":"Kye","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B112","doi-asserted-by":"publisher","first-page":"R46","DOI":"10.1093\/hmg\/ddq137","article-title":"TDP-43 and FUS\/TLS: emerging roles in RNA processing and neurodegeneration","volume":"19","author":"Lagier-Tourenne","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1093\/hmg\/ddw044","article-title":"Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stages","volume":"25","author":"Laird","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B114","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.molcel.2009.08.020","article-title":"miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to \u201cseedless\u201d 3\u2032UTR microRNA recognition elements","volume":"35","author":"Lal","year":"2009","journal-title":"Mol. Cell"},{"key":"B115","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/sj.cdd.4401925","article-title":"The complexity of p53 stabilization and activation","volume":"13","author":"Lavin","year":"2006","journal-title":"Cell Death Differ."},{"key":"B116","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1523\/JNEUROSCI.10-07-02451.1990","article-title":"Lineage, arrangement, and death of clonally related motoneurons in chick spinal cord","volume":"10","author":"Leber","year":"1990","journal-title":"J. Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"B118","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"B120","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/sj.emboj.7600942","article-title":"The role of PACT in the RNA silencing pathway","volume":"25","author":"Lee","year":"2006","journal-title":"EMBO J."},{"key":"B121","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J."},{"key":"B117","doi-asserted-by":"publisher","first-page":"6568","DOI":"10.1093\/nar\/gkt361","article-title":"Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing","volume":"41","author":"Lee","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B122","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"B123","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1146\/annurev.neuro.31.060407.125547","article-title":"Descending pathways in motor control","volume":"31","author":"Lemon","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1093\/cercor\/bhw003","article-title":"Compensatory actions of Ldb adaptor proteins during corticospinal motor neuron differentiation","volume":"27","author":"Leone","year":"2017","journal-title":"Cereb. Cortex"},{"key":"B125","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/978-1-4614-5107-5_10","article-title":"Quantifying Argonaute proteins in and out of GW\/P-bodies: implications in microRNA activities","volume":"768","author":"Leung","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev.neuro.19.1.289","article-title":"Physiology of the neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s13238-013-3001-5","article-title":"Nuclear microRNAs and their unconventional role in regulating non-coding RNAs","volume":"4","author":"Liang","year":"2013","journal-title":"Protein Cell"},{"key":"B128","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.yexcr.2015.01.004","article-title":"Regulation of mitochondrial transport in neurons","volume":"334","author":"Lin","year":"2015","journal-title":"Exp. Cell Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.4161\/cc.25134","article-title":"A meta-analysis of the genomic and transcriptomic composition of complex life","volume":"12","author":"Liu","year":"2013","journal-title":"Cell Cycle"},{"key":"B130","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/s1097-2765(02)00636-6","article-title":"Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control","volume":"10","author":"Loewith","year":"2002","journal-title":"Mol. Cell"},{"key":"B131","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/nmeth.1402","article-title":"Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms","volume":"6","author":"Loya","year":"2009","journal-title":"Nat. Methods"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1242\/dev.105791","article-title":"miR-8 controls synapse structure by repression of the actin regulator enabled","volume":"141","author":"Loya","year":"2014","journal-title":"Development"},{"key":"B133","doi-asserted-by":"publisher","first-page":"20130517","DOI":"10.1098\/rstb.2013.0517","article-title":"MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development","volume":"369","author":"Lu","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"18312","DOI":"10.3390\/ijms160818312","article-title":"A perturbed microRNA expression pattern characterizes embryonic neural stem cells derived from a severe mouse model of spinal muscular atrophy (SMA)","volume":"16","author":"Luchetti","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1126\/science.1090599","article-title":"Nuclear export of microRNA precursors","volume":"303","author":"Lund","year":"2004","journal-title":"Science"},{"key":"B136","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.ydbio.2013.12.023","article-title":"MicroRNA-9 promotes the switch from early-born to late-born motor neuron populations by regulating Onecut transcription factor expression","volume":"386","author":"Luxenhofer","year":"2014","journal-title":"Dev. Biol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"6053","DOI":"10.4049\/jimmunol.0902308","article-title":"MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation","volume":"184","author":"Ma","year":"2010","journal-title":"J. Immunol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"4332","DOI":"10.1172\/JCI58675","article-title":"Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice","volume":"121","author":"Ma","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B139","doi-asserted-by":"publisher","first-page":"345","DOI":"10.7150\/ijbs.10921","article-title":"MiR-206, a key modulator of skeletal muscle development and disease","volume":"11","author":"Ma","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S1474-4422(10)70195-2","article-title":"TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"9","author":"Mackenzie","year":"2010","journal-title":"Lancet Neurol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1242\/dev.068346","article-title":"The regulation of Hox gene expression during animal development","volume":"140","author":"Mallo","year":"2013","journal-title":"Development"},{"key":"B142","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.expneurol.2013.12.007","article-title":"Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells","volume":"253","author":"Marcuzzo","year":"2014","journal-title":"Exp. Neurol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/j.febslet.2011.05.001","article-title":"The central role of RNA in human development and cognition","volume":"585","author":"Mattick","year":"2011","journal-title":"FEBS Lett."},{"key":"B144","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1126\/science.1231197","article-title":"Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation","volume":"340","author":"Meijer","year":"2013","journal-title":"Science"},{"key":"B145","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1242\/jcs.01130","article-title":"Axonal mitochondrial transport and potential are correlated","volume":"117","author":"Miller","year":"2004","journal-title":"J. Cell Sci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1471-4159.2011.07583.x","article-title":"Brain-derived neurotrophic factor expression is repressed during myogenic differentiation by miR-206","volume":"120","author":"Miura","year":"2012","journal-title":"J. Neurochem."},{"key":"B147","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.neuron.2005.08.030","article-title":"Fezl is required for the birth and specification of corticospinal motor neurons","volume":"47","author":"Molyneaux","year":"2005","journal-title":"Neuron"},{"key":"B148","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nrn2151","article-title":"Neuronal subtype specification in the cerebral cortex","volume":"8","author":"Molyneaux","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B149","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nsmb.2309","article-title":"PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding","volume":"19","author":"Moretti","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1261\/rna.2384610","article-title":"Mechanism of translational regulation by miR-2 from sites in the 5\u2032 untranslated region or the open reading frame","volume":"16","author":"Moretti","year":"2010","journal-title":"RNA"},{"key":"B151","doi-asserted-by":"publisher","first-page":"4502","DOI":"10.1038\/emboj.2012.319","article-title":"FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment","volume":"31","author":"Morlando","year":"2012","journal-title":"EMBO J."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3390\/ijms17081231","article-title":"SMA Human iPSC-derived motor neurons show perturbed differentiation and reduced miR-335\u20135p expression","volume":"17","author":"Murdocca","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/nrn2478","article-title":"Functional role of the supplementary and pre-supplementary motor areas","volume":"9","author":"Nachev","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.neuroscience.2013.10.055","article-title":"microRNA-124 is down regulated in nerve-injured motor neurons and it potentially targets mRNAs for KLF6 and STAT3","volume":"256","author":"Nagata","year":"2014","journal-title":"Neuroscience"},{"key":"B155","doi-asserted-by":"publisher","first-page":"33394","DOI":"10.1074\/jbc.M804788200","article-title":"Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1","volume":"283","author":"Nasser","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B156","doi-asserted-by":"publisher","first-page":"e68385","DOI":"10.1371\/journal.pone.0068385","article-title":"The miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction","volume":"8","author":"Nesler","year":"2013","journal-title":"PLoS One"},{"key":"B157","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/s0896-6273(01)00407-x","article-title":"Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2","volume":"31","author":"Novitch","year":"2001","journal-title":"Neuron"},{"key":"B158","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1523\/JNEUROSCI.4330-10.2011","article-title":"MicroRNA miR-9 modifies motor neuron columns by a tuning regulation of FoxP1 levels in developing spinal cords","volume":"31","author":"Otaegi","year":"2011","journal-title":"J. Neurosci."},{"key":"B159","doi-asserted-by":"publisher","first-page":"3172","DOI":"10.1101\/gad.1706508","article-title":"Chromatin structure analyses identify miRNA promoters","volume":"22","author":"Ozsolak","year":"2008","journal-title":"Genes Dev."},{"key":"B160","doi-asserted-by":"publisher","first-page":"e959","DOI":"10.1038\/cddis.2013.491","article-title":"Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation","volume":"4","author":"Parisi","year":"2013","journal-title":"Cell Death Dis."},{"key":"B161","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature10198","article-title":"Dicer recognizes the 5\u2032 end of RNA for efficient and accurate processing","volume":"475","author":"Park","year":"2011","journal-title":"Nature"},{"key":"B162","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4161\/epi.27473","article-title":"Non-coding RNAs as direct and indirect modulators of epigenetic regulation","volume":"9","author":"Peschansky","year":"2014","journal-title":"Epigenetics"},{"key":"B163","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nmeth746","article-title":"Identification of microRNAs of the herpesvirus family","volume":"2","author":"Pfeffer","year":"2005","journal-title":"Nat. Methods"},{"key":"B164","doi-asserted-by":"publisher","first-page":"5598","DOI":"10.1074\/jbc.m707304200","article-title":"In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein","volume":"283","author":"Piazzon","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B165","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-1-4614-0332-6_5","article-title":"Spatiotemporal aspects of MicroRNA-mediated gene regulation","volume":"722","author":"Pothof","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/nan.12147","article-title":"Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions","volume":"41","author":"Raman","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1261\/rna.2191905","article-title":"A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing","volume":"11","author":"Rehwinkel","year":"2005","journal-title":"RNA"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/CIRCHEARTFAILURE.114.001781","article-title":"HDACs regulate miR-133a expression in pressure overload-induced cardiac fibrosis","volume":"8","author":"Renaud","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1101\/gr.2722704","article-title":"Identification of mammalian microRNA host genes and transcription units","volume":"14","author":"Rodriguez","year":"2004","journal-title":"Genome Res."},{"key":"B170","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nature05983","article-title":"Intronic microRNA precursors that bypass Drosha processing","volume":"448","author":"Ruby","year":"2007","journal-title":"Nature"},{"key":"B171","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nbd.2012.08.015","article-title":"Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis","volume":"49","author":"Russell","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B172","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.4161\/cc.5.19.3340","article-title":"Epigenetic activation of tumor suppressor microRNAs in human cancer cells","volume":"5","author":"Saito","year":"2006","journal-title":"Cell Cycle"},{"key":"B173","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/bf02532297","article-title":"Molecules inhibiting neurite growth: a minireview","volume":"21","author":"Schwab","year":"1996","journal-title":"Neurochem. Res."},{"key":"B174","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1158\/0008-5472.CAN-05-3632","article-title":"Rapid alteration of microRNA levels by histone deacetylase inhibition","volume":"66","author":"Scott","year":"2006","journal-title":"Cancer Res."},{"key":"B175","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nature02211","article-title":"Expression and function of orphan nuclear receptor TLX in adult neural stem cells","volume":"427","author":"Shi","year":"2004","journal-title":"Nature"},{"key":"B176","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/s1097-2765(00)80245-2","article-title":"The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor","volume":"5","author":"Slack","year":"2000","journal-title":"Mol. Cell"},{"key":"B177","doi-asserted-by":"publisher","first-page":"15793","DOI":"10.1038\/srep15793","article-title":"miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively","volume":"5","author":"Song","year":"2015","journal-title":"Sci. Rep."},{"key":"B178","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3389\/fncel.2014.00293","article-title":"Motor neurons and the generation of spinal motor neuron diversity","volume":"8","author":"Stifani","year":"2014","journal-title":"Front. Cell Neurosci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/01.jnen.0000173889.71434.ea","article-title":"The pathobiology of amyotrophic lateral sclerosis: a proteinopathy?","volume":"64","author":"Strong","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.mcn.2013.10.006","article-title":"HspB1 silences translation of PDZ-RhoGEF by enhancing miR-20a and miR-128 expression to promote neurite extension","volume":"57","author":"Sun","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"B181","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cell.2006.09.014","article-title":"Dendritic protein synthesis, synaptic plasticity, and memory","volume":"127","author":"Sutton","year":"2006","journal-title":"Cell"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1080\/15476286.2016.1211225","article-title":"Role of FET proteins in neurodegenerative disorders","volume":"13","author":"Svetoni","year":"2016","journal-title":"RNA Biol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.tins.2009.10.002","article-title":"Post-transcriptional control of neurofilaments: new roles in development, regeneration and neurodegenerative disease","volume":"33","author":"Szaro","year":"2010","journal-title":"Trends Neurosci."},{"key":"B184","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1093\/hmg\/ddm327","article-title":"KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy","volume":"17","author":"Tadesse","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B185","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13041-015-0161-7","article-title":"Identification of plasma microRNAs as a biomarker of sporadic Amyotrophic Lateral Sclerosis","volume":"8","author":"Takahashi","year":"2015","journal-title":"Mol. Brain"},{"key":"B186","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/gtc.12009","article-title":"MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain","volume":"17","author":"Tan","year":"2012","journal-title":"Genes Cells"},{"key":"B187","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: from genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"B188","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1523\/JNEUROSCI.11-08-02528.1991","article-title":"Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43","volume":"11","author":"Tetzlaff","year":"1991","journal-title":"J. Neurosci."},{"key":"B189","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1006\/exnr.1996.0084","article-title":"Reductions in motoneuronal neurofilament synthesis by successive axotomies: a possible explanation for the conditioning lesion effect on axon regeneration","volume":"139","author":"Tetzlaff","year":"1996","journal-title":"Exp. Neurol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"7718","DOI":"10.1038\/ncomms9227","article-title":"miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3","volume":"6","author":"Thiebes","year":"2015","journal-title":"Nat. Commun."},{"key":"B191","doi-asserted-by":"publisher","first-page":"e89065","DOI":"10.1371\/journal.pone.0089065","article-title":"MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis","volume":"9","author":"Toivonen","year":"2014","journal-title":"PLoS One"},{"key":"B192","doi-asserted-by":"publisher","first-page":"536","DOI":"10.4161\/rna.6.5.10080","article-title":"How to control miRNA maturation?","volume":"6","author":"Trabucchi","year":"2009","journal-title":"RNA Biol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.neuron.2010.11.016","article-title":"The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction","volume":"68","author":"Tsurudome","year":"2010","journal-title":"Neuron"},{"key":"B194","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1261\/rna.040055.113","article-title":"Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs","volume":"19","author":"Ustianenko","year":"2013","journal-title":"RNA"},{"key":"B195","doi-asserted-by":"publisher","first-page":"970607","DOI":"10.1155\/2014\/970607","article-title":"Mechanisms of miRNA-mediated gene regulation from common downregulation to mRNA-specific upregulation","volume":"2014","author":"Valinezhad Orang","year":"2014","journal-title":"Int. J. Genomics"},{"key":"B196","doi-asserted-by":"publisher","first-page":"e0128560","DOI":"10.1371\/journal.pone.0128560","article-title":"Expression of muscle-specific MiRNA 206 in the progression of disease in a murine SMA model","volume":"10","author":"Valsecchi","year":"2015","journal-title":"PLoS One"},{"key":"B197","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1126\/science.1139089","article-title":"Control of stress-dependent cardiac growth and gene expression by a microRNA","volume":"316","author":"van Rooij","year":"2007","journal-title":"Science"},{"key":"B198","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1126\/science.1149460","article-title":"Switching from repression to activation: microRNAs can up-regulate translation","volume":"318","author":"Vasudevan","year":"2007","journal-title":"Science"},{"key":"B199","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1101\/gad.1519107","article-title":"The microRNA miR-124 antagonizes the anti-neural REST\/SCP1 pathway during embryonic CNS development","volume":"21","author":"Visvanathan","year":"2007","journal-title":"Genes Dev."},{"key":"B200","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/400_2009_16","article-title":"Regulation of mRNA transport and translation in axons","volume":"48","author":"Vuppalanchi","year":"2009","journal-title":"Results Probl. Cell Differ."},{"key":"B201","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1261\/rna.051565.115","article-title":"Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo","volume":"21","author":"Waghray","year":"2015","journal-title":"RNA"},{"key":"B202","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s40478-014-0173-z","article-title":"Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis","volume":"2","author":"Wakabayashi","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"B203","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.kjms.2013.12.007","article-title":"Survival of motor neuron protein downregulates miR-9 expression in patients with spinal muscular atrophy","volume":"30","author":"Wang","year":"2014","journal-title":"Kaohsiung J. Med. Sci."},{"key":"B204","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1038\/onc.2011.584","article-title":"Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer","volume":"31","author":"Wee","year":"2012","journal-title":"Oncogene"},{"key":"B205","doi-asserted-by":"publisher","first-page":"e57080","DOI":"10.1371\/journal.pone.0057080","article-title":"miR-153 regulates SNAP-25, synaptic transmission and neuronal development","volume":"8","author":"Wei","year":"2013","journal-title":"PLoS One"},{"key":"B206","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.cell.2008.12.023","article-title":"Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs","volume":"136","author":"Weinmann","year":"2009","journal-title":"Cell"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22455","article-title":"The corticospinal tract: evolution, development, and human disorders","author":"Welniarz","year":"2016","journal-title":"Dev. Neurobiol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1093\/hmg\/ddw084","article-title":"Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy","volume":"25","author":"Wertz","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B209","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/cdd.2014.112","article-title":"The complexity of miRNA-mediated repression","volume":"22","author":"Wilczynska","year":"2015","journal-title":"Cell Death Differ."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1126\/science.1181046","article-title":"MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice","volume":"326","author":"Williams","year":"2009","journal-title":"Science"},{"key":"B211","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.spen.2006.06.008","article-title":"Spinal muscular atrophy: from gene to therapy","volume":"13","author":"Wirth","year":"2006","journal-title":"Semin. Pediatr. Neurol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1073\/pnas.0510928103","article-title":"MicroRNAs direct rapid deadenylation of mRNA","volume":"103","author":"Wu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B213","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.cell.2012.08.041","article-title":"Human RNA methyltransferase BCDIN3D regulates microRNA processing","volume":"151","author":"Xhemalce","year":"2012","journal-title":"Cell"},{"key":"B214","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.brainresbull.2016.01.011","article-title":"MicroRNA-9 controls apoptosis of neurons by targeting monocyte chemotactic protein-induced protein 1 expression in rat acute spinal cord injury model","volume":"121","author":"Xu","year":"2016","journal-title":"Brain Res. Bull."},{"key":"B215","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.celrep.2012.08.025","article-title":"FUS-SMN protein interactions link the motor neuron diseases ALS and SMA","volume":"2","author":"Yamazaki","year":"2012","journal-title":"Cell Rep."},{"key":"B216","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1101\/gad.1158803","article-title":"Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs","volume":"17","author":"Yi","year":"2003","journal-title":"Genes Dev."},{"key":"B217","doi-asserted-by":"publisher","first-page":"18824","DOI":"10.1038\/srep18824","article-title":"DNA methylation mediated down-regulating of MicroRNA-33b and its role in gastric cancer","volume":"6","author":"Yin","year":"2016","journal-title":"Sci. Rep."},{"key":"B218","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.celrep.2013.09.029","article-title":"Poly(A)-specific ribonuclease mediates 3\u2032-end trimming of Argonaute2-cleaved precursor microRNAs","volume":"5","author":"Yoda","year":"2013","journal-title":"Cell Rep."},{"key":"B219","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/emboj.2013.44","article-title":"GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation","volume":"32","author":"Zekri","year":"2013","journal-title":"EMBO J."},{"key":"B220","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nsmb.1576","article-title":"A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination","volume":"16","author":"Zhao","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B221","first-page":"1826","article-title":"miRNA-9 expression is upregulated in the spinal cord of G93A-SOD1 transgenic mice","volume":"6","author":"Zhou","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1083\/jcb.143.1.183","article-title":"Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin \u03b2,\u03b2\u2032-iminodipropionitrile","volume":"143","author":"Zhu","year":"1998","journal-title":"J. Cell Biol."},{"key":"B222","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.4161\/auto.24135","article-title":"After the banquet: mitochondrial biogenesis, mitophagy and cell survival","volume":"9","author":"Zhu","year":"2013","journal-title":"Autophagy"},{"key":"B224","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.stem.2016.05.004","article-title":"ADAR1 activation drives leukemia stem cell self-renewal by impairing Let-7 biogenesis","volume":"19","author":"Zipeto","year":"2016","journal-title":"Cell Stem Cell"}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2017.00127\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T05:55:31Z","timestamp":1658987731000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2017.00127\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,4]]},"references-count":223,"alternative-id":["10.3389\/fnmol.2017.00127"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2017.00127","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,4]]},"article-number":"127"}}