{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:59:05Z","timestamp":1793944745410,"version":"4.8.0"},"reference-count":190,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["SIR RBSI 144EUA"],"award-info":[{"award-number":["SIR RBSI 144EUA"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004486","name":"Fondazione Cassa di Risparmio di Perugia","doi-asserted-by":"publisher","award":["2014.0254.021"],"award-info":[{"award-number":["2014.0254.021"]}],"id":[{"id":"10.13039\/501100004486","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2017.00191","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T03:57:05Z","timestamp":1497844625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":279,"title":["The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS"],"prefix":"10.3389","volume":"10","author":[{"given":"Cataldo","family":"Arcuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Giambanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Donato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","article-title":"Structure and function of the blood-brain barrier.","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1146\/annurev.immunol.17.1.593","article-title":"Mechanisms of phagocytosis in macrophages.","volume":"17","author":"Aderem","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self- renewal can sustain CNS microglia maintenance and function throughout adult life.","volume":"10","author":"Ajami","year":"2007","journal-title":"Nat. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0165-3806(99)00113-3","article-title":"Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain.","volume":"117","author":"Alliot","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1073\/pnas.88.4.1541","article-title":"Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain.","volume":"88","author":"Alliot","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/jnr.22533","article-title":"Endogenous microglia regulate development of embryonic cortical precursor cells.","volume":"89","author":"Antony","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"268","DOI":"10.2741\/4486","article-title":"Microglia-glioma cross-talk: a two way approach to new strategies against glioma.","volume":"22","author":"Arcuri","year":"2017","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6611","article-title":"Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex.","volume":"5","author":"Arn\u00f2","year":"2014","journal-title":"Nat. Commun."},{"key":"B9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0165-3806(90)90203-B","article-title":"Microglia and cell death in the developing mouse cerebellum.","volume":"55","author":"Ashwell","year":"1990","journal-title":"Dev. Brain Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0165-3806(91)90231-7","article-title":"The distribution of microglia and cell death in the fetal rat forebrain.","volume":"58","author":"Ashwell","year":"1991","journal-title":"Dev. Brain Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1017\/S0952523800012335","article-title":"The appearance and distribution of microglia in the developing retina of the rat.","volume":"2","author":"Ashwell","year":"1989","journal-title":"Vis. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1006\/exnr.1999.7345","article-title":"Interferon-gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro.","volume":"162","author":"Badie","year":"2000","journal-title":"Exp. Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nn.2275","article-title":"Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology.","volume":"12","author":"Ballas","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6813","DOI":"10.1021\/ac901049w","article-title":"Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry.","volume":"81","author":"Bandura","year":"2009","journal-title":"Anal. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/89490","article-title":"CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.","volume":"4","author":"Bezzi","year":"2001","journal-title":"Nat. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.nlm.2010.04.001","article-title":"Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline.","volume":"94","author":"Bilbo","year":"2010","journal-title":"Neurobiol. Learn Mem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.yfrne.2012.08.006","article-title":"The immune system and developmental programming of brain and behavior.","volume":"33","author":"Bilbo","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/nan.12011","article-title":"Review: activation patterns of microglia and their identification in the human brain.","volume":"39","author":"Boche","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a unique TGF-\u03b2-dependent molecular and functional signature in microglia.","volume":"17","author":"Butovsky","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4031","DOI":"10.1242\/dev.106559","article-title":"Development of the cerebellum: simple steps to make a \u201clittle brain.\u201d","volume":"141","author":"Butts","year":"2014","journal-title":"Development"},{"key":"B21","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1001\/jamaneurol.2013.6237","article-title":"TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis.","volume":"71","author":"Cady","year":"2014","journal-title":"JAMA Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1038\/jid.2013.164","article-title":"Local arginase 1 activity is required for cutaneous wound healing.","volume":"133","author":"Campbell","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nn1715","article-title":"Control of microglial neurotoxicity by the fractalkine receptor.","volume":"9","author":"Cardona","year":"2006","journal-title":"Nature Neurosci."},{"key":"B24","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.4049\/jimmunol.163.7.3963","article-title":"Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNFalpha impart neuroprotection to an excitotoxin through distinct pathways.","volume":"163","author":"Carlson","year":"1999","journal-title":"J. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1161\/STROKEAHA.107.498212","article-title":"Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke.","volume":"39","author":"Caso","year":"2008","journal-title":"Stroke"},{"key":"B26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuron.2013.10.052","article-title":"Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice.","volume":"81","author":"Castellan Baldan","year":"2014","journal-title":"Neuron"},{"key":"B27","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology.","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1167\/iovs.05-1522","article-title":"Potential role of microglia in retinal blood vessel formation.","volume":"47","author":"Checchin","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0896-6273(00)00166-5","article-title":"Developmental remodeling of the retinogeniculate synapse.","volume":"28","author":"Chen","year":"2000","journal-title":"Neuron"},{"key":"B30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bbi.2013.02.005","article-title":"Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro.","volume":"32","author":"Chhor","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"18270","DOI":"10.1523\/JNEUROSCI.2211-13.2013","article-title":"Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.","volume":"33","author":"Claude","year":"2013","journal-title":"J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00268","article-title":"The effect of glia\u2013glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases.","volume":"7","author":"Clemente","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/imm.12117","article-title":"Human dendritic cell subsets.","volume":"140","author":"Collin","year":"2013","journal-title":"Immunology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2174\/187152710791012053","article-title":"Assessing activation states in microglia.","volume":"9","author":"Colton","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B35","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/01.jnen.0000202887.22082.63","article-title":"Microglia in the aging brain.","volume":"65","author":"Conde","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.immuni.2015.03.013","article-title":"Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli.","volume":"42","author":"Cronk","year":"2015","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S0301-0082(98)00035-5","article-title":"The origin and differentiation of microglial cells during development.","volume":"56","author":"Cuadros","year":"1998","journal-title":"Progr. Neurobiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/nrn3053","article-title":"Repertoire of microglial and macrophage responses after spinal cord injury.","volume":"12","author":"David","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.it.2008.01.010","article-title":"From bone marrow to microglia: barriers and avenues.","volume":"29","author":"Davoust","year":"2008","journal-title":"Trends Immunol."},{"key":"B40","first-page":"483","article-title":"\u201cMicroglia,\u201d in","author":"del Rio-Hortega","year":"1932","journal-title":"Cytology and Cellular Pathology of the Nervous System"},{"key":"B41","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.mcn.2012.10.003","article-title":"Peripheral and central inflammation in autism spectrum disorders.","volume":"53","author":"Depino","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature10907","article-title":"Wild-type microglia arrest pathology in a mouse model of Rett syndrome.","volume":"484","author":"Derecki","year":"2012","journal-title":"Nature"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.4103\/1673-5374.193220","article-title":"Clearing the corpses: regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain.","volume":"11","author":"Diaz-Aparicio","year":"2016","journal-title":"Neural Regen. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1742-2094-9-71","article-title":"Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice.","volume":"20","author":"Diz-Chaves","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B45","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1084\/jem.20031237","article-title":"Toll-like receptors induce a phagocytic gene program through p38.","volume":"199","author":"Doyle","year":"2004","journal-title":"J. Exp. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain.","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"B47","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0161-5890(03)00109-3","article-title":"\u201cEat me\u201d and \u201cdon\u2019t eat me\u201d signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system.","volume":"40","author":"Elward","year":"2003","journal-title":"Mol. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1056\/nejmoa0907006","article-title":"L-histidine decarboxylase and Tourette\u2019s syndrome.","volume":"362","author":"Ercan-Sencicek","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"8904","DOI":"10.1523\/JNEUROSCI.1146-14.2014","article-title":"IL-4 signaling drives a unique arginase+\/IL-1\u03b2+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4R\u03b1 after traumatic spinal cord injury.","volume":"34","author":"Fenn","year":"2014","journal-title":"J. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0306-4522(90)90281-8","article-title":"Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes.","volume":"39","author":"Ferrer","year":"1990","journal-title":"Neuroscience"},{"key":"B51","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.bbi.2016.07.002","article-title":"Histamine regulation of microglia: gene-environment interaction in the regulation of central nervous system inflammation.","volume":"57","author":"Frick","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/608654","article-title":"Microglial dysregulation in psychiatric disease.","volume":"2013","author":"Frick","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1523\/JNEUROSCI.4837-11.2012","article-title":"MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation.","volume":"32","author":"Fricker","year":"","journal-title":"J. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-196","article-title":"Primary phagocytosis of viable neurons by microglia activated with LPS or A\u03b2 is dependent on calreticulin\/LRP phagocytic signalling.","volume":"9","author":"Fricker","year":"","journal-title":"J. Neuroinflammation"},{"key":"B55","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.dcn.2014.07.001","article-title":"Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity.","volume":"11","author":"Ganguly","year":"2015","journal-title":"Dev. Cogn. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages.","volume":"5","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.bbi.2015.09.015","article-title":"Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies.","volume":"15","author":"Giovanoli","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-24","article-title":"Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRP\u03b1 (signal regulatory protein-\u03b1) on phagocytes.","volume":"8","author":"Gitik","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"B59","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1523\/JNEUROSCI.08-02-00709.1988","article-title":"Interleukin-1 is an astroglial growth factor in the developing brain.","volume":"8","author":"Giulian","year":"1988","journal-title":"J. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/ni.3423","article-title":"Origin, fate and dynamics of macrophages at CNS interfaces.","volume":"17","author":"Goldmann","year":"2016","journal-title":"Nat. Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.","volume":"518","author":"Gomez Perdiguero","year":"2015","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00401-009-0622-0","article-title":"Microglia: biology and pathology.","volume":"119","author":"Graeber","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s11481-007-9090-2","article-title":"Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl\/Mer family of tyrosine kinases.","volume":"3","author":"Grommes","year":"2008","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1189\/jlb.0303114","article-title":"Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification.","volume":"75","author":"Guillemin","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"B65","first-page":"1","article-title":"Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia.","volume":"232","author":"Hakola","year":"1972","journal-title":"Acta Psychiatr. Scand. Suppl."},{"key":"B66","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1055\/s-2008-1071344","article-title":"Elevated CSF glutamate in Rett syndrome.","volume":"23","author":"Hamberger","year":"1992","journal-title":"Neuropediatrics"},{"key":"B67","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/417182a","article-title":"Identification of a factor that links apoptotic cells to phagocytes.","volume":"417","author":"Hanayama","year":"2002","journal-title":"Nature"},{"key":"B68","first-page":"79","article-title":"\u201cMicroglia as a source and target of cytokine activities in the brain,\u201d in","author":"Hanisch","year":"2001","journal-title":"Microglia in the Degenerating and Regenerating CNS"},{"key":"B69","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a source and target of cytokines.","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain.","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"28853","DOI":"10.1074\/jbc.272.46.28853","article-title":"Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity.","volume":"272","author":"Hanisch","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1042\/CS20110164","article-title":"Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential.","volume":"121","author":"Hanke","year":"2011","journal-title":"Clin. Sci. (Lond.)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","article-title":"The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies.","volume":"49","author":"Heim","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"B74","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1242\/dev.126.17.3735","article-title":"Ontogeny and behaviour of early macrophages in the zebrafish embryo.","volume":"126","author":"Herbomel","year":"1999","journal-title":"Development"},{"key":"B75","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1006\/dbio.2001.039","article-title":"Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M- CSF receptor-dependent invasive process.","volume":"238","author":"Herbomel","year":"2001","journal-title":"Dev. Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1038\/nn.3554","article-title":"The microglial sensome revealed by direct RNA sequencing.","volume":"16","author":"Hickman","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/jnr.20480","article-title":"Visualization of microglia in living tissues using Iba-1-EGFP transgenic mice.","volume":"81","author":"Hirasawa","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1126\/science.290.5497.1768","article-title":"Down-regulation of the macrophage lineage through interaction with OX2 (CD200).","volume":"290","author":"Hoek","year":"2000","journal-title":"Science"},{"key":"B79","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/glia.20896","article-title":"Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development.","volume":"58","author":"Hristova","year":"2010","journal-title":"Glia"},{"key":"B80","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","article-title":"Microglial and macrophage polarization-new prospects for brain repair.","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1146\/annurev.neuro.31.060407.125533","article-title":"Mechanisms underlying development of visual maps and receptive fields.","volume":"31","author":"Huberman","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/eji.201141679","article-title":"TREM-2 triggering receptor expressed on myeloid cell-2 negatively regulates TLR responses in dendritic cells.","volume":"42","author":"Ito","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00702-003-0822-z","article-title":"Rett Syndrome-an update.","volume":"110","author":"Jellinger","year":"2003","journal-title":"J. Neural. Transm."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-149","article-title":"Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity.","volume":"9","author":"Jeon","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B85","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease.","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1440-1789.2010.01127.x","article-title":"Nasu-Hakola disease: the first case reported by Nasu and review: the 50th Anniversary of Japanese Society of Neuropathology.","volume":"30","author":"Kaneko","year":"2010","journal-title":"Neuropathology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.conb.2009.05.002","article-title":"Synapse elimination in the central nervous system.","volume":"19","author":"Kano","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nn.3318","article-title":"Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8- dependent pathways.","volume":"16","author":"Kierdorf","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/jnr.20562","article-title":"Microglia in health and disease.","volume":"18","author":"Kim","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nmeth.1405","article-title":"Engineering a polarity- sensitive biosensor for timelapse imaging of apoptotic processes and degeneration.","volume":"7","author":"Kim","year":"2010","journal-title":"Nat. Methods"},{"key":"B91","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/glia.20354","article-title":"Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord.","volume":"54","author":"Kitada","year":"2006","journal-title":"Glia"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1038\/ni1411","article-title":"The TREM receptor family and signal integration.","volume":"7","author":"Klesney-Tait","year":"2006","journal-title":"Nat. Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal immune activation and abnormal brain development across CNS disorders.","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/nature05704","article-title":"UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.","volume":"446","author":"Koizumi","year":"2007","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.nbd.2005.01.023","article-title":"Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson\u2019s disease.","volume":"19","author":"Kokovay","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"B96","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/cr.2008.65","article-title":"MyD88-independent activation of a novel actin- Cdc42\/Rac pathway is required for Toll-like receptor stimulated phagocytosis.","volume":"18","author":"Kong","year":"2008","journal-title":"Cell Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0092-8674(93)80047-I","article-title":"Macrophages are required for cell death and tissue remodeling in the developing mouse eye.","volume":"74","author":"Lang","year":"1993","journal-title":"Cell"},{"key":"B98","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0306-4522(90)90229-W","article-title":"Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain.","volume":"39","author":"Lawson","year":"1990","journal-title":"Neuroscience"},{"key":"B99","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/0306-4522(92)90500-2","article-title":"Turnover of resident microglia in the normal adult mouse brain.","volume":"48","author":"Lawson","year":"1992","journal-title":"Neuroscience"},{"key":"B100","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s00702-010-04334","article-title":"The role of microglia in amyloid clearance from the AD brain.","volume":"117","author":"Lee","year":"2010","journal-title":"J. Neural Transm."},{"key":"B101","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/j.1471-4159.2011.07543.x","article-title":"Atp8a1 deficiency is associated with PS externalization in hippocampus and delayed hippocampus-dependent learning.","volume":"120","author":"Levano","year":"2012","journal-title":"J. Neurochem."},{"key":"B102","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1172\/JCI37934","article-title":"The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders.","volume":"119","author":"Levitt","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B103","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1523\/JNEUROSCI.3830-11.2012","article-title":"Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia.","volume":"32","author":"Linnartz","year":"2012","journal-title":"J. Neurosci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.neuroscience.2014.09.050","article-title":"What happens to microglial TREM2 in Alzheimer\u2019s disease: immunoregulatory turned into immunopathogenic?","volume":"302","author":"Lue","year":"2015","journal-title":"Neuroscience"},{"key":"B105","doi-asserted-by":"publisher","first-page":"5346","DOI":"10.1523\/JNEUROSCI.5966-09.2010","article-title":"Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate.","volume":"30","author":"Maezawa","year":"2010","journal-title":"J. Neurosci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/eji.201545774","article-title":"The end of gating? An introduction to automated analysis of high dimensional cytometry data.","volume":"46","author":"Mair","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.nbd.2004.09.009","article-title":"Bone marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP\/PS1 double transgenic Alzheimer mice.","volume":"18","author":"Malm","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"B108","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/sj.cdd.4401979","article-title":"Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis.","volume":"14","author":"Mann","year":"2007","journal-title":"Cell Death Differ."},{"key":"B109","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0896-6273(04)00069-8","article-title":"Microglia promote the death of developing Purkinje cells.","volume":"41","author":"Mar\u00edn-Teva","year":"2004","journal-title":"Neuron"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-261","article-title":"LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein.","volume":"9","author":"Marker","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8670","article-title":"Microglia development follows a stepwise program to regulate brain homeostasis.","volume":"353","author":"Matcovitch-Natan","year":"2016","journal-title":"Science"},{"key":"B112","doi-asserted-by":"publisher","first-page":"6317","DOI":"10.4049\/jimmunol.1001095","article-title":"Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia.","volume":"185","author":"McArthur","year":"2010","journal-title":"J. Immunol."},{"key":"B113","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1002\/j.1460-2075.1996.tb00949.x","article-title":"Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.","volume":"15","author":"McKercher","year":"1996","journal-title":"EMBO J."},{"key":"B114","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.imlet.2014.11.006","article-title":"Evidence supporting an altered immune response in ASD.","volume":"163","author":"Mead","year":"2015","journal-title":"Immunol. Lett."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1038\/nn2015","article-title":"Microglia in the adult brain arise from Ly-6ChiCCR2+monocytes only under defined host conditions.","volume":"10","author":"Mildner","year":"2007","journal-title":"Nat. Neurosci."},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12540","article-title":"Microglia contact induces synapse formation in developing somatosensory cortex.","volume":"7","author":"Miyamoto","year":"2016","journal-title":"Nat. Commun."},{"key":"B117","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1097\/nen.0b013e3180517b46","article-title":"Entry and distribution of microglial cells in human embryonic and fetal cerebral cortex.","volume":"66","author":"Monier","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.biopsych.2010.05.024","article-title":"Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism.","volume":"68","author":"Morgan","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B119","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0736-5748(93)90081-N","article-title":"Microglia- derived plasminogen enhances neurite outgrowth from explant cultures of rat brain.","volume":"11","author":"Nagata","year":"1993","journal-title":"Int. J. Dev. Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/oxfordjournals.jbchem.a002969","article-title":"Microglia: activation and their significance in the central nervous system.","volume":"130","author":"Nakajima","year":"2001","journal-title":"J. Biochem."},{"key":"B121","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1460-9568.2007.05309.x","article-title":"Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem\/progenitor cells.","volume":"25","author":"Nakanishi","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"E4098","DOI":"10.1073\/pnas.1308679110","article-title":"Phagocytosis executes delayed neuronal death after focal brain ischemia.","volume":"110","author":"Neher","year":"2013","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"B123","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/jnc.12288","article-title":"Lactadherin\/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid \u03b2.","volume":"126","author":"Neniskyte","year":"2013","journal-title":"J. Neurochem."},{"key":"B124","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/glia.1108","article-title":"Control of glial immune function by neurons.","volume":"36","author":"Neumann","year":"2001","journal-title":"Glia"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"B126","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1074\/jbc.M110.169839","article-title":"Fractalkine attenuates excitoneurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression.","volume":"286","author":"Noda","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1007\/s00256-014-1887-5","article-title":"Membranous lipodystrophy: skeletal findings on CT and MRI.","volume":"43","author":"Nwawka","year":"2014","journal-title":"Skeletal Radiol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jneuroim.2013.09.002","article-title":"MeCP2 deficiency enhances glutamate release through NF-\u03baB signaling in myeloid derived cells.","volume":"265","author":"O\u2019Driscoll","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev.ne.14.030191.002321","article-title":"Cell death during development of the nervous system.","volume":"14","author":"Oppenheim","year":"1991","journal-title":"Annu. Rev. Neurosci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/ni.1744","article-title":"Macrophage colony stimulating factor induces macrophage proliferation and survival through a pathway involving DAP12 and \u03b2-catenin.","volume":"10","author":"Otero","year":"2009","journal-title":"Nat. Immunol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development.","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0211-6","article-title":"Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4.","volume":"11","author":"Pepe","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0036-15.2015","article-title":"Morphological and phagocytic profile of microglia in the developing rat cerebellum.","volume":"2","author":"Perez-Pouchoulen","year":"2015","journal-title":"eNeuro"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000371","article-title":"Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.","volume":"5","author":"Pesce","year":"2009","journal-title":"PLoS Pathog."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1002\/eji.200636837","article-title":"Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis.","volume":"37","author":"Piccio","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1111\/ejn.12508","article-title":"Microglia shape corpus callosum axon tract fasciculation: functional impact of prenatal inflammation.","volume":"39","author":"Pont-Lezica","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"B138","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/nrn3722","article-title":"Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease.","volume":"15","author":"Prinz","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B139","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/ng.1027","article-title":"Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.","volume":"44","author":"Rademakers","year":"2011","journal-title":"Nat. Genet."},{"key":"B140","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0165-0173(99)00007-7","article-title":"Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function.","volume":"30","author":"Raivich","year":"1999","journal-title":"Brain Res. Rev."},{"key":"B141","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4338","article-title":"A polarizing question: do M1 and M2 microglia exist?","volume":"10","author":"Ransohoff","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nature09615","article-title":"The myeloid cells of the central nervous system parenchyma.","volume":"468","author":"Ransohoff","year":"2010","journal-title":"Nature"},{"key":"B143","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0889-1591(02)00055-7","article-title":"Molecular insights on the cerebral innate immune system.","volume":"17","author":"Rivest","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"B144","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1034\/j.1601-183X.2003.00037.x","article-title":"Model of autism: increased ratio of excitation\/inhibition in key neural systems.","volume":"2","author":"Rubenstein","year":"2003","journal-title":"Genes Brain Behav."},{"key":"B145","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nri3086","article-title":"Microglial cell origin and phenotypes in the health and disease.","volume":"11","author":"Saijo","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/cne.21538","article-title":"Embryonic and postnatal development of microglial cells in the mouse retina.","volume":"506","author":"Santos","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1440-1789.2011.01256.x","article-title":"Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains.","volume":"32","author":"Satoh","year":"2012","journal-title":"Neuropathology"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1046\/j.1471-4159.1999.721466.x","article-title":"Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia.","volume":"72","author":"Sawada","year":"1999","journal-title":"J. Neurochem"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15224","article-title":"Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression.","volume":"5","author":"Schafer","year":"2016","journal-title":"eLife"},{"key":"B150","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"B151","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1471-4159.2009.05984.x","article-title":"Differential gene expression in LPS\/IFN activated microglia and macrophages: in vitro versus in vivo.","author":"Schmid","year":"2009","journal-title":"J. Neurochem."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1046\/j.1471-4159.2002.01243.x","article-title":"Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia.","volume":"83","author":"Schmid","year":"2002","journal-title":"J. Neurochem"},{"key":"B153","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1126\/science.1219179","article-title":"A lineage of myeloid cells independent of Myb and hematopoietic stem cells.","volume":"336","author":"Schulz","year":"2012","journal-title":"Science"},{"key":"B154","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1523\/JNEUROSCI.4464-03.2004","article-title":"Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death.","volume":"24","author":"Sedel","year":"2004","journal-title":"J. Neurosci."},{"key":"B155","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.conb.2011.06.006","article-title":"Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met.","volume":"21","author":"Shepherd","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1523\/JNEUROSCI.1619-13.2014","article-title":"Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone.","volume":"34","author":"Shigemoto-Mogami","year":"2014","journal-title":"J. Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/glia.20468","article-title":"Microglia derived from aging mice exhibit an altered inflammatory profile.","volume":"55","author":"Sierra","year":"2007","journal-title":"Glia"},{"key":"B158","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1146\/annurev.cellbio.23.090506.123237","article-title":"Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum.","volume":"23","author":"Sillitoe","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/656481","article-title":"S100B protein, a damage associated molecular pattern protein in the brain and heart, and beyond.","volume":"2010","author":"Sorci","year":"2010","journal-title":"Cardiovasc. Psychiatry Neurol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.celrep.2016.12.011","article-title":"Major shifts in glial regional identity are a transcriptional hallmark of human brain aging.","volume":"18","author":"Soreq","year":"2017","journal-title":"Cell Rep."},{"key":"B161","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/sj.jcbfm.9600206","article-title":"Rat neonatal immune challenge alters adult responses to cerebral ischaemia.","volume":"26","author":"Spencer","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B162","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.celrep.2014.07.042","article-title":"Microglia modulate wiring of the embryonic forebrain.","volume":"8","author":"Squarzoni","year":"2014","journal-title":"Cell Rep."},{"key":"B163","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1007\/s10072-016-2634-6","article-title":"Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): update on molecular genetics.","volume":"37","author":"Stabile","year":"2016","journal-title":"Neurol. Sci."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination.","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"B165","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1179\/016164105X49463","article-title":"Role of microglia in the central nervous system\u2019s immune response.","volume":"27","author":"Streit","year":"2005","journal-title":"Neurol. Res."},{"key":"B166","doi-asserted-by":"publisher","first-page":"13305","DOI":"10.1074\/jbc.M113.457937","article-title":"Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.","volume":"288","author":"Suzuki","year":"","journal-title":"J. Biol. Chem."},{"key":"B167","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1126\/science.1236758","article-title":"Xk- related protein 8 and CED-8 promote PS exposure in apoptotic cells.","volume":"341","author":"Suzuki","year":"","journal-title":"Science"},{"key":"B168","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1001\/jamapsychiatry.2013.272","article-title":"Microglial activation in young adults with autism spectrum disorder.","volume":"70","author":"Suzuki","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"B169","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.neuron.2014.07.040","article-title":"Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.","volume":"83","author":"Tang","year":"2014","journal-title":"Neuron"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.06.018","article-title":"Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes.","volume":"35","author":"Thelen","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B171","article-title":"The microglial \u201cactivation\u201d continuum: from innate to adaptive responses.","volume":"2","author":"Town","year":"2005","journal-title":"J. Neuroin?ammation"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000527","article-title":"Microglial interactions with synapses are modulated by visual experience.","volume":"8","author":"Tremblay","year":"2010","journal-title":"PLoS Biol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nn.3358","article-title":"Layer V cortical neurons require microglial support for survival during postnatal development.","volume":"16","author":"Ueno","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"3362","DOI":"10.1167\/iovs.09-4978","article-title":"SDF-1\/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis.","volume":"51","author":"Unoki","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B175","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism.","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann. Neurol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1046\/j.1471-4159.2000.740457.x","article-title":"\u201cInflammatory\u201d cytokines: neuromodulators in normal brain?","volume":"74","author":"Vitkovic","year":"2000","journal-title":"J. Neurochem."},{"key":"B177","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nature10110","article-title":"Transcriptomic analysis of autistic brain reveals convergent molecular pathology.","volume":"474","author":"Voineagu","year":"2011","journal-title":"Nature"},{"key":"B178","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","article-title":"Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals.","volume":"29","author":"Wake","year":"2009","journal-title":"J. Neurosci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"8138","DOI":"10.1523\/JNEUROSCI.1006-08.2008","article-title":"Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor.","volume":"28","author":"Wakselman","year":"2008","journal-title":"J. Neurosci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1038\/nature14444","article-title":"Wild type microglia do not arrest pathology in mouse models of Rett syndrome.","volume":"521","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"B181","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1523\/JNEUROSCI.3940-09.2010","article-title":"Alleviation of neurotoxicity by microglial human Siglec-11.","volume":"30","author":"Wang","year":"2010","journal-title":"J. Neurosci."},{"key":"B182","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.bbadis.2015.09.019","article-title":"Genetic manipulation of microglia during brain development and disease.","volume":"1862","author":"Wieghofer","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B183","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1242\/jcs.01632","article-title":"A role for Mer tyrosine kinase in \u03b1v\u03b25 integrin mediated phagocytosis of apoptotic cells.","volume":"118","author":"Wu","year":"2005","journal-title":"J. Cell Sci."},{"key":"B184","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/87945","article-title":"TGF-beta1 promotes microglial amyloid beta clearance and reduces plaque burden in transgenic mice.","volume":"7","author":"Wyss-Coray","year":"2001","journal-title":"Nat. Med."},{"key":"B185","doi-asserted-by":"publisher","first-page":"992","DOI":"10.15252\/emmm.201606370","article-title":"TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance.","volume":"8","author":"Xiang","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1126\/science.aaa1934","article-title":"Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq.","volume":"347","author":"Zeisel","year":"2015","journal-title":"Science"},{"key":"B187","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nn.3641","article-title":"Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.","volume":"17","author":"Zhan","year":"2014","journal-title":"Nature Neurosci."},{"key":"B188","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.neuron.2014.01.043","article-title":"Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase.","volume":"82","author":"Zhang","year":"2014","journal-title":"Neuron"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002853","article-title":"Mutations in a P-type ATPase gene cause axonal degeneration.","volume":"8","author":"Zhu","year":"2012","journal-title":"PLoS Genet."},{"key":"B190","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/nn1629","article-title":"Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood.","volume":"9","author":"Ziv","year":"2016","journal-title":"Nat. Neurosci."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2017.00191\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:20:37Z","timestamp":1692843637000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2017.00191\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,19]]},"references-count":190,"alternative-id":["10.3389\/fnmol.2017.00191"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2017.00191","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,19]]},"article-number":"191"}}