{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:36:43Z","timestamp":1780497403861,"version":"3.54.1"},"reference-count":49,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371102"],"award-info":[{"award-number":["31371102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2017.00205","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T04:17:17Z","timestamp":1498623437000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Tlx3 Function in the Dorsal Root Ganglion is Pivotal to Itch and Pain Sensations"],"prefix":"10.3389","volume":"10","author":[{"given":"Chengcheng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/j.1398-9995.2009.01937.x","article-title":"TRPV1-mediated itch in seasonal allergic rhinitis","volume":"64","author":"Alenmyr","year":"2009","journal-title":"Allergy"},{"key":"B2","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/s0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"B3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature05910","article-title":"The menthol receptor TRPM8 is the principal detector of environmental cold","volume":"448","author":"Bautista","year":"2007","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1126\/science.aac8653","article-title":"Gate control of mechanical itch by a subpopulation of spinal cord interneurons","volume":"350","author":"Bourane","year":"2015","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"9075","DOI":"10.1073\/pnas.0901507106","article-title":"Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli","volume":"106","author":"Cavanaugh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B6","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.neuron.2005.10.036","article-title":"Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain","volume":"49","author":"Chen","year":"2006","journal-title":"Neuron"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e04660","DOI":"10.7554\/eLife.04660","article-title":"Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity","volume":"3","author":"Chiu","year":"2014","journal-title":"Elife"},{"key":"B8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","article-title":"Attenuated cold sensitivity in TRPM8 null mice","volume":"54","author":"Colburn","year":"2007","journal-title":"Neuron"},{"key":"B9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.neuron.2007.02.024","article-title":"TRPM8 is required for cold sensation in mice","volume":"54","author":"Dhaka","year":"2007","journal-title":"Neuron"},{"key":"B10","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/ni1084","article-title":"Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice","volume":"5","author":"Dillon","year":"2004","journal-title":"Nat. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.jpain.2014.09.010","article-title":"Molecular signatures of mouse TRPV1-lineage neurons revealed by RNA-Seq transcriptome analysis","volume":"15","author":"Goswami","year":"2014","journal-title":"J. Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nn.3289","article-title":"A subpopulation of nociceptors specifically linked to itch","volume":"16","author":"Han","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2006.09.036","article-title":"Phospholipase C\u03b2 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons","volume":"52","author":"Han","year":"2006","journal-title":"Neuron"},{"key":"B14","doi-asserted-by":"publisher","first-page":"11330","DOI":"10.1073\/pnas.0905605106","article-title":"TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms","volume":"106","author":"Imamachi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1008e1","DOI":"10.1053\/j.gastro.2010.05.009","article-title":"Lysophosphatidic acid is a potential mediator of cholestatic pruritus","volume":"139","author":"Kremer","year":"2010","journal-title":"Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.neuroscience.2015.05.043","article-title":"The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms","volume":"300","author":"Li","year":"2015","journal-title":"Neuroscience"},{"key":"B16","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/cr.2016.90","article-title":"Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity","volume":"26","author":"Li","year":"2016","journal-title":"Cell Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"14532","DOI":"10.1523\/JNEUROSCI.3509-12.2012","article-title":"Mechanisms of itch evoked by \u03b2-alanine","volume":"32","author":"Liu","year":"2012","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.cell.2009.11.034","article-title":"Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus","volume":"139","author":"Liu","year":"2009","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"ra45","DOI":"10.1126\/scisignal.2001925","article-title":"The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia","volume":"4","author":"Liu","year":"2011","journal-title":"Sci. Signal."},{"key":"B21","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1523\/JNEUROSCI.4472-07.2008","article-title":"Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors","volume":"28","author":"Liu","year":"2008","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"9706","DOI":"10.1523\/JNEUROSCI.1109-12.2012","article-title":"Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors and pruriceptors","volume":"32","author":"Lopes","year":"2012","journal-title":"J. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1523\/JNEUROSCI.3942-12.2013","article-title":"Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechano receptors","volume":"33","author":"Lou","year":"2013","journal-title":"J. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1126\/science.1233765","article-title":"The cells and circuitry for itch responses in mice","volume":"340","author":"Mishra","year":"2013","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/emboj.2010.325","article-title":"TRPV1-lineage neurons are required for thermal sensation","volume":"30","author":"Mishra","year":"2011","journal-title":"EMBO J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1097\/01.don.0000155259.22746.ae","article-title":"Expression and characterization of vanilloid receptor subtype 1 in human dental pulp cell cultures","volume":"31","author":"Miyamoto","year":"2005","journal-title":"J. Endod."},{"key":"B27","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.neuron.2015.05.044","article-title":"HTR7 mediates serotonergic acute and chronic itch","volume":"87","author":"Morita","year":"2015","journal-title":"Neuron"},{"key":"B28","doi-asserted-by":"publisher","first-page":"5533","DOI":"10.1523\/JNEUROSCI.5788-12.2013","article-title":"The cellular code for mammalian thermosensation","volume":"33","author":"Pogorzala","year":"2013","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.1523\/JNEUROSCI.0716-08.2008","article-title":"Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors","volume":"28","author":"Reddy","year":"2008","journal-title":"J. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1038\/jid.2009.430","article-title":"Cathepsin S elicits itch and signals via protease-activated receptors","volume":"130","author":"Reddy","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/nn.3404","article-title":"Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons","volume":"16","author":"Roberson","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1600-0625.2008.00762.x","article-title":"Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation","volume":"18","author":"Rossbach","year":"2009","journal-title":"Exp. Dermatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1523\/JNEUROSCI.4643-06.2007","article-title":"TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase","volume":"27","author":"Shim","year":"2007","journal-title":"J. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"7563","DOI":"10.1523\/JNEUROSCI.1192-11.2011","article-title":"BAM8\u201322 peptide produces itch and nociceptive sensations in humans independent of histamine release","volume":"31","author":"Sikand","year":"2011","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/s0896-6273(00)81003-x","article-title":"Tackling pain at the source: new ideas about nociceptors","volume":"20","author":"Snider","year":"1998","journal-title":"Neuron"},{"key":"B36","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1476-5381.2010.00705.x","article-title":"Signal transduction by protease-activated receptors","volume":"160","author":"Soh","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1523\/JNEUROSCI.2955-14.2015","article-title":"Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein and antibody concerns","volume":"35","author":"Solorzano","year":"2015","journal-title":"J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"585","DOI":"10.15252\/embr.201540983","article-title":"A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression","volume":"17","author":"Stantcheva","year":"2016","journal-title":"EMBO Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0014-2999(98)00288-x","article-title":"Effects of histamine H1 receptor antagonists on compound 48\/80-induced scratching behavior in mice","volume":"351","author":"Sugimoto","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nature06029","article-title":"A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord","volume":"448","author":"Sun","year":"2007","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1126\/science.1174868","article-title":"Cellular basis of itch sensation","volume":"325","author":"Sun","year":"2009","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.1600-0625.2012.01487.x","article-title":"Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin","volume":"21","author":"Szegedi","year":"2012","journal-title":"Exp. Dermatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nature11810","article-title":"Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo","volume":"493","author":"Vrontou","year":"2013","journal-title":"Nature"},{"key":"B45","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nn.2789","article-title":"TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch","volume":"14","author":"Wilson","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"14738","DOI":"10.1523\/JNEUROSCI.5512-12.2013","article-title":"Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities","volume":"33","author":"Xu","year":"2013","journal-title":"J. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"806.e9","DOI":"10.1016\/j.neuron.2017.01.009","article-title":"FGF13 selectively regulates heat nociception by interacting with Nav1.7","volume":"93","author":"Yang","year":"2017","journal-title":"Neuron"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/jid.2011.87","article-title":"Antipruritic effects of TRPV1 antagonist in murine atopic dermatitis and itching models","volume":"131","author":"Yun","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1172\/jci70528","article-title":"Chronic itch development in sensory neurons requires BRAF signaling pathways","volume":"123","author":"Zhao","year":"2013","journal-title":"J. Clin. Invest."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2017.00205\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T04:17:21Z","timestamp":1498623441000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2017.00205\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":49,"alternative-id":["10.3389\/fnmol.2017.00205"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2017.00205","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]},"article-number":"205"}}