{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:01:12Z","timestamp":1773680472755,"version":"3.50.1"},"reference-count":68,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25461756"],"award-info":[{"award-number":["25461756"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["S2603"],"award-info":[{"award-number":["S2603"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2017.00341","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T04:24:16Z","timestamp":1509078256000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Perinatal Asphyxia in Rat Alters Expression of Novel Schizophrenia Risk Genes"],"prefix":"10.3389","volume":"10","author":[{"given":"Alessandra","family":"Paparelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyasu","family":"Wakuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"Iyegbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin M.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nori","family":"Takei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1001\/jamapsychiatry.2013.288","article-title":"A comprehensive family-based replication study of schizophrenia genes.","volume":"70","author":"Aberg","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"B2","first-page":"551","article-title":"Implantation metastases from gastrointestinal cancer after percutaneous puncture or biliary drainage.","volume":"162","author":"Andersson","year":"1996","journal-title":"Eur. J. Surg."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004267","article-title":"CNNM2 mutations cause impaired brain development and seizures in patients with hypomagnesemia.","volume":"10","author":"Arjona","year":"2014","journal-title":"PLOS Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.schres.2008.10.003","article-title":"Prenatal immune challenge induces developmental changes in the morphology of pyramidal neurons of the prefrontal cortex and hippocampus in rats.","volume":"107","author":"Baharnoori","year":"2009","journal-title":"Schizophr. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.schres.2009.01.017","article-title":"Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia.","volume":"109","author":"Beasley","year":"2009","journal-title":"Schizophr. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/10298420290031414","article-title":"Neonatal exposure to the glutamate receptor antagonist MK-801: effects on locomotor activity and pre-pulse inhibition before and after sexual maturity in rats.","volume":"4","author":"Beninger","year":"2002","journal-title":"Neurotox. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1007\/s002219900305","article-title":"Interactive effects of anoxia and general anesthesia during birth on the degree of CNS and systemic hypoxia produced in neonatal rats.","volume":"131","author":"Berger","year":"2000","journal-title":"Exp. Brain Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(91)91041-X","article-title":"Asphyctic lesion: proliferation of tyrosine hydroxylase-immunoreactive nerve cell bodies in the rat substantia nigra and functional changes in dopamine neurotransmission.","volume":"543","author":"Bjelke","year":"1991","journal-title":"Brain Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresrev.2004.01.001","article-title":"Animal models of obstetric complications in relation to schizophrenia.","volume":"45","author":"Boksa","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0149-7634(03)00012-5","article-title":"Birth insult interacts with stress at adulthood to alter dopaminergic function in animal models: possible implications for schizophrenia and other disorders.","volume":"27","author":"Boksa","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00213-008-1213-9","article-title":"Epinephrine administration at birth prevents long-term changes in dopaminergic parameters caused by Cesarean section birth in the rat.","volume":"200","author":"Boksa","year":"2008","journal-title":"Psychopharmacology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuroscience.2015.05.055","article-title":"Using human brain imaging studies as a guide toward animal models of schizophrenia.","volume":"321","author":"Bolkan","year":"2016","journal-title":"Neuroscience"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1621\/nrs.01012","article-title":"Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways.","volume":"1","author":"Bookout","year":"2003","journal-title":"Nucl. Recept. Signal."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/S0278-5846(02)00300-7","article-title":"Does risperidone act better in schizophrenic patients who have a family or obstetric history?","volume":"26","author":"Borkowska","year":"2002","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B15","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1523\/JNEUROSCI.20-14-05538.2000","article-title":"Perinatal distress leads to lateralized medial prefrontal cortical dopamine hypofunction in adult rats.","volume":"20","author":"Brake","year":"2000","journal-title":"J. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1192\/bjp.176.6.531","article-title":"Labour and delivery complications and schizophrenia. Case-control study using contemporaneous labour ward records.","volume":"176","author":"Byrne","year":"2000","journal-title":"Br. J. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1176\/appi.ajp.159.7.1080","article-title":"Obstetric complications and schizophrenia: historical and meta-analytic review.","volume":"159","author":"Cannon","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.biopsych.2008.04.012","article-title":"Decreased neurotrophic response to birth hypoxia in the etiology of schizophrenia.","volume":"64","author":"Cannon","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.expneurol.2009.06.007","article-title":"Protein ubiquitination in postsynaptic densities after hypoxia in rat neostriatum is blocked by hypothermia.","volume":"219","author":"Capani","year":"2009","journal-title":"Exp. Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","article-title":"Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.","volume":"381","year":"2013","journal-title":"Lancet"},{"key":"B21","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/jcpp.12351","article-title":"Research review: birth by caesarean section and development of autism spectrum disorder and attention-deficit\/hyperactivity disorder: a systematic review and meta-analysis.","volume":"56","author":"Curran","year":"2015","journal-title":"J. Child Psychol. Psychiatry"},{"key":"B22","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1001\/archpsyc.56.3.234","article-title":"Obstetric complications and the risk of schizophrenia: a longitudinal study of a national birth cohort.","volume":"56","author":"Dalman","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1177\/070674371205700708","article-title":"Molecular genetics of the psychosis phenotype.","volume":"57","author":"DeRosse","year":"2012","journal-title":"Can. J. Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1093\/brain\/awm184","article-title":"Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia.","volume":"130","author":"Douaud","year":"2007","journal-title":"Brain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1006\/exnr.1997.6437","article-title":"Long-term reciprocal changes in dopamine levels in prefrontal cortex versus nucleus accumbens in rats born by caesarean section compared to vaginal birth.","volume":"145","author":"El-Khodor","year":"1997","journal-title":"Exp. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0166-4328(99)00119-9","article-title":"Transient birth hypoxia increases behavioral responses to repeated stress in the adult rat.","volume":"107","author":"El-Khodor","year":"2000","journal-title":"Behav. Brain Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/syn.10147","article-title":"Effects of birth insult and stress at adulthood on in vivo tyrosine hydroxylase and tryptophan hydroxylase activities in rat brain.","volume":"47","author":"El-Khodor","year":"2003","journal-title":"Synapse"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/00207459708988460","article-title":"Long term changes in NADPH-diaphorase reactivity in striatal and cortical neurons following experimental perinatal asphyxia: neuroprotective effects of hypothermia.","volume":"89","author":"Fabian Loidl","year":"1997","journal-title":"Int. J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.euroneuro.2009.03.004","article-title":"Prenatal viral infection of mice at E16 causes changes in gene expression in hippocampi of the offspring.","volume":"19","author":"Fatemi","year":"2009","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1055\/s-2008-1058107","article-title":"Behavioural alterations in rats following neonatal hypoxia and effects of clozapine: implications for schizophrenia.","volume":"41","author":"Fendt","year":"2008","journal-title":"Pharmacopsychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nature11007","article-title":"Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.","volume":"485","author":"Funfschilling","year":"2012","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/syn.21660","article-title":"Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats.","volume":"67","author":"Galeano","year":"2013","journal-title":"Synapse"},{"key":"B33","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/oxfordjournals.schbul.a033389","article-title":"Schizophrenia and complications of pregnancy and labor: an individual patient data meta-analysis.","volume":"25","author":"Geddes","year":"1999","journal-title":"Schizophr. Bull."},{"key":"B34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1176\/appi.ajp.2010.10091340","article-title":"After GWAS: searching for genetic risk for schizophrenia and bipolar disorder.","volume":"168","author":"Gershon","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1152\/physiolgenomics.00058.2005","article-title":"Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter.","volume":"22","author":"Goytain","year":"2005","journal-title":"Physiol. Genomics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0020-7292(93)90271-W","article-title":"Influence of labor and route of delivery on the frequency of respiratory morbidity in term neonates.","volume":"43","author":"Hales","year":"1993","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"B37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.biopsych.2011.01.030","article-title":"The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.","volume":"70","author":"Havik","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1016\/j.cellsig.2015.06.003","article-title":"Epigenetic signaling in schizophrenia.","volume":"27","author":"Ibi","year":"2015","journal-title":"Cell. Signal."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1038\/npp.2008.19","article-title":"Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes.","volume":"33","author":"Katsel","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.schres.2014.02.017","article-title":"The CSMD1 genome-wide associated schizophrenia risk variant rs10503253 affects general cognitive ability and executive function in healthy males.","volume":"154","author":"Koiliari","year":"2014","journal-title":"Schizophr. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.4049\/jimmunol.176.7.4419","article-title":"CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues.","volume":"176","author":"Kraus","year":"2006","journal-title":"J. Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neulet.2011.10.055","article-title":"Sex differences in the effects of perinatal anoxia on dopamine function in rats.","volume":"506","author":"Laplante","year":"2012","journal-title":"Neurosci. Lett."},{"key":"B43","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0304-3940(94)91065-0","article-title":"Long-term effects of perinatal asphyxia on basal ganglia neurotransmitter systems studied with microdialysis in rat.","volume":"175","author":"Loidl","year":"1994","journal-title":"Neurosci. Lett."},{"key":"B44","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/mp.2012.183","article-title":"Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","volume":"19","author":"Luykx","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1200\/JCO.1999.17.7.2264","article-title":"Molecular biology of neuroblastoma.","volume":"17","author":"Maris","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jpsychires.2009.07.007","article-title":"Proteome and transcriptome analysis suggests oligodendrocyte dysfunction in schizophrenia.","volume":"44","author":"Martins-de-Souza","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/neu.480260212","article-title":"A human glial hybrid cell line differentially expressing genes subserving oligodendrocyte and astrocyte phenotype.","volume":"26","author":"McLaurin","year":"1995","journal-title":"J. Neurobiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrn2392","article-title":"Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.","volume":"9","author":"Mei","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.schres.2007.09.032","article-title":"Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.","volume":"98","author":"Mitkus","year":"2008","journal-title":"Schizophr. Res."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00184","article-title":"An overview of the association between schizotypy and dopamine.","volume":"5","author":"Mohr","year":"2014","journal-title":"Front. Psychiatry"},{"key":"B51","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/schbul\/sbw108","article-title":"Testing the validity of taxonic schizotypy using genetic and environmental risk variables.","volume":"43","author":"Morton","year":"2017","journal-title":"Schizophr. Bull."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-9-40","article-title":"The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia.","volume":"9","author":"Ohi","year":"2013","journal-title":"Behav. Brain Funct."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/ng.2742","article-title":"Genome-wide association analysis identifies 13 new risk loci for schizophrenia.","volume":"45","author":"Ripke","year":"2013","journal-title":"Nat. Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1192\/bjp.bp.113.131359","article-title":"Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style.","volume":"204","author":"Rose","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"B55","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons.","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/jhg.2015.153","article-title":"Individual risk alleles of susceptibility to schizophrenia are associated with poor clinical and social outcomes.","volume":"61","author":"Sakamoto","year":"2016","journal-title":"J. Hum. Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.expneurol.2016.08.017","article-title":"Consequences of excessive plasticity in the hippocampus induced by perinatal asphyxia.","volume":"286","author":"Saraceno","year":"2016","journal-title":"Exp. Neurol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/ng.940","article-title":"Genome-wide association study identifies five new schizophrenia loci.","volume":"43","year":"2011","journal-title":"Nat. Genet."},{"key":"B59","doi-asserted-by":"publisher","first-page":"9749","DOI":"10.1074\/jbc.272.15.9749","article-title":"Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain.","volume":"272","author":"Shofuda","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s00424-016-1816-7","article-title":"Human CNNM2 is not a Mg2+ transporter per se.","volume":"468","author":"Sponder","year":"2016","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1006\/exnr.1999.7201","article-title":"Effects of vaginal birth versus caesarean section birth with general anesthesia on blood gases and brain energy metabolism in neonatal rats.","volume":"160","author":"Vaillancourt","year":"1999","journal-title":"Exp. Neurol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0301-2115(01)00292-5","article-title":"Neonatal respiratory morbidity following elective caesarean section in term infants. A 5-year retrospective study and a review of the literature.","volume":"98","author":"van den Berg","year":"2001","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"9396","DOI":"10.1073\/pnas.161288698","article-title":"Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells.","volume":"98","author":"Wainwright","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.pnpbp.2014.08.002","article-title":"Perinatal asphyxia alters neuregulin-1 and COMT gene expression in the medial prefrontal cortex in rats.","volume":"56","author":"Wakuda","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003648","article-title":"Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood.","volume":"3","author":"Wakuda","year":"2008","journal-title":"PLOS ONE"},{"key":"B66","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0378-1119(02)01210-6","article-title":"Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP).","volume":"306","author":"Wang","year":"2003","journal-title":"Gene"},{"key":"B67","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s004010050904","article-title":"Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues.","volume":"96","author":"Yoshiyama","year":"1998","journal-title":"Acta Neuropathol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1176\/appi.ajp.157.2.196","article-title":"Hypoxic-ischemia-related fetal\/neonatal complications and risk of schizophrenia and other nonaffective psychoses: a 19-year longitudinal study.","volume":"157","author":"Zornberg","year":"2000","journal-title":"Am. J. Psychiatry"}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2017.00341\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T06:50:37Z","timestamp":1570258237000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2017.00341\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":68,"alternative-id":["10.3389\/fnmol.2017.00341"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2017.00341","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,27]]},"article-number":"341"}}