{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:16:06Z","timestamp":1787912166077,"version":"build-2784847793"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T00:00:00Z","timestamp":1545609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["26101117, A-HKUST603\/17, N_HKUST613\/17, 16101518"],"award-info":[{"award-number":["26101117, A-HKUST603\/17, N_HKUST613\/17, 16101518"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2018.00478","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T09:59:40Z","timestamp":1547719180000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Altered Synaptic Vesicle Release and Ca2+ Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington\u2019s Disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Sidong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Hei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyokeun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,12,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1523\/jneurosci.17-10-03538.1997","article-title":"Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia\/aglycemia or to excitotoxins","volume":"17","author":"Abdel-Hamid","year":"1997","journal-title":"J. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.bbrc.2017.08.103","article-title":"Real-time subpixel-accuracy tracking of single mitochondria in neurons reveals heterogeneous mitochondrial motion","volume":"493","author":"Alsina","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"10151","DOI":"10.1523\/JNEUROSCI.2432-08.2008","article-title":"Spontaneous and evoked glutamate release activates two populations of NMDA receptors with limited overlap","volume":"28","author":"Atasoy","year":"2008","journal-title":"J. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/s0143-4160(02)00206-3","article-title":"Altered calcium regulation in freshly isolated aortic smooth muscle cells from bile duct-ligated rats: role of nitric oxide","volume":"33","author":"Atucha","year":"2003","journal-title":"Cell Calcium"},{"key":"B5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.5483\/bmbrep.2017.50.5.038","article-title":"Synapses in neurodegenerative diseases","volume":"50","author":"Bae","year":"2017","journal-title":"BMB Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1126\/science.1553547","article-title":"Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction","volume":"255","author":"Betz","year":"1992","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.molmed.2009.01.001","article-title":"Calcium signaling and neurodegenerative diseases","volume":"15","author":"Bezprozvanny","year":"2009","journal-title":"Trends Mol. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"8027","DOI":"10.1073\/pnas.87.20.8027","article-title":"Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex","volume":"87","author":"Blanton","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/currents.hd.34957c4f8bd7cb1f5ec47381dfc811c3","article-title":"Differential synaptic and extrasynaptic glutamate-receptor alterations in striatal medium-sized spiny neurons of aged YAC128 Huntington\u2019s disease mice","volume":"6","author":"Botelho","year":"2014","journal-title":"PLoS Curr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nrn2634","article-title":"The probability of neurotransmitter release: variability and feedback control at single synapses","volume":"10","author":"Branco","year":"2009","journal-title":"Neuroscience"},{"key":"B11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.neuron.2008.07.006","article-title":"Local dendritic activity sets release probability at hippocampal synapses","volume":"59","author":"Branco","year":"2008","journal-title":"Neuron"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","article-title":"Neuronal calcium signaling: function and dysfunction","volume":"71","author":"Brini","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/978-3-319-71779-1_3","article-title":"Mitochondrial dysfunction in Huntington\u2019s disease","volume":"1049","author":"Carmo","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"a003947","DOI":"10.1101\/cshperspect.a003947","article-title":"Voltage-gated calcium channels","volume":"3","author":"Catterall","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1111\/j.1460-9568.2008.06038.x","article-title":"Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons","volume":"27","author":"Cepeda","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1523\/jneurosci.23-03-00961.2003","article-title":"Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington\u2019s disease","volume":"23","author":"Cepeda","year":"2003","journal-title":"J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"14670","DOI":"10.1523\/JNEUROSCI.1349-09.2009","article-title":"Functional heterogeneity at dopamine release sites","volume":"29","author":"Daniel","year":"2009","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ncl.2014.09.003","article-title":"Huntington disease: pathogenesis and treatment","volume":"33","author":"Dayalu","year":"2015","journal-title":"Neurol. Clin."},{"key":"B20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1113\/jphysiol.1996.sp021204","article-title":"Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release","volume":"491","author":"Debanne","year":"1996","journal-title":"J. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/0896-6273(95)90346-1","article-title":"Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons","volume":"14","author":"DiFiglia","year":"1995","journal-title":"Neuron"},{"key":"B23","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/s0896-6273(00)80338-4","article-title":"Heterogeneity of release probability, facilitation and depletion at central synapses","volume":"18","author":"Dobrunz","year":"1997","journal-title":"Neuron"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e1001396","DOI":"10.1371\/journal.pbio.1001396","article-title":"Independent regulation of basal neurotransmitter release efficacy by variable Ca2+ influx and bouton size at small central synapses","volume":"10","author":"Ermolyuk","year":"2012","journal-title":"PLoS Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"13614","DOI":"10.1523\/JNEUROSCI.3455-07.2007","article-title":"Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington\u2019s disease","volume":"27","author":"Fernandes","year":"2007","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3389\/fnins.2018.00342","article-title":"Mitochondrial quality control in neurodegenerative diseases: focus on Parkinson\u2019s disease and Huntington\u2019s disease","volume":"12","author":"Franco-Iborra","year":"2018","journal-title":"Front. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/bf00239522","article-title":"Quantitative distribution of GABA-immunoreactive neurons in the visual cortex (area 17) of the cat","volume":"61","author":"Gabbott","year":"1986","journal-title":"Exp. Brain Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1038\/nprot.2006.476","article-title":"Imaging synaptic vesicle exocytosis and endocytosis with FM dyes","volume":"1","author":"Gaffield","year":"2006","journal-title":"Nat. Protoc."},{"key":"B29","doi-asserted-by":"publisher","first-page":"10814","DOI":"10.1523\/jneurosci.2660-08.2008","article-title":"Dichotomous anatomical properties of adult striatal medium spiny neurons","volume":"28","author":"Gertler","year":"2008","journal-title":"J. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-e","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"12748","DOI":"10.1073\/pnas.171442798","article-title":"Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1\u201343 photoconversion","volume":"98","author":"Harata","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e50717","DOI":"10.1371\/journal.pone.0050717","article-title":"Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington\u2019s disease","volume":"7","author":"Heikkinen","year":"2012","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1523\/jneurosci.07-05-01503.1987","article-title":"Numbers and proportions of GABA-immunoreactive neurons in different areas of monkey cerebral cortex","volume":"7","author":"Hendry","year":"1987","journal-title":"J. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1073\/pnas.93.5.1918","article-title":"FM1\u201343 dye ultrastructural localization in and release from frog motor nerve terminals","volume":"93","author":"Henkel","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B35","doi-asserted-by":"publisher","first-page":"14286","DOI":"10.1523\/jneurosci.4122-07.2007","article-title":"Quantitative analysis of calcium-dependent vesicle recruitment and its functional role at the calyx of Held synapse","volume":"27","author":"Hosoi","year":"2007","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/nn.2838","article-title":"A readily retrievable pool of synaptic vesicles","volume":"14","author":"Hua","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1529\/biophysj.105.061663","article-title":"Visualization of synaptic vesicle movement in intact synaptic boutons using fluorescence fluctuation spectroscopy","volume":"89","author":"Jordan","year":"2005","journal-title":"Biophys. J."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1523\/jneurosci.5687-08.2009","article-title":"Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease","volume":"29","author":"Joshi","year":"2009","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1152\/jn.2001.86.6.2667","article-title":"Electrophysiological and morphological changes in striatal spiny neurons in R6\/2 Huntington\u2019s disease transgenic mice","volume":"86","author":"Klapstein","year":"2001","journal-title":"J. Neurophysiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fnsyn.2016.00005","article-title":"Molecular machines regulating the release probability of synaptic vesicles at the active zone","volume":"8","author":"K\u00f6rber","year":"2016","journal-title":"Front. Synaptic Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nature05506","article-title":"Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson\u2019s disease models","volume":"445","author":"Kreitzer","year":"2007","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/1742-2094-9-230","article-title":"Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro","volume":"9","author":"Leow-Dyke","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"B43","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.molmed.2003.08.006","article-title":"Huntington\u2019s disease: a synaptopathy?","volume":"9","author":"Li","year":"2003","journal-title":"Trends Mol. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1006\/mcne.2002.1152","article-title":"Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6\/2 Huntington\u2019s disease transgenic mice","volume":"20","author":"Li\u00e9vens","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/0028-3908(95)00143-t","article-title":"Synaptic transmission at single visualized hippocampal boutons","volume":"34","author":"Liu","year":"1995","journal-title":"Neuropharmacology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.ceca.2015.10.003","article-title":"A comparison of fluorescent Ca2+ indicators for imaging local Ca2+ signals in cultured cells","volume":"58","author":"Lock","year":"2015","journal-title":"Cell Calcium"},{"key":"B47","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/0896-6273(93)90119-c","article-title":"Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus","volume":"11","author":"Luebke","year":"1993","journal-title":"Neuron"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e49838","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington\u2019s disease: zQ175","volume":"7","author":"Menalled","year":"2012","journal-title":"PLoS One"},{"key":"B49","doi-asserted-by":"publisher","first-page":"735","DOI":"10.2217\/fnl.10.41","article-title":"Corticostriatal circuit dysfunction in Huntington\u2019s disease: intersection of glutamate, dopamine and calcium","volume":"5","author":"Miller","year":"2010","journal-title":"Future Neurol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"53072","DOI":"10.1074\/jbc.m306230200","article-title":"Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin","volume":"278","author":"Miller","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2010.01.008","article-title":"Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington\u2019s disease mice","volume":"65","author":"Milnerwood","year":"2010","journal-title":"Neuron"},{"key":"B52","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/s0361-9230(01)00611-6","article-title":"Abnormalities in the synaptic vesicle fusion machinery in Huntington\u2019s disease","volume":"56","author":"Morton","year":"2001","journal-title":"Brain Res. Bull."},{"key":"B53","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/s0896-6273(00)80301-3","article-title":"Heterogeneous release properties of visualized individual hippocampal synapses","volume":"18","author":"Murthy","year":"1997","journal-title":"Neuron"},{"key":"B54","doi-asserted-by":"publisher","first-page":"217","DOI":"10.5607\/en.2018.27.3.217","article-title":"Cortical axonal secretion of BDNF in the striatum is disrupted in the mutant-huntingtin knock-in mouse model of Huntington\u2019s disease","volume":"27","author":"Park","year":"2018","journal-title":"Exp. Neurobiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1126\/science.1216937","article-title":"Influence of synaptic vesicle position on release probability and exocytotic fusion mode","volume":"335","author":"Park","year":"2012","journal-title":"Science"},{"key":"B56","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2014.05.032","article-title":"Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington\u2019s disease","volume":"83","author":"Plotkin","year":"2014","journal-title":"Neuron"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.bbrc.2016.07.058","article-title":"Striatal synaptic dysfunction and altered calcium regulation in Huntington disease","volume":"483","author":"Raymond","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B58","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.08.052","article-title":"Pathophysiology of Huntington\u2019s disease: time-dependent alterations in synaptic and receptor function","volume":"198","author":"Raymond","year":"2011","journal-title":"Neuroscience"},{"key":"B59","doi-asserted-by":"publisher","first-page":"9992","DOI":"10.1523\/jneurosci.1270-12.2012","article-title":"In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy","volume":"32","author":"Reznichenko","year":"2012","journal-title":"J. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1083\/jcb.200407148","article-title":"Two modes of exocytosis at hippocampal synapses revealed by rate of FM1\u201343 efflux from individual vesicles","volume":"168","author":"Richards","year":"2005","journal-title":"J. Cell Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuron.2007.11.025","article-title":"Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm","volume":"57","author":"Romero","year":"2008","journal-title":"Neuron"},{"key":"B62","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1460-9568.2010.07268.x","article-title":"Glutamate-induced alterations in Ca2+ signaling are modulated by mitochondrial Ca2+ handling capacity in brain slices of R6\/1 transgenic mice","volume":"32","author":"Rosenstock","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1523\/JNEUROSCI.2011-10.2011","article-title":"Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease","volume":"31","author":"Rozas","year":"2011","journal-title":"J. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/0896-6273(93)90081-2","article-title":"The kinetics of synaptic vesicle recycling measured at single presynaptic boutons","volume":"11","author":"Ryan","year":"1993","journal-title":"Neuron"},{"key":"B65","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.drudis.2014.02.006","article-title":"Mechanisms of synaptic dysfunction and excitotoxicity in Huntington\u2019s disease","volume":"19","author":"Sepers","year":"2014","journal-title":"Drug Discov. Today"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2017.03.015","article-title":"N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington\u2019s disease","volume":"55","author":"Silva","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B67","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neuron.2014.03.016","article-title":"Neuronal voltage-gated calcium channels: structure, function and dysfunction","volume":"82","author":"Simms","year":"2014","journal-title":"Neuron"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1007\/s00018-005-5084-5","article-title":"Synaptic dysfunction in Huntington\u2019s disease: a new perspective","volume":"62","author":"Smith","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"a011353","DOI":"10.1101\/cshperspect.a011353","article-title":"Calcium control of neurotransmitter release","volume":"4","author":"S\u00fcdhof","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.mcn.2005.07.016","article-title":"Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels","volume":"30","author":"Swayne","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1111\/ejn.12476","article-title":"A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo","volume":"39","author":"Tada","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1073\/pnas.0409402102","article-title":"Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington\u2019s disease","volume":"102","author":"Tang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1111\/j.1460-9568.2004.03633.x","article-title":"HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca2+ release in primary culture of striatal medium spiny neurons","volume":"20","author":"Tang","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1523\/JNEUROSCI.23-02-00403.2003","article-title":"Modulation of type 1 inositol (1,4,5)-trisphosphate receptor function by protein kinase a and protein phosphatase 1\u03b1","volume":"23","author":"Tang","year":"2003","journal-title":"J. Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/290527a0","article-title":"A non-disruptive technique for loading calcium buffers and indicators into cells","volume":"290","author":"Tsien","year":"1981","journal-title":"Nature"},{"key":"B76","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.pneurobio.2017.03.008","article-title":"Synaptopathic mechanisms of neurodegeneration and dementia: insights from Huntington\u2019s disease","volume":"153","author":"Tyebji","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1152\/jn.1994.72.4.1973","article-title":"Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro","volume":"72","author":"Tymianski","year":"1994","journal-title":"J. Neurophysiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0896-6273(93)90180-y","article-title":"Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo","volume":"11","author":"Tymianski","year":"1993","journal-title":"Neuron"},{"key":"B79","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3233\/JHD-130080","article-title":"Striatal synaptosomes from Hdh140Q\/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation","volume":"2","author":"Valencia","year":"2013","journal-title":"J. Huntingtons Dis."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1111\/j.1460-9568.1997.tb01369.x","article-title":"Presynaptic modulation of glutamate release targets different calcium channels in rat cerebrocortical nerve terminals","volume":"9","author":"V\u00e1zquez","year":"1997","journal-title":"Eur. J. Neurosci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.celrep.2017.12.013","article-title":"Reconstituting corticostriatal network on-a-chip reveals the contribution of the presynaptic compartment to Huntington\u2019s disease","volume":"22","author":"Virlogeux","year":"2018","journal-title":"Cell Rep."},{"key":"B82","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/28645","article-title":"High-frequency firing helps replenish the readily releasable pool of synaptic vesicles","volume":"394","author":"Wang","year":"1998","journal-title":"Nature"},{"key":"B84","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.bpj.2010.12.3706","article-title":"Systematic heterogeneity of fractional vesicle pool sizes and release rates of hippocampal synapses","volume":"100","author":"Welzel","year":"2011","journal-title":"Biophys. J."},{"key":"B85","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1126\/science.7832825","article-title":"Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission","volume":"264","author":"Wheeler","year":"1994","journal-title":"Science"},{"key":"B86","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1523\/JNEUROSCI.1038-15.2016","article-title":"Enhanced store-operated calcium entry leads to striatal synaptic loss in a Huntington\u2019s disease mouse model","volume":"36","author":"Wu","year":"2016","journal-title":"J. Neurosci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"16976","DOI":"10.1038\/s41598-018-34883-w","article-title":"Decreased BDNF release in cortical neurons of a knock-in mouse model of Huntington\u2019s disease","volume":"8","author":"Yu","year":"2018","journal-title":"Sci. Rep."},{"key":"B88","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11515-016-1397-z","article-title":"Real-time imaging of single synaptic vesicles in live neurons","volume":"11","author":"Yu","year":"2016","journal-title":"Front. Biol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1254\/jphs.92.79","article-title":"Regulation of presynaptic calcium channels by synaptic proteins","volume":"92","author":"Zamponi","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"17843","DOI":"10.1073\/pnas.0706906104","article-title":"Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles","volume":"104","author":"Zhang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1126\/science.1167373","article-title":"The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles","volume":"323","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"B92","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nrneurol.2009.54","article-title":"Brain-derived neurotrophic factor in neurodegenerative diseases","volume":"5","author":"Zuccato","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/978-3-642-45106-5_14","article-title":"Huntington\u2019s disease","volume":"220","author":"Zuccato","year":"2014","journal-title":"Handb. Exp. Pharmacol."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnmol.2018.00478\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T09:59:43Z","timestamp":1547719183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnmol.2018.00478\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,24]]},"references-count":92,"alternative-id":["10.3389\/fnmol.2018.00478"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2018.00478","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,24]]},"article-number":"478"}}