{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:02:43Z","timestamp":1791489763247,"version":"4.3.4"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000924","name":"Multiple Sclerosis Research Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2019.00205","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:49:56Z","timestamp":1566866996000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum"],"prefix":"10.3389","volume":"12","author":[{"given":"Huynh T. H.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhiannon J.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa R.","family":"Prawdiuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian G. B.","family":"Furness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon S.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/dneu.22518","article-title":"Intrinsic and adaptive myelincation-a sequential mechanism for smart wiring in the brain","volume":"78","author":"Bechler","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"eaal1670","DOI":"10.1126\/scisignal.aal1670","article-title":"Multiplex quantitative assays indicate a need for re-evaluating reported small-molecule TrkB agonists","volume":"10","author":"Boltaev","year":"2017","journal-title":"Sci. Signal."},{"key":"B3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their receptors: a convergence point for many signalling pathways","volume":"4","author":"Chao","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1038\/nn.2410","article-title":"The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination","volume":"12","author":"Chen","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1083\/jcb.200404076","article-title":"Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development","volume":"167","author":"Colognato","year":"2004","journal-title":"J. Cell Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1002\/glia.22729","article-title":"Interaction of mTOR and Erk1\/2 signaling to regulate oligodendrocyte differentiation","volume":"62","author":"Dai","year":"2014","journal-title":"Glia"},{"key":"B8","unstructured":"Regionally specific effects of BDNF on oligodendrocytes24\n            DuY.\n            FischerT. Z.\n            LeeL. N.\n            LercherL. D.\n            DreyfusC. F.\n          Dev. Neurosci.252003"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1002\/jnr.21080","article-title":"Mitogen-activated protein kinase pathway mediates effects of brain-derived neurotrophic factor on differentiation of basal forebrain oligodendrocytes","volume":"84","author":"Du","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/1097-4547(20001101)62:3<336::AID-JNR3>3.0.CO;2-H","article-title":"Distinct roles for PI3K in proliferation and survival of oligodendrocyte progenitor cells","volume":"62","author":"Ebner","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"E4131","DOI":"10.3390\/ijms19124131","article-title":"Brain-derived neurotrophic factor in central nervous system myelination: a new mechanism to promote myelin plasticity and repair","volume":"19","author":"Fletcher","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"7088","DOI":"10.1523\/JNEUROSCI.0487-18.2018","article-title":"Targeting TrkB with a brain-derived neurotrophic factor mimetic promotes myelin repair in the brain","volume":"38","author":"Fletcher","year":"","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"8518","DOI":"10.1038\/ncomms9518","article-title":"Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors","volume":"6","author":"Gautier","year":"2015","journal-title":"Nat. Commun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"6121","DOI":"10.1038\/ncomms7121","article-title":"The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development","volume":"6","author":"Giera","year":"2015","journal-title":"Nat. Commun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/nn.4425","article-title":"A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination","volume":"20","author":"Goebbels","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.nbd.2018.01.018","article-title":"Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons","volume":"113","author":"Gu","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1161\/STROKEAHA.111.641878","article-title":"Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke","volume":"43","author":"Han","year":"2012","journal-title":"Stroke"},{"key":"B17","doi-asserted-by":"publisher","first-page":"6471","DOI":"10.1523\/JNEUROSCI.0299-16.2016","article-title":"Strength of ERK1\/2 MAPK activation determines its effect on myelin and axonal integrity in the adult CNS","volume":"36","author":"Ishii","year":"2016","journal-title":"J. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1002\/glia.23602","article-title":"Independent and cooperative roles of the Mek\/ERK1\/2-MAPK and PI3K\/Akt\/mTOR pathways during developmental myelination and in adulthood","volume":"67","author":"Ishii","year":"2019","journal-title":"Glia"},{"key":"B19","doi-asserted-by":"publisher","first-page":"8855","DOI":"10.1523\/JNEUROSCI.0137-12.2012","article-title":"ERK1\/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination","volume":"32","author":"Ishii","year":"2012","journal-title":"J. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/ng1095","article-title":"Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination","volume":"33","author":"Lappe-Siefke","year":"2003","journal-title":"Nat. Genet."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1073\/pnas.061020198","article-title":"Activation of Trk neurotrophin receptors in the absence of neurotrophins","volume":"98","author":"Lee","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B22","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nrd4024","article-title":"Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease","volume":"12","author":"Longo","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3774","DOI":"10.1523\/JNEUROSCI.0041-05.2005","article-title":"TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses","volume":"25","author":"Luikart","year":"2005","journal-title":"J. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1172\/JCI41356","article-title":"Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents","volume":"120","author":"Massa","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B25","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.1523\/jneurosci.18-14-05354.1998","article-title":"Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord","volume":"18","author":"McTigue","year":"1998","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1159\/000069050","article-title":"IGF-I and NT-3 signaling pathways in developing oligodendrocytes: differential regulation and activation of receptors and the downstream effector Akt","volume":"24","author":"Ness","year":"2002","journal-title":"Dev. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"25738","DOI":"10.1074\/jbc.M303209200","article-title":"Design of potent peptide mimetics of brain-derived neurotrophic factor","volume":"278","author":"O\u2019Leary","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/glia.22927","article-title":"Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination","volume":"64","author":"Peckham","year":"2016","journal-title":"Glia"},{"key":"B29","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/0169-328x(95)00250-v","article-title":"Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF","volume":"36","author":"Poduslo","year":"1996","journal-title":"Mol. Brain Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.mcn.2006.06.002","article-title":"A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling","volume":"33","author":"Rajagopal","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"6650","DOI":"10.1523\/JNEUROSCI.0010-04.2004","article-title":"Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes","volume":"24","author":"Rajagopal","year":"2004","journal-title":"J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1523\/JNEUROSCI.0865-11.2012","article-title":"A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome","volume":"32","author":"Schmid","year":"2012","journal-title":"J. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"18712","DOI":"10.1523\/JNEUROSCI.1310-13.2013","article-title":"A small molecule TrkB ligand reduces motor impairment and neuropathology in R6\/2 and BACHD mouse models of Huntington\u2019s disease","volume":"33","author":"Simmons","year":"2013","journal-title":"J. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1523\/jneurosci.21-06-02039.2001","article-title":"A unique role for Fyn in CNS myelination","volume":"21","author":"Sperber","year":"2001","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1365-2990.1980.tb00219.x","article-title":"Myelination of the mouse corpus callosum","volume":"6","author":"Sturrock","year":"1980","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1759091414566878","DOI":"10.1177\/1759091414566878","article-title":"Brain-derived neurotrophic factor deficiency restricts proliferation of oligodendrocyte progenitors following cuprizone-induced demyelination","volume":"7","author":"Tsiperson","year":"2015","journal-title":"ASN Neuro"},{"key":"B37","doi-asserted-by":"publisher","first-page":"14182","DOI":"10.1523\/JNEUROSCI.6595-10.2011","article-title":"Levels of BDNF impact oligodendrocyte lineage cells following a cuprizone lesion","volume":"31","author":"VonDran","year":"2011","journal-title":"J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1029","DOI":"10.1212\/WNL.0000000000007044","article-title":"The prevalence of MS in the United States","volume":"92","author":"Wallin","year":"2019","journal-title":"Neurology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.mcn.2014.10.002","article-title":"TDP6, a brain-derived neurotrophic factor-based TrkB peptide mimetic, promotes oligodendrocyte myelination","volume":"63","author":"Wong","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.1523\/JNEUROSCI.3990-12.2013","article-title":"Oligodendroglial expression of TrkB independently regulates myelination and progenitor cell proliferation","volume":"33","author":"Wong","year":"2013","journal-title":"J. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000323170","article-title":"Brain-derived neurotrophic factor promotes central nervous system myelination via a direct effect upon oligodendrocytes","volume":"18","author":"Xiao","year":"2011","journal-title":"Neurosignals"},{"key":"B42","doi-asserted-by":"publisher","first-page":"10884","DOI":"10.1038\/ncomms10884","article-title":"G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination","volume":"7","author":"Yang","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnmol.2019.00205\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T11:45:54Z","timestamp":1568979954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnmol.2019.00205\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":42,"alternative-id":["10.3389\/fnmol.2019.00205"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2019.00205","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/642918","asserted-by":"object"}]},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,27]]},"article-number":"205"}}