{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:56:03Z","timestamp":1790607363531,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZR2017MH043, 81171604, 2016GSF201201, 81971968, 2018M642663"],"award-info":[{"award-number":["ZR2017MH043, 81171604, 2016GSF201201, 81971968, 2018M642663"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2020.00077","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T13:32:24Z","timestamp":1589549544000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Downregulation of lncRNA-11496 in the Brain Contributes to Microglia Apoptosis via Regulation of Mef2c in Chronic T. gondii Infection Mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiahui","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.nbd.2012.02.006","article-title":"Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures","volume":"46","author":"Abraham","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.biopsych.2015.09.018","article-title":"Postnatal loss of Mef2c results in dissociation of effects on synapse number and learning and memory","volume":"80","author":"Adachi","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00441-017-2711-z","article-title":"Forging our understanding of lncRNAs in the brain","volume":"371","author":"Andersen","year":"2018","journal-title":"Cell Tissue Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1089.e3","DOI":"10.1016\/j.celrep.2019.01.004","article-title":"A late phase of long-term synaptic depression in cerebellar purkinje cells requires activation of MEF2","volume":"26","author":"Andzelm","year":"2019","journal-title":"Cell Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/j.cell.2016.05.075","article-title":"A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation","volume":"165","author":"Atianand","year":"2016","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/pim.12173","article-title":"Persistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between the parasite, the brain and the immune system","volume":"37","author":"Blanchard","year":"2015","journal-title":"Parasite Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e1415","DOI":"10.1128\/mbio.01428-15","article-title":"Toxoplasma gondii infections alter GABAergic synapses and signaling in the central nervous system","volume":"6","author":"Brooks","year":"2015","journal-title":"mBio"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1005447","DOI":"10.1371\/journal.ppat.1005447","article-title":"Neurons are the primary target cell for the brain-tropic intracellular parasite toxoplasma gondii","volume":"12","author":"Cabral","year":"2016","journal-title":"PLoS Pathog."},{"key":"B9","doi-asserted-by":"publisher","first-page":"C780","DOI":"10.1152\/ajpcell.00351.2015","article-title":"HDAC2 regulates FoxO1during RANKL-induced osteoclastogenesis","volume":"310","author":"Dou","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1016\/j.ajpath.2018.07.007","article-title":"The neurotropic parasite toxoplasma gondii induces sustained neuroinflammation with microvascular dysfunction in infected mice","volume":"188","author":"Estato","year":"2018","journal-title":"Am. J. Pathol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.12659\/msm.913420","article-title":"lncRNA colorectal neoplasia differentially expressed (CRNDE) promotes proliferation and inhibits apoptosis in non-small cell lung cancer cells by Regulating the miR-641\/CDK6 Axis","volume":"25","author":"Fan","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"B12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nature09701","article-title":"lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3\u2019 UTRs via Alu elements","volume":"470","author":"Gong","year":"2011","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.7754\/clin.lab.2018.180817","article-title":"Long non-coding RNA 001089 is a prognostic marker and inhibits glioma cells proliferation and invasion","volume":"65","author":"Gu","year":"2019","journal-title":"Clin. Lab."},{"key":"B14","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1128\/cmr.00005-17","article-title":"Toxoplasma effectors targeting host signaling and transcription","volume":"30","author":"Hakimi","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.4088\/jcp.15m10133","article-title":"Effects of cumulative herpesviridae and toxoplasma gondii infections on cognitive function in healthy, bipolar, and schizophrenia subjects","volume":"78","author":"Hamdani","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"B16","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1007\/s12035-018-1363-7","article-title":"Myocyte enhancer factor 2c regulates dendritic complexity and connectivity of cerebellar purkinje cells","volume":"56","author":"Kamath","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.parint.2018.07.004","article-title":"Congenital toxoplasmosis: an overview of the neurological and ocular manifestations","volume":"67","author":"Khan","year":"2018","journal-title":"Parasitol. Int."},{"key":"B18","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.cell.2018.05.022","article-title":"A network of noncoding regulatory RNAs acts in the mammalian brain","volume":"174","author":"Kleaveland","year":"2018","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1136\/jmg.2009.069732","article-title":"MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and\/or cerebral malformations","volume":"47","author":"Le Meur","year":"2010","journal-title":"Clin. Genet."},{"key":"B20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/1756-3305-7-133","article-title":"Phylogeny and virulence divergency analyses of Toxoplasma gondii isolates from China","volume":"7","author":"Li","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s10753-015-0262-6","article-title":"Toxoplasma gondii infection promotes neuroinflammation through cytokine networks and induced hyperalgesia in BALB\/c mice","volume":"39","author":"Mahmoudvand","year":"2016","journal-title":"Inflammation"},{"key":"B22","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nrc2602","article-title":"Cell cycle, CDKs and cancer: a changing paradigm","volume":"9","author":"Malumbres","year":"2009","journal-title":"NatRev Cancer."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1007\/s00436-018-6040-2","article-title":"Toxoplasma gondii infection and behavioral outcomes in humans: a systematic review","volume":"117","author":"Martinez","year":"2018","journal-title":"Parasitol. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e1006351","DOI":"10.1371\/journal.ppat.1006351","article-title":"Toxoplasma gondii: entry, association, and physiological influence on the central nervous system","volume":"13","author":"Mendez","year":"2017","journal-title":"PLoS Pathog."},{"key":"B25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/mp.2016.254","article-title":"MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophreniaand improves cognition in mice","volume":"23","author":"Mitchell","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"11496","DOI":"10.1038\/s41598-017-10675-6","article-title":"Toxoplasma modulates signature pathways of human epilepsy, neurodegeneration and cancer","volume":"7","author":"Ng\u00f4","year":"2017","journal-title":"Sci Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1523\/JNEUROSCI.2444-14.2015","article-title":"HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death","volume":"35","author":"Peng","year":"2015","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1021\/acschemneuro.6b00372","article-title":"Expression of HDAC2 but not HDAC1 transcript is reduced in Dorsolateral prefrontal cortexof patients with schizophrenia","volume":"8","author":"Schroeder","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e71323","DOI":"10.1371\/journal.pone.0071323","article-title":"A selective HDAC 1\/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests","volume":"8","author":"Schroeder","year":"2013","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","first-page":"E19","DOI":"10.3390\/pathogens6020019","article-title":"Neurophysiological changes induced by chronic toxoplasma gondii infection","volume":"6","author":"Tedford","year":"2017","journal-title":"Pathogens"},{"key":"B31","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.neubiorev.2018.11.012","article-title":"Toxoplasmosis: a pathway to neuropsychiatric disorders","volume":"96","author":"Tyebji","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","article-title":"lincRNAs: genomics, evolution, and mechanisms","volume":"154","author":"Ulitsky","year":"2013","journal-title":"Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/s41419-019-1440-5","article-title":"The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN\/AKT\/p53 signaling pathway","volume":"10","author":"Wan","year":"2019","journal-title":"Cell Death Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.bbr.2018.09.011","article-title":"From inflammatory reactions to neurotransmitter changes: implications for understanding the neurobehavioral changes in mice chronically infected with Toxoplasma gondii","volume":"359","author":"Wang","year":"2019","journal-title":"Behav. Brain Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.pt.2017.04.001","article-title":"Brains and brawn: toxoplasma infections of the central nervous system and skeletal muscle","volume":"33","author":"Wohlfert","year":"2017","journal-title":"Trends Parasitol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1093\/schbul\/sby082","article-title":"Toxoplasma gondii: biological parameters of the connection to schizophrenia","volume":"44","author":"Xiao","year":"2018","journal-title":"Schizophr. Bull."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3565","DOI":"10.2147\/cmar.s194848","article-title":"lncRNA BANCR suppresses cell viability and invasion and promotesapoptosis in non-small-cell lung cancer cells in vitro and in vivo","volume":"11","author":"Yang","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12943-019-0955-9","article-title":"Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin \u03b23 transcriptional activating and MAPK\/AKT signalling","volume":"18","author":"Yang","year":"2019","journal-title":"Mol. Cancer"},{"key":"B40","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s13046-018-0896-y","article-title":"LncRNA SLCO4A1-AS1 facilitates growth and metastasis of colorectal cancer through \u03b2-catenin-dependent Wnt pathway","volume":"37","author":"Yu","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1186\/1756-3305-7-372","article-title":"Activated microgliacontribute to neuronal apoptosis in Toxoplasmic encephalitis","volume":"7","author":"Zhang","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B42","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1159\/000337496","article-title":"The MEF2C-related and 5q14.3q15 microdeletion syndrome","volume":"2","author":"Zweier","year":"2012","journal-title":"Mol. Syndromol."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnmol.2020.00077\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T13:32:28Z","timestamp":1589549548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnmol.2020.00077\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,15]]},"references-count":41,"alternative-id":["10.3389\/fnmol.2020.00077"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2020.00077","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,15]]},"article-number":"77"}}