{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:58:11Z","timestamp":1787432291091,"version":"build-2736575974"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2020.00100","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T04:39:46Z","timestamp":1591331986000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Hypothermia-Induced Ubiquitination of Voltage-Dependent Anion Channel 3 Protects BV2 Microglia Cells From Cytotoxicity Following Oxygen-Glucose Deprivation\/Recovery"],"prefix":"10.3389","volume":"13","author":[{"given":"Shen","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caijing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziren","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15370","DOI":"10.1073\/pnas.0808115105","article-title":"Structure of the human voltage-dependent anion channel","volume":"105","author":"Bayrhuber","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/0271678x17742260","article-title":"SUMOylation in brain ischemia: patterns, targets, and translational implications","volume":"38","author":"Bernstock","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"S465","DOI":"10.1161\/CIR.0000000000000262","article-title":"Part 8: post-cardiac arrest care: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"132","author":"Callaway","year":"2015","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fnmol.2017.00261","article-title":"Regulation of microglia and macrophage polarization via apoptosis signal-regulating kinase 1 silencing after ischemic\/hypoxic injury","volume":"10","author":"Cheon","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/j.febslet.2010.02.049","article-title":"Voltage-dependent anion-selective channel (VDAC) in the plasma membrane","volume":"584","author":"De Pinto","year":"2010","journal-title":"FEBS Lett."},{"key":"B6","doi-asserted-by":"publisher","first-page":"414","DOI":"10.2174\/1871527316666170320150659","article-title":"Utilizing delta opioid receptors and peptides for cytoprotection: implications in stroke and other neurological disorders","volume":"16","author":"Crowley","year":"2017","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B7","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.neuroimage.2004.09.034","article-title":"Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study","volume":"24","author":"Gerhard","year":"2005","journal-title":"NeuroImage"},{"key":"B8","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/jcbfm.2013.33","article-title":"Hypothermia-induced neuroprotection is associated with reduced mitochondrial membrane permeability in a swine model of cardiac arrest","volume":"33","author":"Gong","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1089\/neu.2009.1186","article-title":"Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death","volume":"27","author":"Hazelton","year":"2010","journal-title":"J. Neurotrauma"},{"key":"B10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","article-title":"Microglia and macrophage polarization\u2014new prospects for brain repair","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.1002\/jnr.22520","article-title":"Hypothermia-induced increase of oligodendrocyte precursor cells: possible involvement of plasmalemmal voltage-dependent anion channel 1","volume":"88","author":"Imada","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.2174\/0929867324666170530073238","article-title":"VDAC-targeted drugs affecting cytoprotection and mitochondrial physiology in cerebrovascular and cardiovascular diseases","volume":"24","author":"Karachitos","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.resuscitation.2018.09.012","article-title":"Brain imaging in comatose survivors of cardiac arrest: pathophysiological correlates and prognostic properties","volume":"133","author":"Keijzer","year":"2018","journal-title":"Resuscitation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jns.2014.11.015","article-title":"Impact of hyperthermia before and during ischemia-reperfusion on neuronal damage and gliosis in the gerbil hippocampus induced by transient cerebral ischemia","volume":"348","author":"Kim","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1001\/jama.2017.8978","article-title":"Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial","volume":"318","author":"Kirkegaard","year":"2017","journal-title":"JAMA"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7494","DOI":"10.1073\/pnas.0602217103","article-title":"A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC","volume":"103","author":"Lai","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B17","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s12017-013-8239-9","article-title":"SUMO and ischemic tolerance","volume":"15","author":"Lee","year":"2013","journal-title":"Neuromolecular Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/sj.jcbfm.9600395","article-title":"Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells","volume":"27","author":"Lee","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B19","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s12031-017-1012-z","article-title":"Picroside II exerts a neuroprotective effect by inhibiting mptp permeability and endog release after cerebral ischemia\/reperfusion injury in rats","volume":"64","author":"Li","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.3892\/ijmm.2017.3167","article-title":"Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation","volume":"40","author":"Liu","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.brainres.2017.11.030","article-title":"Madecassoside protects BV2 microglial cells from oxygen-glucose deprivation\/reperfusion-induced injury via inhibition of the toll-like receptor 4 signaling pathway","volume":"1679","author":"Luo","year":"2018","journal-title":"Brain Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.pneurobio.2016.01.005","article-title":"The biphasic function of microglia in ischemic stroke","volume":"157","author":"Ma","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"10680","DOI":"10.1096\/fj.201900070R","article-title":"Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice","volume":"33","author":"McCrary","year":"2019","journal-title":"FASEB J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1177\/1073858408327809","article-title":"The role of the ubiquitin proteasome system in ischemia and ischemic tolerance","volume":"15","author":"Meller","year":"2009","journal-title":"Neuroscientist"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1757-5036-3-4","article-title":"Two-color STED microscopy reveals different degrees of colocalization between hexokinase-I and the three human VDAC isoforms","volume":"3","author":"Neumann","year":"2010","journal-title":"PMC Biophys."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1161\/01.str.0000226980.95389.0b","article-title":"Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke","volume":"37","author":"Price","year":"2006","journal-title":"Stroke"},{"key":"B27","doi-asserted-by":"publisher","first-page":"7006","DOI":"10.3892\/mmr.2017.7425","article-title":"Moderate hypothermia induces protein SUMOylation in bone marrow stromal cells and enhances their tolerance to hypoxia","volume":"16","author":"Ren","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e949","DOI":"10.1038\/cddis.2013.471","article-title":"Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death","volume":"4","author":"Rimmerman","year":"2013","journal-title":"Cell Death Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1074\/mcp.t600009-mcp200","article-title":"Hunting interactomes of a membrane protein: obtaining the largest set of voltage-dependent anion channel-interacting protein epitopes","volume":"5","author":"Roman","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s13054-018-2060-7","article-title":"Prognostication after cardiac arrest","volume":"22","author":"Sandroni","year":"2018","journal-title":"Crit. Care"},{"key":"B31","doi-asserted-by":"publisher","first-page":"278","DOI":"10.4161\/chan.27748","article-title":"Temperature sensitivity of acid-sensitive outwardly rectifying (ASOR) anion channels in cortical neurons is involved in hypothermic neuroprotection against acidotoxic necrosis","volume":"8","author":"Sato-Numata","year":"2014","journal-title":"Channels"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1007\/s11011-018-0232-4","article-title":"Role of microglia under cardiac and cerebral ischemia\/reperfusion (I\/R) injury","volume":"33","author":"Surinkaew","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1161\/strokeaha.110.598821","article-title":"Imaging of microglia activation in stroke","volume":"42","author":"Thiel","year":"2011","journal-title":"Stroke"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.2967\/jnumed.110.076612","article-title":"The temporal dynamics of poststroke neuroinflammation: a longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke","volume":"51","author":"Thiel","year":"2010","journal-title":"J. Nucl. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00540-008-0617-3","article-title":"Probing the molecular mechanisms of neuronal degeneration: importance of mitochondrial dysfunction and calcineurin activation","volume":"22","author":"Uchino","year":"2008","journal-title":"J. Anesth."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","article-title":"Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals","volume":"29","author":"Wake","year":"2009","journal-title":"J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1038\/jcbfm.2013.146","article-title":"Microglia\/macrophage polarization dynamics in white matter after traumatic brain injury","volume":"33","author":"Wang","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B38","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/jcbfm.2009.16","article-title":"Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass","volume":"29","author":"Yang","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/s41419-018-1089-5","article-title":"Ischemic postconditioning confers cerebroprotection by stabilizing VDACs after brain ischemia","volume":"9","author":"Yao","year":"2018","journal-title":"Cell Death Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3390\/ijms18030591","article-title":"GSK3\u03b2 and VDAC involvement in ER stress and apoptosis modulation during orthotopic liver transplantation","volume":"18","author":"Zaouali","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12031-018-1227-7","article-title":"Non-invasive vagus nerve stimulation protects against cerebral ischemia\/reperfusion injury and promotes microglial M2 polarization via interleukin-17A inhibition","volume":"67","author":"Zhao","year":"2019","journal-title":"J. Mol. Neurosci."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnmol.2020.00100\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T04:39:48Z","timestamp":1591331988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnmol.2020.00100\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,5]]},"references-count":41,"alternative-id":["10.3389\/fnmol.2020.00100"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2020.00100","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,5]]},"article-number":"100"}}