{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T14:25:24Z","timestamp":1776003924317,"version":"3.50.1"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"DOI":"10.3389\/fnmol.2020.605918","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:35:52Z","timestamp":1605602152000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The Serine Protease HTRA-1 Is a Biomarker for ROP and Mediates Retinal Neovascularization"],"prefix":"10.3389","volume":"13","author":[{"given":"Leah A.","family":"Owen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinsey","family":"Shirer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel A.","family":"Collazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Szczotka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawna","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Haaland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi D.","family":"Katikaneni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/s0029-7844(01)01747-1","article-title":"ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002","volume":"99","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"557.e1","DOI":"10.1016\/j.ajog.2008.04.046","article-title":"Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion","volume":"199","author":"Ajayi","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.ajo.2009.07.002","article-title":"Comprehensive analysis of complement factor H and LOC387715\/ARMS2\/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration","volume":"148","author":"Andreoli","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.biochi.2018.06.019","article-title":"The role of the retinal pigment epithelium and m\u00fcller cells secretome in neovascular retinal pathologies","volume":"155","author":"Ara\u00fajo","year":"2018","journal-title":"Biochimie"},{"key":"B5","unstructured":"ARUP Laboratories.2020"},{"key":"B6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12886-018-0732-3","article-title":"Prevalence and risk factors of retinopathy of prematurity in Iran: a systematic review and meta-analysis","volume":"18","author":"Azami","year":"2018","journal-title":"BMC Ophthalmol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1515\/CCLM.2000.087","article-title":"Preeclampsia is associated with alterations in insulin-like growth factor (IGF)-1 and IGF-binding proteins in wharton\u2019s jelly of the umbilical cord","volume":"38","author":"Ba\u0144kowski","year":"2000","journal-title":"Clin. Chem. Lab. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"42301","DOI":"10.1038\/srep42301","article-title":"Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth","volume":"7","author":"Becker","year":"2017","journal-title":"Sci. Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1111\/j.1582-4934.2009.00820.x","article-title":"Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model","volume":"14","author":"Bergmann","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1001\/archophthalmol.2012.2524","article-title":"The CHOP postnatal weight gain, birth weight, and gestational age retinopathy of prematurity risk model","volume":"130","author":"Binenbaum","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1056\/NEJMoa1302298","article-title":"Oxygen saturation and outcomes in preterm infants","volume":"368","author":"Stenson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4","DOI":"10.37349\/emed.2020.00002","article-title":"Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions","volume":"1","author":"Carroll","year":"2020","journal-title":"Explor. Med."},{"key":"B13","first-page":"97","article-title":"Human HtrA1 in the archived eyes with age-related macular degeneration","volume":"105","author":"Chan","year":"2007","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"B15","doi-asserted-by":"publisher","first-page":"22958","DOI":"10.1074\/jbc.M114.576744","article-title":"Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion","volume":"289","author":"Chen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.matbio.2018.03.013","article-title":"N-terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration","volume":"70","author":"Chen","year":"2018","journal-title":"Matrix Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat. Protoc."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1001\/archopht.119.8.1110","article-title":"Multicenter trial of cryotherapy for retinopathy of prematurity: ophthalmological outcomes at 10 years","volume":"119","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1001\/jamaophthalmol.2015.0460","article-title":"Validated system for centralized grading of retinopathy of prematurity: telemedicine approaches to evaluating acute-phase retinopathy of prematurity (e-ROP) study","volume":"133","author":"Daniel","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1209.e7","DOI":"10.1016\/j.ophtha.2007.10.032","article-title":"Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration","volume":"115","author":"Deangelis","year":"2008","journal-title":"Ophthalmology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1126\/science.1133807","article-title":"HTRA1 promoter polymorphism in wet age-related macular degeneration","volume":"314","author":"Dewan","year":"2006","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00441-014-2104-5","article-title":"PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy","volume":"360","author":"Dong","year":"2015","journal-title":"Cell Tissue Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/jcp.21706","article-title":"Transforming growth factor-\u03b2 1 (TGF-\u03b21) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis","volume":"219","author":"Ferrari","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.jpeds.2010.08.051","article-title":"Maternal preeclampsia protects preterm infants against severe retinopathy of prematurity","volume":"158","author":"Fortes","year":"2011","journal-title":"J. Pediatr."},{"key":"B24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1017\/S2040174411000535","article-title":"Novel thromboxane A2 analog-induced IUGR mouse model","volume":"2","author":"Fung","year":"2011","journal-title":"J. Dev. Orig. Health Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/s41372-018-0177-9","article-title":"Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors","volume":"38","author":"Gaynon","year":"2018","journal-title":"J. Perinatol."},{"key":"B26","first-page":"46","article-title":"Twenty years of childhood blindness: what have we learnt?","volume":"21","author":"Gilbert","year":"2008","journal-title":"Community Eye Health"},{"key":"B28","first-page":"233","article-title":"Final results of the early treatment for retinopathy of prematurity (ETROP) randomized trial","volume":"102","author":"Good","year":"2004","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/s0161-6420(01)00540-1","article-title":"The multicenter study of early treatment for retinopathy of prematurity (ETROP)","volume":"108","author":"Good","year":"2001","journal-title":"Ophthalmology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ydbio.2014.10.015","article-title":"Abnormal development of placenta in HtrA1-deficient mice","volume":"397","author":"Hasan","year":"2015","journal-title":"Dev. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ghir.2016.09.005","article-title":"IGF-I in the clinics: use in retinopathy of prematurity","author":"Hellstr\u00f6m","year":"2016","journal-title":"Growth Horm. IGF Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5804","DOI":"10.1073\/pnas.101113998","article-title":"Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity","volume":"98","author":"Hellstrom","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.3109\/14767058.2014.980231","article-title":"Influence of maternal pre-eclampsia on VEGF\/PlGF heterodimer levels in preterm infants","volume":"28","author":"Hentges","year":"","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1055\/s-0035-1552932","article-title":"Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia","volume":"32","author":"Hentges","year":"","journal-title":"Am. J. Perinatol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1074\/jbc.M114.593384","article-title":"HTRA1 (high temperature requirement a serine peptidase 1) gene is transcriptionally regulated by insertion\/deletion nucleotides located at the 3\u2019 end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular degeneration","volume":"290","author":"Iejima","year":"","journal-title":"J. Biol. Chem."},{"key":"B34","first-page":"193","article-title":"HTRA1 overexpression induces the exudative form of age-related macular degeneration","volume":"10","author":"Iejima","year":"","journal-title":"J. Stem Cells"},{"key":"B36","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1001\/archopht.123.7.991","article-title":"The international classification of retinopathy of prematurity revisited","volume":"123","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1128\/MCB.01283-12","article-title":"Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1","volume":"33","author":"Jacobo","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"14578","DOI":"10.1073\/pnas.1102853108","article-title":"Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice","volume":"108","author":"Jones","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1038\/s41388-018-0258-4","article-title":"Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis","volume":"37","author":"Klose","year":"2018","journal-title":"Oncogene"},{"key":"B40","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.preghy.2017.07.148","article-title":"Maternal serum IGF-1, IGFBP-1 and 3, and placental growth hormone at 20 weeks\u2019 gestation in pregnancies complicated by preeclampsia","volume":"10","author":"Liao","year":"2017","journal-title":"Pregnancy Hypertension"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.3892\/mmr.2018.9289","article-title":"Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functions","volume":"18","author":"Liu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e0216808","DOI":"10.1371\/journal.pone.0216808","article-title":"HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression","volume":"14","author":"Lu","year":"2019","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e0126815","DOI":"10.1371\/journal.pone.0126815","article-title":"Circulating angiogenic factors and the risk of adverse outcomes among haitian women with preeclampsia","volume":"10","author":"March","year":"2015","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1080\/14767058.2017.1401996","article-title":"How does preeclampsia affect neonates? Highlights in the disease\u2019s immunity","volume":"32","author":"Marins","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.placenta.2012.09.011","article-title":"Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR","volume":"33","author":"Marzioni","year":"2012","journal-title":"Placenta"},{"key":"B46","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1159\/000489039","article-title":"Reduced prevalence of severe intraventricular hemorrhage in very preterm infants delivered after maternal preeclampsia","volume":"114","author":"Morsing","year":"2018","journal-title":"Neonatology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.amjhyper.2003.12.010","article-title":"Transforming growth factor-\u03b21 (TGF-\u03b21) in plasma is associated with preeclampsia risk in peruvian women with systemic inflammation","volume":"17","author":"Muy-Rivera","year":"2004","journal-title":"Am. J. Hypertens."},{"key":"B48","doi-asserted-by":"publisher","first-page":"6514","DOI":"10.1167\/iovs.14-14453","article-title":"Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice","volume":"55","author":"Nakayama","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1136\/bjo.82.11.1246","article-title":"Longer-term visual outcome of eyes with retinopathy of prematurity treated with cryotherapy or diode laser","volume":"82","author":"O\u2019Keefe","year":"1998","journal-title":"Br. J. Ophthalmol."},{"key":"B51","first-page":"94","article-title":"Current concepts of oxygen management in retinopathy of prematurity","volume":"9","author":"Owen","year":"2014","journal-title":"J. Ophthalmic Vis. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"e0171467","DOI":"10.1371\/journal.pone.0171467","article-title":"Retinopathy of prematurity: a comprehensive risk analysis for prevention and prediction of disease","volume":"12","author":"Owen","year":"2017","journal-title":"PLoS One"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1167\/iovs.18-24254","article-title":"The utah protocol for postmortem eye phenotyping and molecular biochemical analysis","volume":"60","author":"Owen","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e13263","DOI":"10.1371\/journal.pone.0013263","article-title":"Soluble fms-like tyrosine kinase 1 (SFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies","volume":"5","author":"Powers","year":"2010","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2147\/EB.S94436","article-title":"Retinopathy of prematurity blindness worldwide: phenotypes in the third epidemic","volume":"8","author":"Quinn","year":"2016","journal-title":"Eye Brain"},{"key":"B55","first-page":"2929","article-title":"Retinopathy of prematurity: an epidemic in the making","volume":"123","author":"Quinn","year":"2010","journal-title":"Chinese Med. J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1001\/jamaophthalmol.2014.1604","article-title":"Validity of a telemedicine system for the evaluation of acute-phase retinopathy of prematurity","volume":"132","author":"Quinn","year":"2014","journal-title":"JAMA Ophthalmol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/jp.2017.162","article-title":"Pregnancy-induced hypertension and neonatal outcomes: a systematic review and meta-analysis","volume":"38","author":"Razak","year":"2018","journal-title":"J. Perinatol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1001\/jamaophthalmol.2017.2697","article-title":"Association of maternal preeclampsia with infant risk of premature birth and retinopathy of prematurity","volume":"135","author":"Shulman","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.ophtha.2015.12.019","article-title":"Neonatal risk factors for treatment-demanding retinopathy of prematurity: a Danish National Study","volume":"123","author":"Slidsborg","year":"2016","journal-title":"Ophthalmology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1167\/iovs.10-5176","article-title":"The mouse retina as an angiogenesis model","volume":"51","author":"Stahl","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1056\/NEJMoa0911781","article-title":"Target ranges of oxygen saturation in extremely preterm infants","volume":"362","author":"Carlo","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.placenta.2015.07.001","article-title":"Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia","volume":"36","author":"Teoh","year":"2015","journal-title":"Placenta"},{"key":"B63","doi-asserted-by":"publisher","first-page":"9952","DOI":"10.1073\/pnas.1917608117","article-title":"Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy","volume":"117","author":"Tom","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B64","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1126\/science.1133811","article-title":"A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration","volume":"314","author":"Yang","year":"2006","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s10792-014-9956-2","article-title":"Incidence and risk factors for retinopathy of prematurity in extreme low birth weight chinese infants","volume":"35","author":"Yau","year":"2015","journal-title":"Int. Ophthalmol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/APO.0000000000000167","article-title":"Incidence and risk factors of retinopathy of prematurity from 2 neonatal intensive care units in a hong kong chinese population","volume":"5","author":"Yau","year":"2016","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-1-4419-1399-9_9","article-title":"Increased expression of TGF-\u03b21 and Smad 4 on oxygen-induced retinopathy in neonatal mice","volume":"664","author":"Yingchuan","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1542\/peds.2011-3881","article-title":"Preeclampsia and retinopathy of prematurity in preterm births","volume":"130","author":"Yu","year":"2012","journal-title":"Pediatrics"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1074\/jbc.M111.275990","article-title":"High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-\u03b2 family member growth differentiation factor 6","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2020.605918\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:36:08Z","timestamp":1605602168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2020.605918\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":69,"alternative-id":["10.3389\/fnmol.2020.605918"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2020.605918","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"article-number":"605918"}}