{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:00:17Z","timestamp":1781931617585,"version":"3.54.5"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>Autism spectrum disorders (ASD) are ~4-times more common in males than females, and CHD8 (a chromatin remodeler)-related ASD shows a strong male bias (~4:1), although the underlying mechanism remains unclear. <jats:italic>Chd8<\/jats:italic>-mutant mice with a C-terminal protein-truncating mutation (N2373K) display male-preponderant behavioral deficits as juveniles and adults, although whether this also applies to other <jats:italic>Chd8<\/jats:italic> mutations remains unknown. In addition, it remains unclear whether sexually dimorphic phenotypes in <jats:italic>Chd8<\/jats:italic>-mutant mice are differentially observed in males and females across different ages. We here generated new <jats:italic>Chd8<\/jats:italic>-mutant (knock-in) mice carrying a patient-derived mutation causing an N-terminal and stronger protein truncation (<jats:italic>Chd8<jats:sup>+\/S62X<\/jats:sup><\/jats:italic> mice) and characterized the mice by behavioral analyses. Juvenile <jats:italic>Chd8<jats:sup>+\/S62X<\/jats:sup><\/jats:italic> mice displayed male-preponderant autistic-like behaviors; hypoactivity and enhanced mother-seeking\/attachment behavior in males but not in females. Adult male and female <jats:italic>Chd8<jats:sup>+\/S62X<\/jats:sup><\/jats:italic> mice showed largely similar deficits in repetitive and anxiety-like behavioral domains. Therefore, the CHD8-S62X mutation induces ASD-like behaviors in juvenile male mice and adult male and female mice, pointing to an age-differential sexual dimorphism and also distinct sexual dimorphisms in different <jats:italic>Chd8<\/jats:italic> mutations (N2373K and S62X).<\/jats:p>","DOI":"10.3389\/fnmol.2022.1022306","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T07:42:51Z","timestamp":1666683771000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors"],"prefix":"10.3389","volume":"15","author":[{"given":"Soo Yeon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanseul","family":"Kweon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3109\/09540261.2010.515205","article-title":"Sex differences in schizophrenia","volume":"22","author":"Abel","year":"2010","journal-title":"Int. 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