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Presently, the superiority of RNA interference (RNAi) and extracellular vesicles (EVs) in improving SCA has attracted extensive attention. Both can serve as the potential biomarkers for the diagnosing and monitoring disease progression. Herein, we analyzed the basis and prospect of therapies for SCA. Meanwhile, we elaborated the development and application of miRNAs, siRNAs, shRNAs, and EVs in the diagnosis and treatment of SCA. We propose the combination of RNAi and EVs to avoid the adverse factors of their respective treatment and maximize the benefits of treatment through the technology of EVs loaded with RNA. Obviously, the combinational therapy of RNAi and EVs may more accurately diagnose and cure SCA.<\/jats:p>","DOI":"10.3389\/fnmol.2022.1043947","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T06:04:12Z","timestamp":1665641052000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia"],"prefix":"10.3389","volume":"15","author":[{"given":"Yingying","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105185","DOI":"10.1016\/j.nbd.2020.105185","article-title":"Oligomeric \u03b1-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson\u2019s disease.","volume":"148","author":"Agliardi","year":"2021","journal-title":"Neurobiol. 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