{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:45:01Z","timestamp":1774313101431,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1704600"],"award-info":[{"award-number":["2018YFC1704600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1704605"],"award-info":[{"award-number":["2018YFC1704605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2012CB518501"],"award-info":[{"award-number":["2012CB518501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81590950"],"award-info":[{"award-number":["81590950"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273154"],"award-info":[{"award-number":["81273154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473602"],"award-info":[{"award-number":["81473602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acupuncture is an effective adjunctive therapy for chronic stable angina pectoris (CSAP), while the underlying mechanism is unclear. This study aimed to investigate the central pathophysiology of CSAP and explore the mechanism of different acupoint prescriptions for CSAP from the perspective of brain-heart interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty-seven CSAP patients and sixty-five healthy subjects (HS) were enrolled, and thirty CSAP patients were divided into two acupoint prescriptions groups (Group A: acupoints on the meridian directly related to the <jats:italic>Heart<\/jats:italic>; Group B: acupoints on the meridian indirectly related to the <jats:italic>Heart<\/jats:italic>). The Magnetic Resonance Imaging data and clinical data were collected at baseline and after treatment. The comparisons of brain spontaneous activity patterns were performed between CSAP patients and HS, as well as between baseline and after treatment in CSAP patients. Then, the changes in resting-state functional connectivity before and after treatment were compared between the two acupoint prescriptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic stable angina pectoris patients manifested higher spontaneous activity on the bilateral calcarine, left middle occipital gyrus, right superior temporal gyrus, and right postcentral gyrus. After acupuncture treatment, the spontaneous activity of the left calcarine, left cuneus, and right orbitofrontal gyrus was decreased. The left calcarine was identified as region-of-interest for functional connectivity analysis. Compared with group B, CSAP patients in group A had significantly increased functional connectivity between left calcarine and the left inferior temporal gyrus\/cerebellum crus 1, left hippocampus, left thalamus, and left middle cingulate cortex after treatment. Thresholds for all comparisons were <jats:italic>p<\/jats:italic> &amp;lt; 0.05, Gaussian Random Field corrected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regulating the aberrant spontaneous activity of the calcarine might be an underlying mechanism of acupuncture for CSAP. The multi-threaded modulation of functional connectivity between calcarine and multiple pain-related brain regions might be a potential mechanism for better efficacy of acupuncture at points on the meridian directly related to the <jats:italic>Heart<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnmol.2022.842674","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T11:29:12Z","timestamp":1650972552000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Acupuncture Modulates the Spontaneous Activity and Functional Connectivity of Calcarine in Patients With Chronic Stable Angina Pectoris"],"prefix":"10.3389","volume":"15","author":[{"given":"Lei","family":"Lan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanrong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm.","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"B2","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/s0025-6196(12)62272-1","article-title":"The central autonomic network: functional organization, dysfunction, and perspective.","volume":"68","author":"Benarroch","year":"1993","journal-title":"Mayo Clin. Proc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/cir.0000000000000485","article-title":"Heart Disease and Stroke Statistics-2017 Update: a Report From the American Heart Association.","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/j.jpain.2021.05.004","article-title":"Associations of Regional and Network Functional Connectivity With Exercise-Induced Low Back Pain.","volume":"22","author":"Bush","year":"2021","journal-title":"J. Pain"},{"key":"B5","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain.","volume":"14","author":"Bushnell","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/nrcardio.2011.129","article-title":"Stable angina pectoris: antianginal therapies and future directions.","volume":"9","author":"Chaitman","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-021-00961-4","article-title":"Evidence of Potential Mechanisms of Acupuncture from Functional MRI Data for Migraine Prophylaxis.","volume":"25","author":"Chang","year":"2021","journal-title":"Curr. Pain Headache Rep."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.721822","article-title":"Aberrant Intraregional Brain Activity and Functional Connectivity in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.","volume":"15","author":"Chen","year":"2021","journal-title":"Front. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3760\/j.issn:0253-3758.2007.03.002","article-title":"Guideline for diagnosis and treatment of patients with chronic stable angina.","volume":"35","year":"2007","journal-title":"Chin. J. Cardiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"305","DOI":"10.5056\/jnm.2012.18.3.305","article-title":"Does acupuncture therapy alter activation of neural pathway for pain perception in irritable bowel syndrome?: a comparative study of true and sham acupuncture using functional magnetic resonance imaging.","volume":"18","author":"Chu","year":"2012","journal-title":"J. Neurogastroenterol. Motil."},{"key":"B11","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/nrneurol.2017.122","article-title":"Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations.","volume":"13","author":"Davis","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic Pain: from Mechanisms to Treatment.","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1016\/s0140-6736(21)00392-5","article-title":"Nociplastic pain: towards an understanding of prevalent pain conditions.","volume":"397","author":"Fitzcharles","year":"2021","journal-title":"Lancet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1016\/j.jacc.2007.08.002","article-title":"2007 chronic angina focused update of the ACC\/AHA 2002 guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 guidelines for the management of patients with chronic stable angina.","volume":"50","author":"Fraker","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7228033","article-title":"The Preventive Value of Acupoint Sensitization for Patients with Stable Angina Pectoris: a Randomized, Double-Blind, Positive-Controlled, Multicentre Trial.","volume":"2021","author":"Huang","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/s1053-8119(02)91132-8","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images.","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.pain.2012.03.018","article-title":"Enhanced affect\/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients.","volume":"153","author":"Lee","year":"2012","journal-title":"Pain"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00415","article-title":"Altered Brain Functional Hubs and Connectivity Underlie Persistent Somatoform Pain Disorder.","volume":"13","author":"Liu","year":"2019","journal-title":"Front. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.608688","article-title":"Brain Functional Interaction of Acupuncture Effects in Diarrhea-Dominant Irritable Bowel Syndrome.","volume":"14","author":"Ma","year":"2020","journal-title":"Front. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9460695","article-title":"A Narrative Review of Neuroimaging Studies in Acupuncture for Migraine.","volume":"2021","author":"Ma","year":"2021","journal-title":"Pain Res. Manag."},{"key":"B21","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0304-3959(75)90044-5","article-title":"The McGill Pain Questionnaire: major properties and scoring methods.","volume":"1","author":"Melzack","year":"1975","journal-title":"Pain"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.1093\/brain\/awy281","article-title":"The search for pain biomarkers in the human brain.","volume":"141","author":"Mouraux","year":"2018","journal-title":"Brain"},{"key":"B23","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/s0140-6736(15)61220-x","article-title":"Stable coronary artery disease: revascularisation and invasive strategies.","volume":"386","author":"Piccolo","year":"2015","journal-title":"Lancet"},{"key":"B24","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/s0140-6736(94)92755-3","article-title":"Central nervous pathways mediating angina pectoris.","volume":"344","author":"Rosen","year":"1994","journal-title":"Lancet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tins.2012.06.002","article-title":"Pain-related changes in the brain: diagnostic and therapeutic potentials.","volume":"35","author":"Saab","year":"2012","journal-title":"Trends Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/s1474-4422(14)70193-0","article-title":"Functional MRI of migraine.","volume":"14","author":"Schwedt","year":"2015","journal-title":"Lancet Neurol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.732144","article-title":"Quality of the Evidence Supporting the Role of Acupuncture for Stable Angina Pectoris: an Umbrella Review of Systematic Reviews.","volume":"8","author":"Shen","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2015.0181","article-title":"Brain-heart interactions: physiology and clinical implications.","volume":"374","author":"Silvani","year":"2016","journal-title":"Philos. Trans. A Math. Phys. Eng. Sci."},{"key":"B29","first-page":"439","article-title":"The angina grading system of the Canadian Cardiovascular Society.","volume":"18","author":"Smith","year":"2002","journal-title":"Can. J. Cardiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1093\/eurheartj\/ehz068","article-title":"Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome.","volume":"40","author":"Templin","year":"2019","journal-title":"Eur. Heart J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cortex.2012.12.007","article-title":"Subdivision of the occipital lobes: an anatomical and functional MRI connectivity study.","volume":"56","author":"Thiebaut de Schotten","year":"2014","journal-title":"Cortex"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01259-x","article-title":"Functional connectivity of the visual cortex differentiates anxiety comorbidity from episodic migraineurs without aura.","volume":"22","author":"Wei","year":"2021","journal-title":"J. Headache Pain"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1065-1","article-title":"Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura.","volume":"20","author":"Wei","year":"2019","journal-title":"J. Headache Pain"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.730322","article-title":"Neuroimaging Studies of Acupuncture on Low Back Pain: a Systematic Review.","volume":"15","author":"Wen","year":"2021","journal-title":"Front. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2020.110110","article-title":"Neural responses during acute mental stress are associated with angina pectoris.","volume":"134","author":"Wittbrodt","year":"2020","journal-title":"J. Psychosom. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/b978-0-12-411545-3.00003-1","article-title":"Acupuncture point specificity.","volume":"111","author":"Xing","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: data Processing & Analysis for (Resting-State) Brain Imaging.","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01114","article-title":"Acupuncture Effect and Mechanism for Treating Pain in Patients With Parkinson\u2019s Disease.","volume":"10","author":"Yu","year":"2019","journal-title":"Front. Neurol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1001\/jamainternmed.2019.2407","article-title":"Acupuncture as Adjunctive Therapy for Chronic Stable Angina: a Randomized Clinical Trial.","volume":"179","author":"Zhao","year":"2019","journal-title":"JAMA Intern. Med."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6634404","article-title":"Acupuncture as Adjuvant Therapy for Treating Stable Angina Pectoris with Moderate Coronary Artery Lesions and the Mechanism of Heart-Brain Interactions: a Randomized Controlled Trial Protocol.","volume":"2021","author":"Zhao","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2022.842674\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T11:29:29Z","timestamp":1650972569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2022.842674\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":40,"alternative-id":["10.3389\/fnmol.2022.842674"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2022.842674","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"article-number":"842674"}}