{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T15:34:34Z","timestamp":1794065674147,"version":"4.8.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>\n                    Respirable fine particulate matter (PM\n                    <jats:sub>2.5<\/jats:sub>\n                    ) has been one of the most widely publicized indicators of pollution in recent years. Epidemiological studies have established a strong association between PM\n                    <jats:sub>2.5<\/jats:sub>\n                    , lung disease, and cardiovascular disease. Recent studies have shown that PM\n                    <jats:sub>2.5<\/jats:sub>\n                    is also strongly associated with brain damage, mainly cerebrovascular damage (stroke) and neurological damage to the brain (changes in cognitive function, dementia, psychiatric disorders, etc.). PM\n                    <jats:sub>2.5<\/jats:sub>\n                    can pass through the lung\u2013gas\u2013blood barrier and the \u201cgut\u2013microbial\u2013brain\u201d axis to cause systemic oxidative stress and inflammation, or directly enter brain tissue\n                    <jats:italic>via<\/jats:italic>\n                    the olfactory nerve, eventually damaging the cerebral blood vessels and brain nerves. It is worth mentioning that there is a time window for PM\n                    <jats:sub>2.5<\/jats:sub>\n                    -induced brain damage to repair itself. However, the exact pathophysiological mechanisms of brain injury and brain repair are not yet fully understood. This article collects and discusses the mechanisms of PM\n                    <jats:sub>2.5<\/jats:sub>\n                    -induced brain injury and self-repair after injury, which may provide new ideas for the prevention and treatment of cerebrovascular and cerebral neurological diseases.\n                  <\/jats:p>","DOI":"10.3389\/fnmol.2022.967174","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T01:42:11Z","timestamp":1662514931000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":115,"title":["A review of respirable fine particulate matter (PM2.5)-induced brain damage"],"prefix":"10.3389","volume":"15","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaixing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erqing","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1002\/tox.22335","article-title":"Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus","volume":"32","author":"Chao","year":"2017","journal-title":"Environ. 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