{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:44:38Z","timestamp":1793817878916,"version":"4.6.1"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>Neurodegenerative disorders (NDDs) such as Huntington\u2019s disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable populations of neurons. Although often associated with motor impairments, these NDDs share several commonalities in early symptoms and signs that extend beyond motor dysfunction. These include impairments in social cognition and psychiatric symptoms. Oxytocin (OXT) is a neuropeptide known to play a pivotal role in the regulation of social cognition as well as in emotional behaviors such as anxiety and depression. Here, we present an overview of key results implicating OXT in the pathology of HD, ALS and FTD and seek to identify commonalities across these NDDs. OXT is produced in the hypothalamus, a region in the brain that during the past decade has been shown to be affected in HD, ALS, and FTD. Several studies using human post-mortem neuropathological analyses, measurements of cerebrospinal fluid, experimental treatments with OXT as well as genetic animal models have collectively implicated an important role of central OXT in the development of altered social cognition and psychiatric features across these diseases. Understanding central OXT signaling may unveil the underlying mechanisms of early signs of the social cognitive impairment and the psychiatric features in NDDs. It is therefore possible that OXT might have potential therapeutic value for early disease intervention and better symptomatic treatment in NDDs.<\/jats:p>","DOI":"10.3389\/fnmol.2022.984317","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T04:42:20Z","timestamp":1663130540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Oxytocin in Huntington\u2019s disease and the spectrum of amyotrophic lateral sclerosis-frontotemporal dementia"],"prefix":"10.3389","volume":"15","author":[{"given":"Sofia","family":"Bergh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Y.","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Peters\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Gabery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1007\/s00415-016-8168-2","article-title":"Cognition and eating behavior in amyotrophic lateral sclerosis: Effect on survival.","volume":"263","author":"Ahmed","year":"2016","journal-title":"J. Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/B978-0-12-820107-7.00020-3","article-title":"Hypothalamus and weight loss in amyotrophic lateral sclerosis.","volume":"180","author":"Ahmed","year":"","journal-title":"Handb. Clin. Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-51140-1_1","article-title":"Behavioural Variant Frontotemporal Dementia: Recent Advances in the Diagnosis and Understanding of the Disorder.","volume":"1281","author":"Ahmed","year":"","journal-title":"Adv. Exp. Med. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/B978-0-12-819973-2.00019-8","article-title":"Hypothalamic symptoms of frontotemporal dementia disorders.","volume":"182","author":"Ahmed","year":"","journal-title":"Handb. Clin. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1212\/WNL.0000000000000993","article-title":"Systemic metabolism in frontotemporal dementia.","volume":"83","author":"Ahmed","year":"2014","journal-title":"Neurology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/321168a0","article-title":"Replication of the neurochemical characteristics of Huntington\u2019s disease by quinolinic acid.","volume":"321","author":"Beal","year":"1986","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1523\/JNEUROSCI.11-06-01649.1991","article-title":"Chronic quinolinic acid lesions in rats closely resemble Huntington\u2019s disease.","volume":"11","author":"Beal","year":"1991","journal-title":"J. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1080\/14737175.2020.1788389","article-title":"Understanding and managing metabolic dysfunction in Amyotrophic Lateral Sclerosis.","volume":"20","author":"Blasco","year":"2020","journal-title":"Expert Rev. Neurother."},{"key":"B9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11910-020-01047-1","article-title":"Sleep and Sleep Disruption in Amyotrophic Lateral Sclerosis.","volume":"20","author":"Boentert","year":"2020","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"439","DOI":"10.2217\/nmt.14.34","article-title":"Frontotemporal dementia: Diagnosis, deficits and management.","volume":"4","author":"Bott","year":"2014","journal-title":"Neurodegener. Dis. Manag."},{"key":"B11","doi-asserted-by":"publisher","first-page":"867","DOI":"10.2741\/2727","article-title":"Multiple roles of Tdp-43 in gene expression, splicing regulation, and human disease.","volume":"13","author":"Buratti","year":"2008","journal-title":"Front. Biosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.tibs.2012.03.003","article-title":"Tdp-43: Gumming up neurons through protein-protein and protein-Rna interactions.","volume":"37","author":"Buratti","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1093\/brain\/awr195","article-title":"Motor neuron dysfunction in frontotemporal dementia.","volume":"134","author":"Burrell","year":"2011","journal-title":"Brain"},{"key":"B14","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00415-017-8688-4","article-title":"Apathy and its impact on patient outcome in amyotrophic lateral sclerosis.","volume":"265","author":"Caga","year":"2018","journal-title":"J. Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cortex.2021.02.029","article-title":"Apathy is associated with parietal cortical-subcortical dysfunction in Als.","volume":"145","author":"Caga","year":"2021","journal-title":"Cortex"},{"key":"B16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3233\/JHD-190372","article-title":"The Role of Hypothalamic Pathology for Non-Motor Features of Huntington\u2019s Disease.","volume":"8","author":"Cheong","year":"2019","journal-title":"J. Huntingtons Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"104773","DOI":"10.1016\/j.psyneuen.2020.104773","article-title":"Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the Bachd mouse model of Huntington disease.","volume":"119","author":"Cheong","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1849794","DOI":"10.1155\/2018\/1849794","article-title":"Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications.","volume":"2018","author":"Christidi","year":"2018","journal-title":"Behav. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e382","DOI":"10.1038\/cddis.2012.121","article-title":"An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity.","volume":"3","author":"Cisbani","year":"2012","journal-title":"Cell Death Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1001\/archneur.63.4.489","article-title":"Frontotemporal lobar degeneration with motor neuron disease: A clinical and pathological spectrum.","volume":"63","author":"Clark","year":"2006","journal-title":"Arch. Neurol."},{"key":"B21","first-page":"219","article-title":"Behavioral Changes in Huntington Disease.","volume":"14","author":"Craufurd","year":"2001","journal-title":"Neuropsychiatry Neuropsychol. Behav. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded Ggggcc hexanucleotide repeat in noncoding region of C9orf72 causes chromosome 9p-linked Ftd and Als.","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1093\/brain\/awaa018","article-title":"Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders.","volume":"143","author":"Ducharme","year":"2020","journal-title":"Brain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.biopsych.2006.11.034","article-title":"Psychiatric symptoms in Huntington\u2019s disease before diagnosis: The predict-Hd study.","volume":"62","author":"Duff","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1474-4422(10)70224-6","article-title":"Energy metabolism in amyotrophic lateral sclerosis.","volume":"10","author":"Dupuis","year":"2011","journal-title":"Lancet Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/ng0893-387","article-title":"Trinucleotide repeat length instability and age of onset in Huntington\u2019s disease.","volume":"4","author":"Duyao","year":"1993","journal-title":"Nat. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature09320","article-title":"Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for Als.","volume":"466","author":"Elden","year":"2010","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1006\/exnr.1993.1006","article-title":"Excitotoxin Lesions in Primates as a Model for Huntington\u2019s Disease: Histopathologic and Neurochemical Characterization.","volume":"119","author":"Ferrante","year":"1993","journal-title":"Exp. Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1212\/WNL.0000000000001133","article-title":"Oxytocin for frontotemporal dementia: A randomized dose-finding study of safety and tolerability.","volume":"84","author":"Finger","year":"2015","journal-title":"Neurology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3233\/JHD-210467","article-title":"The Relationship Between Plasma Oxytocin and Executive Functioning in Huntington\u2019s Disease: A Pilot Study.","volume":"10","author":"Fisher","year":"2021","journal-title":"J. Huntingtons Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1093\/brain\/awm090","article-title":"Hypocretin (orexin) loss in Parkinson\u2019s disease.","volume":"130","author":"Fronczek","year":"2007","journal-title":"Brain"},{"key":"B33","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1111\/nan.12709","article-title":"Loss of the metabolism and sleep regulating neuronal populations expressing orexin and oxytocin in the hypothalamus in amyotrophic lateral sclerosis.","volume":"47","author":"Gabery","year":"2021","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/nan.12236","article-title":"Selective loss of oxytocin and vasopressin in the hypothalamus in early Huntington disease: A case study.","volume":"41","author":"Gabery","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s00401-010-0742-6","article-title":"Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses.","volume":"120","author":"Gabery","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10673229.2011.549771","article-title":"The role of oxytocin in mother-infant relations: A systematic review of human studies.","volume":"19","author":"Galbally","year":"2011","journal-title":"Harv. Rev. Psychiatry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: Structure, function, and regulation.","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol. Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1136\/jnnp-2017-315795","article-title":"Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis.","volume":"88","author":"Gorges","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1007\/s00415-019-09363-4","article-title":"An update on genetic frontotemporal dementia.","volume":"266","author":"Greaves","year":"2019","journal-title":"J. Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes The Huntington\u2019s Disease Collaborative Research Group.","volume":"72","year":"1993","journal-title":"Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.yfrne.2009.05.005","article-title":"Oxytocin, vasopressin, and human social behavior.","volume":"30","author":"Heinrichs","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.parkreldis.2022.05.003","article-title":"Decreased Csf oxytocin relates to measures of social cognitive impairment in Huntington\u2019s disease patients.","volume":"99","author":"Hellem","year":"2022","journal-title":"Parkinsonism Relat. Disord."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e07808","DOI":"10.1016\/j.heliyon.2021.e07808","article-title":"Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease.","volume":"7","author":"Henningsen","year":"2021","journal-title":"Heliyon"},{"key":"B44","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3389\/fpsyt.2019.00221","article-title":"Sleep Disorders in Huntington\u2019s Disease.","volume":"10","author":"Herzog-Krzywoszanska","year":"2019","journal-title":"Front. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1093\/brain\/aws033","article-title":"Familial frontotemporal dementia and amyotrophic lateral sclerosis associated with the C9orf72 hexanucleotide repeat.","volume":"135","author":"Hodges","year":"2012","journal-title":"Brain"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/S1474-4422(07)70266-1","article-title":"Semantic dementia: A unique clinicopathological syndrome.","volume":"6","author":"Hodges","year":"2007","journal-title":"Lancet Neurol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.cmet.2011.02.013","article-title":"Mutant Huntingtin Causes Metabolic Imbalance by Disruption of Hypothalamic Neurocircuits.","volume":"13","author":"Hult","year":"2011","journal-title":"Cell Metab."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1093\/brain\/awr171","article-title":"The effects of oxytocin on social cognition and behaviour in frontotemporal dementia.","volume":"134","author":"Jesso","year":"2011","journal-title":"Brain"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The Oxytocin Receptor: From Intracellular Signaling to Behavior.","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol. Rev."},{"key":"B50","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0028-3932(01)00156-7","article-title":"Face and emotion processing in frontal variant frontotemporal dementia.","volume":"40","author":"Keane","year":"2002","journal-title":"Neuropsychologia"},{"key":"B51","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.psyneuen.2017.09.022","article-title":"Intranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis.","volume":"87","author":"Keech","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.tics.2012.09.006","article-title":"The social brain in psychiatric and neurological disorders.","volume":"16","author":"Kennedy","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s10571-020-01003-0","article-title":"Oxytocin Prevents the Development of 3-Np-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of Oxtr and mGluR2.","volume":"42","author":"Khodagholi","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/j.1471-4159.2005.03035.x","article-title":"Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-Egfp fluorescent aggregates.","volume":"93","author":"Kotliarova","year":"2005","journal-title":"J. Neurochem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.pnpbp.2017.09.023","article-title":"Oxytocin selectively modulates brain processing of disgust in Huntington\u2019s disease gene carriers.","volume":"81","author":"Labuschagne","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.tig.2015.03.005","article-title":"Defining the genetic connection linking amyotrophic lateral sclerosis (Als) with frontotemporal dementia (Ftd).","volume":"31","author":"Lattante","year":"2015","journal-title":"Trends Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s11910-016-0680-3","article-title":"Sleep Disturbances in Frontotemporal Dementia.","volume":"16","author":"McCarter","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1212\/WNL.0000000000000023","article-title":"Neuropsychiatric changes precede classic motor symptoms in Als and do not affect survival.","volume":"82","author":"Mioshi","year":"2014","journal-title":"Neurology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria.","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.tins.2012.08.004","article-title":"Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors.","volume":"35","author":"Neumann","year":"2012","journal-title":"Trends Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated Tdp-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"B62","doi-asserted-by":"publisher","first-page":"c3109","DOI":"10.1136\/bmj.c3109","article-title":"Huntington\u2019s disease.","volume":"340","author":"Novak","year":"2010","journal-title":"BMJ"},{"key":"B63","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.mehy.2013.07.044","article-title":"Synthetic oxytocin and breastfeeding: Reasons for testing an hypothesis.","volume":"81","author":"Odent","year":"2013","journal-title":"Med. Hypotheses"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e2635","DOI":"10.1212\/WNL.0000000000010933","article-title":"Neural effects of oxytocin and mimicry in frontotemporal dementia: A randomized crossover study.","volume":"95","author":"Oliver","year":"2020","journal-title":"Neurology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e12700","DOI":"10.1111\/jne.12700","article-title":"Role of oxytocin in the control of stress and food intake.","volume":"31","author":"Onaka","year":"2019","journal-title":"J. Neuroendocrinol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1111\/ene.15388","article-title":"Social cognition deficits in amyotrophic lateral sclerosis: A pilot cross-sectional population-based study.","volume":"29","author":"Palumbo","year":"2022","journal-title":"Eur. J. Neurol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","article-title":"Detection of Huntington\u2019s disease decades before diagnosis: The Predict-Hd study.","volume":"79","author":"Paulsen","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B68","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-3-030-51140-1_2","article-title":"The Neuropsychiatric Features of Behavioral Variant Frontotemporal Dementia.","volume":"1281","author":"Peet","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/S1474-4422(07)70265-X","article-title":"Cognitive impairment in amyotrophic lateral sclerosis.","volume":"6","author":"Phukan","year":"2007","journal-title":"Lancet Neurol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/ana.22244","article-title":"Eating and hypothalamus changes in behavioral-variant frontotemporal dementia.","volume":"69","author":"Piguet","year":"2011","journal-title":"Ann. Neurol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1093\/brain\/awn244","article-title":"Hypothalamic involvement in Huntington\u2019s disease: An in vivo Pet study.","volume":"131","author":"Politis","year":"2008","journal-title":"Brain"},{"key":"B72","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/nrn3570","article-title":"Choosing an animal model for the study of Huntington\u2019s disease.","volume":"14","author":"Pouladi","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/01.wnn.0000152225.05377.ab","article-title":"Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration.","volume":"18","author":"Rankin","year":"2005","journal-title":"Cogn. Behav. Neurol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"B75","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9orf72 is the cause of chromosome 9p21-linked Als-Ftd.","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/s41386-022-01305-5","article-title":"Oxytocin receptor expression patterns in the human brain across development.","volume":"47","author":"Rokicki","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1159\/000077154","article-title":"Recognition of emotion in the frontal and temporal variants of frontotemporal dementia.","volume":"17","author":"Rosen","year":"2004","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"B78","doi-asserted-by":"publisher","first-page":"S135","DOI":"10.1016\/S1353-8020(09)70800-4","article-title":"Huntington disease: Pathogenesis, biomarkers, and approaches to experimental therapeutics.","volume":"15","author":"Ross","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"B79","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","article-title":"Huntington disease: Natural history, biomarkers and prospects for therapeutics.","volume":"10","author":"Ross","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06226-1","article-title":"Polymorphisms in the oxytocin receptor and their association with apathy and impaired social cognition in Huntington\u2019s disease.","author":"Saiz-Rodr\u00edguez","year":"2022","journal-title":"Neurol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/ana.25739","article-title":"Frontotemporal Dementia: Correlations Between Psychiatric Symptoms and Pathology.","volume":"87","author":"Scarioni","year":"2020","journal-title":"Ann. Neurol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1007\/s11011-021-00844-y","article-title":"Metabolism in Huntington\u2019s disease: A major contributor to pathology.","volume":"37","author":"Singh","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"B83","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.nbd.2010.07.013","article-title":"Early changes in the hypothalamic region in prodromal Huntington disease revealed by Mri analysis.","volume":"40","author":"Soneson","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B84","doi-asserted-by":"publisher","first-page":"28322","DOI":"10.1038\/srep28322","article-title":"Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the Bachd mouse model of Huntington\u2019s disease.","volume":"6","author":"Soylu-Kucharz","year":"2016","journal-title":"Sci. Rep."},{"key":"B85","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000306055","article-title":"Factors affecting survival of patients with neurodegenerative disease.","volume":"35","author":"Steenland","year":"2010","journal-title":"Neuroepidemiology"},{"key":"B86","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/21678421.2016.1267768","article-title":"Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (Als-Ftsd): Revised diagnostic criteria.","volume":"18","author":"Strong","year":"2017","journal-title":"Amyotroph. Lateral. Scler. Frontotemporal. Degener."},{"key":"B87","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding Als: From genes to mechanism.","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1002\/ana.24801","article-title":"Psychiatric disorders prior to amyotrophic lateral sclerosis.","volume":"80","author":"Turner","year":"2016","journal-title":"Ann. Neurol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3389\/fneur.2018.00413","article-title":"Hypocretin as a Hub for Arousal and Motivation.","volume":"9","author":"Tyree","year":"2018","journal-title":"Front. Neurol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/brainsci8090161","article-title":"Social Cognition and Oxytocin in Huntington\u2019s Disease: New Insights.","volume":"8","author":"Unti","year":"2018","journal-title":"Brain Sci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/j.1750-3639.2012.00565.x","article-title":"Paraventricular nucleus neuropeptide expression in Huntington\u2019s disease patients.","volume":"22","author":"van Wamelen","year":"2012","journal-title":"Brain Pathol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnmol.2018.00002","article-title":"Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism.","volume":"11","author":"Vercruysse","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease.","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01141-x","article-title":"Chronic oxytocin-driven alternative splicing of Crfr2\u03b1 induces anxiety.","author":"Winter","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1212\/01.wnl.0000277461.06713.23","article-title":"Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia.","volume":"69","author":"Woolley","year":"2007","journal-title":"Neurology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4088\/JCP.10m06382oli","article-title":"The diagnostic challenge of psychiatric symptoms in neurodegenerative disease: Rates of and risk factors for prior psychiatric diagnosis in patients with early neurodegenerative disease.","volume":"72","author":"Woolley","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"B97","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-981-32-9705-0_7","article-title":"The Role of the Oxytocin System in Anxiety Disorders.","volume":"1191","author":"Yoon","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"171","DOI":"10.4103\/2152-7806.169561","article-title":"A comprehensive review of amyotrophic lateral sclerosis.","volume":"6","author":"Zarei","year":"2015","journal-title":"Surg. Neurol. Int."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2022.984317\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T04:42:27Z","timestamp":1663130547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2022.984317\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":98,"alternative-id":["10.3389\/fnmol.2022.984317"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2022.984317","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,14]]},"article-number":"984317"}}