{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T01:57:38Z","timestamp":1778378258797,"version":"3.51.4"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p><jats:italic>Chd8<jats:sup>+\/N2373K<\/jats:sup><\/jats:italic> mice with a human C-terminal-truncating mutation (N2373K) display autistic-like behaviors in juvenile and adult males but not in females. In contrast, <jats:italic>Chd8<jats:sup>+\/S62X<\/jats:sup><\/jats:italic> mice with a human N-terminal-truncating mutation (S62X) display behavioral deficits in juvenile males (not females) and adult males and females, indicative of age-differential sexually dimorphic behaviors. Excitatory synaptic transmission is suppressed and enhanced in male and female <jats:italic>Chd8<jats:sup>+\/S62X<\/jats:sup><\/jats:italic> juveniles, respectively, but similarly enhanced in adult male and female mutants. ASD-like transcriptomic changes are stronger in newborn and juvenile (but not adult) <jats:italic>Chd8<jats:sup>+\/S62X<\/jats:sup><\/jats:italic> males but in newborn and adult (not juvenile) <jats:italic>Chd8<jats:sup>+\/S62X<\/jats:sup><\/jats:italic> females. These results point to age-differential sexual dimorphisms in <jats:italic>Chd8<jats:sup>+\/S62X<\/jats:sup><\/jats:italic> mice at synaptic and transcriptomic levels, in addition to the behavioral level.<\/jats:p>","DOI":"10.3389\/fnmol.2023.1111388","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T12:42:44Z","timestamp":1676551364000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes"],"prefix":"10.3389","volume":"16","author":[{"given":"Soo Yeon","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanseul","family":"Kweon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyojin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunjoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jneuroim.2004.09.007","article-title":"Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression","volume":"157","author":"Albright","year":"2004","journal-title":"J. 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