{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:22:23Z","timestamp":1791404543900,"version":"4.3.3"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>Many neurodegenerative diseases including Alzheimer\u2019s disease, Parkinson\u2019s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological features may be related to axonal transport deficits in neurons, which lead to failures in pathological protein targeting to specific sites for degradation and organelle transportation to designated areas needed for normal physiological functioning. Axonal transport deficits are most likely early pathological events in such diseases and gradually lead to the loss of axonal integrity and other degenerative changes. In this review, we investigated reports of mechanisms underlying the development of axonal transport deficits in a variety of common neurodegenerative diseases, such as Alzheimer\u2019s disease, amyotrophic lateral sclerosis, Parkinson\u2019s disease and Huntington\u2019s disease to provide new ideas for therapeutic targets that may be used early in the disease process. The mechanisms can be summarized as follows: (1) motor protein changes including expression levels and post-translational modification alteration; (2) changes in microtubules including reducing stability and disrupting tracks; (3) changes in cargoes including diminished binding to motor proteins. Future studies should determine which axonal transport defects are disease-specific and whether they are suitable therapeutic targets in neurodegenerative diseases.<\/jats:p>","DOI":"10.3389\/fnmol.2023.1172197","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T04:16:04Z","timestamp":1682309764000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaoman","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoran","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piaopiao","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1083\/jcb.200303138","article-title":"Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments","volume":"161","author":"Ackerley","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"110598","DOI":"10.1016\/j.celrep.2022.110598","article-title":"ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function","volume":"39","author":"Baron","year":"2022","journal-title":"Cell Rep."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1091\/mbc.e04-11-1004","article-title":"Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in drosophila","volume":"16","author":"Bettencourt da Cruz","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"20523","DOI":"10.1073\/pnas.1006869107","article-title":"Deficits in axonal transport precede ALS symptoms in vivo","volume":"107","author":"Bilsland","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1016\/j.cub.2021.02.061","article-title":"Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes","volume":"31","author":"Boecker","year":"2021","journal-title":"Curr. Biol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.1093\/hmg\/ddr381","article-title":"Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease","volume":"20","author":"Calkins","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1083\/jcb.200410136","article-title":"Sunday driver links axonal transport to damage signaling","volume":"168","author":"Cavalli","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.nbd.2005.12.007","article-title":"Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons","volume":"22","author":"Chang","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13024-017-0164-1","article-title":"Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of A\u03b2-induced impaired axonal transport","volume":"12","author":"Choi","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1093\/brain\/aws133","article-title":"Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease","volume":"135","author":"Chu","year":"2012","journal-title":"Brain"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1523\/JNEUROSCI.5427-08.2009","article-title":"Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy","volume":"29","author":"Chung","year":"2009","journal-title":"J. Neurosci."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"9431","DOI":"10.1523\/JNEUROSCI.1914-20.2021","article-title":"Frontotemporal lobar dementia mutant tau impairs axonal transport through a protein phosphatase 1\u03b3-dependent mechanism","volume":"41","author":"Combs","year":"2021","journal-title":"J. Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"15962","DOI":"10.1523\/JNEUROSCI.2526-14.2014","article-title":"Futsch\/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a drosophila model of amyotrophic lateral sclerosis","volume":"34","author":"Coyne","year":"2014","journal-title":"J. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1093\/hmg\/ddm226","article-title":"Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content","volume":"16","author":"De Vos","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.3390\/ijms22083985","article-title":"DCTN1 binds to TDP-43 and regulates TDP-43 aggregation","volume":"22","author":"Deshimaru","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1126\/science.1152993","article-title":"Differential regulation of dynein and kinesin motor proteins by tau","volume":"319","author":"Dixit","year":"2008","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e1003303","DOI":"10.1371\/journal.pgen.1003303","article-title":"JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes","volume":"9","author":"Drerup","year":"2013","journal-title":"PLoS Genet."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.nbd.2018.07.005","article-title":"Autophagy and mitophagy in ALS","volume":"122","author":"Evans","year":"2019","journal-title":"Neurobiol. 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Adv."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cells"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/bpa.12046","article-title":"\u03b1-Synuclein: the long distance runner","volume":"23","author":"George","year":"2013","journal-title":"Brain Pathol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.tibs.2015.08.003","article-title":"Regulation of axonal transport by protein kinases","volume":"40","author":"Gibbs","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/s41419-018-0624-8","article-title":"Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS","volume":"9","author":"Gibbs","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"621.e1","DOI":"10.1016\/j.neurobiolaging.2011.02.014","article-title":"Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a \"P301L\" tau knockin mouse","volume":"33","author":"Gilley","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"5245","DOI":"10.1038\/ncomms6245","article-title":"Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 roc-COR domain mutations","volume":"5","author":"Godena","year":"2014","journal-title":"Nat. Commun."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","article-title":"100 years of Lewy pathology","volume":"9","author":"Goedert","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.nbd.2018.11.015","article-title":"P\u03b1-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria","volume":"124","author":"Grassi","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e54914","DOI":"10.1371\/journal.pone.0054914","article-title":"Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons","volume":"8","author":"Guo","year":"2013","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1091\/mbc.e09-01-0044","article-title":"Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons","volume":"21","author":"Hammond","year":"2010","journal-title":"Mol. Biol. 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Neurosci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","author":"Hubbert","year":"2002","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e8310","DOI":"10.1371\/journal.pone.0008310","article-title":"Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a drosophila model of Alzheimer's disease","volume":"4","author":"Iijima-Ando","year":"2009","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e1002918","DOI":"10.1371\/journal.pgen.1002918","article-title":"Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1","volume":"8","author":"Iijima-Ando","year":"2012","journal-title":"PLoS Genet."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1134\/S0006297918090043","article-title":"Molecular pathogenesis in Huntington's disease","volume":"83","author":"Illarioshkin","year":"2018","journal-title":"Biochemistry"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"20909","DOI":"10.1074\/jbc.M109.014472","article-title":"Phosphorylated tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease","volume":"284","author":"Ittner","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1042\/BJ20060205","article-title":"Role of MAP1B in axonal retrograde transport of mitochondria","volume":"397","author":"Jim\u00e9nez-Mateos","year":"2006","journal-title":"Biochem. J."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1242\/jcs.01558","article-title":"Tau phosphorylation in neuronal cell function and dysfunction","volume":"117","author":"Johnson","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1073\/pnas.1618627114","article-title":"\u03b1-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation","volume":"114","author":"Kang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1083\/jcb.200501085","article-title":"A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice","volume":"169","author":"Kieran","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e42983","DOI":"10.1371\/journal.pone.0042983","article-title":"HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"34097","DOI":"10.1074\/jbc.M110.154831","article-title":"Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS\/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA","volume":"285","author":"Kim","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e1811","DOI":"10.1038\/cddis.2015.169","article-title":"Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons","volume":"6","author":"Koch","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1016\/j.ajpath.2011.07.004","article-title":"Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain","volume":"179","author":"Kopeikina","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-020-00420-5","article-title":"Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS\/FTD","volume":"16","author":"Kumar","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1073\/pnas.0400243101","article-title":"Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a drosophila model of Huntington's disease","volume":"101","author":"Lee","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1080\/15548627.2017.1356552","article-title":"Removing dysfunctional mitochondria from axons independent of mitophagy under pathophysiological conditions","volume":"13","author":"Lin","year":"2017","journal-title":"Autophagy"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"114143","DOI":"10.1016\/j.expneurol.2022.114143","article-title":"Multiple roles for the cytoskeleton in ALS","volume":"355","author":"Liu","year":"2022","journal-title":"Exp. Neurol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"11205","DOI":"10.1074\/jbc.M611279200","article-title":"The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3","volume":"282","author":"Lo","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1093\/hmg\/ddt528","article-title":"Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models","volume":"23","author":"Magran\u00e9","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1523\/JNEUROSCI.1233-11.2012","article-title":"Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons","volume":"32","author":"Magran\u00e9","year":"2012","journal-title":"J. Neurosci."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.neubiorev.2020.07.038","article-title":"The role of norepinephrine in the pathophysiology of schizophrenia","volume":"118","author":"M\u00e4ki-Marttunen","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.neurobiolaging.2003.04.007","article-title":"Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses","volume":"24","author":"Mandelkow","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.1073\/pnas.1200658109","article-title":"Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis","volume":"109","author":"Marinkovic","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.arr.2012.06.003","article-title":"Tau protein kinases: involvement in Alzheimer's disease","volume":"12","author":"Martin","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrn3380","article-title":"Axonal transport deficits and neurodegenerative diseases","volume":"14","author":"Millecamps","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/acn3.51482","article-title":"Quantifying regional \u03b1-synuclein, amyloid \u03b2, and tau accumulation in Lewy body dementia","volume":"9","author":"Miller","year":"2022","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e65235","DOI":"10.1371\/journal.pone.0065235","article-title":"Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase","volume":"8","author":"Morfini","year":"2013","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nn1717","article-title":"JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport","volume":"9","author":"Morfini","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1093\/hmg\/dds011","article-title":"Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria","volume":"21","author":"M\u00f3rotz","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1212\/01.wnl.0000134608.83927.b1","article-title":"Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS","volume":"63","author":"M\u00fcnch","year":"2004","journal-title":"Neurology"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.neuron.2018.02.027","article-title":"Genome-wide analyses identify KIF5A as a novel ALS gene","volume":"97","author":"Nicolas","year":"2018","journal-title":"Neuron"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.4161\/cc.8.10.8406","article-title":"Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, auroras and polo-like kinases] M-phase cell cycle genes in human breast cancer cells","volume":"8","author":"Oliveras-Ferraros","year":"2009","journal-title":"Cell Cycle"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/srep00898","article-title":"Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice","volume":"2","author":"Pan-Montojo","year":"2012","journal-title":"Sci. Rep."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1756-6606-3-17","article-title":"pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking","volume":"3","author":"Pardo","year":"2010","journal-title":"Mol. Brain"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00401-018-1903-2","article-title":"Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease","volume":"136","author":"Pickett","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"7813","DOI":"10.1073\/pnas.1713129115","article-title":"\u03b1-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies","volume":"115","author":"Prots","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/ng1123","article-title":"Mutant dynactin in motor neuron disease","volume":"33","author":"Puls","year":"2003","journal-title":"Nat. Genet."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1083\/jcb.201701045","article-title":"Stabilization of dynamic microtubules by mDia1 drives tau-dependent A\u03b2 synaptotoxicity","volume":"216","author":"Qu","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41419-020-02862-7","article-title":"N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance","volume":"11","author":"Ripon","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1093\/hmg\/ddu011","article-title":"Interactions between tau and \u03b1-synuclein augment neurotoxicity in a drosophila model of Parkinson's disease","volume":"23","author":"Roy","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"927195","DOI":"10.3389\/fnmol.2022.927195","article-title":"Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons","volume":"15","author":"Sabui","year":"2022","journal-title":"Front. Mol. 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Neurosci."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/neup.12512","article-title":"Dynactin is involved in Lewy body pathology","volume":"38","author":"Shen","year":"2018","journal-title":"Neuropathology"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrn3156","article-title":"Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration","volume":"13","author":"Sheng","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1093\/hmg\/ddr475","article-title":"Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease","volume":"21","author":"Shirendeb","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1016\/j.celrep.2020.02.078","article-title":"Mice carrying ALS mutant TDP-43, but not mutant FUS, display in vivo defects in axonal transport of signaling endosomes","volume":"30","author":"Sleigh","year":"2020","journal-title":"Cell Rep."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.neuron.2014.09.027","article-title":"Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS","volume":"84","author":"Smith","year":"2014","journal-title":"Neuron"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.mib.2011.09.013","article-title":"Motors in fungal morphogenesis: cooperation versus competition","volume":"14","author":"Steinberg","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/diagnostics11020231","article-title":"Diagnostics of amyotrophic lateral sclerosis: up to date","volume":"11","author":"\u0160t\u011btk\u00e1\u0159ov\u00e1","year":"2021","journal-title":"Diagnostics"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"4027","DOI":"10.1007\/s00018-017-2568-z","article-title":"JIP1 and JIP3 cooperate to mediate TrkB anterograde axonal transport by activating kinesin-1","volume":"74","author":"Sun","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s11010-012-1465-x","article-title":"The JNK\/c-Jun signaling axis contributes to the TDP-43-induced cell death","volume":"372","author":"Suzuki","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"e21776","DOI":"10.7554\/eLife.21776","article-title":"Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons","volume":"6","author":"Tammineni","year":"2017","journal-title":"Elife"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.pneurobio.2018.12.005","article-title":"It's all about tau","volume":"175","author":"Tapia-Rojas","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s40478-022-01418-4","article-title":"BDNF-dependent modulation of axonal transport is selectively impaired in ALS","volume":"10","author":"Tosolini","year":"2022","journal-title":"Acta Neuropathol. 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Biol. Cell"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1083\/jcb.201407065","article-title":"Tau reduction prevents A\u03b2-induced axonal transport deficits by blocking activation of GSK3\u03b2","volume":"209","author":"Vossel","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1093\/hmg\/ddt319","article-title":"The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons","volume":"22","author":"Wang","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"9090","DOI":"10.1523\/JNEUROSCI.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer's disease","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jocn.2021.11.002","article-title":"The increase of \u03b1-synuclein and alterations of dynein in A53T transgenic and aging mouse","volume":"96","author":"Wang","year":"2022","journal-title":"J. Clin. Neurosci."},{"key":"ref97","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.nbd.2019.03.021","article-title":"Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement","volume":"127","author":"Wang","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.3233\/JPD-223294","article-title":"Dual effects: Intrastriatal injection of \u03b1-syn N103\/tau N368 preformed fibrils promotes endogenous \u03b1-synuclein aggregates in the proximal colon","volume":"12","author":"Wang","year":"2022","journal-title":"J. Parkinsons Dis."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nm.4269","article-title":"\u03b1-Synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies","volume":"23","author":"Wong","year":"2017","journal-title":"Nat. Med."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.3390\/ijms22094705","article-title":"Molecular mechanisms underlying TDP-43 pathology in cellular and animal models of ALS and FTLD","volume":"22","author":"Wood","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1083\/jcb.200301026","article-title":"Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A","volume":"161","author":"Xia","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"10851","DOI":"10.1523\/JNEUROSCI.1630-10.2010","article-title":"Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice","volume":"30","author":"Xu","year":"2010","journal-title":"J. Neurosci."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"1049418","DOI":"10.3389\/fnagi.2022.1049418","article-title":"Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by \u03b1-Syn and tau fragments","volume":"14","author":"Yang","year":"2022","journal-title":"Front. 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