{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:08Z","timestamp":1787026988502,"version":"build-2736575974"},"reference-count":168,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Herpes simplex virus (HSV) and varicella-zoster virus (VZV) are neurotropic human alphaherpesviruses endemic worldwide. Upon primary infection, both viruses establish lifelong latency in neurons and reactivate intermittently to cause a variety of mild to severe diseases. Acute retinal necrosis (ARN) is a rare, sight-threatening eye disease induced by ocular VZV or HSV infection. The virus and host factors involved in ARN pathogenesis remain incompletely described. We hypothesize an underlying genetic defect in at least part of ARN cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected blood from 17 patients with HSV-or VZV-induced ARN, isolated DNA and performed Whole Exome Sequencing by Illumina followed by analysis in Varseq with criteria of CADD score\u2009&amp;gt;\u200915 and frequency in GnomAD &amp;lt; 0.1% combined with biological filters. Gene modifications relative to healthy control genomes were filtered according to high quality and read-depth, low frequency, high deleteriousness predictions and biological relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified a total of 50 potentially disease-causing genetic variants, including missense, frameshift and splice site variants and on in-frame deletion in 16 of the 17 patients. The vast majority of these genes are involved in innate immunity, followed by adaptive immunity, autophagy, and apoptosis; in several instances variants within a given gene or pathway was identified in several patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We propose that the identified variants may contribute to insufficient viral control and increased necrosis ocular disease presentation in the patients and serve as a knowledge base and starting point for the development of improved diagnostic, prophylactic, and therapeutic applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnmol.2023.1253040","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:24:32Z","timestamp":1698215072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Whole exome sequencing of patients with varicella-zoster virus and herpes simplex virus induced acute retinal necrosis reveals rare disease-associated genetic variants"],"prefix":"10.3389","volume":"16","author":[{"given":"Johanna L.","family":"Heinz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid M. A.","family":"Swagemakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"von Hofsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Helleberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"De Keukeleere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke H.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Ilginis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges M. G. M.","family":"Verjans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"van Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"van der Spek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine H.","family":"Mogensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.18502\/ijaai.v20i1.5416","article-title":"Leukemia inhibitory factor suppresses NKG2D mRNA expression and presentation on human natural killer cells","volume":"20","author":"Abdoli","year":"2021","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.1182\/blood-2011-09-378158","article-title":"The phenotype of human STK4 deficiency","volume":"119","author":"Abdollahpour","year":"2012","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"ref4","first-page":"215","article-title":"Association of herpetic encephalitis with acute retinal necrosis syndrome","volume":"23","author":"Ahmadieh","year":"1991","journal-title":"Ann. Ophthalmol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e11583","DOI":"10.7759\/cureus.11583","article-title":"Varicella-zoster virus meningitis and encephalitis: an understated cause of central nervous system infections","volume":"12","author":"Alvarez","year":"2020","journal-title":"Cureus"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3389\/fmicb.2019.01495","article-title":"Host genetics, innate immune responses, and cellular death pathways in poliomyelitis patients","volume":"10","author":"Andersen","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1084\/jem.20142274","article-title":"Functional IRF3 deficiency in a patient with herpes simplex encephalitis","volume":"212","author":"Andersen","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"11338","DOI":"10.3390\/ijms222111338","article-title":"Mitochondria as a cellular hub in infection and inflammation","volume":"22","author":"Andrieux","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature22078","article-title":"Polyglutamine tracts regulate beclin 1-dependent autophagy","volume":"545","author":"Ashkenazi","year":"2017","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e139980","DOI":"10.1172\/JCI139980","article-title":"Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency","volume":"131","author":"Bastard","year":"2021","journal-title":"J. Clin. Invest."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1056\/NEJM198906293202605","article-title":"Severe herpesvirus infections in an adolescent without natural killer cells","volume":"320","author":"Biron","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/8904_2013_251","article-title":"Heterozygous mutations in the ADCK3 gene in siblings with cerebellar atrophy and extreme phenotypic variability","volume":"12","author":"Blumkin","year":"2014","journal-title":"JIMD Reports"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1099\/vir.0.039917-0","article-title":"Inhibition of integrin \u03b16 expression by cell-free varicella-zoster virus","volume":"93","author":"Bowles","year":"2012","journal-title":"J. Gen. Virol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.exer.2004.09.007","article-title":"The role of viral and host genes in corneal infection with herpes simplex virus type 1","volume":"80","author":"Brandt","year":"2005","journal-title":"Exp. Eye Res."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/82_2010_9","article-title":"VZV molecular epidemiology","volume":"342","author":"Breuer","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1172\/JCI114884","article-title":"A novel X-linked combined immunodeficiency disease","volume":"86","author":"Brooks","year":"1990","journal-title":"J. Clin. Invest."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s41435-018-0027-y","article-title":"Mutations in RNA polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection","volume":"20","author":"Carter-Timofte","year":"2019","journal-title":"Genes Immun."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e500","DOI":"10.1212\/NXI.0000000000000500","article-title":"Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins","volume":"5","author":"Carter-Timofte","year":"","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.molmed.2018.07.009","article-title":"RNA polymerase III as a gatekeeper to prevent severe VZV infections","volume":"24","author":"Carter-Timofte","year":"","journal-title":"Trends Mol. Med."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.3389\/fmicb.2017.02525","article-title":"HHV-6A infection of endometrial epithelial cells induces increased endometrial NK cell-mediated cytotoxicity","volume":"8","author":"Caselli","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1002\/jmv.23771","article-title":"High prevalence of HHV8 infection and specific killer cell immunoglobulin-like receptors allotypes in Sardinian patients with type 2 diabetes mellitus","volume":"86","author":"Caselli","year":"2014","journal-title":"J. Med. Virol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1126\/science.1128346","article-title":"Herpes simplex virus encephalitis in human UNC-93B deficiency","volume":"314","author":"Casrouge","year":"2006","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/IIO.0000000000000414","article-title":"Retinal detachment associated with acute retinal necrosis","volume":"62","author":"Cox","year":"2022","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e1004939","DOI":"10.1371\/journal.ppat.1004939","article-title":"Selective recruitment of nuclear factors to productively replicating herpes simplex virus genomes","volume":"11","author":"Dembowski","year":"2015","journal-title":"PLoS Pathog."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10545-014-9749-9","article-title":"Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency","volume":"38","author":"Desbats","year":"2015","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e69705","DOI":"10.7554\/eLife.69705","article-title":"The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells","volume":"11","author":"Detilleux","year":"2022","journal-title":"elife"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1056\/NEJMoa1413462","article-title":"Inherited DOCK2 deficiency in patients with early-onset invasive infections","volume":"372","author":"Dobbs","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1084\/jem.20030705","article-title":"Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation","volume":"198","author":"Doyen","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/ng1097","article-title":"Impaired response to interferon-alpha\/beta and lethal viral disease in human STAT1 deficiency","volume":"33","author":"Dupuis","year":"2003","journal-title":"Nat. Genet."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1128\/JVI.80.4.1710-1723.2006","article-title":"Phosphorylation of the varicella-zoster virus (VZV) major transcriptional regulatory protein IE62 by the VZV open reading frame 66 protein kinase","volume":"80","author":"Eisfeld","year":"2006","journal-title":"J. Virol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.cell.2016.03.022","article-title":"Whole-genome sequencing of a healthy aging cohort","volume":"165","author":"Erikson","year":"2016","journal-title":"Cells"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1399-0039.2007.00844.x","article-title":"Influence of KIR gene diversity on the course of HSV-1 infection: resistance to the disease is associated with the absence of KIR2DL2 and KIR2DS2","volume":"70","author":"Estefan\u00eda","year":"2007","journal-title":"Tissue Antigens"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1128\/JCM.01900-07","article-title":"Comparison of immunoblotting, calculation of the Goldmann-Witmer coefficient, and real-time PCR using aqueous humor samples for diagnosis of ocular toxoplasmosis","volume":"46","author":"Fekkar","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref34","volume-title":"Fields virology: Chapter 12: Epidemiologz","author":"Fields","year":""},{"key":"ref35","volume-title":"Fields virology: Chapter 60: pathogenesis of human infection","author":"Fields","year":""},{"key":"ref36","volume-title":"Fields virology: Chapter 63: Pathogenesis & pathology","author":"Fields","year":""},{"key":"ref37","volume-title":"Fields virology: Chapter 63: Varicella-zoster virus","author":"Fields","year":""},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e2304884120","DOI":"10.1073\/pnas.2304884120","article-title":"Coenzyme Q10 trapping in mitochondrial complex I underlies Leber's hereditary optic neuropathy","volume":"120","author":"Fuller","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/s0002-9394(99)00316-5","article-title":"Viral causes of the acute retinal necrosis syndrome","volume":"129","author":"Ganatra","year":"2000","journal-title":"Am J. Ophthalmol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.neuron.2014.07.036","article-title":"The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity","volume":"83","author":"Garc\u00eda-Caballero","year":"2014","journal-title":"Neuron"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"8192","DOI":"10.1038\/ncomms9192","article-title":"mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. Nature","volume":"6","author":"Gebhardt","year":"2015","journal-title":"Communications"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2020.00001","article-title":"Manipulation of the innate immune response by varicella zoster virus","volume":"11","author":"Gerada","year":"2020","journal-title":"Front. Immunol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.01140-19","article-title":"Granzyme B cleaves multiple herpes simplex virus 1 and varicella-zoster virus (VZV) gene products, and VZV ORF4 inhibits natural killer cell cytotoxicity","volume":"93","author":"Gerada","year":"2019","journal-title":"J. Virol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1172\/JCI61014","article-title":"Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency","volume":"122","author":"Gineau","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"656004","DOI":"10.3389\/fonc.2021.656004","article-title":"Interleukin-17 receptor D in physiology, inflammation and cancer","volume":"11","author":"Girondel","year":"2021","journal-title":"Front. Oncol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.00800-20","article-title":"Exocytosis of progeny infectious varicella-zoster virus particles via a Mannose-6-phosphate receptor pathway without Xenophagy following secondary envelopment","volume":"94","author":"Girsch","year":"2020","journal-title":"J. Virol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jinf.2015.06.004","article-title":"Varicella-zoster virus infections of the central nervous system \u2013 prognosis, diagnostics and treatment","volume":"71","author":"Grahn","year":"2015","journal-title":"J. Infect."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/pathogens5040067","article-title":"Varicella-zoster virus infectious cycle: ER stress, autophagic flux, and amphisome-mediated trafficking","volume":"5","author":"Grose","year":"2016","journal-title":"Pathogens"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1128\/MCB.01603-12","article-title":"Human DEAD box helicase 3 couples I\u03baB kinase \u03b5 to interferon regulatory factor 3 activation","volume":"33","author":"Gu","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1471-2199-8-99","article-title":"The varicella-zoster virus immediate-early 63 protein affects chromatin-controlled gene transcription in a cell-type dependent manner","volume":"8","author":"Habran","year":"2007","journal-title":"BMC Mol. Biol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"eabc2691","DOI":"10.1126\/sciimmunol.abc2691","article-title":"Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans","volume":"5","author":"Hait","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1093\/infdis\/jiaa589","article-title":"Whole-exome sequencing of patients with recurrent HSV-2 lymphocytic mollaret meningitis","volume":"223","author":"Hait","year":"2021","journal-title":"J. Infect. Dis."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"8348","DOI":"10.1128\/JVI.79.13.8348-8360.2005","article-title":"Herpes simplex virus ICP27 activation of stress kinases JNK and p38","volume":"79","author":"Hargett","year":"2005","journal-title":"J. Virol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3390\/v13061053","article-title":"The role of autophagy in varicella zoster virus infection","volume":"13","author":"Heinz","year":"2021","journal-title":"Viruses"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1093\/cid\/ciaa185","article-title":"Varicella zoster virus encephalitis in Denmark from 2015 to 2019-A nationwide prospective cohort study","volume":"72","author":"Herlin","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1084\/jem.20111316","article-title":"Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood","volume":"209","author":"Herman","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1016\/j.ophtha.2009.03.029","article-title":"Acute retinal necrosis: clinical features, early vitrectomy, and outcomes","volume":"116","author":"Hillenkamp","year":"2009","journal-title":"Ophthalmology"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1167\/iovs.61.6.20","article-title":"Role of TH17 responses in increasing herpetic keratitis in the eyes of mice infected with HSV-1","volume":"61","author":"Hirose","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/s0002-9394(14)70075-3","article-title":"Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society","volume":"117","author":"Holland","year":"1994","journal-title":"Am J. Ophthalmol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12879-017-2305-0","article-title":"Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo","volume":"17","author":"Hou","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3389\/fimmu.2020.00356","article-title":"HSV-2 infection of human genital epithelial cells upregulates TLR9 expression through the SP1\/JNK signaling pathway","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Immunol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41590-019-0323-3","article-title":"A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape","volume":"20","author":"Hubel","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13041-022-00900-3","article-title":"Loss of Drosophila Coq8 results in impaired survival, locomotor deficits and photoreceptor degeneration","volume":"15","author":"Hura","year":"2022","journal-title":"Mol. Brain"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.ajhg.2016.08.016","article-title":"REVEL: an ensemble method for predicting the pathogenicity of rare missense variants","volume":"99","author":"Ioannidis","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nmeth.3739","article-title":"The mutation significance cutoff: gene-level thresholds for variant predictions","volume":"13","author":"Itan","year":"2016","journal-title":"Nat. Methods"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s10384-012-0211-y","article-title":"Acute retinal necrosis: factors associated with anatomic and visual outcomes","volume":"57","author":"Iwahashi-Shima","year":"2013","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/ng.3358","article-title":"Exome sequencing identifies somatic mutations of DDX3X in natural killer\/T-cell lymphoma","volume":"47","author":"Jiang","year":"2015","journal-title":"Nat. Genet."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1128\/jvi.77.2.1268-1280.2003","article-title":"Microarray analysis of host cell gene transcription in response to varicella-zoster virus infection of human T cells and fibroblasts in vitro and SCIDhu skin xenografts in vivo","volume":"77","author":"Jones","year":"2003","journal-title":"J. Virol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10875-020-00891-7","article-title":"STK4 deficiency impairs innate immunity and interferon production through negative regulation of TBK1-IRF3 signaling","volume":"41","author":"J\u00f8rgensen","year":"2021","journal-title":"J. Clin. Immunol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1091\/mbc.e08-12-1249","article-title":"ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery","volume":"20","author":"Jung","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41525-022-00330-z","article-title":"Biallelic variants in coenzyme Q10 biosynthesis pathway genes cause a retinitis pigmentosa phenotype. NPJ","volume":"7","author":"Jurkute","year":"2022","journal-title":"Genomic Med."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1007\/s13365-016-0457-0","article-title":"Varicella zoster virus infection of human fetal lung cells alters mitochondrial morphology","volume":"22","author":"Keller","year":"2016","journal-title":"J. Neurovirol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s13365-020-00831-6","article-title":"Varicella-Zoster Virus infected human neurons are resistant to apoptosis","volume":"26","author":"Kennedy","year":"2020","journal-title":"J. Neurovirol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/s13365-020-00857-w","article-title":"Determinants of neurological syndromes caused by varicella zoster virus (VZV)","volume":"26","author":"Kennedy","year":"2020","journal-title":"J. Neurovirol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"35324","DOI":"10.18632\/oncotarget.6117","article-title":"Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model","volume":"6","author":"Kim","year":"2015","journal-title":"Oncotarget"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"15181","DOI":"10.1073\/pnas.1006539107","article-title":"Aspartate-glutamate-alanine-histidine box motif (DEAH)\/RNA helicase a helicases sense microbial DNA in human plasmacytoid dendritic cells","volume":"107","author":"Kim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1083\/jcb.201503023","article-title":"TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity","volume":"210","author":"Kimura","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat. Genet."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"770","DOI":"10.5858\/2001-125-0770-VZVIOT","article-title":"Varicella-Zoster virus infections of the nervous system: clinical and pathologic correlates","volume":"125","author":"Kleinschmidt-DeMasters","year":"2001","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"6796","DOI":"10.1016\/j.febslet.2005.11.016","article-title":"ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes","volume":"579","author":"Kohroki","year":"2005","journal-title":"FEBS Lett."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"e1005499","DOI":"10.1371\/journal.ppat.1005499","article-title":"Quantitative trait locus based virulence determinant mapping of the HSV-1 genome in murine ocular infection: genes involved in viral regulatory and innate immune networks contribute to virulence","volume":"12","author":"Kolb","year":"2016","journal-title":"PLoS Pathog."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"9533","DOI":"10.1128\/jvi.77.17.9533-9541.2003","article-title":"Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression","volume":"77","author":"Kramer","year":"2003","journal-title":"J. Virol."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1084\/jem.20140280","article-title":"Human TYK2 deficiency: mycobacterial and viral infections without hyper-IgE syndrome","volume":"212","author":"Kreins","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/nprot.2009.86","article-title":"Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm","volume":"4","author":"Kumar","year":"2009","journal-title":"Nat. Protoc."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.00640-17","article-title":"Role of the JNK pathway in varicella-zoster virus lytic infection and reactivation","volume":"91","author":"Kurapati","year":"2017","journal-title":"J. Virol."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1038\/s41591-019-0672-3","article-title":"Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis","volume":"25","author":"Lafaille","year":"2019","journal-title":"Nat. Med."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1084\/jem.20161759","article-title":"Recurrent rhinovirus infections in a child with inherited MDA5 deficiency","volume":"214","author":"Lamborn","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.ophtha.2006.08.037","article-title":"Acute retinal necrosis features, management, and outcomes","volume":"114","author":"Lau","year":"2007","journal-title":"Ophthalmology"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.coi.2008.01.001","article-title":"Autophagy and antiviral immunity","volume":"20","author":"Lee","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1136\/bjo.83.1.123a","article-title":"Acute retinal necrosis after neonatal herpes encephalitis","volume":"83","author":"Levinson","year":"1999","journal-title":"Br. J. Ophthalmol."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"741054","DOI":"10.3389\/fneur.2021.741054","article-title":"Change in Cav3.2 T-type calcium channel induced by varicella-zoster virus participates in the maintenance of herpetic neuralgia","volume":"12","author":"Li","year":"2021","journal-title":"Front. Neurol."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1093\/infdis\/jiz229","article-title":"Recurrent herpes zoster ophthalmicus in a patient with a novel toll-like receptor 3 variant linked to compromised activation capacity in fibroblasts","volume":"221","author":"Liang","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41564-021-00884-1","article-title":"ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity","volume":"6","author":"Liu","year":"2021","journal-title":"Nat. Microbiol."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.3389\/fimmu.2019.02521","article-title":"Functions of the WNT signaling network in shaping host responses to infection","volume":"10","author":"Ljungberg","year":"2019","journal-title":"Front. Immunol."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/s0092-8674(02)00671-2","article-title":"Hairpin opening and overhang processing by an Artemis\/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination","volume":"108","author":"Ma","year":"2002","journal-title":"Cells"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1182\/blood-2012-09-453969","article-title":"Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset","volume":"121","author":"Mace","year":"2013","journal-title":"Blood"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/1531-8249(200101)49:1<104::aid-ana15>3.0.co;2-y","article-title":"Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1","volume":"49","author":"Maertzdorf","year":"2001","journal-title":"Ann. Neurol."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"7674","DOI":"10.1128\/JVI.00500-14","article-title":"Cellular transcriptome analysis reveals differential expression of pro-and antiapoptosis genes by varicella-zoster virus-infected neurons and fibroblasts","volume":"88","author":"Markus","year":"2014","journal-title":"J. Virol."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"4412","DOI":"10.4049\/jimmunol.1103434","article-title":"Host genetic factors in susceptibility to herpes simplex type 1 virus infection: contribution of polymorphic genes at the interface of innate and adaptive immunity","volume":"188","author":"Moraru","year":"2012","journal-title":"J. Immunol."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"12281","DOI":"10.1073\/pnas.182618999","article-title":"STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation","volume":"99","author":"Morinobu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/gene.2015.46","article-title":"Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis","volume":"16","author":"M\u00f8rk","year":"2015","journal-title":"Genes Immun."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s41232-018-0089-2","article-title":"Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics","volume":"38","author":"Murakami","year":"2018","journal-title":"Inflammat. Regenerat."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1136\/bjo.2007.114884","article-title":"Acute retinal necrosis: a national population-based study to assess the incidence, methods of diagnosis, treatment strategies and outcomes in the UK","volume":"91","author":"Muthiah","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/cr.2010.165","article-title":"Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes","volume":"21","author":"Nie","year":"2011","journal-title":"Cell Res."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1093\/infdis\/jit472","article-title":"Genital herpes simplex virus type 2 infection in humanized HIV-transgenic mice triggers HIV shedding and is associated with greater neurological disease","volume":"209","author":"Nixon","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"3543","DOI":"10.1172\/JCI92280","article-title":"Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections","volume":"127","author":"Ogunjimi","year":"2017","journal-title":"J. Clin. Invest."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/pathogens8040183","article-title":"Whole transcriptome analyses reveal differential mRNA and microRNA expression profiles in primary human dermal fibroblasts infected with clinical or vaccine strains of varicella zoster virus","volume":"8","author":"Oh","year":"2019","journal-title":"Pathogens"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1091\/mbc.E11-09-0746","article-title":"Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy","volume":"23","author":"Orsi","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"13666","DOI":"10.1038\/s41598-017-13936-6","article-title":"Inferred father-to-son transmission of herpes simplex virus results in near-perfect preservation of viral genome identity and in vivo phenotypes","volume":"7","author":"Pandey","year":"2017","journal-title":"Sci. Rep."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"19430","DOI":"10.18632\/oncotarget.7103","article-title":"Amyloid precursor protein and amyloid precursor-like protein 2 in cancer","volume":"7","author":"Pandey","year":"2016","journal-title":"Oncotarget"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.clinmicnews.2019.02.003","article-title":"Herpes simplex virus disease management and diagnostics in the era of high-throughput sequencing","volume":"41","author":"Pandey","year":"2019","journal-title":"Clin. Microbiol. Newsl."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.immuni.2010.08.014","article-title":"Human TRAF3 adaptor molecule deficiency leads to impaired toll-like receptor 3 response and susceptibility to herpes simplex encephalitis","volume":"33","author":"P\u00e9rez de Diego","year":"2010","journal-title":"Immunity"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1167\/iovs.08-2656","article-title":"Coenzyme Q10 in the human retina","volume":"50","author":"Qu","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref114","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1099\/vir.0.80347-0","article-title":"Replication of varicella-zoster virus is influenced by the levels of JNK\/SAPK and p38\/MAPK activation","volume":"85","author":"Rahaus","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref115","doi-asserted-by":"publisher","first-page":"751892","DOI":"10.3389\/fcell.2021.751892","article-title":"The TSC complex-mTORC1 Axis: from lysosomes to stress granules and Back","volume":"9","author":"Rehbein","year":"2021","journal-title":"Front. Cell Development. Biol."},{"key":"ref116","doi-asserted-by":"publisher","first-page":"e118","DOI":"10.1093\/nar\/gkr407","article-title":"Predicting the functional impact of protein mutations: application to cancer genomics","volume":"39","author":"Reva","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref117","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"ref118","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1093\/infdis\/144.5.464","article-title":"Differences in neurovirulence among isolates of Herpes simplex virus types 1 and 2 in mice using four routes of infection","volume":"144","author":"Richards","year":"1981","journal-title":"J. Infect. Dis."},{"key":"ref119","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jneuroim.2012.07.004","article-title":"Altered natural killer cells' response to herpes virus infection in multiple sclerosis involves KIR2DL2 expression","volume":"251","author":"Rizzo","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1016\/s0301-472x(99)00077-6","article-title":"Listeria monocytogenes and recurrent mycobacterial infections in a child with complete interferon-gamma-receptor (IFNgammaR1) deficiency: mutational analysis and evaluation of therapeutic options","volume":"27","author":"Roesler","year":"1999","journal-title":"Exp. Hematol."},{"key":"ref121","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1172\/JCI59259","article-title":"Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency","volume":"121","author":"Sancho-Shimizu","year":"2011","journal-title":"J. Clin. Invest."},{"key":"ref122","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1074\/jbc.274.3.1848","article-title":"Enzymatic characteristics of recombinant medium isozyme of 2\u2032-5\u2032 oligoadenylate synthetase","volume":"274","author":"Sarkar","year":"","journal-title":"J. Biol. Chem."},{"key":"ref123","doi-asserted-by":"publisher","first-page":"25535","DOI":"10.1074\/jbc.274.36.25535","article-title":"The nature of the catalytic domain of 2\u2032-5\u2032-oligoadenylate synthetases","volume":"274","author":"Sarkar","year":"","journal-title":"J. Biol. Chem."},{"key":"ref124","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nmeth.2890","article-title":"MutationTaster2: mutation prediction for the deep-sequencing age","volume":"11","author":"Schwarz","year":"2014","journal-title":"Nat. Methods"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.1217141","article-title":"GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals","volume":"336","author":"Shenoy","year":"2012","journal-title":"Science"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1479-7364-8-11","article-title":"Ranking non-synonymous single nucleotide polymorphisms based on disease concepts","volume":"8","author":"Shihab","year":"2014","journal-title":"Hum. Genomics"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/s0014-5793(99)00966-7","article-title":"The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein","volume":"456","author":"Shimizu","year":"1999","journal-title":"FEBS Lett."},{"key":"ref128","doi-asserted-by":"publisher","first-page":"624284","DOI":"10.3389\/fimmu.2021.624284","article-title":"AHR regulates NK cell migration via ASB2-mediated ubiquitination of Filamin A","volume":"12","author":"Shin","year":"2021","journal-title":"Front. Immunol."},{"key":"ref129","doi-asserted-by":"publisher","first-page":"8259","DOI":"10.1080\/21655979.2021.1982846","article-title":"Role of adaptin protein complexes in intracellular trafficking and their impact on diseases","volume":"12","author":"Shin","year":"2021","journal-title":"Bioengineered"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/infdis\/jiy216","article-title":"Genome-wide surveillance of genital herpes simplex virus type 1 from multiple anatomic sites over time","volume":"218","author":"Shipley","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref131","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3390\/healthcare10030487","article-title":"Antioxidant and anti-inflammatory effects of coenzyme Q10 supplementation on infectious diseases","volume":"10","author":"Sifuentes-Franco","year":"2022","journal-title":"Healthcare"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"D447-52","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein-protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref133","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.1128\/JVI.02670-08","article-title":"Varicella-zoster virus infection induces autophagy in both cultured cells and human skin vesicles","volume":"83","author":"Takahashi","year":"2009","journal-title":"J. Virol."},{"key":"ref134","doi-asserted-by":"publisher","first-page":"e92342","DOI":"10.1371\/journal.pone.0092342","article-title":"A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice","volume":"9","author":"Thompson","year":"2014","journal-title":"PLoS One"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1093\/infdis\/jiab254","article-title":"Genetic variants and immune responses in a cohort of patients with varicella zoster virus encephalitis","volume":"224","author":"Thomsen","year":"2021","journal-title":"J. Infect. Dis."},{"key":"ref136","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.3390\/cancers14061436","article-title":"Emerging canonical and non-canonical roles of Granzyme B in health and disease","volume":"14","author":"Tibbs","year":"2022","journal-title":"Cancers"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.jid.2019.08.448","article-title":"Kallikrein-mediated cytokeratin 10 degradation is required for varicella zoster virus propagation in skin","volume":"140","author":"Tommasi","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref138","doi-asserted-by":"publisher","first-page":"37315","DOI":"10.1074\/jbc.M205900200","article-title":"TRIM8\/GERP RING finger protein interacts with SOCS-1","volume":"277","author":"Toniato","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref139","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/ana.25751","article-title":"Clinico-genetic, imaging and molecular delineation of COQ8A-Ataxia: a multicenter study of 59 patients","volume":"88","author":"Trasch\u00fctz","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref140","first-page":"57A","article-title":"Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret's","volume":"11","author":"Tyler","year":"2004","journal-title":"Herpes"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"e1002124","DOI":"10.1371\/journal.ppat.1002124","article-title":"Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism","volume":"7","author":"Vastag","year":"2011","journal-title":"PLoS Pathog."},{"key":"ref142","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.preteyeres.2018.03.005","article-title":"Non-syndromic retinitis pigmentosa","volume":"66","author":"Verbakel","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref143","doi-asserted-by":"publisher","first-page":"7361","DOI":"10.1093\/hmg\/ddv437","article-title":"DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency","volume":"24","author":"Volk","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref144","doi-asserted-by":"publisher","first-page":"e000247","DOI":"10.1136\/bmjophth-2018-000247","article-title":"Alpha herpes virus type and viral load in intraocular fluids in patients with acute retinal necrosis","volume":"4","author":"von Hofsten","year":"2019","journal-title":"BMJ Open Ophthalmol."},{"key":"ref145","doi-asserted-by":"publisher","first-page":"ofaa198","DOI":"10.1093\/ofid\/ofaa198","article-title":"Deep sequencing of varicella-zoster virus in aqueous humor from a patient with acute retinal necrosis presenting with acute glaucoma","volume":"7","author":"von Hofsten","year":"2020","journal-title":"Open Forum Infect. Dis."},{"key":"ref146","doi-asserted-by":"publisher","first-page":"13884","DOI":"10.1073\/pnas.241358198","article-title":"Caspase-10 is an initiator caspase in death receptor signalling","volume":"98","author":"Wang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref147","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1182\/blood.V95.10.3183","article-title":"Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4","volume":"95","author":"Wang","year":"2000","journal-title":"Blood"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref149","doi-asserted-by":"publisher","first-page":"5059","DOI":"10.1128\/JVI.80.10.5059-5064.2006","article-title":"Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses","volume":"80","author":"Weber","year":"2006","journal-title":"J. Virol."},{"key":"ref150","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(02)07681-X","article-title":"Viral encephalitis: familiar infections and emerging pathogens","volume":"359","author":"Whitley","year":"2002","journal-title":"Lancet"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2431-11-31","article-title":"Varicella-zoster virus infections in immunocompromised patients - a single Centre 6-years analysis","volume":"11","author":"Wiegering","year":"2011","journal-title":"BMC Pediatr."},{"key":"ref152","doi-asserted-by":"publisher","first-page":"e1004580","DOI":"10.1371\/journal.ppat.1004580","article-title":"Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults","volume":"11","author":"Wilcox","year":"2015","journal-title":"PLoS Pathog."},{"key":"ref153","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/ng.3833","article-title":"Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes","volume":"49","author":"Witzel","year":"2017","journal-title":"Nat. Genet."},{"key":"ref154","doi-asserted-by":"publisher","first-page":"665931","DOI":"10.3389\/fnmol.2021.665931","article-title":"Transcriptome analysis reveals the role of cellular calcium disorder in varicella zoster virus-induced post-herpetic neuralgia","volume":"14","author":"Wu","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"ref155","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.4049\/jimmunol.1900667","article-title":"NOD1 promotes antiviral signaling by binding viral RNA and regulating the interaction of MDA5 and MAVS","volume":"204","author":"Wu","year":"2020","journal-title":"J. Immunol."},{"key":"ref156","doi-asserted-by":"publisher","first-page":"9730","DOI":"10.1038\/srep09730","article-title":"Autophagy stimulation abrogates herpes simplex virus-1 infection","volume":"5","author":"Yakoub","year":"2015","journal-title":"Sci. Rep."},{"key":"ref157","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1002\/hep.28971","article-title":"The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis","volume":"65","author":"Yan","year":"2017","journal-title":"Hepatology"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.4049\/jimmunol.1601647","article-title":"TRIM8 negatively regulates TLR3\/4-mediated innate immune response by blocking TRIF-TBK1 interaction","volume":"199","author":"Ye","year":"2017","journal-title":"J. Immunol."},{"key":"ref159","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.jaci.2015.08.020","article-title":"Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association","volume":"137","author":"Yee","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref160","doi-asserted-by":"publisher","first-page":"6282","DOI":"10.1128\/JVI.78.12.6282-6286.2004","article-title":"Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway","volume":"78","author":"Yokota","year":"2004","journal-title":"J. Virol."},{"key":"ref161","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1128\/MMBR.00043-14","article-title":"JNK signaling: regulation and functions based on complex protein-protein partnerships","volume":"80","author":"Zeke","year":"2016","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.cell.2018.02.019","article-title":"Inborn errors of RNA lariat metabolism in humans with brainstem viral infection","volume":"172","author":"Zhang","year":"2018","journal-title":"Cells"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","article-title":"Combined immunodeficiency associated with DOCK8 mutations","volume":"361","author":"Zhang","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref164","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1126\/science.1139522","article-title":"TLR3 deficiency in patients with herpes simplex encephalitis","volume":"317","author":"Zhang","year":"2007","journal-title":"Science"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.2174\/0929867324666170801100516","article-title":"Therapeutic potential of co-enzyme Q10 in retinal diseases","volume":"24","author":"Zhang","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"ref166","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1038\/s41418-022-01017-9","article-title":"Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection","volume":"29","author":"Zhang","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref167","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.molcel.2017.08.005","article-title":"The ER-localized transmembrane protein EPG-3\/VMP1 regulates SERCA activity to control ER-isolation membrane contacts for autophagosome formation","volume":"67","author":"Zhao","year":"2017","journal-title":"Mol. Cell"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"144","DOI":"10.5501\/wjv.v5.i4.144","article-title":"Regulation of Wnt\/\u03b2-catenin signaling by herpesviruses","volume":"5","author":"Zwezdaryk","year":"2016","journal-title":"World J. Virol."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2023.1253040\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:24:40Z","timestamp":1698215080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2023.1253040\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,25]]},"references-count":168,"alternative-id":["10.3389\/fnmol.2023.1253040"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2023.1253040","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,25]]},"article-number":"1253040"}}