{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:53:22Z","timestamp":1789588402599,"version":"build-2803163510"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Axonal plasticity is strongly related to neuronal development as well as regeneration. It was recently demonstrated that active mechanical tension, intended as an extrinsic factor, is a valid contribution to the modulation of axonal plasticity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In previous publications, our team validated a the \u201cnano-pulling\u201d method used to apply mechanical forces to developing axons of isolated primary neurons using magnetic nanoparticles (MNP) actuated by static magnetic fields. This method was found to promote axon growth and synaptic maturation. Here, we explore the use of nano-pulling as an extrinsic factor to promote axon regeneration in a neuronal tissue explant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Whole dorsal root ganglia (DRG) were thus dissected from a mouse spinal cord, incubated with MNPs, and then stretched. We found that particles were able to penetrate the ganglion and thus become localised both in the somas and in sprouting axons. Our results highlight that nano-pulling doubles the regeneration rate, and this is accompanied by an increase in the arborizing capacity of axons, an accumulation of cellular organelles related to mass addition (endoplasmic reticulum and mitochondria) and pre-synaptic proteins with respect to spontaneous regeneration. In line with the previous results on isolated hippocampal neurons, we observed that this process is coupled to an increase in the density of stable microtubules and activation of local translation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our data demonstrate that nano-pulling enhances axon regeneration in whole spinal ganglia exposed to MNPs and external magnetic fields. These preliminary data represent an encouraging starting point for proposing nano-pulling as a biophysical tool for the design of novel therapies based on the use of force as an extrinsic factor for promoting nerve regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnmol.2024.1340958","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T11:25:21Z","timestamp":1712143521000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation"],"prefix":"10.3389","volume":"17","author":[{"given":"Alessandro","family":"Falconieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Folino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Da Palmata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Raffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"ref1","volume-title":"Neuroanatomy, dorsal root ganglion","author":"Ahimsadasan","year":"2018"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12195-012-0223-1","article-title":"Mechanical tension modulates local and global vesicle dynamics in neurons","volume":"5","author":"Ahmed","year":"2012","journal-title":"Cell. Mol. Bioeng."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-07402-6","article-title":"Neurite elongation is highly correlated with bulk forward translocation of microtubules","volume":"7","author":"Athamneh","year":"2017","journal-title":"Sci. Rep."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1083\/jcb.111.2.495","article-title":"Individual microtubules in the axon consist of domains that differ in both composition and stability","volume":"111","author":"Baas","year":"1990","journal-title":"J. Cell Biol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e2669","DOI":"10.21769\/BioProtoc.2669","article-title":"The RiboPuromycylation method (RPM): an immunofluorescence technique to map translation sites at the sub-cellular level","volume":"8","author":"Bastide","year":"2018","journal-title":"Bio Protoc."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1080\/14728222.2017.1328057","article-title":"Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain","volume":"21","author":"Berta","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3390\/pharmaceutics15020640","article-title":"Recent advances in polymeric drug delivery Systems for Peripheral Nerve Regeneration","volume":"15","author":"Bianchini","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.tcb.2021.01.001","article-title":"Coordination between transport and local translation in neurons","volume":"31","author":"Broix","year":"2021","journal-title":"Trends Cell Biol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/foc.2004.16.5.2","article-title":"Pathophysiology of peripheral nerve injury: a brief review","volume":"16","author":"Burnett","year":"2004","journal-title":"Neurosurg. Focus."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1016\/j.clinph.2008.03.018","article-title":"Evaluation and management of peripheral nerve injury","volume":"119","author":"Campbell","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"135900","DOI":"10.1016\/j.neulet.2021.135900","article-title":"Microtubule acetylation: a reading key to neural physiology and degeneration","volume":"755","author":"Cappelletti","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"733253","DOI":"10.1101\/733253","article-title":"Magnetic manipulation of axonal endosome transport in live neurons","author":"Chowdary","year":"2019","journal-title":"bioRxiv"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"652a","DOI":"10.1016\/j.bpj.2012.11.3600","article-title":"Magnetic manipulation of axonal transport in live neurons","volume":"104","author":"Chowdary","year":"2013","journal-title":"Biophys. J."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cell.2018.11.030","article-title":"Late endosomes act as mRNA translation platforms and sustain mitochondria in axons","volume":"176","author":"Cioni","year":"2019","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1085\/jgp.202012743","article-title":"Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle","volume":"153","author":"Coleman","year":"2021","journal-title":"J. Gen. Physiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e2205871","DOI":"10.1002\/smll.202205871","article-title":"Low forces push the maturation of neural precursors into neurons","volume":"19","author":"De Vincentiis","year":"2023","journal-title":"Small"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4997","DOI":"10.1523\/JNEUROSCI.3075-19.2020","article-title":"Extremely low forces induce extreme axon growth","volume":"40","author":"De Vincentiis","year":"2020","journal-title":"J. Neurosci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1515\/hsz-2023-0173","article-title":"Microtubules as a signal hub for axon growth in response to mechanical force","volume":"405","author":"Falconieri","year":"","journal-title":"Biol. Chem."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"111912","DOI":"10.1016\/j.celrep.2022.111912","article-title":"Axonal plasticity in response to active forces generated through magnetic nano-pulling","volume":"42","author":"Falconieri","year":"","journal-title":"Cell Rep."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.2217\/nnm-2019-0103","article-title":"Recent advances in the use of magnetic nanoparticles to promote neuroregeneration","volume":"14","author":"Falconieri","year":"2019","journal-title":"Nanomedicine"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.bpj.2021.12.041","article-title":"Magnetically-actuated microposts stimulate axon growth","volume":"121","author":"Falconieri","year":"2022","journal-title":"Biophys. J."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.3390\/nano11123432","article-title":"A comprehensive updated review on magnetic nanoparticles in diagnostics","volume":"11","author":"Farinha","year":"2021","journal-title":"Nano"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1038\/nmeth.3125","article-title":"Neuronal morphometry directly from bitmap images","volume":"11","author":"Ferreira","year":"2014","journal-title":"Nat. Methods"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s00018-009-0227-8","article-title":"The role of synapsins in neuronal development","volume":"67","author":"Fornasiero","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1242\/dev.079145","article-title":"The mechanical control of nervous system development","volume":"140","author":"Franze","year":"2013","journal-title":"Development"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-bioeng-071811-150045","article-title":"Mechanics in neuronal development and repair","volume":"15","author":"Franze","year":"2013","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"141","DOI":"10.12998\/wjcc.v3.i2.141","article-title":"Clinical outcomes for conduits and scaffolds in peripheral nerve repair","volume":"3","author":"Gerth","year":"2015","journal-title":"World J. Clin. Cases"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1601429","DOI":"10.1002\/adhm.201601429","article-title":"Magnetic nanoparticles for efficient delivery of growth factors: stimulation of peripheral nerve regeneration","volume":"6","author":"Giannaccini","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1146\/annurev.neuro.23.1.579","article-title":"The relationship between neuronal survival and regeneration","volume":"23","author":"Goldberg","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"eaaw9997","DOI":"10.1126\/science.aaw9997","article-title":"Axonal transport: driving synaptic function","volume":"366","author":"Guedes-Dias","year":"2019","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fncel.2019.00271","article-title":"Human dorsal root ganglia","volume":"13","author":"Haberberger","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/brainsci10070409","article-title":"Ultrasound stimulation increases neurite regeneration in injured dorsal root ganglion neurons through mammalian target of rapamycin activation","volume":"10","author":"Han","year":"2020","journal-title":"Brain Sci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0033-8389(03)00162-3","article-title":"Nerves in a pinch: imaging of nerve compression syndromes","volume":"42","author":"Hochman","year":"2004","journal-title":"Radiol. Clin."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/400_2009_19","article-title":"Axon regeneration in the peripheral and central nervous systems","volume":"48","author":"Huebner","year":"2009","journal-title":"Cell Biol. axon"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1039\/C6LC01349J","article-title":"Modulating motility of intracellular vesicles in cortical neurons with nanomagnetic forces on-chip","volume":"17","author":"Kunze","year":"2017","journal-title":"Lab Chip"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1021\/nn505330w","article-title":"Engineering cortical neuron polarity with nanomagnets on a chip","volume":"9","author":"Kunze","year":"2015","journal-title":"ACS Nano"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/dneu.20764","article-title":"Growth and elongation within and along the axon","volume":"70","author":"Lamoureux","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1002\/dneu.20662","article-title":"Quantitative analysis of microtubule dynamics during adhesion-mediated growth cone guidance","volume":"68","author":"Lee","year":"2008","journal-title":"Dev. Neurobiol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e1803758","DOI":"10.1002\/smll.201803758","article-title":"Rapid growth cone uptake and dynein-mediated axonal retrograde transport of negatively charged nanoparticles in neurons is dependent on size and cell type","volume":"15","author":"Lesniak","year":"2019","journal-title":"Small"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/nprot.2006.461","article-title":"Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity","volume":"2","author":"Malin","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/nrn1914","article-title":"Cancer pain and its impact on diagnosis, survival and quality of life","volume":"7","author":"Mantyh","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3390\/nano8090707","article-title":"Magnetic targeting of growth factors using iron oxide nanoparticles","volume":"8","author":"Marcus","year":"2018","journal-title":"Nano"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/251204","article-title":"Neurotrauma and inflammation: CNS and PNS responses","volume":"2015","author":"Mietto","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e20813","DOI":"10.7554\/eLife.20813","article-title":"Acetylated tubulin is essential for touch sensation in mice","volume":"5","author":"Morley","year":"2016","journal-title":"eLife"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-68405-4","article-title":"Uranium-free X solution: a new generation contrast agent for biological samples ultrastructure","volume":"10","author":"Moscardini","year":"2020","journal-title":"Sci. Rep."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.pneurobio.2018.05.002","article-title":"The intriguing nature of dorsal root ganglion neurons: linking structure with polarity and function","volume":"168","author":"Nascimento","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"196","DOI":"10.2478\/v10039-012-0031-9","article-title":"Magnetic nanoparticles as new diagnostic tools in medicine","volume":"57","author":"Niemirowicz","year":"2012","journal-title":"Adv. Med. Sci."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e62241","DOI":"10.1371\/journal.pone.0062241","article-title":"Targeted brain derived neurotropic factors (BDNF) delivery across the blood-brain barrier for neuro-protection using magnetic nano carriers: an in-vitro study","volume":"8","author":"Pilakka-Kanthikeel","year":"2013","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.nano.2014.11.011","article-title":"Promoting filopodial elongation in neurons by membrane-bound magnetic nanoparticles","volume":"11","author":"Pita-Thomas","year":"2015","journal-title":"Nanomedicine"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1016\/j.bpj.2018.10.009","article-title":"Piconewton mechanical forces promote neurite growth","volume":"115","author":"Raffa","year":"2018","journal-title":"Biophys. J."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.2106\/00004623-199911000-00013","article-title":"Pathophysiology of nerve compression syndromes: response of peripheral nerves to loading","volume":"81","author":"Rempel","year":"1999","journal-title":"JBJS"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.nano.2013.12.008","article-title":"The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field","volume":"10","author":"Riggio","year":"2014","journal-title":"Nanomedicine"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/(sici)1097-4598(200006)23:6<863::aid-mus4>3.0.co;2-0","article-title":"Traumatic injury to peripheral nerves","volume":"23","author":"Robinson","year":"2000","journal-title":"Muscle Nerve"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e1700635","DOI":"10.1002\/biot.201700635","article-title":"Strategic design and fabrication of nerve guidance conduits for peripheral nerve regeneration","volume":"13","author":"Sarker","year":"2018","journal-title":"Biotechnol. J."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.devcel.2008.05.003","article-title":"Coordination of actin filament and microtubule dynamics during neurite outgrowth","volume":"15","author":"Schaefer","year":"2008","journal-title":"Dev. Cell"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/neu.480080503","article-title":"Adult mouse dorsal root ganglia neurons in cell culture","volume":"8","author":"Scott","year":"1977","journal-title":"J. Neurobiol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"12611","DOI":"10.1073\/pnas.0901867106","article-title":"Mechanical tension contributes to clustering of neurotransmitter vesicles at presynaptic terminals","volume":"106","author":"Siechen","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"19042","DOI":"10.1073\/pnas.1019624108","article-title":"Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth","volume":"108","author":"Steketee","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.pneurobio.2011.04.002","article-title":"The emerging role of forces in axonal elongation","volume":"94","author":"Suter","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1073\/pnas.1917171117","article-title":"Microtubules regulate cardiomyocyte transversal Young\u2019s modulus","volume":"117","author":"Swiatlowska","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"112817","DOI":"10.1016\/j.expneurol.2018.08.014","article-title":"Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration","volume":"319","author":"Tajdaran","year":"2019","journal-title":"Exp. Neurol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1242\/jcs.103.4.953","article-title":"Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau","volume":"103","author":"Takemura","year":"1992","journal-title":"J. Cell Sci."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1021\/acs.nanolett.6b04200","article-title":"Magnetic nanoparticle-based mechanical stimulation for restoration of mechano-sensitive ion channel equilibrium in neural networks","volume":"17","author":"Tay","year":"2017","journal-title":"Nano Lett."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1021\/acsnano.5b07118","article-title":"Induction of calcium influx in cortical neural networks by nanomagnetic forces","volume":"10","author":"Tay","year":"2016","journal-title":"ACS Nano"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"14003","DOI":"10.1038\/s41598-022-18333-2","article-title":"Synaptic branch stability is mediated by non-enzymatic functions of MEC-17\/\u03b1TAT1 and ATAT-2","volume":"12","author":"Teoh","year":"2022","journal-title":"Sci. Rep."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-020-00621-6","article-title":"Growth and elongation of axons through mechanical tension mediated by fluorescent-magnetic bifunctional Fe 3 O 4\u00b7 rhodamine 6G@ PDA superparticles","volume":"18","author":"Wang","year":"2020","journal-title":"J. Nanobiotechnology"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e0164867","DOI":"10.1371\/journal.pone.0164867","article-title":"Improved auditory nerve survival with nanoengineered supraparticles for neurotrophin delivery into the deafened cochlea","volume":"11","author":"Wise","year":"2016","journal-title":"PLoS One"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1083\/jcb.200707042","article-title":"Microtubule stabilization specifies initial neuronal polarization","volume":"180","author":"Witte","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.celrep.2018.09.075","article-title":"Microtubule acetylation is required for mechanosensation in Drosophila","volume":"25","author":"Yan","year":"2018","journal-title":"Cell Rep."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1007\/s00204-011-0725-y","article-title":"Variation in the internalization of differently sized nanoparticles induces different DNA-damaging effects on a macrophage cell line","volume":"85","author":"Zhang","year":"2011","journal-title":"Arch. Toxicol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/267808","article-title":"The role of neurotrophic factors conjugated to iron oxide nanoparticles in peripheral nerve regeneration: in vitro studies","volume":"2014","author":"Ziv-Polat","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1021\/acschemneuro.5b00189","article-title":"Magnetic NGF-releasing PLLA\/iron oxide nanoparticles direct extending neurites and preferentially guide neurites along aligned electrospun microfibers","volume":"6","author":"Zuidema","year":"2015","journal-title":"ACS Chem. Neurosci."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2024.1340958\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T11:25:39Z","timestamp":1712143539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2024.1340958\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":73,"alternative-id":["10.3389\/fnmol.2024.1340958"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2024.1340958","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.29.564574","asserted-by":"object"}]},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"article-number":"1340958"}}