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Mol. Neurosci."],"abstract":"<jats:p>Tuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states. TSC is an autosomal dominant disease where 90% of affected individuals develop epilepsy. Epilepsy results from aberrant neuronal excitability that leads to recurring seizures. Under neurotypical conditions, the coordinated activity of voltage-gated ion channels keep neurons operating in an optimal range, thus providing network stability. Interestingly, loss or gain of function mutations in voltage-gated potassium, sodium, or calcium channels leads to altered excitability and seizures. To date, little is known about voltage-gated ion channel expression and function in TSC. However, data is beginning to emerge on how mTOR signaling regulates voltage-gated ion channel expression in neurons. Herein, we provide a comprehensive review of the literature describing common seizure types in patients with TSC, and suggest possible parallels between acquired epilepsies with known voltage-gated ion channel dysfunction. Furthermore, we discuss possible links toward mTOR regulation of voltage-gated ion channels expression and channel kinetics and the underlying epileptic manifestations in patients with TSC.<\/jats:p>","DOI":"10.3389\/fnmol.2024.1404884","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T06:01:20Z","timestamp":1724652080000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex"],"prefix":"10.3389","volume":"17","author":[{"given":"Hailey X.","family":"Egido-Betancourt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy E.","family":"Strowd III","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly F.","family":"Raab-Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"B1","author":"Alliance","year":"2020","journal-title":"Infantile spasms [Online]."},{"key":"B2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1515\/tnsci-2018-0023","article-title":"Tuberous sclerosis complex: Clinical spectrum and epilepsy: A retrospective chart review study.","volume":"9","author":"Almobarak","year":"2018","journal-title":"Transl. 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