{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:10:52Z","timestamp":1793722252488,"version":"4.6.1"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is the leading cause of dementia, accounting for 60\u201380% of all cases globally. Hallmark pathologies of AD include the accumulation of amyloid\n                    <jats:italic>\u03b2<\/jats:italic>\n                    peptide and phosphorylated tau, leading to neuronal circuit dysfunction, defective axonal transport, and neurotransmitter system (NTS) abnormalities. Disruptions in acetylcholine, GABA, dopamine, serotonin, and glutamate levels, as well as the loss of cholinergic, GABAergic, and monoaminergic neurons, contribute to the progression of AD. Additionally, neurotrophic factors like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are significantly reduced in AD, impacting neuronal health and synaptic integrity. This review highlights the emerging role of neurotrophic factor alpha 1 (NF-\u03b11), also known as carboxypeptidase E, in AD. NF-\u03b11 shows neuroprotective and neurogenesis-promoting properties, offering potential for therapeutic interventions. The review compares NF-\u03b11 gene therapy with other neurotrophin-based treatments, providing insights into its efficacy in AD management.\n                  <\/jats:p>","DOI":"10.3389\/fnmol.2025.1518868","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T01:32:25Z","timestamp":1743471145000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Neurotrophic factor alpha 1 gene therapy in Alzheimer\u2019s disease: scope and advancements"],"prefix":"10.3389","volume":"18","author":[{"given":"Ammara","family":"Shaikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fairus","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Lin","family":"Teoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Fairuz","family":"Yahaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.2174\/1570159X13666150403231920","article-title":"Nerve growth factor: a focus on neuroscience and therapy","volume":"13","author":"Aloe","year":"2015","journal-title":"Curr. 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Neurosci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-derived neurotrophic factor and its clinical implications","volume":"6","author":"Bathina","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3390\/genes13081370","article-title":"Appraisal for the potential of viral and nonviral vectors in gene therapy: a review","volume":"13","author":"Butt","year":"2022","journal-title":"Genes"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1089\/hum.2019.367","article-title":"Postmortem analysis in a clinical trial of AAV2-NGF gene therapy for Alzheimer\u2019s disease identifies a need for improved vector delivery","volume":"31","author":"Castle","year":"2020","journal-title":"Hum. Gene Ther."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1210\/er.2011-1039","article-title":"New roles of carboxypeptidase E in endocrine and neural function and Cancer","volume":"33","author":"Cawley","year":"2012","journal-title":"Endocr. Rev."},{"key":"ref9","unstructured":"What is dementia?\n          \n          2022"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e71578","DOI":"10.1371\/journal.pone.0071578","article-title":"Carboxypeptidase E\/NF\u03b11: a new neurotrophic factor against oxidative stress-induced apoptotic cell death mediated by ERK and PI3-K\/AKT pathways","volume":"8","author":"Cheng","year":"2013","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e973","DOI":"10.1038\/tp.2016.237","article-title":"A human carboxypeptidase E\/NF-\u03b11 gene mutation in an Alzheimer\u2019s disease patient leads to dementia and depression in mice","volume":"6","author":"Cheng","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/mp.2014.136","article-title":"Neurotrophic factor-\u03b11 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone","volume":"20","author":"Cheng","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40478-015-0193-3","article-title":"Pro-aggregant tau impairs mossy fiber plasticity due to structural changes and CA++ dysregulation","volume":"3","author":"Decker","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12974-022-02567-y","article-title":"Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer\u2019s disease","volume":"19","author":"Dong","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1159\/000336051","article-title":"Encapsulated cell biodelivery of nerve growth factor to the basal forebrain in patients with Alzheimer\u2019s disease","volume":"33","author":"Eriksdotter-J\u00f6nhagen","year":"2012","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s13195-016-0195-9","article-title":"Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer\u2019s disease patients: application of a second-generation encapsulated cell biodelivery device","volume":"8","author":"Eyjolfsdottir","year":"2016","journal-title":"Alzheimers Res. Ther."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40035-022-00279-0","article-title":"Brain-derived neurotrophic factor in Alzheimer\u2019s disease and its pharmaceutical potential","volume":"11","author":"Gao","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"104540","DOI":"10.1016\/j.nbd.2019.104540","article-title":"Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology","volume":"132","author":"Ginsberg","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"114583","DOI":"10.1016\/j.addr.2022.114583","article-title":"Applications of focused ultrasound-mediated blood-brain barrier opening","volume":"191","author":"Gorick","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1001\/archneur.57.6.846","article-title":"Region-specific Neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in Hippocampus and cortical areas","volume":"57","author":"Hock","year":"2000","journal-title":"Arch. Neurol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles for mRNA delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat. Rev. Mat."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3390\/neurosci5020010","article-title":"Cytotoxic effect of amyloid-\u03b21-42 oligomers on endoplasmic reticulum and Golgi apparatus arrangement in SH-SY5Y neuroblastoma cells","volume":"5","author":"Jarero-Basulto","year":"2024","journal-title":"NeuroSci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40035-024-00414-z","article-title":"Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer\u2019s disease","volume":"13","author":"Jiang","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1178555","DOI":"10.3389\/fnins.2023.1178555","article-title":"Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process","volume":"17","author":"Kasakura","year":"2023","journal-title":"Front. Neurosci."},{"key":"ref9002","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.trci.2015.06.007","article-title":"Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer\u2019s disease dementia: A phase 1 clinical trial","volume":"1","author":"Kim","year":"2015","journal-title":"Alzheimer\u2019s & dementia (New York, NY)"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"101139","DOI":"10.1016\/j.omtm.2023.101139","article-title":"Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering","volume":"31","author":"Kitte","year":"2023","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref9005","doi-asserted-by":"publisher","first-page":"63","DOI":"10.5599\/admet.2043","article-title":"Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review","volume":"12","author":"Kulkarni","year":"2023","journal-title":"ADMET & DMPK"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"15557","DOI":"10.1038\/s41598-019-51914-2","article-title":"A\u03b2 modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"143152","DOI":"10.1016\/j.cej.2023.143152","article-title":"Engineering brain-derived neurotrophic factor mRNA delivery for the treatment of Alzheimer\u2019s disease","volume":"466","author":"Li","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"6987","DOI":"10.1523\/JNEUROSCI.0236-21.2021","article-title":"Carboxypeptidase E regulates activity-dependent TrkB neuronal surface insertion and hippocampal memory","volume":"41","author":"Li","year":"2021","journal-title":"J. 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Natl. Acad. Sci. U. S. A."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41582-020-00418-z","article-title":"Applications of focused ultrasound in the brain: from thermoablation to drug delivery","volume":"17","author":"Meng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3389\/fncel.2019.00363","article-title":"Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain","volume":"13","author":"Miranda","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nm.1912","article-title":"Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer\u2019s disease","volume":"15","author":"Nagahara","year":"2009","journal-title":"Nat. Med."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41434-018-0010-2","article-title":"MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human Primates","volume":"25","author":"Nagahara","year":"2018","journal-title":"Gene Ther."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"S239","DOI":"10.3233\/JAD-180496","article-title":"Tocotrienol rich fraction supplementation modulate brain hippocampal gene expression in APPswe\/PS1dE9 Alzheimer\u2019s disease mouse model","volume":"70","author":"Nasri","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.bbr.2010.02.024","article-title":"The cholinergic system, nerve growth factor and the cytoskeleton","volume":"221","author":"Niewiadomska","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3390\/life13030647","article-title":"Neurotrophins and other growth factors in the pathogenesis of Alzheimer\u2019s disease","volume":"13","author":"Numakawa","year":"2023","journal-title":"Life"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"102226","DOI":"10.1016\/j.npep.2022.102226","article-title":"Neurotrophin-3 and Neurotrophin-4: the unsung heroes that lies behind the meninges","volume":"92","author":"Omar","year":"2022","journal-title":"Neuropeptides"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1111\/bph.14585","article-title":"Mitochondrial dysfunction in Alzheimer\u2019s disease: role in pathogenesis and novel therapeutic opportunities","volume":"176","author":"Ortiz","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jconrel.2021.01.027","article-title":"Minimally invasive nasal depot (MIND) technique for direct BDNF AntagoNAT delivery to the brain","volume":"331","author":"Padmakumar","year":"2021","journal-title":"J. Controlled Release Off. Release Soc."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.3390\/pharmaceutics13111882","article-title":"In vivo electroporation of plasmid DNA: a promising strategy for rapid, inexpensive, and flexible delivery of anti-viral monoclonal antibodies","volume":"13","author":"Pagant","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer\u2019s disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines \u2014 a new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mcn.2008.05.016","article-title":"A bi-directional carboxypeptidase E - driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons","volume":"39","author":"Park","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1089\/hum.2017.160","article-title":"Clinical gene therapy for neurodegenerative diseases: past, present, and future","volume":"28","author":"Piguet","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jalz.2013.09.004","article-title":"A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer\u2019s disease","volume":"10","author":"Rafii","year":"2014","journal-title":"Alzheimers Dement."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.neurobiolaging.2016.08.020","article-title":"Tau down-regulates BDNF expression in animal and cellular models of Alzheimer\u2019s disease","volume":"48","author":"Rosa","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"14984","DOI":"10.1038\/s41598-020-72061-z","article-title":"A comprehensive p75 neurotrophin receptor gene network and pathway analyses identifying new target genes","volume":"10","author":"Sajanti","year":"2020","journal-title":"Sci. Rep."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.mcn.2015.08.005","article-title":"Neurotrophic factor-\u03b11 modulates NGF-induced neurite outgrowth through interaction with Wnt-3a and Wnt-5a in PC12 cells and cortical neurons","volume":"68","author":"Selvaraj","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1292858","DOI":"10.3389\/fncel.2023.1292858","article-title":"Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer\u2019s disease","volume":"17","author":"Shaikh","year":"","journal-title":"Front. Cell. Neurosci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1002\/med.21954","article-title":"Perspectives on pain in down syndrome","volume":"43","author":"Shaikh","year":"","journal-title":"Med. Res. Rev."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s00018-021-04021-3","article-title":"Novel interaction between neurotrophic factor-\u03b11\/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative\/neuroexcitotoxic stress via \u03b2-arrestin\/ERK signaling","volume":"79","author":"Sharma","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1101\/lm.76006","article-title":"NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis","volume":"13","author":"Shimazu","year":"2006","journal-title":"Learn. Mem."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-7571-6_1","article-title":"Neurotrophic factors: An overview","volume":"1727","author":"Skaper","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/bpa.12289","article-title":"Precortical phase of Alzheimer\u2019s disease (AD)-related tau cytoskeletal pathology","volume":"26","author":"Stratmann","year":"2016","journal-title":"Brain Pathol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41593-020-00778-1","article-title":"Gene-based therapies for neurodegenerative diseases","volume":"24","author":"Sun","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s13195-023-01282-x","article-title":"Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to AppNL\u2212G\u2212F knock-in Alzheimer mice","volume":"15","author":"Tambaro","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13041-018-0348-9","article-title":"Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer\u2019s disease","volume":"11","author":"Tan","year":"2018","journal-title":"Mol. Brain"},{"key":"ref9003","doi-asserted-by":"publisher","first-page":"90","DOI":"10.28982\/josam.7643","article-title":"Stereotactic surgery and its application in Alzheimer\u2019s disease rat models: Stereotaxy in Alzheimer\u2019s rat models","volume":"8","author":"Tekin","year":"2024","journal-title":"Journal of Surgery and Medicine"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nm1239","article-title":"A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease","volume":"11","author":"Tuszynski","year":"2005","journal-title":"Nat. Med."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"Van","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.3892\/ijmm.2018.3467","article-title":"Experimental study on the neurotoxic effect of \u03b2-amyloid on the cytoskeleton of PC12 cells","volume":"41","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.celrep.2019.06.054","article-title":"Deficiency in BDNF\/TrkB neurotrophic activity stimulates \u03b4-secretase by upregulating C\/EBP\u03b2 in Alzheimer\u2019s disease","volume":"28","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"108071","DOI":"10.1016\/j.clineuro.2023.108071","article-title":"Targeted examination of amyloid beta and tau protein accumulation via positron emission tomography for the differential diagnosis of Alzheimer\u2019s disease based on the a\/T(N) research framework","volume":"236","author":"Wang","year":"2024","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref9006","doi-asserted-by":"publisher","first-page":"785","DOI":"10.3233\/JAD-230199","article-title":"Microglia-Astrocyte Communication in Alzheimer\u2019s Disease","volume":"95","author":"Wu","year":"2023","journal-title":"Journal of Alzheimer\u2019s disease: JAD"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1093\/brain\/awab460","article-title":"Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies","volume":"145","author":"Xhima","year":"2022","journal-title":"Brain"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"918852","DOI":"10.3389\/fnmol.2022.918852","article-title":"Neurotrophic factor-\u03911\/carboxypeptidase E functions in neuroprotection and alleviates depression","volume":"15","author":"Xiao","year":"2022","journal-title":"Front. Mol. 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