{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:06:14Z","timestamp":1789880774394,"version":"4.0.1"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>Epilepsy is a chronic neurological disorder characterized by abnormal synchronous discharges of neurons in the brain. It affects approximately 70 million people worldwide, and approximately 30% of patients are resistant to existing antiepileptic drugs. Repeated seizures can lead to neuronal damage, glial cell activation and neuroinflammation, creating a vicious cycle of seizures, inflammation, and neuronal damage. Recent studies have shown that microRNAs play a key role in the pathological process of epilepsy by regulating the phenotype, inflammatory response and metabolic function of astrocytes and microglia. In addition, long noncoding RNAs, as upstream regulators of miRNAs, influence miRNA function by acting as competitive endogenous RNAs, further regulating glial cell activation and inflammatory responses. This paper is the first to systematically elucidate the synergistic role of miRNAs and lncRNAs in epilepsy through glial cell polarization, metabolic imbalance and exosome-mediated transcellular communication, providing a theoretical framework for the development of multitargeted intervention strategies.<\/jats:p>","DOI":"10.3389\/fnmol.2025.1616804","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T06:17:10Z","timestamp":1753683430000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Silencing epileptic storms: targeting miRNA-lncRNA crosstalk in astrocytes and microglia to disarm neuroinflammatory triggers"],"prefix":"10.3389","volume":"18","author":[{"given":"Jing","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuropharm.2018.11.038","article-title":"Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy","volume":"146","author":"Ahmadian","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref2","first-page":"3867","article-title":"The Reck gene and biological malignancy--its significance in angiogenesis and inhibition of matrix metalloproteinases","volume":"34","author":"Alexius-Lindgren","year":"2014","journal-title":"Anticancer Res."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12974-023-02745-6","article-title":"Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-\u03b2 pathology but causes hyperexcitability and seizures","volume":"20","author":"Aloi","year":"2023","journal-title":"J. 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Pract."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.brainres.2017.11.019","article-title":"Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3","volume":"1689","author":"Huang","year":"2018","journal-title":"Brain Res."},{"key":"ref51","first-page":"1119","article-title":"Pathogenesis of epilepsy: challenges in animal models","volume":"16","author":"Hui Yin","year":"2013","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1073\/pnas.1422916112","article-title":"miR-155 augments Cd8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic \u03b3c cytokines","volume":"112","author":"Ji","year":"2015","journal-title":"Proc. Natl. Acad. Sci. 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Cell Biol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41537-019-0071-2","article-title":"The expression of long noncoding Rna Neat1 is reduced in schizophrenia and modulates oligodendrocytes transcription","volume":"5","author":"Katsel","year":"2019","journal-title":"NPJ Schizophr."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1007\/s10571-021-01093-4","article-title":"Role of Micrornas, aptamers in Neuroinflammation and neurodegenerative disorders","volume":"42","author":"Khan","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41374-020-0444-1","article-title":"Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating Sirt1 in immature rats with epilepsy","volume":"100","author":"Kong","year":"2020","journal-title":"Lab. 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Neuroinflammation"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1111\/bpa.12865","article-title":"Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation","volume":"30","author":"Korotkov","year":"2020","journal-title":"Brain Pathol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1080\/02713683.2020.1826976","article-title":"Dual specific phosphatase 14 deletion rescues retinal ganglion cells and optic nerve axons after experimental anterior ischemic optic neuropathy","volume":"46","author":"Kumar","year":"2021","journal-title":"Curr. 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