{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:28:05Z","timestamp":1793752085100,"version":"4.6.1"},"reference-count":163,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>Peripheral neuropathic pain is a chronic, secondary pain state caused by damage or diseases of the peripheral nervous system, typically accompanied by edema, inflammatory responses, increased neuronal excitability, and glutamate accumulation. Matrix metalloproteinase-9 (MMP-9), an important enzyme, plays a key role in various physiological and pathological processes, primarily by degrading the extracellular matrix. Recent studies have shown that MMP-9 plays a crucial role in the onset and progression of central nervous system disorders, particularly neuropathic pain. This review discusses the mechanisms underlying the involvement of MMP-9 in various models of peripheral neuropathic pain, with the aim of exploring its potential as a therapeutic target.<\/jats:p>","DOI":"10.3389\/fnmol.2025.1647316","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:22:20Z","timestamp":1761805340000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The role and mechanisms of matrix metalloproteinase-9 in peripheral neuropathic pain"],"prefix":"10.3389","volume":"18","author":[{"given":"Shuai Ying","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.2337\/dc11-1108","article-title":"Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K.","volume":"34","author":"Abbott","year":"2011","journal-title":"Diabetes Care"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"14170","DOI":"10.1038\/s41598-020-71042-6","article-title":"Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice","volume":"10","author":"Acklin","year":"2020","journal-title":"Sci. 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