{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:11:59Z","timestamp":1792084319571,"version":"4.4.0"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>The underlying mechanisms of post-traumatic stress disorder (PTSD) are still not fully understood, creating significant obstacles for developing effective therapeutic strategies. Recently, ferroptosis, an iron-dependent form of regulated cell death, has been shown to play a role in several psychiatric disorders, such as major depressive disorder (MDD), stress-induced anxiety, Alzheimer\u2019s disease (AD), and Parkinson\u2019s disease (PD). While direct evidence for the role of ferroptosis in PTSD is still limited, an increasing number of studies suggest that the pathological features of PTSD may trigger the ferroptosis cascade. Additionally, the typical hallmarks of ferroptosis, such as iron dysregulation, lipid peroxidation, and failure of antioxidant defense systems, may intersect with the pathogenesis of PTSD. Importantly, some treatments for PTSD, such as antioxidants and free radical scavengers, have been proven to inhibit ferroptosis, which further supports the case for ferroptosis as a potential pathogenic mechanism in PTSD. To thoroughly investigate the mechanistic links between ferroptosis and PTSD, we analyze the relevant literature on ferroptosis and PTSD in this review. Our aim is to elucidate the potential relationships between ferroptosis and PTSD, thereby providing novel insights for future research directions. Furthermore, we call for more experimental and clinical studies to explore this relationship further, with the ultimate goal of developing more effective therapeutic strategies for PTSD.<\/jats:p>","DOI":"10.3389\/fnmol.2025.1648047","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:35:40Z","timestamp":1761197740000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ferroptosis as a potential therapeutic target for post-traumatic stress disorder"],"prefix":"10.3389","volume":"18","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Dong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00213-019-05395-w","article-title":"Vitamin E prevents the cognitive impairments in post-traumatic stress disorder rat model: Behavioral and molecular study.","volume":"237","author":"Ahmed","year":"2020","journal-title":"Psychopharmacology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"111930","DOI":"10.1016\/j.bbr.2019.111930","article-title":"Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones.","volume":"369","author":"Alzoubi","year":"2019","journal-title":"Behav. Brain Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.psychres.2018.10.008","article-title":"Prevention of memory impairment induced by post-traumatic stress disorder by cerebrolysin.","volume":"270","author":"Alzoubi","year":"","journal-title":"Psychiatry Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.physbeh.2017.12.002","article-title":"Tempol prevents post-traumatic stress disorder induced memory impairment.","volume":"184","author":"Alzoubi","year":"","journal-title":"Physiol. Behav."},{"key":"B5","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.chembiol.2020.03.011","article-title":"Breakdown of an ironclad defense system: The critical role of NRF2 in mediating ferroptosis.","volume":"27","author":"Anandhan","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00406-015-0638-5","article-title":"Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors.","volume":"266","author":"Atli","year":"2016","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer\u2019s disease.","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ."},{"key":"B8","doi-asserted-by":"publisher","first-page":"15256","DOI":"10.1038\/s41598-024-62971-7","article-title":"An exploratory study on lipidomic profiles in a cohort of individuals with posttraumatic stress disorder.","volume":"14","author":"Bhargava","year":"2024","journal-title":"Sci. Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"174361","DOI":"10.1016\/j.ejphar.2021.174361","article-title":"Supplementation of taurine improves ionic homeostasis and mitochondrial function in the rats exhibiting post-traumatic stress disorder-like symptoms.","volume":"908","author":"Bhattacharjee","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1177\/0004563214528882","article-title":"Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder.","volume":"52","author":"Borovac \u0160tefanovi\u0107","year":"2015","journal-title":"Ann. Clin. Biochem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"148744","DOI":"10.1016\/j.brainres.2023.148744","article-title":"Electroacupuncture improves cognitive function in APP\/PS1 mice by inhibiting oxidative stress related hippocampal neuronal ferroptosis","volume":"1831","author":"Chen","year":"2024","journal-title":"Brain Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1124\/jpet.118.252759","article-title":"Ferroptosis as a novel therapeutic target for friedreich\u2019s ataxia.","volume":"369","author":"Cotticelli","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12974-022-02400-6","article-title":"Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1\/Nrf2\/HO-1\/Gpx4 pathway.","volume":"19","author":"Dang","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"B14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bcp.2017.12.001","article-title":"Dopamine promotes cellular iron accumulation and oxidative stress responses in macrophages.","volume":"148","author":"Dichtl","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1097\/CM9.0000000000002533","article-title":"Acyl-CoA synthase ACSL4: An essential target in ferroptosis and fatty acid metabolism.","volume":"136","author":"Ding","year":"2023","journal-title":"Chin. Med. J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death.","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e2006203","DOI":"10.1371\/journal.pbio.2006203","article-title":"Unsolved mysteries: How does lipid peroxidation cause ferroptosis?","volume":"16","author":"Feng","year":"2018","journal-title":"PLoS Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e202105043","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis.","volume":"220","author":"Gan","year":"2021","journal-title":"J. Cell Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fphar.2014.00019","article-title":"Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases.","volume":"5","author":"Gao","year":"2014","journal-title":"Front. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/978-981-13-9589-5_2","article-title":"Cellular iron metabolism and regulation.","volume":"1173","author":"Gao","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s13311-020-00954-y","article-title":"Iron and ferroptosis as therapeutic targets in Alzheimer\u2019s disease.","volume":"18","author":"Gleason","year":"2021","journal-title":"Neurotherapeutics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.3390\/cells11132034","article-title":"Involvement of nuclear Factor-\u03baB in inflammation and neuronal plasticity associated with post-traumatic stress disorder.","volume":"11","author":"Gupta","year":"2022","journal-title":"Cells"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1007\/s10787-024-01519-7","article-title":"Nrf2-mediated ferroptosis inhibition: A novel approach for managing inflammatory diseases.","volume":"32","author":"Han","year":"2024","journal-title":"Inflammopharmacology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/brain\/aww022","article-title":"Iron and dopamine: A toxic couple.","volume":"139","author":"Hare","year":"2016","journal-title":"Brain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"113331","DOI":"10.1016\/j.expneurol.2020.113331","article-title":"PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry.","volume":"330","author":"Harnett","year":"2020","journal-title":"Exp. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.2174\/1381612822666160307145931","article-title":"Association of oxidative stress with psychiatric disorders.","volume":"22","author":"Hassan","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"B27","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/pcn.12820","article-title":"Inflammation and post-traumatic stress disorder.","volume":"73","author":"Hori","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2018.01.019","article-title":"Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis.","volume":"117","author":"Jelinek","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"106013","DOI":"10.1016\/j.phrs.2021.106013","article-title":"p53: A double-edged sword in tumor ferroptosis.","volume":"177","author":"Ji","year":"2022","journal-title":"Pharmacol. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: Mechanisms, biology and role in disease.","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B31","first-page":"207","article-title":"Ferritin: An iron storage protein with diverse functions.","volume":"1","author":"Joshi","year":"1988","journal-title":"Biofactors"},{"key":"B32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2018.06.037","article-title":"Transferrin and transferrin receptors update.","volume":"133","author":"Kawabata","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"100476","DOI":"10.1016\/j.ynstr.2022.100476","article-title":"Labelfree mapping and profiling of altered lipid homeostasis in the rat hippocampus after traumatic stress: Role of oxidative homeostasis.","volume":"20","author":"Kelley","year":"2022","journal-title":"Neurobiol. Stress"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1089\/ars.2017.7176","article-title":"The roles of NRF2 in modulating cellular iron homeostasis.","volume":"29","author":"Kerins","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1038\/s12276-023-01077-y","article-title":"An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis.","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1266575","DOI":"10.3389\/fphys.2023.1266575","article-title":"Potential oxidative stress related targets of mitochondria-focused therapy of PTSD.","volume":"14","author":"Kmita","year":"2023","journal-title":"Front. Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5453","DOI":"10.3390\/nu6125453","article-title":"Effects of vitamin E on cognitive performance during ageing and in Alzheimer\u2019s disease.","volume":"6","author":"La Fata","year":"2014","journal-title":"Nutrients"},{"key":"B38","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis.","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/biology10030184","article-title":"Lipid metabolism and ferroptosis.","volume":"10","author":"Lee","year":"2021","journal-title":"Biology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1051395","DOI":"10.3389\/fgene.2022.1051395","article-title":"P53 protein and the diseases in central nervous system.","volume":"13","author":"Lei","year":"2022","journal-title":"Front. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/s41568-020-0262-1","article-title":"p53: 800 million years of evolution and 40 years of discovery.","volume":"20","author":"Levine","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1111\/cns.13973","article-title":"Ferroptosis contributes to hypoxic-ischemic brain injury in neonatal rats: Role of the SIRT1\/Nrf2\/GPx4 signaling pathway.","volume":"28","author":"Li","year":"","journal-title":"CNS Neurosci. Ther."},{"key":"B43","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future.","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3999083","DOI":"10.1155\/2022\/3999083","article-title":"Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders.","volume":"2022","author":"Li","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks.","volume":"19","author":"Li","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis.","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J."},{"key":"B47","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","article-title":"p53 in ferroptosis regulation: The new weapon for the old guardian.","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Death Differ."},{"key":"B48","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/jmcb\/mjz060","article-title":"p53 modifications: Exquisite decorations of the powerful guardian.","volume":"11","author":"Liu","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"33478","DOI":"10.31083\/RN33478","article-title":"Neuroplasticity in post-traumatic stress disorder.","volume":"80","author":"L\u00f3pez-L\u00f3pez","year":"2025","journal-title":"Rev. Neurol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1094076","DOI":"10.3389\/fphys.2022.1094076","article-title":"An orchestrating role of mitochondria in the origin and development of post-traumatic stress disorder.","volume":"13","author":"Lushchak","year":"2022","journal-title":"Front. Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.2147\/JMDH.S382643","article-title":"The relationship between ferroptosis and diseases.","volume":"15","author":"Lv","year":"2022","journal-title":"J. Multidiscip. Healthc."},{"key":"B52","doi-asserted-by":"publisher","first-page":"300","DOI":"10.5603\/fm.95727","article-title":"Oxidative stress mediates hippocampal neuronal apoptosis through ROS\/JNK\/P53 pathway in rats with PTSD triggered by high-voltage electrical burn.","volume":"83","author":"Lv","year":"2024","journal-title":"Folia Morphol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity.","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0140-6736(22)00821-2","article-title":"Complex post-traumatic stress disorder.","volume":"400","author":"Maercker","year":"2022","journal-title":"Lancet"},{"key":"B55","doi-asserted-by":"publisher","first-page":"101890","DOI":"10.1016\/j.pneurobio.2020.101890","article-title":"Ferroptosis and its potential role in the physiopathology of Parkinson\u2019s Disease.","volume":"196","author":"Mahoney-S\u00e1nchez","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1186\/s12888-020-02793-9","article-title":"A multi-centre, double-blind, 12-week, randomized, placebo-controlled trial to assess the efficacy of adjunctive N-Acetylcysteine for treatment-resistant PTSD: A study protocol.","volume":"20","author":"Maier","year":"2020","journal-title":"BMC Psychiatry"},{"key":"B57","doi-asserted-by":"publisher","first-page":"C1117","DOI":"10.1152\/ajpcell.00444.2004","article-title":"Iron alters glutamate secretion by regulating cytosolic aconitase activity.","volume":"288","author":"McGahan","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/HRP.0000000000000167","article-title":"Oxidative stress, inflammation, and neuroprogression in chronic PTSD.","volume":"26","author":"Miller","year":"2018","journal-title":"Harv. Rev. Psychiatry"},{"key":"B59","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/iub.2008","article-title":"Vitamin E: Regulatory redox interactions.","volume":"71","author":"Miyazawa","year":"2019","journal-title":"IUBMB Life"},{"key":"B60","first-page":"24","article-title":"The psychobiology of posttraumatic stress disorder.","volume":"61","author":"Nutt","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/0-306-46838-7_8","article-title":"The mitochondrial permeability transition and taurine.","volume":"483","author":"Palmi","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"105837","DOI":"10.1016\/j.neubiorev.2024.105837","article-title":"Mitochondrial dynamics and psychiatric disorders: The missing link.","volume":"165","author":"Papageorgiou","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B63","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/978-981-19-7376-5_11","article-title":"PTSD, immune system, and inflammation.","volume":"1411","author":"Pivac","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","article-title":"Regulation of ferroptosis by lipid metabolism.","volume":"33","author":"Pope","year":"2023","journal-title":"Trends Cell Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jad.2024.01.045","article-title":"Suvorexant improves mitochondrial dynamics with the regulation of orexinergic and mTOR activation in rats exhibiting PTSD-like symptoms.","volume":"350","author":"Prajapati","year":"2024","journal-title":"J. Affect. Disord."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1007\/s12035-023-03782-1","article-title":"A disintegrin and metalloproteinase-8 Protects against erastin-induced neuronal ferroptosis via activating Nrf2\/HO-1\/FTH1 signaling pathway.","volume":"61","author":"Qian","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41582-022-00635-8","article-title":"Post-traumatic stress disorder: Clinical and translational neuroscience from cells to circuits.","volume":"18","author":"Ressler","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the role of lipoxygenases in the initiation and execution of ferroptosis.","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.freeradbiomed.2024.07.006","article-title":"Role of mitochondrial reactive oxygen species in chemically-induced ferroptosis.","volume":"223","author":"Song","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3389\/fphar.2017.00615","article-title":"Using the single prolonged stress model to examine the pathophysiology of PTSD.","volume":"8","author":"Souza","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"5617","DOI":"10.1038\/onc.2015.32","article-title":"HSPB1 as a novel regulator of ferroptotic cancer cell death.","volume":"34","author":"Sun","year":"2015","journal-title":"Oncogene"},{"key":"B72","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications.","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00406-003-0413-x","article-title":"Free radicals in patients with post-traumatic stress disorder.","volume":"253","author":"Tezcan","year":"2003","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1007\/s10571-023-01343-7","article-title":"Ferroptosis and neurodegenerative diseases: Insights into the regulatory roles of SLC7A11.","volume":"43","author":"Wang","year":"2023","journal-title":"Cell Mol. Neurobiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"119551","DOI":"10.1016\/j.lfs.2021.119551","article-title":"Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis.","volume":"278","author":"Wang","year":"2021","journal-title":"Life Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1195012","DOI":"10.3389\/fpsyt.2023.1195012","article-title":"Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: A combined [1H]MRS and peripheral blood study.","volume":"14","author":"Watling","year":"2023","journal-title":"Front. Psychiatry"},{"key":"B77","doi-asserted-by":"publisher","first-page":"104769","DOI":"10.1016\/j.phrs.2020.104769","article-title":"Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways.","volume":"157","author":"Welcome","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"e76146","DOI":"10.1371\/journal.pone.0076146","article-title":"Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model.","volume":"8","author":"Wilson","year":"2013","journal-title":"PLoS One"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e21174","DOI":"10.1096\/fj.202000167RR","article-title":"Brain iron deficiency and affected contextual fear memory in mice with conditional Ferroportin1 ablation in the brain.","volume":"35","author":"Wu","year":"2021","journal-title":"FASEB J."},{"key":"B80","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: Process and function.","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1002\/mds.27120","article-title":"Dietary antioxidants and risk of Parkinson\u2019s disease in two population-based cohorts.","volume":"32","author":"Yang","year":"2017","journal-title":"Mov. Disord."},{"key":"B82","doi-asserted-by":"publisher","first-page":"e267","DOI":"10.1002\/mco2.267","article-title":"The epigenetic regulatory mechanisms of ferroptosis and its implications for biological processes and diseases.","volume":"4","author":"Yang","year":"2023","journal-title":"MedComm"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1002\/1873-3468.14077","article-title":"Mitochondrial dynamics in health and disease.","volume":"595","author":"Yapa","year":"2021","journal-title":"FEBS Lett."},{"key":"B84","doi-asserted-by":"publisher","first-page":"844","DOI":"10.5137\/1019-5149.JTN.8723-13.1","article-title":"Altered neurotransmitter levels with post-traumatic stress disorder.","volume":"24","author":"Zhang","year":"2014","journal-title":"Turk. Neurosurg."},{"key":"B85","doi-asserted-by":"publisher","first-page":"116512","DOI":"10.1016\/j.biopha.2024.116512","article-title":"GPX4, ferroptosis, and diseases.","volume":"174","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B86","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroscience.2016.05.025","article-title":"Iron-induced neuronal damage in a rat model of post-traumatic stress disorder.","volume":"330","author":"Zhao","year":"2016","journal-title":"Neuroscience"},{"key":"B87","doi-asserted-by":"publisher","first-page":"102760","DOI":"10.1016\/j.redox.2023.102760","article-title":"Energy stress modulation of AMPK\/FoxO3 signaling inhibits mitochondria-associated ferroptosis.","volume":"63","author":"Zhong","year":"2023","journal-title":"Redox Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3389\/fncel.2019.00275","article-title":"Electroacupuncture pretreatment ameliorates PTSD-Like behaviors in rats by enhancing hippocampal neurogenesis via the Keap1\/Nrf2 antioxidant signaling pathway.","volume":"13","author":"Zhou","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11011-024-01485-7","article-title":"Unlocking NAC\u2019s potential ATF4 and m6A dynamics in rescuing cognitive impairments in PTSD.","volume":"40","author":"Zhou","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1142\/S0192415X24500770","article-title":"Research progress of traditional Chinese medicine in treating central nervous system diseases by modulating ferroptosis.","volume":"52","author":"Zhou","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"841999","DOI":"10.3389\/fpsyt.2022.841999","article-title":"Blood transcriptome analysis: Ferroptosis and potential inflammatory pathways in post-traumatic stress disorder.","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B92","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1007\/s11064-024-04185-x","article-title":"Electroacupuncture downregulating neuronal ferroptosis in MCAO\/R rats by activating Nrf2\/SLC7A11\/GPX4 axis.","volume":"49","author":"Zhu","year":"2024","journal-title":"Neurochem. Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/sj.mp.4001905","article-title":"Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder.","volume":"12","author":"Zieker","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"B94","doi-asserted-by":"publisher","first-page":"7929","DOI":"10.3390\/molecules28237929","article-title":"Effects of natural products on enzymes involved in ferroptosis: Regulation and implications.","volume":"28","author":"Zuo","year":"2023","journal-title":"Molecules"}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2025.1648047\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:35:41Z","timestamp":1761197741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2025.1648047\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":94,"alternative-id":["10.3389\/fnmol.2025.1648047"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2025.1648047","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]},"article-number":"1648047"}}