{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:05:45Z","timestamp":1786460745649,"version":"build-2736575974"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trigeminal neuralgia (TN) is relatively prevalent among the elderly population. Mitochondria-regulated programmed cell death has been identified as an important mechanism in the pathogenesis of a series of diseases; however, its role in TN remains poorly understood. This study aimed to uncover mitochondria-related genes (MRGs) and programmed cell death-related genes (PCDRGs) implicated in TN and elucidate their potential mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The transcriptomic data of TN were obtained from clinical datasets, while MRGs and PCDRGs were retrieved from published literature. The processed transcriptome data were subjected to differential expression analysis and intersected with MRGs and PCDRGs to identify candidate genes. Subsequently, candidate biomarkers were further screened out via machine learning, and a nomogram was constructed. Additional analyses mainly included protein structure prediction, functional enrichment analysis, regulatory network analysis, drug prediction, and immune microenvironment analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 10 candidate genes, two candidate biomarkers (BCL2A1 and DBT) were employed to build a nomogram that exhibits favorable predictive performance. The protein structures of these biomarkers were predicted using the Human Protein Atlas (HPA) database, with a high level of confidence. Functional enrichment analysis revealed that these two candidate biomarkers might play a critical role in the progression of TN by regulating pathways such as \u201cinsulin signaling\u201d and \u201cFc gamma R-mediated phagocytosis.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identified two candidate biomarkers (BCL2A1 and DBT), which are linked to mitochondria and programmed cell death in TN, and explored their application value in clinical identification, offering novel research orientations for the diagnosis and treatment of TN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnmol.2026.1798469","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:45:47Z","timestamp":1782279947000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and validation of candidate biomarkers associated with mitochondria and 18 types of programmed cell death in trigeminal neuralgia: insights from transcriptome sequencing"],"prefix":"10.3389","volume":"19","author":[{"given":"Liqin","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pain, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pain, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Pain, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pain, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pain, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Hebei Medical University Third Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"otac002","DOI":"10.1093\/crocol\/otac002","article-title":"Systematic review with meta-analysis: Safety and effectiveness of combining biologics and small molecules in inflammatory bowel disease.","volume":"4","author":"Alayo","year":"2022","journal-title":"Crohns Colitis 360"},{"key":"B2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s10194-022-01520-x","article-title":"Microvascular decompression in trigeminal neuralgia - a prospective study of 115 patients.","volume":"23","author":"Andersen","year":"2022","journal-title":"J. Headache Pain"},{"key":"B3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","article-title":"xCell: Digitally portraying the tissue cellular heterogeneity landscape.","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nrneurol.2017.185","article-title":"Brain insulin resistance in type 2 diabetes and Alzheimer disease: Concepts and conundrums.","volume":"14","author":"Arnold","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3833","DOI":"10.1007\/s00701-023-05871-5","article-title":"Microvascular decompression using autologous muscle graft for trigeminal neuralgia: A case series and meta-analysis.","volume":"165","author":"Bezerra","year":"2023","journal-title":"Acta Neurochir."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1002\/iub.2395","article-title":"Silencing of lncRNA Gm14461 alleviates pain in trigeminal neuralgia through inhibiting astrocyte activation.","volume":"72","author":"Cai","year":"2020","journal-title":"IUBMB Life"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e1616","DOI":"10.1002\/mgg3.1616","article-title":"Molecular basis of various forms of maple syrup urine disease in Chilean patients.","volume":"9","author":"Campanholi","year":"2021","journal-title":"Mol. Genet. Genomic Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1750-1326-5-42","article-title":"Fc\u03b3 receptors are required for NF-\u03baB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson\u2019s disease.","volume":"5","author":"Cao","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"B9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2105-12-35","article-title":"VennDiagram: A package for the generation of highly-customizable Venn and Euler diagrams in R.","volume":"12","author":"Chen","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s10194-023-01681-3","article-title":"BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination.","volume":"24","author":"Chen","year":"2023","journal-title":"J. Headache Pain"},{"key":"B11","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41419-024-06712-8","article-title":"Research progress on morphology and mechanism of programmed cell death.","volume":"15","author":"Chen","year":"2024","journal-title":"Cell Death Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.trsl.2025.03.001","article-title":"Soluble ST2 is an early marker and treatment target for hypertensive nephrosclerosis signatured in glomerular mesangial cells.","volume":"279","author":"Cho","year":"2025","journal-title":"Transl. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1177\/03009858241306400","article-title":"Mesangial cell hypercellularity and iron accumulation in the kidney associated with administration of a sickle hemoglobin modulator in CD-1 mice.","volume":"62","author":"Choudhary","year":"2025","journal-title":"Vet. Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1212\/WNL.0000000000002840","article-title":"Trigeminal neuralgia: New classification and diagnostic grading for practice and research.","volume":"87","author":"Cruccu","year":"2016","journal-title":"Neurology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1146\/annurev.immunol.15.1.203","article-title":"Fc receptor biology.","volume":"15","author":"Da\u00ebron","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/s0092-8674(04)00046-7","article-title":"Cell death: Critical control points.","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1007\/s10072-023-06923-5","article-title":"Sex differences in trigeminal neuralgia: A focus on radiological and clinical characteristics.","volume":"44","author":"De Stefano","year":"2023","journal-title":"Neurol. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent.","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"B19","doi-asserted-by":"publisher","first-page":"10338","DOI":"10.1038\/s41598-017-09449-x","article-title":"Human primary bone marrow mesenchymal stromal cells and their in vitro progenies display distinct transcriptional profile signatures.","volume":"7","author":"Ghazanfari","year":"2017","journal-title":"Sci. Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.3390\/cells10071765","article-title":"Programmed cell death in health and disease.","volume":"10","author":"Gibellini","year":"2021","journal-title":"Cells"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: Cellular and molecular mechanisms.","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.immuni.2016.02.026","article-title":"Phagocytosis: An immunobiologic process.","volume":"44","author":"Gordon","year":"2016","journal-title":"Immunity"},{"key":"B23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/s0962-8924(98)01273-2","article-title":"The central executioners of apoptosis: Caspases or mitochondria?","volume":"8","author":"Green","year":"1998","journal-title":"Trends Cell Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1093\/bioinformatics\/btab806","article-title":"Make interactive complex heatmaps in R.","volume":"38","author":"Gu","year":"2022","journal-title":"Bioinformatics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"17448069251332100","DOI":"10.1177\/17448069251332100","article-title":"Mitochondrial dysfunction in trigeminal ganglion contributes to nociceptive behavior in a nitroglycerin-induced migraine mouse model.","volume":"21","author":"Guan","year":"2025","journal-title":"Mol. Pain"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1093\/bioinformatics\/btac409","article-title":"ggtranscript: An R package for the visualization and interpretation of transcript isoforms using ggplot2.","volume":"38","author":"Gustavsson","year":"2022","journal-title":"Bioinformatics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1177\/0333102413485658","article-title":"The international classification of headache disorders, 3rd edition (beta version).","volume":"33","year":"2013","journal-title":"Cephalalgia"},{"key":"B28","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1186\/s12879-022-07694-8","article-title":"Combining metabolome and clinical indicators with machine learning provides some promising diagnostic markers to precisely detect smear-positive\/negative pulmonary tuberculosis.","volume":"22","author":"Hu","year":"2022","journal-title":"BMC Infect. Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e43555","DOI":"10.7759\/cureus.43555","article-title":"Role of microglia in neuropathic pain.","volume":"15","author":"Karavis","year":"2023","journal-title":"Cureus"},{"key":"B30","doi-asserted-by":"publisher","first-page":"104613","DOI":"10.1016\/j.neuint.2019.104613","article-title":"Upregulation of Cdh1 in the trigeminal spinal subnucleus caudalis attenuates trigeminal neuropathic pain via inhibiting GABAergic neuronal apoptosis.","volume":"133","author":"Li","year":"2020","journal-title":"Neurochem. Int."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3023127","DOI":"10.1155\/2020\/3023127","article-title":"Potential molecular mechanisms of plantain in the treatment of gout and hyperuricemia based on network pharmacology.","volume":"2020","author":"Liu","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13058-025-01962-6","article-title":"Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption.","volume":"27","author":"Lopez","year":"2025","journal-title":"Breast Cancer Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.11607\/ofph.2157","article-title":"Comparison of the neuropathic pain symptoms and psychosocial impacts of trigeminal neuralgia and painful posttraumatic trigeminal neuropathy.","volume":"33","author":"Melek","year":"2019","journal-title":"J. Oral Facial Pain Headache"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities.","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1016\/j.immuni.2023.10.004","article-title":"Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.","volume":"56","author":"Miao","year":"2023","journal-title":"Immunity"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1016\/j.cell.2024.04.009","article-title":"FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.","volume":"187","author":"Momenilandi","year":"2024","journal-title":"Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.ajpath.2011.11.034","article-title":"Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac- 1-, and p38 MAPK-dependent mechanisms.","volume":"180","author":"Ninkovi\u0107","year":"2012","journal-title":"Am. J. Pathol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.3390\/life14121535","article-title":"The intensity of BCL2A1 expression increases according to the stage progression of acute histologic chorioamnionitis in the extra-placental membranes of spontaneous preterm birth.","volume":"14","author":"Park","year":"2024","journal-title":"Life"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown.","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat. Protoc."},{"key":"B40","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1186\/s12964-024-01782-9","article-title":"Inhibition of bromodomain and extra-terminal proteins targets constitutively active NF\u03baB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC.","volume":"22","author":"Pieper","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"B41","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1186\/s12967-023-04468-x","article-title":"Integrated machine learning survival framework develops a prognostic model based on inter-crosstalk definition of mitochondrial function and cell death patterns in a large multicenter cohort for lower-grade glioma.","volume":"21","author":"Qin","year":"2023","journal-title":"J. Transl. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e13852","DOI":"10.1111\/apha.13852","article-title":"Mitochondria - More than just batteries for cellular function.","volume":"235","author":"Reuter","year":"2022","journal-title":"Acta Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"27610","DOI":"10.1074\/jbc.273.42.27610","article-title":"Fcgamma receptor-mediated mitogen-activated protein kinase activation in monocytes is independent of Ras.","volume":"273","author":"S\u00e1nchez-Mejorada","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B44","volume-title":"Trigeminal Neuralgia.","author":"Shankar Kikkeri","year":"2025"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks.","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"373","DOI":"10.4158\/EP.14.3.373","article-title":"Role of insulin signaling in maintaining energy homeostasis.","volume":"14","author":"Sharma","year":"2008","journal-title":"Endocr. Pract."},{"key":"B47","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3390\/genes16030339","article-title":"Common regulatory mechanisms mediated by cuproptosis genes in inflammatory bowel disease and major depressive disorder.","volume":"16","author":"Shi","year":"2025","journal-title":"Genes"},{"key":"B48","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/ejp.2081","article-title":"Incidence of trigeminal neuralgia: A population-based study in Central Sweden.","volume":"27","author":"Svedung Wettervik","year":"2023","journal-title":"Eur. J. Pain"},{"key":"B49","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/cdd.2016.155","article-title":"The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.","volume":"24","author":"Tuzlak","year":"2017","journal-title":"Cell Death Differ."},{"key":"B50","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","article-title":"The role of mitochondria in metabolism and cell death.","volume":"482","author":"Vakifahmetoglu-Norberg","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B51","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/s41419-024-07064-z","article-title":"Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-XL in a murine cell model of myeloid differentiation.","volume":"15","author":"Vier","year":"2024","journal-title":"Cell Death Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1744806920908092","DOI":"10.1177\/1744806920908092","article-title":"Trigeminal neuralgia causes neurodegeneration in rats associated with upregulation of the CD95\/CD95L pathway.","volume":"16","author":"Wang","year":"2020","journal-title":"Mol. Pain"},{"key":"B53","doi-asserted-by":"publisher","first-page":"989286","DOI":"10.3389\/fimmu.2022.989286","article-title":"Cuproptosis related genes associated with Jab1 shapes tumor microenvironment and pharmacological profile in nasopharyngeal carcinoma.","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.1016\/j.immuni.2023.11.011","article-title":"Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders.","volume":"56","author":"Wilk","year":"2023","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data.","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"B56","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s10194-015-0548-y","article-title":"Risk of psychiatric disorders following trigeminal neuralgia: A nationwide population-based retrospective cohort study.","volume":"16","author":"Wu","year":"2015","journal-title":"J. Headache Pain"},{"key":"B57","doi-asserted-by":"publisher","first-page":"105945","DOI":"10.1016\/j.intimp.2019.105945","article-title":"Ginsenoside Rg3 promotes Fc gamma receptor-mediated phagocytosis of bacteria by macrophages via an extracellular signal-regulated kinase 1\/2 and p38 mitogen-activated protein kinase-dependent mechanism.","volume":"77","author":"Xin","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.freeradbiomed.2024.11.011","article-title":"Restoration of mitochondrial function alleviates trigeminal neuropathic pain in mice.","volume":"226","author":"Yang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/35037739","article-title":"Apoptosis in the nervous system.","volume":"407","author":"Yuan","year":"2000","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1097\/j.pain.0000000000000853","article-title":"Evaluating the impact of trigeminal neuralgia.","volume":"158","author":"Zakrzewska","year":"2017","journal-title":"Pain"},{"key":"B61","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12920-024-01901-y","article-title":"Identification of mitochondria-related biomarkers in childhood allergic asthma.","volume":"17","author":"Zhao","year":"2024","journal-title":"BMC Med. Genomics"},{"key":"B62","doi-asserted-by":"publisher","first-page":"106936","DOI":"10.1016\/j.ijsu.2022.106936","article-title":"Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.","volume":"107","author":"Zou","year":"2022","journal-title":"Int. J. Surg."}],"updated-by":[{"DOI":"10.3389\/fnmol.2026.1932955","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000}}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2026.1798469\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:55:52Z","timestamp":1786452952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2026.1798469\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":62,"alternative-id":["10.3389\/fnmol.2026.1798469"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2026.1798469","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"article-number":"1798469"}}