{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:06:58Z","timestamp":1784099218180,"version":"3.55.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Individuals with a fragile X premutation (PM) are at an increased risk for a variety of physical and mental health conditions, including sleep problems. Sleep problems in children in the general population have been shown to adversely affect development, cognition, behavior, and mood. Because information on the impact of sleep problems in children with a PM is limited, this study aimed to explore the extent of sleep problems in an unreferred cohort of children with a PM and with no PM (NP) and the relationship between sleep and mental health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using the parent-completed Child Behavior Checklist, sleep and mental health were assessed across two distinct study samples. First, a cross-sectional preschool cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f324; ages 3\u20135\u202fyears) was used to identify early associations and CGG-moderated effects. Second, a longitudinal cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f128) was assessed at Time 1 (3\u20137\u202fyears) and Time 2 (8\u201313\u202fyears) to examine cross-sectional and longitudinal associations of sleep and mental health outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Females with a PM exhibited significantly more sleep problems than females with NP at ages 3\u20135\u202fyears. In the preschool cohort, CGG repeat size moderated the relationship between sleep and mental health in a sex- and symptom-specific manner. Longitudinal trajectories differed by PM status: for children with NP, early sleep problems appear stable and predict later sleep outcomes. In contrast, for children with a PM, later sleep problems appear emergent and were associated with concurrent mental health symptoms independent of earlier sleep difficulties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results demonstrate that females with a PM are more likely than females with NP to experience sleep problems at young ages, and the relationship between sleep and mental health in children with a PM is moderated by CGG repeat size. Children with a PM appear to follow a unique developmental pathway characterized by longitudinal trajectories that diverge from those of children with NP, suggesting different underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnmol.2026.1820313","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:11:49Z","timestamp":1784095909000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Parental report\u2013based assessment of sleep problems and mental health in an unreferred cohort of children with a fragile X premutation"],"prefix":"10.3389","volume":"19","author":[{"given":"Nicole D.","family":"Tortora","sequence":"first","affiliation":[{"name":"Department of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities (IBR)","place":["Staten Island, NY, United 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States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Russell-Giller","sequence":"additional","affiliation":[{"name":"Queens College, City University of New York","place":["Flushing, NY, United States"]},{"name":"The Graduate Center, City University of New York","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Kenepp","sequence":"additional","affiliation":[{"name":"Queens College, City University of New York","place":["Flushing, NY, United States"]},{"name":"The Graduate Center, City University of New York","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantal","family":"Taveras","sequence":"additional","affiliation":[{"name":"Queens College, City University of New York","place":["Flushing, NY, United States"]},{"name":"The Graduate Center, City University of New York","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Seehra","sequence":"additional","affiliation":[{"name":"Queens College, City University of New York","place":["Flushing, NY, United States"]},{"name":"The Graduate Center, City University of New York","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Goldman","sequence":"additional","affiliation":[{"name":"Queens College, City University of New York","place":["Flushing, NY, United States"]},{"name":"The Graduate Center, City University of New York","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica J.","family":"Hinton","sequence":"additional","affiliation":[{"name":"Queens College, City University of New York","place":["Flushing, NY, United States"]},{"name":"The Graduate Center, City University of New York","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Shubeck","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Graves","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Adayev","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities (IBR)","place":["Staten Island, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref1","volume-title":"Manual for the Child Behavior Checklist\/4\u201318 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