{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:11:13Z","timestamp":1793373073624,"version":"4.5.0"},"reference-count":150,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>Histone lactylation is an emerging epigenetic modification that covalently links the glycolytic metabolite lactate to histones, thereby establishing a direct link between cellular metabolic status and gene transcription programs. Recent studies have shown that this modification plays a key role in regulating cellular sensitivity to ferroptosis, forming a novel regulatory axis of \u201cglycolysis-lactylation-ferroptosis.\u201d This article systematically reviews the biological functions of histone lactylation in the nervous system, with a focus on elucidating how it participates in the pathological processes of various neurological diseases, including Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), cerebral stroke, and amyotrophic lateral sclerosis (ALS), by regulating the expression of ferroptosis-related genes. The article integrates the latest research on molecular mechanisms, explores the value of this regulatory axis as a potential biomarker for disease diagnosis and a therapeutic target, and provides an outlook on future research directions in this field.<\/jats:p>","DOI":"10.3389\/fnmol.2026.1820758","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:40:21Z","timestamp":1783057221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Histone lactylation-mediated glycolysis-ferroptosis axis in neurological diseases"],"prefix":"10.3389","volume":"19","author":[{"given":"Zengrong","family":"Wei","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Bai","sequence":"additional","affiliation":[{"name":"Shenzhen Bao\u2019an Authentic TCM Therapy Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zou","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3390\/antiox12020261","article-title":"\u03b1-synuclein toxicity in drosophila melanogaster is enhanced by the presence of iron: Implications for Parkinson\u2019s disease.","volume":"12","author":"Agostini","year":"2023","journal-title":"Antioxidants"},{"key":"B2","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3390\/biomedicines13020265","article-title":"Targeting ferroptosis in rare neurological disorders including pediatric conditions: Innovations and therapeutic challenges.","volume":"13","author":"Alatawi","year":"2025","journal-title":"Biomedicines"},{"key":"B3","doi-asserted-by":"publisher","first-page":"121920","DOI":"10.1016\/j.lfs.2023.121920","article-title":"Exploring microglia and their phenomenal concatenation of stress responses in neurodegenerative disorders.","volume":"328","author":"Asveda","year":"2023","journal-title":"Life Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41531-024-00735-w","article-title":"Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates.","volume":"10","author":"Balzano","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/ana.26375","article-title":"Tregs attenuate peripheral oxidative stress and acute phase proteins in ALS.","volume":"92","author":"Beers","year":"2022","journal-title":"Ann. 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