{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:48:47Z","timestamp":1791884927147,"version":"4.3.4"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>\n                    Parkinson\u2019s Disease (PD) is a common neurodegenerative disorder that has been widely investigated using omics approaches over 2020\u20132025. This review focuses on the transition from single-omics to integrative multi-omics analysis, which helps overcome the constraints of individual omics strategies and provides a more systematic understanding of PD pathogenesis. Key topics include the elucidation of core mechanisms (mitochondrial dysfunction, lipid metabolic disturbance,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -synucleinopathy, and gut\u2013brain axis impairment), the development of biomarkers (shifting from invasive cerebrospinal fluid samples to less invasive plasma\/urine panels with improved performance), and the identification of potential interventional targets (signaling pathways, key molecules, and gut microbiota). Technical advances include refined single-omics detection, AI-assisted multi-omics integration, and the emergence of multi-center large cohorts. Despite notable progress, major challenges remain, including limited sample diversity, insufficient technical standardization, and gaps between basic research and clinical translation. Future directions should prioritize the establishment of multi-center longitudinal biobanks, high-sensitivity detection methods, and clinical translation through precision subtyping and targeted intervention. Integrative multi-omics has significantly advanced PD research from fragmented studies to a more systematic framework, providing a foundation for early diagnosis and precision therapy. Further efforts are needed to address current limitations and translate findings into clinical benefit for PD patients.\n                  <\/jats:p>","DOI":"10.3389\/fnmol.2026.1821875","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:40:21Z","timestamp":1784180421000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Omics research in Parkinson\u2019s disease: evolution, integrated analysis, pathogenic mechanisms, biomarkers, and therapeutic targets"],"prefix":"10.3389","volume":"19","author":[{"given":"Ruizhe","family":"Cao","sequence":"first","affiliation":[{"name":"School of Nursing, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Nursing, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of British Columbia","place":["Vancouver, BC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e958","DOI":"10.1002\/ctm2.958","article-title":"Monocyte biomarkers define sargramostim treatment outcomes for Parkinson\u2019s disease","volume":"12","author":"Abdelmoaty","year":"2022","journal-title":"Clin Transl Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"105997","DOI":"10.1016\/j.nbd.2023.105997","article-title":"Cross-sectional proteomic expression in Parkinson\u2019s disease-related proteins in drug-na\u00efve patients vs healthy controls with longitudinal clinical follow-up","volume":"177","author":"Abdi","year":"2023","journal-title":"Neurobiol. 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