{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:27:49Z","timestamp":1786429669729,"version":"build-2736575974"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>\n                    Using genetic and behavioral analyses, we identified a role for canonical Wnt\/\u03b2-catenin signaling in the regulation of avoidance behavior toward\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    PA14 in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    . RNAi analysis indicated a possible involvement of the Wnt ligand\n                    <jats:italic>cwn-2<\/jats:italic>\n                    , although interpretation of\n                    <jats:italic>cwn-2<\/jats:italic>\n                    mutant phenotypes was limited by locomotor defects. Genetic and behavioral analyses further implicated the receptor\n                    <jats:italic>cfz-2<\/jats:italic>\n                    , the transducer\n                    <jats:italic>dsh-1<\/jats:italic>\n                    , and the \u03b2-catenin homologue\n                    <jats:italic>bar-1<\/jats:italic>\n                    in this behavior, whereas\n                    <jats:italic>gsk-3<\/jats:italic>\n                    acted as a negative regulator. Epistasis analyses further supported that\n                    <jats:italic>cfz-2<\/jats:italic>\n                    functions genetically upstream of\n                    <jats:italic>gsk-3<\/jats:italic>\n                    and\n                    <jats:italic>bar-1<\/jats:italic>\n                    in the regulation of avoidance. Reporter analyses showed overlapping expression of\n                    <jats:italic>cfz-2<\/jats:italic>\n                    and\n                    <jats:italic>dsh-1<\/jats:italic>\n                    in a subset of head-region cells with neuron-like morphology, supporting a possible association between Wnt pathway expression and cells potentially relevant to avoidance-related regulation. However, these data do not establish a neuron-specific site of action. Systems-level analyses further indicated that genes identified through Wnt pathway screening are closely connected to known avoidance-related regulatory networks and are enriched in pathways associated with neuronal development, receptor-mediated signaling, and intercellular communication. Overall, these findings support a role for canonical Wnt\/\u03b2-catenin signaling in PA14 avoidance and support a potential association between Wnt pathway activity and avoidance-related cellular or regulatory networks.\n                  <\/jats:p>","DOI":"10.3389\/fnmol.2026.1851614","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:35:20Z","timestamp":1786426520000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of Caenorhabditis elegans avoidance behavior toward Pseudomonas aeruginosa PA14 by the canonical Wnt signaling pathway"],"prefix":"10.3389","volume":"19","author":[{"given":"Rong","family":"Lin","sequence":"first","affiliation":[{"name":"Zhaotong Health Vocational College, Zhaotong","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshu","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Kunming Medical University, Kunming","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhaotong Health Vocational College, Zhaotong","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanxue","family":"Xiao","sequence":"additional","affiliation":[{"name":"Zhaotong Health Vocational College, Zhaotong","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhaotong Health Vocational College, Zhaotong","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Public Health and Biosafety and School of Public Health, Kunming Medical University, Kunming","place":["Yunnan, China"]},{"name":"Infection Control Office, Xi\u2019an Public Health Center (Xi\u2019an Emergency Medical Center), Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zou","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Public Health and Biosafety and School of Public Health, Kunming Medical University, Kunming","place":["Yunnan, China"]},{"name":"Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development, Kunming Medical University, Kunming","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"966","DOI":"10.4161\/cc.8.7.8074","article-title":"Neural regulation of immunity: Role of NPR-1 in pathogen avoidance and regulation of innate immunity.","volume":"8","author":"Aballay","year":"2009","journal-title":"Cell Cycle"},{"key":"B2","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/dneu.22146","article-title":"Wnt-signaling and planar cell polarity genes regulate axon guidance along the anteroposterior axis in C. elegans.","volume":"74","author":"Ackley","year":"2014","journal-title":"Dev. 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