{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:44:52Z","timestamp":1790948692108,"version":"4.1.0"},"reference-count":299,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>The epidermal growth factor receptor (EGFR; ErbB1\/HER1) is a receptor tyrosine kinase that regulates cell proliferation, survival, differentiation, and tissue repair. In the nervous system, EGFR is expressed in neural progenitors, astrocytes, oligodendrocyte precursor cells, and neuronal populations, where its functions are context dependent. EGFR signaling contributes to neural regeneration by promoting progenitor proliferation, neuronal survival, neurogenesis, and remyelination following injury. However, sustained or excessive EGFR activation can drive reactive astrogliosis, neuroinflammation, glial scar formation, and neurotoxicity. Emerging evidence suggests that transient, regulated EGFR activation supports neural repair, whereas chronic or dysregulated signaling may contribute to neurodegeneration. These apparently opposing effects likely reflect differences in timing, duration, cellular context, ligand availability, and downstream signaling pathways engaged by EGFR activation, rather than inherently contradictory biological functions. In experimental models of Parkinson\u2019s disease, Alzheimer\u2019s disease, and Multiple sclerosis-like conditions, EGFR modulation has shown therapeutic potential, although the mechanisms remain incompletely understood. While EGFR ligands often exert neurotrophic and pro-remyelinating effects, disease-associated EGFR activation may promote maladaptive signaling pathways. In this review, we summarize current knowledge of EGFR signaling in neural repair and neurodegenerative diseases, discuss the context-dependent roles of this pathway, and highlight therapeutic strategies. We further propose a conceptual framework in which EGFR functions as a context-dependent signaling hub, with its outcomes determined by the spatiotemporal regulation of receptor activation. Although challenges remain, including optimal timing, dosing, and safety considerations, preclinical evidence suggests that modulation of EGFR signaling may be a therapeutic approach to promote neural repair while limiting neurodegenerative pathology.<\/jats:p>","DOI":"10.3389\/fnmol.2026.1891964","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:03:49Z","timestamp":1785305029000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidermal growth factor receptor modulation for neural repair: Implications for neurodegenerative disease therapy"],"prefix":"10.3389","volume":"19","author":[{"given":"Abdulbasit","family":"Amin","sequence":"first","affiliation":[{"name":"Gulbenkian Institute for Molecular Medicine","place":["Lisbon, Portugal"]},{"name":"Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin","place":["Ilorin, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Badenes","sequence":"additional","affiliation":[{"name":"Research in Veterinary Medicine (I-MVET), Lus\u00f3fona University - Lisbon University Centre","place":["Lisbon, Portugal"]},{"name":"Veterinary and Animal Research Centre (CECAV), Faculty of Veterinary Medicine, Lus\u00f3fona University - Lisbon University Centre","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/brain\/awac068","article-title":"Reactive astrocytes promote proteostasis in Huntington's disease through the Jak2-Stat3 pathway","volume":"146","author":"Abjean","year":"2023","journal-title":"Brain"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.2147\/IJGM.S295939","article-title":"Circulating miR-155 and Jak2\/Stat3 axis in acute ischemic stroke patients and its relation to post-ischemic inflammation and associated ischemic stroke risk factors","volume":"14","author":"Adly Sadik","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1111\/febs.17143","article-title":"Can the Hb-Egf\/Egfr pathway restore injured neurons?","volume":"291","author":"Adrain","year":"2024","journal-title":"FEBS J."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/cells13070581","article-title":"Nf-\u03baB and Jak\/Stat signaling pathways as crucial regulators of Neuroinflammation and astrocyte modulation in spinal cord injury","volume":"13","author":"Ageeva","year":"2024","journal-title":"Cells"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1038\/nn1938","article-title":"A functional role for Egfr signaling in myelination and remyelination","volume":"10","author":"Aguirre","year":"2007","journal-title":"Nat. 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Immunol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1091\/mbc.E19-05-0303","article-title":"Pi3K activation prevents A\u03b242-induced synapse loss and favors insoluble amyloid deposit formation","volume":"31","author":"Arn\u00e9s","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00401-011-0850-y","article-title":"Cell stress induces Tdp-43 pathological changes associated with Erk1\/2 dysfunction: implications in Als","volume":"122","author":"Ayala","year":"2011","journal-title":"Acta Neuropathol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"172","DOI":"10.4103\/REGENMED.REGENMED-D-24-00020","article-title":"Epidermal growth factor receptor pathway in central nervous system regenerative medicine: a narrative review","volume":"1","author":"Badenes","year":"2024","journal-title":"Regener. Med. 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Sci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/bies.201100116","article-title":"A novel target for Huntington\u2019s disease: Erk at the crossroads of signaling. The Erk signaling pathway is implicated in Huntington\u2019s disease and its upregulation ameliorates pathology","volume":"34","author":"Bodai","year":"2012","journal-title":"BioEssays"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1002\/glia.24357","article-title":"Neurotoxicity of ischemic astrocytes involves Stat3-mediated metabolic switching and depends on glycogen usage","volume":"71","author":"Borbor","year":"2023","journal-title":"Glia"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e0144864","DOI":"10.1371\/journal.pone.0144864","article-title":"Huntingtin subcellular localisation is regulated by kinase Signalling activity in the StHdhQ111 model of Hd","volume":"10","author":"Bowles","year":"2015","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.4049\/jimmunol.0803851","article-title":"Inhibition of Erk Mapk suppresses Il-23- and Il-1-driven Il-17 production and attenuates autoimmune disease","volume":"183","author":"Brereton","year":"2009","journal-title":"J. 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Res."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"791","DOI":"10.3892\/ijmm.2012.1074","article-title":"Electroacupuncture at the Quchi and Zusanli acupoints exerts neuroprotective role in cerebral ischemia-reperfusion injured rats via activation of the Pi3K\/Akt pathway","volume":"30","author":"Chen","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"103552","DOI":"10.1016\/j.mcn.2020.103552","article-title":"Matrix metalloprotease-mediated cleavage of neural glial-related cell adhesion molecules activates quiescent olfactory stem cells via Egfr","volume":"108","author":"Chen","year":"2020","journal-title":"Mol. Cell. Neurosci."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"8089","DOI":"10.1073\/pnas.1620664114","article-title":"Acute inflammation regulates neuroregeneration through the Nf-\u03baB pathway in olfactory epithelium","volume":"114","author":"Chen","year":"2017","journal-title":"Proc. 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Signal"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"8930","DOI":"10.1007\/s12017-026-08930-z","article-title":"Lep knockdown improves functional recovery after spinal cord injury and potentially regulates microglial polarization via Jak-Stat signaling pathway","volume":"28","author":"Chen","year":"2026","journal-title":"NeuroMolecular Med."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1002\/jnr.22057","article-title":"Amyloid-beta interrupts the Pi3K-Akt-mtor signaling pathway that could be involved in brain-derived neurotrophic factor-induced arc expression in rat cortical neurons","volume":"87","author":"Chen","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuint.2014.01.006","article-title":"Tetramethylpyrazine analogue Cxc195 protects against cerebral ischemia\/reperfusion-induced apoptosis through Pi3K\/Akt\/Gsk3\u03b2 pathway in rats","volume":"66","author":"Chen","year":"2014","journal-title":"Neurochem. Int."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1517\/14728220903213426","article-title":"Targeting the Jak2\/Stat3 axis in Alzheimer\u2019s disease","volume":"13","author":"Chiba","year":"","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/mp.2008.105","article-title":"Amyloid-beta causes memory impairment by disturbing the Jak2\/Stat3 axis in hippocampal neurons","volume":"14","author":"Chiba","year":"","journal-title":"Mol. Psychiatry"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1238639","DOI":"10.3389\/fphar.2023.1238639","article-title":"Egfr is a potential dual molecular target for cancer and Alzheimer's disease","volume":"14","author":"Choi","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/glia.10186","article-title":"Upregulation of gp130 and Stat3 activation in the rat hippocampus following transient forebrain ischemia","volume":"41","author":"Choi","year":"","journal-title":"Glia"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.molbrainres.2003.08.010","article-title":"Upregulation of gp130 and differential activation of Stat and p42\/44 Mapk in the rat hippocampus following kainic acid-induced seizures","volume":"119","author":"Choi","year":"","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s12974-021-02325-6","article-title":"Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation","volume":"18","author":"Chu","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.brainres.2005.05.060","article-title":"Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (Erk) in the central nervous system of Sod1G93A transgenic mice","volume":"1050","author":"Chung","year":"2005","journal-title":"Brain Res."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/BF00313927","article-title":"Epidermal growth factor in human cerebrospinal fluid: reduced levels in amyotrophic lateral sclerosis","volume":"233","author":"Cie\u015blak","year":"1986","journal-title":"J. Neurol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"4857","DOI":"10.1038\/s41467-023-40486-5","article-title":"Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer","volume":"14","author":"Cigliola","year":"2023","journal-title":"Nat. Commun."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.1016\/S0021-9258(19)85573-4","article-title":"Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity","volume":"255","author":"Cohen","year":"1980","journal-title":"J. Biol. Chem."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1111\/j.1460-9568.2005.03985.x","article-title":"Akt is altered in an animal model of Huntington's disease and in patients","volume":"21","author":"Colin","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00018-023-05007-z","article-title":"Emerging roles and mechanisms of Erk pathway mechanosensing","volume":"80","author":"Crozet","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s12035-020-02139-2","article-title":"App binds to the Egfr ligands Hb-Egf and Egf, acting synergistically with Egf to promote Erk signaling and Neuritogenesis","volume":"58","author":"Da Rocha","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"650708","DOI":"10.3389\/fimmu.2021.650708","article-title":"Baricitinib ameliorates experimental autoimmune encephalomyelitis by modulating the Janus kinase\/signal transducer and activator of transcription signaling pathway","volume":"12","author":"Dang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3233\/RNN-2011-0595","article-title":"Coadministration of epidermal growth factor and growth hormone releasing peptide-6 improves clinical recovery in experimental autoimmune encephalitis","volume":"29","author":"Del Barco","year":"2011","journal-title":"Restor. Neurol. Neurosci."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"113792","DOI":"10.1016\/j.expneurol.2021.113792","article-title":"Agonism of the \u03b1 7 -acetylcholine receptor\/Pi3K\/Akt pathway promotes neuronal survival after subarachnoid hemorrhage in mice","volume":"344","author":"Dienel","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.26402\/jpp.2024.6.01","article-title":"The role of the neuregulin 1-ErbB4 signaling pathway in neurological disorders","volume":"75","author":"Ding","year":"2024","journal-title":"J. Physiol. Pharmacol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/S0896-6273(02)01133-9","article-title":"Egf converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells","volume":"36","author":"Doetsch","year":"2002","journal-title":"Neuron"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s11064-020-03207-8","article-title":"Salidroside inhibits reactive Astrogliosis and glial scar formation in late cerebral ischemia via the Akt\/Gsk-3\u03b2 pathway","volume":"46","author":"Dong","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41392-023-01353-3","article-title":"Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions","volume":"8","author":"Dong-Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"3102","DOI":"10.1093\/brain\/awp240","article-title":"Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth","volume":"132","author":"Douglas","year":"2009","journal-title":"Brain"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1559-0275-8-9","article-title":"The Adams family of proteases: new biomarkers and therapeutic targets for cancer?","volume":"8","author":"Duffy","year":"2011","journal-title":"Clin. Proteomics"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fnmol.2014.00057","article-title":"Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis","volume":"7","author":"Dzamko","year":"2014","journal-title":"Front. Mol. 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Pharmacol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"120569","DOI":"10.1016\/j.lfs.2022.120569","article-title":"Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2ar\/Bdnf\/Trkb\/Erk\/Creb signaling pathway","volume":"300","author":"El-Shamarka","year":"2022","journal-title":"Life Sci."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"6428","DOI":"10.1523\/JNEUROSCI.1037-07.2007","article-title":"Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury","volume":"27","author":"Erschbamer","year":"2007","journal-title":"J. Neurosci."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/ncb1441","article-title":"A regulated interaction with the Uim protein Eps15 implicates parkin in Egf receptor trafficking and pi(3)K-Akt signalling","volume":"8","author":"Fallon","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3389\/fnagi.2015.00245","article-title":"Hippocampal injections of oligomeric amyloid \u03b2-peptide (1-42) induce selective working memory deficits and long-lasting alterations of Erk signaling pathway","volume":"7","author":"Faucher","year":"2015","journal-title":"Front. 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Sci."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/ncb0806-787","article-title":"Egfr trafficking: Parkinson in a jam","volume":"8","author":"Husnjak","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s10020-025-01308-0","article-title":"Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington's disease pathologies via Pkm2 restoration and Jak2\/Stat3 inhibition","volume":"31","author":"Ibiayo","year":"2025","journal-title":"Mol. Med."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fncel.2013.00004","article-title":"ErbB1-4-dependent Egf\/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson's disease","volume":"7","author":"Iwakura","year":"2013","journal-title":"Front. Cell. 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Neurosci."},{"key":"ref111","doi-asserted-by":"publisher","first-page":"18414","DOI":"10.1074\/jbc.M110.209718","article-title":"Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sapp(alpha)) by modulating phosphatidylinositol 3-kinase (Pi3K)\/Akt-Gsk-3beta pathway in Alzheimer mouse model","volume":"286","author":"Jimenez","year":"2011","journal-title":"J. Biol. 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Med."},{"key":"ref114","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.3390\/biomedicines10061432","article-title":"Molecular pathophysiological mechanisms in Huntington\u2019s disease","volume":"10","author":"Jurcau","year":"2022","journal-title":"Biomedicine"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1007\/s00204-024-03829-9","article-title":"Unraveling the Akt\/Erk cascade and its role in Parkinson disease","volume":"98","author":"Keshri","year":"2024","journal-title":"Arch. Toxicol."},{"key":"ref116","doi-asserted-by":"publisher","first-page":"eadd0499","DOI":"10.1126\/scitranslmed.add0499","article-title":"Enhanced mtorc1 signaling and protein synthesis in pathologic \u03b1-synuclein cellular and animal models of Parkinson's disease","volume":"15","author":"Khan","year":"2023","journal-title":"Sci. Transl. 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Res."},{"key":"ref125","doi-asserted-by":"publisher","first-page":"9671","DOI":"10.1073\/pnas.1818347116","article-title":"Mapk pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis","volume":"116","author":"Kotelnikova","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref126","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/s41419-025-07524-0","article-title":"Opposing roles for Gsk3\u03b2 and Erk1-dependent phosphorylation of huntingtin during neuronal dysfunction and cell death in Huntington's disease","volume":"16","author":"Krzystek","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref127","doi-asserted-by":"publisher","first-page":"5820","DOI":"10.1523\/JNEUROSCI.17-15-05820.1997","article-title":"Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain","volume":"17","author":"Kuhn","year":"1997","journal-title":"J. Neurosci."},{"key":"ref128","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1046\/j.1471-4159.2001.00304.x","article-title":"Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson\u2019s disease","volume":"77","author":"Kulich","year":"2001","journal-title":"J. Neurochem."},{"key":"ref129","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1007\/s12035-023-03902-x","article-title":"Guggulsterone selectively modulates Stat-3, mtor, and Ppar-gamma signaling in a methylmercury-exposed experimental neurotoxicity: evidence from Csf, blood plasma, and brain samples","volume":"61","author":"Kumar","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"ref130","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.nbd.2013.04.005","article-title":"Estrogen receptor \u03b2 ligand therapy activates Pi3K\/Akt\/mtor signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis","volume":"56","author":"Kumar","year":"2013","journal-title":"Neurobiol. 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Res."},{"key":"ref255","doi-asserted-by":"publisher","first-page":"71328","DOI":"10.1039\/c6ra11759g","article-title":"Neuroprotective effects of nitidine in Parkinson's disease models through inhibiting microglia activation: role of the Jak2\u2013Stat3 pathway","volume":"6","author":"Wang","year":"2016","journal-title":"RSC Adv."},{"key":"ref256","doi-asserted-by":"publisher","first-page":"12870","DOI":"10.1523\/JNEUROSCI.2121-13.2013","article-title":"Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via Stat3-dependent mechanisms after spinal cord injury","volume":"33","author":"Wanner","year":"2013","journal-title":"J. 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Neurosci."},{"key":"ref261","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s10753-024-02099-y","article-title":"Methylprednisolone modulates the Tfr\/Tfh ratio in Eae-induced Neuroinflammation through the Pi3K\/Akt\/FoxO1 and Pi3K\/Akt\/mtor Signalling pathways","volume":"48","author":"Wu","year":"2025","journal-title":"Inflammation"},{"key":"ref262","doi-asserted-by":"publisher","first-page":"e1702","DOI":"10.1038\/cddis.2015.69","article-title":"Induction of Cox-2-Pge2 synthesis by activation of the Mapk\/Erk pathway contributes to neuronal death triggered by Tdp-43-depleted microglia","volume":"6","author":"Xia","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref263","doi-asserted-by":"publisher","first-page":"113881","DOI":"10.1016\/j.biopha.2022.113881","article-title":"The role of Pi3K\/Akt signalling pathway in spinal cord injury","volume":"156","author":"Xiao","year":"2022","journal-title":"Biomed. 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