{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:26:50Z","timestamp":1792520810265,"version":"4.5.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>Parkinson\u2019s disease (PD), a common degenerative disorder in middle-aged and elderly individuals, has an unclear etiology and pathogenesis, and there is currently no cure. In recent years, the ketogenic diet (KD), a dietary regimen characterized by high-fat, extremely low carbohydrates, and moderate protein intake, has shown promise in the treatment of PD. This review systematically analyzes the multiple mechanisms through which KD exerts its effects in PD, such as energy metabolism reprogramming, neuroinflammation suppression, epigenetic regulation, and modulation of the brain-gut axis. The aim of this review is to provide theoretical foundations and practical guidance for the clinical application of the ketogenic diet as an adjunctive therapeutic strategy for PD.<\/jats:p>","DOI":"10.3389\/fnmol.2026.1914756","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:41:08Z","timestamp":1785908468000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ketogenic diet and Parkinson\u2019s disease"],"prefix":"10.3389","volume":"19","author":[{"given":"Yuzhao","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University","place":["Haikou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University","place":["Haikou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University","place":["Haikou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"101593","DOI":"10.1016\/j.xcrm.2024.101593","article-title":"Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice.","volume":"5","author":"Acu\u00f1a-Catal\u00e1n","year":"2024","journal-title":"Cell. Rep. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.cell.2020.04.027","article-title":"Ketogenic diets alter the gut microbiome resulting in decreased intestinal Th17 Cells.","volume":"181","author":"Ang","year":"2020","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41531-021-00215-5","article-title":"Parkinson\u2019s disease patients\u2019 short chain fatty acids production capacity after in vitro fecal fiber fermentation.","volume":"7","author":"Baert","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"ead7063","DOI":"10.1126\/sciadv.adp7063","article-title":"The role of dopaminergic medication and specific pathway alterations in idiopathic and PRKN\/PINK1-mediated Parkinson\u2019s disease.","volume":"11","author":"Balck","year":"2025","journal-title":"Sci. Adv."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.3390\/nu13082795","article-title":"Effect of diet and dietary components on the composition of the gut microbiota.","volume":"13","author":"Beam","year":"2021","journal-title":"Nutrients"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1016\/j.cell.2021.03.048","article-title":"Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.","volume":"184","author":"Bourdenx","year":"2021","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease.","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"B8","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/mds.27556","article-title":"Gut-brain axis and the spread of alpha-synuclein pathology: Vagal highway or dead end?","volume":"34","author":"Breen","year":"2019","journal-title":"Mov. Disord."},{"key":"B9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.brainres.2009.06.060","article-title":"Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson\u2019s disease.","volume":"1286","author":"Cheng","year":"2009","journal-title":"Brain Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/s41419-021-04049-0","article-title":"Fibrillar \u03b1-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-\u03baB.","volume":"12","author":"Chou","year":"2021","journal-title":"Cell. Death Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.yjmcc.2023.11.001","article-title":"\u03b2-hydroxybutyrate administered at reperfusion reduces infarct size and preserves cardiac function by improving mitochondrial function through autophagy in male mice.","volume":"186","author":"Chu","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7777","DOI":"10.3390\/ijms21207777","article-title":"Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer.","volume":"21","author":"Colucci-D\u2019Amato","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis.","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome.","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00702-020-02167-1","article-title":"Parkinson\u2019s disease treatment: Past, present, and future.","volume":"127","author":"Elsworth","year":"2020","journal-title":"J. Neural Transm."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.3390\/cells11193153","article-title":"TFEB; Beyond Its role as an autophagy and lysosomes regulator.","volume":"11","author":"Franco-Ju\u00e1rez","year":"2022","journal-title":"Cells"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1194\/jlr.R048975","article-title":"Ketogenic diets, mitochondria, and neurological diseases.","volume":"55","author":"Gano","year":"2014","journal-title":"J. Lipid Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1038\/s41401-025-01499-6","article-title":"Epigenetic regulation of iron metabolism and ferroptosis in Parkinson\u2019s disease: Identifying novel epigenetic targets.","volume":"46","author":"Gao","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"B19","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3390\/cells12030486","article-title":"Effect of the ketone body, D-\u03b2-hydroxybutyrate, on Sirtuin2-mediated regulation of mitochondrial quality control and the autophagy-lysosomal pathway.","volume":"12","author":"G\u00f3mora-Garc\u00eda","year":"2023","journal-title":"Cells"},{"key":"B20","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s41586-021-04059-0","article-title":"Disruption of mitochondrial complex I induces progressive parkinsonism.","volume":"599","author":"Gonz\u00e1lez-Rodr\u00edguez","year":"2021","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jmb.2004.02.006","article-title":"Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis.","volume":"338","author":"Gregoretti","year":"2004","journal-title":"J. Mol. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.expneurol.2007.12.029","article-title":"Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions.","volume":"211","author":"Haces","year":"2008","journal-title":"Exp. Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"591177","DOI":"10.3389\/fnins.2020.591177","article-title":"Beta-hydroxybutyrate enhances BDNF expression by increasing H3K4me3 and decreasing H2AK119ub in hippocampal neurons.","volume":"14","author":"Hu","year":"2020","journal-title":"Front. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1093\/brain\/awm086","article-title":"Changes in network activity with the progression of Parkinson\u2019s disease.","volume":"130","author":"Huang","year":"2007","journal-title":"Brain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"8767","DOI":"10.3390\/ijms21228767","article-title":"Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases.","volume":"21","author":"Jensen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic diagramming platform (GDP): A comprehensive database of high-quality biomedical graphics.","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.14336\/AD.2021.1217","article-title":"Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases.","volume":"13","author":"Jiang","year":"2022","journal-title":"Aging Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"235","DOI":"10.16424\/j.cnki.cn32-1807\/r.2018.03.023","article-title":"Observation on the clinical efficacy of ketogenic diet in the treatment of Parkinson\u2019s disease: A case study of 39 patients.","volume":"38","author":"Juan","year":"2018","journal-title":"J. Nantong Univer."},{"key":"B29","doi-asserted-by":"publisher","first-page":"105028","DOI":"10.1016\/j.nbd.2020.105028","article-title":"Microglia and astrocyte dysfunction in Parkinson\u2019s disease.","volume":"144","author":"Kam","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5256","DOI":"10.1523\/JNEUROSCI.0984-06.2006","article-title":"Parkinson\u2019s disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.","volume":"26","author":"Keeney","year":"2006","journal-title":"J. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"4472","DOI":"10.3390\/nu14214472","article-title":"The role of diet and dietary patterns in Parkinson\u2019s disease.","volume":"14","author":"Knight","year":"2022","journal-title":"Nutrients"},{"key":"B32","doi-asserted-by":"publisher","first-page":"eadi7828","DOI":"10.1126\/scitranslmed.adi7828","article-title":"Neuroinflammation: An astrocyte perspective.","volume":"15","author":"Lee","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"664","DOI":"10.5114\/aoms\/130287","article-title":"Inhibition of histone deacetylase promotes a neuroprotective mechanism in an experimental model of Parkinson\u2019s disease.","volume":"20","author":"Li","year":"2024","journal-title":"Arch. Med. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1038\/s42255-024-01072-1","article-title":"Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption.","volume":"6","author":"Li","year":"2024","journal-title":"Nat. Metab."},{"key":"B35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.aehs.2025.05.004","article-title":"Ketone bodies in exercise, health and disease: Metabolic mechanisms, pathophysiology, and therapeutic implications.","volume":"2","author":"Li","year":"2025","journal-title":"Adv. Exerc. Health Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia.","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.chembiol.2024.11.001","article-title":"\u03b2-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.","volume":"32","author":"Madhavan","year":"2025","journal-title":"Cell. Chem. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12937-023-00893-2","article-title":"Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review.","volume":"22","author":"Mazandarani","year":"2023","journal-title":"Nutr. J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"7529","DOI":"10.1038\/s41467-023-43224-z","article-title":"Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson\u2019s disease.","volume":"14","author":"McFleder","year":"2023","journal-title":"Nat. Commun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.nbd.2010.05.030","article-title":"Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet.","volume":"40","author":"Milder","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5157645","DOI":"10.1155\/2018\/5157645","article-title":"Nutritional ketosis and mitohormesis: Potential implications for mitochondrial function and human health.","volume":"2018","author":"Miller","year":"2018","journal-title":"J. Nutr. Metab."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1425816","DOI":"10.3389\/fimmu.2024.1425816","article-title":"Exploring the ketogenic diet\u2019s potential in reducing neuroinflammation and modulating immune responses.","volume":"15","author":"Monda","year":"2024","journal-title":"Front. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson\u2019s disease.","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"B44","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41467-024-44732-2","article-title":"Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson\u2019s disease model.","volume":"15","author":"Morrone Parfitt","year":"2024","journal-title":"Nat. Commun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/metabo10120504","article-title":"The ketogenic diet increases in vivo glutathione levels in patients with epilepsy.","volume":"10","author":"Napolitano","year":"2020","journal-title":"Metabolites"},{"key":"B46","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tem.2013.09.002","article-title":"Ketone bodies as signaling metabolites.","volume":"25","author":"Newman","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"B47","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-nutr-071816-064916","article-title":"\u03b2-Hydroxybutyrate: A signaling metabolite.","volume":"37","author":"Newman","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"B48","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/metabo15030208","article-title":"Metabolomics in Parkinson\u2019s disease and correlation with disease state.","volume":"15","author":"Ostrakhovitch","year":"2025","journal-title":"Metabolites"},{"key":"B49","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1080\/15548627.2021.1898748","article-title":"AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.","volume":"17","author":"Paquette","year":"2021","journal-title":"Autophagy"},{"key":"B50","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41582-024-01043-w","article-title":"alpha-Synuclein pathology as a target in neurodegenerative diseases.","volume":"21","author":"Park","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/mds.27390","article-title":"Low-fat versus ketogenic diet in Parkinson\u2019s disease: A pilot randomized controlled trial.","volume":"33","author":"Phillips","year":"2018","journal-title":"Mov. Disord."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s43440-025-00799-2","article-title":"The ketogenic diet in Parkinson\u2019s disease: A potential therapeutic strategy.","volume":"77","author":"Pokora","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics.","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell. Metab."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1097\/CM9.0000000000003627","article-title":"Lipid metabolism in health and disease: Mechanistic and therapeutic insights for Parkinson\u2019s disease.","volume":"138","author":"Qin","year":"2025","journal-title":"Chin. Med. J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"ra42","DOI":"10.1126\/scisignal.2002790","article-title":"The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.","volume":"5","author":"Roczniak-Ferguson","year":"2012","journal-title":"Sci. Signal."},{"key":"B56","doi-asserted-by":"publisher","first-page":"11022","DOI":"10.3390\/ijms241311022","article-title":"Are therapies that target \u03b1-synuclein effective at halting Parkinson\u2019s disease progression? A systematic review.","volume":"24","author":"Rodger","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.jand.2017.06.006","article-title":"Practice paper of the academy of nutrition and dietetics: Classic and modified ketogenic diets for treatment of epilepsy.","volume":"117","author":"Roehl","year":"2017","journal-title":"J. Acad. Nutr. Diet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41531-023-00541-w","article-title":"To restrict or not to restrict? Practical considerations for optimizing dietary protein interactions on levodopa absorption in Parkinson\u2019s disease.","volume":"9","author":"Rusch","year":"2023","journal-title":"NPJ Parkinsons Dis"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease.","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"B60","doi-asserted-by":"publisher","first-page":"7830","DOI":"10.1007\/s12035-024-03974-3","article-title":"The alpha-synuclein gene (SNCA) is a genomic target of methyl-CpG binding protein 2 (MeCP2)-implications for Parkinson\u2019s disease and rett syndrome.","volume":"61","author":"Schmitt","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"eadx0043","DOI":"10.1126\/science.adx0043","article-title":"Neuroinflammation across neurological diseases.","volume":"388","author":"Shi","year":"2025","journal-title":"Science"},{"key":"B62","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor.","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.3389\/fmicb.2017.01141","article-title":"Reduced mass and diversity of the colonic microbiome in patients with multiple sclerosis and their improvement with ketogenic diet.","volume":"8","author":"Swidsinski","year":"2017","journal-title":"Front. Microbiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1002\/mds.29157","article-title":"Epigenetic clock acceleration is linked to age at onset of Parkinson\u2019s disease.","volume":"37","author":"Tang","year":"2022","journal-title":"Mov. Disord."},{"key":"B65","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1172\/JCI18797","article-title":"D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.","volume":"112","author":"Tieu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"B66","doi-asserted-by":"publisher","first-page":"e70168","DOI":"10.1111\/jnc.70168","article-title":"Ergothioneine treatment ameliorates the pathological phenotypes of Parkinson\u2019s disease models.","volume":"169","author":"Tng","year":"2025","journal-title":"J. Neurochem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson\u2019s disease.","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"eadv8448","DOI":"10.1126\/sciadv.adv8448","article-title":"ACSS2 coupled with KAT7 regulates histone \u03b2-hydroxybutyrylation to enhance transcription.","volume":"11","author":"Wang","year":"2025","journal-title":"Sci. Adv."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1601446","DOI":"10.3389\/fnut.2025.1601446","article-title":"A mixed methods feasibility study of a ketogenic diet as treatment for Parkinson\u2019s disease.","volume":"12","author":"Worster","year":"2025","journal-title":"Front. Nutr."},{"key":"B70","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.bbi.2025.02.013","article-title":"Dectin-1 participates in neuroinflammation and dopaminergic neurodegeneration through synergistic signaling crosstalk with TLR4.","volume":"126","author":"Xue","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2003410","DOI":"10.1002\/advs.202003410","article-title":"Ketone body 3-hydroxybutyrate ameliorates atherosclerosis via receptor Gpr109a-Mediated calcium influx.","volume":"8","author":"Zhang","year":"2021","journal-title":"Adv. Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/s41420-023-01549-0","article-title":"Neuroprotective effect of a medium-chain triglyceride ketogenic diet on MPTP-induced Parkinson\u2019s disease mice: A combination of transcriptomics and metabolomics in the substantia nigra and fecal microbiome.","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discov."},{"key":"B74","doi-asserted-by":"publisher","first-page":"3506213","DOI":"10.1155\/2022\/3506213","article-title":"The Anti-inflammatory effect of preventive intervention with ketogenic diet mediated by the histone acetylation of mGluR5 promotor region in rat Parkinson\u2019s disease model: A dual-tracer PET study.","volume":"2022","author":"Zhu","year":"2022","journal-title":"Parkinsons Dis."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2026.1914756\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:41:10Z","timestamp":1785908470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2026.1914756\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":74,"alternative-id":["10.3389\/fnmol.2026.1914756"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2026.1914756","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"article-number":"1914756"}}