{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:01:57Z","timestamp":1789988517091,"version":"4.0.1"},"reference-count":170,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>HSPA5 is a member of the HSP70 family of heat shock proteins (HSPs) and functions as a chaperone protein within the endoplasmic reticulum (ER). It plays a role in maintaining ER homeostasis, assists in correct protein folding, and triggers the unfolded protein response. Environmental toxins\u2013such as heavy metals, microplastics (MPs), and air pollutants\u2013can cause cellular damage. These toxins can trigger ER stress, resulting in the buildup of proteins that are misfolded or not properly folded, which in turn upregulates HSPA5 expression. Moderate activation of HSPA5 serves as a protective mechanism aimed at restoring protein homeostasis and promoting cell survival; however, sustained and severe ER stress may cause HSPA5 to malfunction, ultimately leading to the activation of the apoptotic pathway and resulting in cell death. Furthermore, HSPA5-mediated mechanisms are closely associated with the prodromal initiation and subsequent escalation of neurodegenerative syndromes. This article focuses on the role of HSPA5 in environmental toxin-induced neurotoxicity and neurodegenerative diseases, with the aim of investigating changes in HSPA5 expression and its regulatory functions in neurotoxicity, thereby providing new strategies for the study of environment-related neurodegenerative diseases.<\/jats:p>","DOI":"10.3389\/fnmol.2026.1964213","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:26:51Z","timestamp":1789986411000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression and role of HSPA5 in environmental toxin-induced neurological disorders"],"prefix":"10.3389","volume":"19","author":[{"given":"Yurong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruidong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingchun","family":"Liu","sequence":"additional","affiliation":[{"name":"Central Laboratory of Organ Transplantation, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3390\/toxics10050271","article-title":"Glycine betaine relieves lead-induced hepatic and renal toxicity in albino rats.","volume":"10","author":"Abdelrazek","year":"2022","journal-title":"Toxics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s44319-023-00027-z","article-title":"UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.","volume":"25","author":"Ahlstedt","year":"2024","journal-title":"EMBO Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"172838","DOI":"10.1016\/j.scitotenv.2024.172838","article-title":"Literature review and meta-analysis of environmental toxins associated with increased risk of Parkinson\u2019s disease.","volume":"931","author":"Aravindan","year":"2024","journal-title":"Sci. Total Environ."},{"key":"B4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12989-024-00595-5","article-title":"Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78\/IRE1\u03b1\/JNK axis induced apoptosis and endoplasmic reticulum stress.","volume":"21","author":"Bai","year":"2024","journal-title":"Part Fibre Toxicol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12870-022-04024-7","article-title":"Physiological and transcriptomic analyses provide insight into thermotolerance in desert plant Zygophyllum xanthoxylum.","volume":"23","author":"Bai","year":"2023","journal-title":"BMC Plant Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.1016\/j.febslet.2007.04.028","article-title":"Stress on redox.","volume":"581","author":"B\u00e1nhegyi","year":"2007","journal-title":"FEBS Lett."},{"key":"B7","doi-asserted-by":"publisher","first-page":"105574","DOI":"10.1016\/j.nbd.2021.105574","article-title":"Synaptic pathology in Huntington\u2019s disease: Beyond the corticostriatal pathway.","volume":"162","author":"Barry","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41586-022-04436-3","article-title":"TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.","volume":"603","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"6348","DOI":"10.3390\/ijms23116348","article-title":"Benzo[a]pyrene-Environmental occurrence, human exposure, and mechanisms of toxicity.","volume":"23","author":"Bukowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4732","DOI":"10.3390\/ijerph19084732","article-title":"Residence in an area with environmental exposure to heavy metals and neurobehavioral performance in children 9-11 years old: An explorative study.","volume":"19","author":"Capelo","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3389\/fnins.2017.00177","article-title":"GRP78 at the centre of the stage in cancer and neuroprotection.","volume":"11","author":"Casas","year":"2017","journal-title":"Front. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.18388\/abp.2020_5624","article-title":"The role of GRP78 in oxidative stress induced by tunicamycin in trabecular meshwork cells.","volume":"69","author":"Chai","year":"2022","journal-title":"Acta Biochim Pol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"129325","DOI":"10.1016\/j.jhazmat.2022.129325","article-title":"Ecological risk assessment of priority PAHs pollutants in crude oil contaminated soil and its impacts on soil biological properties.","volume":"437","author":"Chakravarty","year":"2022","journal-title":"J. Hazard Mater."},{"key":"B14","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.3390\/ijms22084024","article-title":"The epstein-barr virus lytic protein BMLF1 induces upregulation of GRP78 expression through ATF6 activation.","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41568-020-00312-2","article-title":"Endoplasmic reticulum stress signals in the tumour and its microenvironment.","volume":"21","author":"Chen","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: Molecular mechanism and therapeutic targets.","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12906-023-03855-7","article-title":"Forsythiaside A ameliorates sepsis-induced acute kidney injury via anti-inflammation and antiapoptotic effects by regulating endoplasmic reticulum stress.","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Compl. Med. Ther."},{"key":"B18","doi-asserted-by":"publisher","first-page":"7977433","DOI":"10.1155\/2022\/7977433","article-title":"Vitexin mitigates Staphylococcus aureus-induced mastitis via regulation of ROS\/ER Stress\/NF-\u03ba B\/MAPK pathway.","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e00791","DOI":"10.1002\/prp2.791","article-title":"Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway.","volume":"9","author":"Cheng","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"key":"B20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12974-023-02720-1","article-title":"\u03b1-Synuclein induces prodromal symptoms of Parkinson\u2019s disease via activating TLR2\/MyD88\/NF-\u03baB pathway in Schwann cells of vagus nerve in a rat model.","volume":"20","author":"Cheng","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"B21","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1128\/MCB.00814-06","article-title":"BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1.","volume":"27","author":"Cho","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"118858","DOI":"10.1016\/j.jep.2024.118858","article-title":"Targeting Nrf2\/HO-1 signaling by crocin: Role in attenuation of arsenic trioxide-induced neurotoxicity in mice.","volume":"337","author":"Chu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"7068","DOI":"10.1021\/acs.est.9b01517","article-title":"Human consumption of microplastics.","volume":"53","author":"Cox","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.3390\/ijms23031918","article-title":"Genome-Wide identification and expression analysis of heat shock protein 70 (HSP70) gene family in pumpkin (Cucurbita moschata) rootstock under drought stress suggested the potential role of these chaperones in stress tolerance.","volume":"23","author":"Davoudi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/s41419-024-06560-6","article-title":"Caspase-2 protects against ferroptotic cell death.","volume":"15","author":"Dawar","year":"2024","journal-title":"Cell Death Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12906-022-03597-y","article-title":"Diosmin mitigates high glucose-induced endoplasmic reticulum stress through PI3K\/AKT pathway in HK-2 cells.","volume":"22","author":"Deng","year":"2022","journal-title":"BMC Compl. Med. Ther."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e2402030","DOI":"10.1002\/advs.202402030","article-title":"SIRT5-Mediated desuccinylation of RAB7A protects against cadmium-induced Alzheimer\u2019s disease-like pathology by restoring autophagic flux.","volume":"11","author":"Deng","year":"2024","journal-title":"Adv. Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1007\/s12035-023-03805-x","article-title":"Environmental toxins and Alzheimer\u2019s disease: A comprehensive analysis of pathogenic mechanisms and therapeutic modulation.","volume":"61","author":"Dhapola","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.3389\/fimmu.2019.02951","article-title":"Crosstalk between hypoxia and ER stress response: A key regulator of macrophage polarization.","volume":"10","author":"D\u00edaz-Bulnes","year":"2020","journal-title":"Front. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12013-024-01248-2","article-title":"Oxidative stress, endoplasmic reticulum stress and apoptosis in the pathology of Alzheimer\u2019s disease.","volume":"82","author":"Ekundayo","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"B31","doi-asserted-by":"publisher","first-page":"118317","DOI":"10.1016\/j.lfs.2020.118317","article-title":"GRP78 targeting: Hitting two birds with a stone.","volume":"260","author":"Elfiky","year":"2020","journal-title":"Life Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"105478","DOI":"10.1016\/j.compbiomed.2022.105478","article-title":"Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspective.","volume":"145","author":"Elshemey","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3390\/ijms21030845","article-title":"PERK-Mediated eIF2\u03b1 phosphorylation contributes to the protection of dopaminergic neurons from chronic heat stress in Drosophila.","volume":"21","author":"Elvira","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"106225","DOI":"10.1016\/j.nbd.2023.106225","article-title":"The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington\u2019s disease R6\/1 mice.","volume":"184","author":"Espina","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","article-title":"Amyotrophic lateral sclerosis.","volume":"400","author":"Feldman","year":"2022","journal-title":"Lancet"},{"key":"B36","doi-asserted-by":"publisher","first-page":"105050","DOI":"10.1016\/j.nbd.2020.105050","article-title":"An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.","volume":"144","author":"Feneberg","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1080\/15548627.2021.1909406","article-title":"How autophagy controls the intestinal epithelial barrier.","volume":"18","author":"Foerster","year":"2022","journal-title":"Autophagy"},{"key":"B38","doi-asserted-by":"publisher","first-page":"8140","DOI":"10.1038\/s41598-022-12191-8","article-title":"Heat shock protein Grp78\/BiP\/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.","volume":"12","author":"Fran\u00e7ois-Moutal","year":"2022","journal-title":"Sci. Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2249749","DOI":"10.1155\/2022\/2249749","article-title":"Role of molecular hydrogen in ageing and ageing-related diseases.","volume":"2022","author":"Fu","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"817392","DOI":"10.3389\/fmolb.2022.817392","article-title":"Endoplasmic reticulum stress of gut enterocyte and intestinal diseases.","volume":"9","author":"Gao","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4415","DOI":"10.1111\/febs.70527","article-title":"Heavy metal toxicity as a driver of endoplasmic reticulum stress and dysfunction.","volume":"293","author":"Ghosh","year":"2026","journal-title":"FEBS J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1002\/iub.2502","article-title":"Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.","volume":"73","author":"Gonzalez-Gronow","year":"2021","journal-title":"IUBMB Life"},{"key":"B43","doi-asserted-by":"publisher","first-page":"100860","DOI":"10.1016\/j.preteyeres.2020.100860","article-title":"Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases.","volume":"79","author":"Gorbatyuk","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S1474-4422(21)00465-8","article-title":"Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis.","volume":"21","author":"Goutman","year":"2022","journal-title":"Lancet Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e108443","DOI":"10.15252\/embj.2021108443","article-title":"Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.","volume":"41","author":"Gruijs da Silva","year":"2022","journal-title":"EMBO J."},{"key":"B46","doi-asserted-by":"publisher","first-page":"116812","DOI":"10.1016\/j.biopha.2024.116812","article-title":"Newsights of endoplasmic reticulum in hypoxia.","volume":"175","author":"Guan","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.3390\/ijms23073609","article-title":"Mechanistic insights into selective autophagy subtypes in Alzheimer\u2019s disease.","volume":"23","author":"Guan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e13598","DOI":"10.1111\/acel.13598","article-title":"Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice.","volume":"21","author":"Hafycz","year":"2022","journal-title":"Aging Cell"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1002\/mds.28643","article-title":"Decoupling of global brain activity and cerebrospinal fluid flow in Parkinson\u2019s disease cognitive decline.","volume":"36","author":"Han","year":"2021","journal-title":"Mov. Disord."},{"key":"B50","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.cell.2024.11.038","article-title":"Long somatic DNA-repeat expansion drives neurodegeneration in Huntington\u2019s disease.","volume":"188","author":"Handsaker","year":"2025","journal-title":"Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response.","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1002\/jnr.25225","article-title":"ER-phagy in neurodegeneration.","volume":"101","author":"Hill","year":"2023","journal-title":"J. Neurosci. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1083\/jcb.200310015","article-title":"Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.","volume":"165","author":"Hitomi","year":"2004","journal-title":"J. Cell Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"106101","DOI":"10.1016\/j.parkreldis.2024.106101","article-title":"Brain-first vs. body-first Parkinson\u2019s disease: An update on recent evidence.","volume":"122","author":"Horsager","year":"2024","journal-title":"Parkinson. Relat. Disord."},{"key":"B55","doi-asserted-by":"publisher","first-page":"101620","DOI":"10.1016\/j.redox.2020.101620","article-title":"Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways.","volume":"37","author":"Hu","year":"2020","journal-title":"Redox Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.1007\/s12011-025-04943-0","article-title":"The effects of lead, cadmium and arsenic exposure alone or in combination on neurotoxicity through neural signaling pathways.","volume":"204","author":"Huang","year":"2026","journal-title":"Biol. Trace Elem. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3390\/brainsci13020258","article-title":"Immunohistochemical distribution and neurochemical characterization of huntingtin-associated protein 1 immunoreactive neurons in the adult mouse lingual ganglia.","volume":"13","author":"Islam","year":"2023","journal-title":"Brain Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/clinchem\/hvad022","article-title":"Elementary overview of heavy metals.","volume":"69","author":"Jannetto","year":"2023","journal-title":"Clin. Chem."},{"key":"B59","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3390\/toxics11020142","article-title":"Effects of sodium arsenite on the myocardial differentiation in mouse embryonic bodies.","volume":"11","author":"Jeong","year":"2023","journal-title":"Toxics"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.7150\/ijbs.69934","article-title":"Radiosensitizer EXO-miR-197-3p inhibits nasopharyngeal carcinoma progression and radioresistance by regulating the AKT\/mTOR axis and HSPA5-mediated autophagy.","volume":"18","author":"Jiang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3390\/brainsci12040463","article-title":"Diffusion tensor imaging reveals deep brain structure changes in early Parkinson\u2019s disease patients with various sleep disorders.","volume":"12","author":"Jiang","year":"2022","journal-title":"Brain Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1080\/15548627.2023.2238579","article-title":"SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1.","volume":"19","author":"Jiao","year":"2023","journal-title":"Autophagy"},{"key":"B63","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00204-024-03903-2","article-title":"Heavy metals: Toxicity and human health effects.","volume":"99","author":"Jomova","year":"2025","journal-title":"Arch. Toxicol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1007\/s10753-024-01989-5","article-title":"Inhibition of endoplasmic reticulum stress improves chronic ischemic hippocampal damage associated with suppression of IRE1\u03b1\/TRAF2\/ASK1\/JNK-Dependent apoptosis.","volume":"47","author":"Kang","year":"2024","journal-title":"Inflammation"},{"key":"B65","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-biophys-090921-120150","article-title":"Large chaperone complexes through the lens of nuclear magnetic resonance spectroscopy.","volume":"51","author":"Karamanos","year":"2022","journal-title":"Annu. Rev. Biophys."},{"key":"B66","doi-asserted-by":"publisher","first-page":"19730","DOI":"10.1038\/s41598-020-76839-z","article-title":"Endoplasmic reticulum chaperone BiP\/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice.","volume":"10","author":"Kawaguchi","year":"2020","journal-title":"Sci. Rep."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer\u2019s disease.","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"101853","DOI":"10.1016\/j.redox.2021.101853","article-title":"Chalcone suppresses tumor growth through NOX4-IRE1\u03b1 sulfonation-RIDD-miR-23b axis.","volume":"40","author":"Kim","year":"2021","journal-title":"Redox Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3390\/cells11030555","article-title":"C53 interacting with UFM1-Protein ligase 1 regulates microtubule nucleation in response to ER stress.","volume":"11","author":"Klebanovych","year":"2022","journal-title":"Cells"},{"key":"B70","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.3390\/ijms23084417","article-title":"Changes in the cardiotoxic effects of lead intoxication in rats induced by muscular exercise.","volume":"23","author":"Klinova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"786420","DOI":"10.3389\/fnagi.2022.786420","article-title":"DNA damage, defective DNA repair, and neurodegeneration in amyotrophic lateral sclerosis.","volume":"14","author":"Konopka","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"110055","DOI":"10.1016\/j.ecoenv.2019.110055","article-title":"The effects of chronic lead exposure on the liver of female Japanese quail (Coturnix japonica): Histopathological damages, oxidative stress and AMP-activated protein kinase based lipid metabolism disorder.","volume":"190","author":"Kou","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1136\/jnnp-2023-332974","article-title":"Exercise as medicine in Parkinson\u2019s disease.","volume":"95","author":"Langeskov-Christensen","year":"2024","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e2412246122","DOI":"10.1073\/pnas.2412246122","article-title":"Stress-induced translocation of the endoplasmic reticulum chaperone GRP78\/BiP and its impact on human disease and therapy.","volume":"122","author":"Lee","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.3390\/biomedicines9081039","article-title":"GRP78 overexpression triggers PINK1-IP3R-Mediated neuroprotective mitophagy.","volume":"9","author":"Leiva-Rodr\u00edguez","year":"2021","journal-title":"Biomedicines"},{"key":"B76","doi-asserted-by":"publisher","first-page":"104021","DOI":"10.1016\/j.ebiom.2022.104021","article-title":"Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.","volume":"80","author":"Levin","year":"2022","journal-title":"EBioMedicine"},{"key":"B77","doi-asserted-by":"publisher","first-page":"470","DOI":"10.21037\/atm-22-1445","article-title":"The diagnostic value of endoplasmic reticulum stress-related specific proteins GRP78 and CHOP in patients with sepsis: A diagnostic cohort study.","volume":"10","author":"Li","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.3390\/antiox11091835","article-title":"Differential effects of arsenic in drinking water on mouse hepatic and intestinal heme oxygenase-1 expression.","volume":"11","author":"Li","year":"2022","journal-title":"Antioxidants"},{"key":"B79","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.jare.2024.01.019","article-title":"Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies.","volume":"67","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"111917","DOI":"10.1016\/j.ecoenv.2021.111917","article-title":"Protective effects of folic acid on oxidative damage of rat spleen induced by lead acetate.","volume":"211","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B81","doi-asserted-by":"publisher","first-page":"114406","DOI":"10.1016\/j.isci.2025.114406","article-title":"Cadmium disrupts hepatic lipid homeostasis: Molecular mechanisms, unresolved controversies, and therapeutic strategies.","volume":"29","author":"Li","year":"2025","journal-title":"iScience"},{"key":"B82","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.omto.2022.08.006","article-title":"The pivotal regulatory factor circBRWD1 inhibits arsenic exposure-induced lung cancer occurrence by binding mRNA and regulating its stability.","volume":"26","author":"Li","year":"2022","journal-title":"Mol. Ther. Oncolytics"},{"key":"B83","doi-asserted-by":"publisher","first-page":"116633","DOI":"10.1016\/j.bcp.2024.116633","article-title":"Exploring heat shock proteins as therapeutic targets for Parkinson\u2019s disease.","volume":"230","author":"Li","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"5572899","DOI":"10.1155\/2021\/5572899","article-title":"Inhibition of \u03b1-Synuclein accumulation improves neuronal apoptosis and delayed postoperative cognitive recovery in aged mice.","volume":"2021","author":"Li","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B85","doi-asserted-by":"publisher","first-page":"117990","DOI":"10.1016\/j.ecoenv.2025.117990","article-title":"Exposure to urinary polycyclic aromatic hydrocarbon metabolites for the effect of lung function among children and adolescents: Epidemiological study and mechanism exploration.","volume":"292","author":"Liu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B86","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s41419-020-2656-0","article-title":"SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response.","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"110538","DOI":"10.1016\/j.fsi.2025.110538","article-title":"Cadmium activated oxidative stress and endoplasmic reticulum stress pathway promote apoptosis in the common carp (Cyprinus carpio L.) brain.","volume":"165","author":"Liu","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"130391","DOI":"10.1016\/j.jhazmat.2022.130391","article-title":"Sporadic Pb accumulation by plants: Influence of soil biogeochemistry, microbial community and physiological mechanisms.","volume":"444","author":"Liu","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"B89","doi-asserted-by":"publisher","first-page":"111050","DOI":"10.1016\/j.fsi.2025.111050","article-title":"Response mechanisms of abalone Haliotis discus hannai to lead (Pb) exposure in vitro: Insights into autophagy, endoplasmic reticulum stress and apoptosis.","volume":"169","author":"Liu","year":"2026","journal-title":"Fish Shellfish Immunol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"125428","DOI":"10.1016\/j.chemosphere.2019.125428","article-title":"Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster.","volume":"243","author":"Liu","year":"2020","journal-title":"Chemosphere"},{"key":"B91","doi-asserted-by":"publisher","first-page":"e2303448120","DOI":"10.1073\/pnas.2303448120","article-title":"ER chaperone GRP78\/BiP translocates to the nucleus under stress and acts as a transcriptional regulator.","volume":"120","author":"Liu","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B92","doi-asserted-by":"publisher","first-page":"115058","DOI":"10.1016\/j.fct.2024.115058","article-title":"Perfluorooctane sulfonate (Pfos) and benzo[a]pyrene (BaP) synergistically induce neurotoxicity in C6 rat glioma cells via the activation of neurotransmitter and Cyp1a1-mediated steroid hormone synthesis pathways.","volume":"193","author":"Lu","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"780","DOI":"10.3390\/ijms23020780","article-title":"Impact of ER stress and ER-Mitochondrial crosstalk in Huntington\u2019s disease.","volume":"23","author":"Maity","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1007\/s00299-021-02774-6","article-title":"Comparative phosphoproteomic analysis of tomato genotypes with contrasting cadmium tolerance.","volume":"40","author":"Marques","year":"2021","journal-title":"Plant Cell Rep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"a004317","DOI":"10.1101\/cshperspect.a004317","article-title":"Endoplasmic-reticulum calcium depletion and disease.","volume":"3","author":"Mekahli","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.3390\/cells11101661","article-title":"ATF6 activation reduces amyloidogenic transthyretin secretion through increased interactions with endoplasmic reticulum proteostasis factors.","volume":"11","author":"Mesgarzadeh","year":"2022","journal-title":"Cells"},{"key":"B97","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41419-023-05898-7","article-title":"Neutrophil extracellular traps aggravate neuronal endoplasmic reticulum stress and apoptosis via TLR9 after traumatic brain injury.","volume":"14","author":"Mi","year":"2023","journal-title":"Cell Death Dis."},{"key":"B98","doi-asserted-by":"publisher","first-page":"e0799252026","DOI":"10.1523\/JNEUROSCI.0799-25.2026","article-title":"Extracellular HSPA5\/Grp78\/BiP, acting through its receptor plexin-B3 and Nkx2.8, regulates oligodendrocyte myelination in mice.","volume":"46","author":"Miyamoto","year":"2026","journal-title":"J. Neurosci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1560980","DOI":"10.3389\/ftox.2025.1560980","article-title":"Promising protective potential of MiR-103a-3p against polystyrene microplastic neurotoxicity in rats.","volume":"7","author":"Mohammadi","year":"2025","journal-title":"Front. Toxicol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3390\/genes13050801","article-title":"Proteomic profiling and pathway analysis of acid stress-induced vasorelaxation of mesenteric arteries in vitro.","volume":"13","author":"Mohanty","year":"2022","journal-title":"Genes"},{"key":"B101","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3390\/biomedicines10050975","article-title":"Incorporation of oxidized phenylalanine derivatives into insulin signaling relevant proteins may link oxidative stress to signaling conditions underlying chronic insulin resistance.","volume":"10","author":"Moh\u00e1s-Cseh","year":"2022","journal-title":"Biomedicines"},{"key":"B102","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson\u2019s disease.","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"B103","doi-asserted-by":"publisher","first-page":"101493","DOI":"10.1016\/j.isci.2020.101493","article-title":"HRD complex self-remodeling enables a novel route of membrane protein retrotranslocation.","volume":"23","author":"Neal","year":"2020","journal-title":"iScience"},{"key":"B104","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/toxics13020114","article-title":"Epigenetic biomarkers driven by environmental toxins associated with Alzheimer\u2019s disease, Parkinson\u2019s disease, and amyotrophic lateral sclerosis in the united states: A systematic review.","volume":"13","author":"Newell","year":"2025","journal-title":"Toxics"},{"key":"B105","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.redox.2014.01.017","article-title":"Molecular chaperones and proteostasis regulation during redox imbalance.","volume":"2","author":"Niforou","year":"2014","journal-title":"Redox Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"6604","DOI":"10.3390\/ijms22126604","article-title":"Erythrocytes as a model for heavy metal-related vascular dysfunction: The protective effect of dietary components.","volume":"22","author":"Notariale","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"8655","DOI":"10.1038\/s41598-021-87944-y","article-title":"Homeostasis of the ER redox state subsequent to proteasome inhibition.","volume":"11","author":"Oku","year":"2021","journal-title":"Sci. Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.123.323617","article-title":"Heavy metal exposure and cardiovascular disease.","volume":"134","author":"Pan","year":"2024","journal-title":"Circ. Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.3390\/ijms25073951","article-title":"Intranasal administration of GRP78 protein (HSPA5) confers neuroprotection in a lactacystin-induced rat model of Parkinson\u2019s disease.","volume":"25","author":"Pazi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3390\/biom14081021","article-title":"The multifaceted impact of environmental pollutants on health and ecosystems.","volume":"14","author":"Piscopo","year":"2024","journal-title":"Biomolecules"},{"key":"B111","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12989-020-00358-y","article-title":"The plastic brain: Neurotoxicity of micro- and nanoplastics.","volume":"17","author":"Pr\u00fcst","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.3390\/cells10112965","article-title":"The unfolded protein response as a guardian of the secretory pathway.","volume":"10","author":"Radanovi\u0107","year":"2021","journal-title":"Cells"},{"key":"B113","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12011-019-01903-3","article-title":"Endoplasmic reticulum stress induced by toxic elements-a review of recent developments.","volume":"196","author":"Rana","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1152\/physrev.00038.2021","article-title":"ER-phagy: Mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum.","volume":"102","author":"Reggiori","year":"2022","journal-title":"Physiol. Rev."},{"key":"B115","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41435-023-00205-y","article-title":"Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease.","volume":"24","author":"Rehati","year":"2023","journal-title":"Genes Immun."},{"key":"B116","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11910-024-01345-y","article-title":"Huntington\u2019s disease: Latest frontiers in therapeutics.","volume":"24","author":"Saade","year":"2024","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B117","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10495-022-01806-0","article-title":"Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: Adding new paradigms to the links with diseases.","volume":"28","author":"Sahoo","year":"2023","journal-title":"Apoptosis"},{"key":"B118","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jare.2022.10.013","article-title":"Gut microbiome and Parkinson\u2019s disease: Perspective on pathogenesis and treatment.","volume":"50","author":"Salim","year":"2023","journal-title":"J. Adv. Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1158\/0008-5472.CAN-20-1540","article-title":"The hydroxyquinoline analogue YUM70 inhibits GRP78 to induce er stress-mediated apoptosis in pancreatic cancer.","volume":"81","author":"Samanta","year":"2021","journal-title":"Cancer Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer\u2019s disease.","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"B121","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3390\/cells9040890","article-title":"Overexpression of Grp78\/BiP in P-glycoprotein-positive L1210 cells is responsible for altered response of cells to tunicamycin as a stressor of the endoplasmic reticulum.","volume":"9","author":"\u0160ere\u0161","year":"2020","journal-title":"Cells"},{"key":"B122","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3390\/biom11030354","article-title":"Perk pathway and neurodegenerative disease: To inhibit or to activate?","volume":"11","author":"Shacham","year":"2021","journal-title":"Biomolecules"},{"key":"B123","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s10815-024-03056-2","article-title":"Association between blood lead levels and unfavorable IVF outcomes: Potential involvement of endoplasmic reticulum stress response in granulosa cells.","volume":"41","author":"Shan","year":"2024","journal-title":"J. Assist Reprod. Genet."},{"key":"B124","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3390\/cells12050818","article-title":"Intermittent lead exposure induces behavioral and cardiovascular alterations associated with neuroinflammation.","volume":"12","author":"Shvachiy","year":"","journal-title":"Cells"},{"key":"B125","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1089\/ars.2022.0076","article-title":"Uncovering the molecular link between lead toxicity and Parkinson\u2019s disease.","volume":"39","author":"Shvachiy","year":"","journal-title":"Antioxid. Redox Signal."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.3390\/ijms26041748","article-title":"Impact of Benzo(a)pyrene and pyrene exposure on activating autophagy and correlation with endoplasmic reticulum stress in human astrocytes.","volume":"26","author":"Siangcham","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1002\/jcp.31134","article-title":"Pirh2 modulates amyloid-\u03b2 aggregation through the regulation of glucose-regulated protein 78 and chaperone-mediated signaling.","volume":"238","author":"Singh","year":"2023","journal-title":"J. Cell Physiol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.3390\/ijms25084209","article-title":"Heat shock response and heat shock proteins: Current understanding and future opportunities in human diseases.","volume":"25","author":"Singh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"148742","DOI":"10.1016\/j.brainres.2023.148742","article-title":"Endoplasmic reticulum stress and its role in various neurodegenerative diseases.","volume":"1826","author":"Singh","year":"2024","journal-title":"Brain Res."},{"key":"B130","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1080\/00207454.2021.1968859","article-title":"Protein misfolding, ER stress and chaperones: An approach to develop chaperone-based therapeutics for Alzheimer\u2019s disease.","volume":"133","author":"Singh","year":"2023","journal-title":"Int. J. Neurosci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"e3001474","DOI":"10.1371\/journal.pbio.3001474","article-title":"A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.","volume":"19","author":"Smith","year":"2021","journal-title":"PLoS Biol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"4841","DOI":"10.1038\/s41598-020-61146-4","article-title":"Microplastics generated when opening plastic packaging.","volume":"10","author":"Sobhani","year":"2020","journal-title":"Sci. Rep."},{"key":"B133","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S1474-4422(22)00121-1","article-title":"Potential disease-modifying therapies for Huntington\u2019s disease: Lessons learned and future opportunities.","volume":"21","author":"Tabrizi","year":"2022","journal-title":"Lancet Neurol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"108394","DOI":"10.1016\/j.reprotox.2023.108394","article-title":"Developmental exposure to polycyclic aromatic hydrocarbons (Pahs): Focus on benzo[a]pyrene neurotoxicity.","volume":"119","author":"Tartaglione","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/jnc.15154","article-title":"The multi-faceted role of mitochondria in the pathology of Parkinson\u2019s disease.","volume":"156","author":"Trinh","year":"2021","journal-title":"J. Neurochem."},{"key":"B136","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s40478-022-01421-9","article-title":"Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: Evidence for multifaceted pathways underlying neurodegeneration.","volume":"10","author":"Trist","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"B137","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12974-022-02437-7","article-title":"Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia\/microglia-like transcriptional response.","volume":"19","author":"Uyar","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41435-022-00192-6","article-title":"Gene-environment interactions and their impact on human health.","volume":"24","author":"Virolainen","year":"2023","journal-title":"Genes Immun."},{"key":"B139","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12989-025-00647-4","article-title":"A systematic review of the potential neurotoxicity of micro-and nanoplastics: The known and unknown.","volume":"22","author":"Vojnits","year":"2025","journal-title":"Part Fibre Toxicol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/ijms24010823","article-title":"Chaperone-Dependent mechanisms as a pharmacological target for neuroprotection.","volume":"24","author":"Voronin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.semcancer.2021.04.004","article-title":"Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis.","volume":"76","author":"Wadgaonkar","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"114863","DOI":"10.1016\/j.expneurol.2024.114863","article-title":"IL-17A exacerbates caspase-12-dependent neuronal apoptosis following ischemia through the Src-PLC\u03b3-calpain pathway.","volume":"379","author":"Wang","year":"2024","journal-title":"Exp. Neurol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"126788","DOI":"10.1016\/j.chemosphere.2020.126788","article-title":"Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells.","volume":"254","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.7150\/ijbs.12657","article-title":"Activation of ER stress and autophagy induced by TDP-43 A315T as pathogenic mechanism and the corresponding histological changes in skin as potential biomarker for ALS with the mutation.","volume":"11","author":"Wang","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"154219","DOI":"10.1016\/j.tox.2025.154219","article-title":"Revealing toxic secrets: How PAHs accelerate cellular ageing and trigger human diseases.","volume":"517","author":"Wang","year":"2025","journal-title":"Toxicology"},{"key":"B146","doi-asserted-by":"publisher","first-page":"e13558","DOI":"10.1111\/acel.13558","article-title":"Aging alters the metabolic flux signature of the ER-unfolded protein response in vivo in mice.","volume":"21","author":"Ward","year":"2022","journal-title":"Aging Cell"},{"key":"B147","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/j.molcel.2022.03.025","article-title":"Reshaping endoplasmic reticulum quality control through the unfolded protein response.","volume":"82","author":"Wiseman","year":"2022","journal-title":"Mol. Cell"},{"key":"B148","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1038\/s41598-020-59237-3","article-title":"Endoplasmic reticulum stress promotes inflammation-mediated proteolytic activity at the ocular surface.","volume":"10","author":"Woodward","year":"2020","journal-title":"Sci. Rep."},{"key":"B149","doi-asserted-by":"publisher","first-page":"108664","DOI":"10.1016\/j.reprotox.2024.108664","article-title":"Integrated transcriptome and metabolomic analyses uncover the mechanism of cadmium-caused mouse spermatogonia apoptosis via inducing endoplasmic reticulum stress.","volume":"129","author":"Wu","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"169260","DOI":"10.1016\/j.scitotenv.2023.169260","article-title":"Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress.","volume":"912","author":"Wu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"B151","doi-asserted-by":"publisher","first-page":"87009","DOI":"10.1289\/EHP10602","article-title":"Associations of heavy metals with activities of daily living disability: An epigenome-wide view of DNA methylation and mediation analysis.","volume":"130","author":"Xiao","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"B152","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.3390\/ijms24043964","article-title":"Biochemical characterization and functional analysis of glucose regulated protein 78 from the Silkworm Bombyx mori.","volume":"24","author":"Xiao","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s40360-025-01024-9","article-title":"Multi-omics-based decoding of circulating biomarkers in amyotrophic lateral sclerosis and risks in environmental toxins.","volume":"26","author":"Xu","year":"2025","journal-title":"BMC Pharmacol. Toxicol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"109975","DOI":"10.1016\/j.cbpc.2024.109975","article-title":"PAHs as environmental pollutants and their neurotoxic effects.","volume":"283","author":"Xu","year":"2024","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"877265","DOI":"10.3389\/fcimb.2022.877265","article-title":"Induction of endoplasmic reticulum stress by CdhM mediates apoptosis of macrophage during mycobacterium tuberculosis infection.","volume":"12","author":"Xu","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"684526","DOI":"10.3389\/fcell.2021.684526","article-title":"ER-Phagy: A new regulator of ER homeostasis.","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"880167","DOI":"10.3389\/fnagi.2022.880167","article-title":"Deciphering the link between ERUPR signaling and MicroRNA in pathogenesis of Alzheimer\u2019s disease.","volume":"14","author":"Yasmeen","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B158","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev-pathmechdis-031521-034145","article-title":"Genetics and pathogenesis of Parkinson\u2019s syndrome.","volume":"18","author":"Ye","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.3390\/ijms24032381","article-title":"Melatonin can modulate neurodegenerative diseases by regulating endoplasmic reticulum stress.","volume":"24","author":"Yoo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"152962","DOI":"10.1016\/j.tox.2021.152962","article-title":"Enhanced GRP78 protein expression via the IRE1\u03b1\/ASK1\/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells.","volume":"462","author":"Yuan","year":"2021","journal-title":"Toxicology"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/s41419-022-05444-x","article-title":"Endoplasmic reticulum stress-mediated cell death in liver injury.","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"B162","doi-asserted-by":"publisher","first-page":"e16844","DOI":"10.7717\/peerj.16844","article-title":"Azoramide ameliorates cadmium-induced cytotoxicity by inhibiting endoplasmic reticulum stress and suppressing oxidative stress.","volume":"12","author":"Zhang","year":"2024","journal-title":"PeerJ"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1002\/tox.23524","article-title":"Endoplasmic reticulum stress regulates pyroptosis in BPDE-induced BEAS-2B cells.","volume":"37","author":"Zhang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"947789","DOI":"10.3389\/fimmu.2022.947789","article-title":"Heat shock proteins and viral infection.","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"168946","DOI":"10.1016\/j.scitotenv.2023.168946","article-title":"The potential toxicity of microplastics on human health.","volume":"912","author":"Zhao","year":"2024","journal-title":"Sci. Total Environ."},{"key":"B166","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.18632\/aging.203930","article-title":"Human endothelial cells promote arsenic-transformed lung epithelial cells to induce tumor growth and angiogenesis through interleukin-8 induction.","volume":"14","author":"Zhao","year":"2022","journal-title":"Aging"},{"key":"B167","doi-asserted-by":"publisher","first-page":"117985","DOI":"10.1016\/j.ecoenv.2025.117985","article-title":"Polystyrene microplastics impaired the function of leydig cells via GRP78\/PERK\/CHOP mediated endoplasmic reticulum stress in vivo and in vitro.","volume":"292","author":"Zhao","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B168","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-023-09893-2","article-title":"Single-cell and transcriptomic analyses reveal the influence of diabetes on ovarian cancer.","volume":"25","author":"Zhao","year":"2024","journal-title":"BMC Genom."},{"key":"B169","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer\u2019s disease: Insights into pathology, molecular mechanisms, and therapy.","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein Cell"},{"key":"B170","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13045-024-01601-1","article-title":"Heat shock proteins as hallmarks of cancer: Insights from molecular mechanisms to therapeutic strategies.","volume":"17","author":"Zuo","year":"2024","journal-title":"J. Hematol. Oncol."}],"container-title":["Frontiers in Molecular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2026.1964213\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:26:53Z","timestamp":1789986413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2026.1964213\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":170,"alternative-id":["10.3389\/fnmol.2026.1964213"],"URL":"https:\/\/doi.org\/10.3389\/fnmol.2026.1964213","relation":{},"ISSN":["1662-5099"],"issn-type":[{"value":"1662-5099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"article-number":"1964213"}}