{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:53:21Z","timestamp":1791194001573,"version":"4.1.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Neurosci."],"abstract":"<jats:p>Chronic low back pain arises from heterogeneous peripheral and central mechanisms, yet the sensory biology of individual lumbar tissues is rarely considered within a unified framework. This Mini Review compares peripheral sensory remodeling and sensitization across four candidate nociceptive niches: the intervertebral disc, vertebral endplate, thoracolumbar fascia, and paraspinal muscle. Disc pathology is characterized by nociceptive ingrowth, endplate pathology by osteochondral sensory remodeling and afferent sensitization, and thoracolumbar fascia by inflammation-associated remodeling of a pre-existing sensory network. Paraspinal muscle remains an emerging sensory\u2013inflammatory niche in which muscle-spindle remodeling is distinct from unproven nociceptor remodeling. Across tissues, recurrent neurotrophic, inflammatory, neuropeptide, and mechanosensory mediators indicate molecular overlap but do not establish functional convergence within common sensory circuits. Dorsal root ganglia and the spinal dorsal horn are therefore considered candidate sites of downstream integration. We propose a dynamic multi-niche model with testable predictions for identifying active niches, tracking shifts in tissue contribution, and distinguishing causal nociceptive mechanisms from incidental degeneration. Future spatial, longitudinal, and epigenomic studies may enable molecular definition of active pain-generating states and mechanism-guided treatment.<\/jats:p>","DOI":"10.3389\/fnmol.2026.1972635","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:12:28Z","timestamp":1791191548000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tissue-specific peripheral sensory remodeling in chronic low back pain: established and emerging nociceptive niches"],"prefix":"10.3389","volume":"19","author":[{"given":"Yizhuan","family":"Huang","sequence":"first","affiliation":[{"name":"Affiliated Sports Hospital of Chengdu Sport University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Sports Hospital of Chengdu Sport University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1186\/s12891-022-05572-7","article-title":"Paraspinal muscle health is related to fibrogenic, adipogenic, and myogenic gene expression in patients with lumbar spine pathology","volume":"23","author":"Anderson","year":"2022","journal-title":"BMC Musculoskelet. 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(Basel)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.spinee.2013.06.075","article-title":"Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc","volume":"14","author":"Fields","year":"2014","journal-title":"Spine J."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1097\/j.pain.0000000000003508","article-title":"Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes","volume":"166","author":"Franco-Enz\u00e1stiga","year":"2025","journal-title":"Pain"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0140-6736(97)02135-1","article-title":"Nerve ingrowth into diseased intervertebral disc in chronic back pain","volume":"350","author":"Freemont","year":"1997","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/path.1108","article-title":"Nerve growth factor expression and innervation of the painful intervertebral disc","volume":"197","author":"Freemont","year":"2002","journal-title":"J. Pathol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/ejp.563","article-title":"Inflammation of the thoracolumbar fascia excites and sensitizes rat dorsal horn neurons","volume":"19","author":"Hoheisel","year":"2015","journal-title":"Eur. J. Pain"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.neuroscience.2015.05.034","article-title":"Innervation changes induced by inflammation of the rat thoracolumbar fascia","volume":"300","author":"Hoheisel","year":"2015","journal-title":"Neuroscience"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"962155","DOI":"10.3389\/fbioe.2022.962155","article-title":"Inhibition of angiogenetic macrophages reduces disc degeneration-associated pain","volume":"10","author":"Hou","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1007\/s00586-025-08646-x","article-title":"ISSLS prize in basic science 2025: structural changes of muscle spindles in the multifidus muscle after intervertebral disk injury are resolved by targeted activation of the muscle","volume":"34","author":"James","year":"2025","journal-title":"Eur. Spine J."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1007\/s00586-022-07235-6","article-title":"Muscle spindles of the multifidus muscle undergo structural change after intervertebral disc degeneration","volume":"31","author":"James","year":"2022","journal-title":"Eur. Spine J."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.3390\/ijms24043425","article-title":"Spinal cord sensitization and spinal inflammation from an in vivo rat endplate injury associated with painful intervertebral disc degeneration","volume":"24","author":"Lai","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.spinee.2024.04.002","article-title":"Intervertebral disc injury triggers neurogenic inflammation of adjacent healthy discs","volume":"24","author":"Li","year":"2024","journal-title":"Spine J."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"9965737","DOI":"10.1155\/2021\/9965737","article-title":"TRPV1 channel activated by the PGE2\/EP4 pathway mediates spinal hypersensitivity in a mouse model of vertebral endplate degeneration","volume":"2021","author":"Liu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1038\/s41467-019-13476-9","article-title":"Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice","volume":"10","author":"Ni","year":"2019","journal-title":"Nat. Commun."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e178","DOI":"10.1016\/S2665-9913(23)00324-7","article-title":"Nociceptive, neuropathic, or nociplastic low back pain? The low back pain phenotyping (BACPAP) consortium's international and multidisciplinary consensus recommendations","volume":"6","author":"Nijs","year":"2024","journal-title":"Lancet Rheumatol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"31927","DOI":"10.1038\/s41598-024-83373-9","article-title":"Microscopic changes in the multifidus muscle in people with low back pain associated with lumbar disc herniation","volume":"14","author":"Purushotham","year":"2024","journal-title":"Sci. Rep."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.pain.2013.09.025","article-title":"Sensory findings after stimulation of the thoracolumbar fascia with hypertonic saline suggest its contribution to low back pain","volume":"155","author":"Schilder","year":"2014","journal-title":"Pain"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1097\/j.pain.0000000000000649","article-title":"Electrical high-frequency stimulation of the human thoracolumbar fascia evokes long-term potentiation-like pain amplification","volume":"157","author":"Schilder","year":"2016","journal-title":"Pain"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1002\/jor.23597","article-title":"Lumbar multifidus muscle degenerates in individuals with chronic degenerative lumbar spine pathology","volume":"35","author":"Shahidi","year":"2017","journal-title":"J. Orthop. Res."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"eabj8186","DOI":"10.1126\/scitranslmed.abj8186","article-title":"Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors","volume":"14","author":"Tavares-Ferreira","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.neuroscience.2011.07.066","article-title":"Sensory innervation of the thoracolumbar fascia in rats and humans","volume":"194","author":"Tesarz","year":"2011","journal-title":"Neuroscience"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/life12030340","article-title":"Dose-dependent pain and pain radiation after chemical stimulation of the thoracolumbar fascia and multifidus muscle: a single-blinded, cross-over study revealing a higher impact of fascia stimulation","volume":"12","author":"Vogel","year":"2022","journal-title":"Life (Basel)"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41368-026-00428-5","article-title":"ANKRD1 sustains a neurogenic BMSC niche and counters cognitive aging","volume":"18","author":"Wang","year":"2026","journal-title":"Int. J. Oral Sci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1097\/j.pain.0000000000003706","article-title":"Spinal disk injury induces germinal center formation, pronociceptive antibody production, and chronic nociceptive sensitization in a male mouse back pain model","volume":"166","author":"Wei","year":"2025","journal-title":"Pain"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e07299","DOI":"10.1002\/advs.202507299","article-title":"Piezo2 mediates a vicious cycle of \u201cmechanical homeostasis imbalance\u2013inflammation\u201d in sensory nerves and the cartilage endplate","volume":"13","author":"Xu","year":"2026","journal-title":"Adv. Sci. 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