{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:50:33Z","timestamp":1790769033042,"version":"4.1.0"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Synaptic Neurosci."],"DOI":"10.3389\/fnsyn.2019.00003","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T23:41:39Z","timestamp":1550706099000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model"],"prefix":"10.3389","volume":"11","author":[{"given":"Rujun","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun S.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1126\/science.1072873","article-title":"Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions.","volume":"298","author":"Aarts","year":"2002","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nchembio.579","article-title":"Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.","volume":"7","author":"Adibekian","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10048-004-0198-8","article-title":"NR2A and NR2B receptor gene variations modify age at onset in Huntington disease.","volume":"6","author":"Arning","year":"2005","journal-title":"Neurogenetics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00439-007-0393-4","article-title":"NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner.","volume":"122","author":"Arning","year":"2007","journal-title":"Hum. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0143-4160(03)00141-6","article-title":"Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity.","volume":"34","author":"Arundine","year":"2003","journal-title":"Cell Calcium"},{"key":"B6","doi-asserted-by":"publisher","first-page":"20941","DOI":"10.1073\/pnas.1011663107","article-title":"Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening.","volume":"107","author":"Bachovchin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1523\/JNEUROSCI.11-06-01649.1991","article-title":"Chronic quinolinic acid lesions in rats closely resemble Huntington\u2019s disease.","volume":"11","author":"Beal","year":"1991","journal-title":"J. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/currents.hd.34957c4f8bd7cb1f5ec47381dfc811c3","article-title":"Differential synaptic and extrasynaptic glutamate-receptor alterations in striatal medium-sized spiny neurons of aged YAC128 Huntington\u2019s disease mice.","volume":"6","author":"Botelho","year":"2014","journal-title":"PLoS Curr. Huntingt. Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/jnr.490350513","article-title":"Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination.","volume":"35","author":"Brewer","year":"1993","journal-title":"J. Neurosci. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1038\/mt.2011.201","article-title":"Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the huntington disease gene \/ allele-specific silencing of mutant huntingtin.","volume":"19","author":"Carroll","year":"2011","journal-title":"Mol. Ther."},{"key":"B11","doi-asserted-by":"publisher","first-page":"12725","DOI":"10.1523\/JNEUROSCI.4619-08.2008","article-title":"Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.","volume":"28","author":"Cowan","year":"2008","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.nbd.2013.11.013","article-title":"Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice.","volume":"62","author":"Dau","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"276","DOI":"10.2144\/04362RR02","article-title":"Labeling and quantifying sites of protein palmitoylation.","volume":"36","author":"Drisdel","year":"2004","journal-title":"Biotechniques"},{"key":"B14","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/nrn940","article-title":"Protein palmitoylation: a regulator of neuronal development and function.","volume":"3","author":"El-Husseini","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.nbd.2011.12.019","article-title":"P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease.","volume":"45","author":"Fan","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1523\/JNEUROSCI.4356-06.2007","article-title":"Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington\u2019s disease.","volume":"27","author":"Fan","year":"2007","journal-title":"J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.pneurobio.2006.11.003","article-title":"N-Methyl-d-aspartate (n.d.) receptor function and excitotoxicity in Huntington\u2019s disease.","volume":"81","author":"Fan","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1471-4159.2007.05016.x","article-title":"Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.","volume":"104","author":"Fan","year":"2008","journal-title":"J. Neurochem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.neuron.2004.12.005","article-title":"Identification of PSD-95 palmitoylating enzymes.","volume":"44","author":"Fukata","year":"2004","journal-title":"Neuron"},{"key":"B20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1042\/BST20140238","article-title":"Postsynaptic nanodomains generated by local palmitoylation cycles.","volume":"43","author":"Fukata","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"B21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1083\/jcb.201302071","article-title":"Local palmitoylation cycles define activity-regulated postsynaptic subdomains.","volume":"202","author":"Fukata","year":"2013","journal-title":"J. Cell Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrn2788","article-title":"Protein palmitoylation in neuronal development and synaptic plasticity.","volume":"11","author":"Fukata","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/jnc.12700","article-title":"Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington\u2019s disease mouse model.","volume":"130","author":"Gladding","year":"2014","journal-title":"J. Neurochem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1093\/hmg\/dds154","article-title":"Calpain and STriatal-Enriched protein tyrosine Phosphatase ( STEP ) activation contribute to extrasynaptic NMDA receptor localization in a Huntington \u2019 s disease mouse model.","volume":"21","author":"Gladding","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1523\/JNEUROSCI.5473-08.2009","article-title":"Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.","volume":"29","author":"Graham","year":"2009","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S1570-9639(02)00455-7","article-title":"Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated.","volume":"1600","author":"Hardingham","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"B27","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nrn2911","article-title":"Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.","volume":"11","author":"Hardingham","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.neuron.2005.06.035","article-title":"Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.","volume":"47","author":"Hayashi","year":"2005","journal-title":"Neuron"},{"key":"B30","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.neuron.2009.08.017","article-title":"Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking.","volume":"64","author":"Hayashi","year":"2009","journal-title":"Neuron"},{"key":"B31","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.conb.2005.08.001","article-title":"Modulation of neuronal protein trafficking and function by palmitoylation.","volume":"15","author":"Huang","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1096\/fj.08-127399","article-title":"Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.","volume":"23","author":"Huang","year":"2009","journal-title":"FASEB J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1093\/hmg\/ddr242","article-title":"Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.","volume":"20","author":"Huang","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.neuron.2004.11.027","article-title":"Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.","volume":"44","author":"Huang","year":"2004","journal-title":"Neuron"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.clinph.2007.01.021","article-title":"The after-effect of human theta burst stimulation is NMDA receptor dependent.","volume":"118","author":"Huang","year":"2007","journal-title":"Clin. Neurophysiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1074\/jbc.274.1.151","article-title":"Turnover analysis of glutamate receptors identifies a rapidly degraded pool of the N -Methyl- D -aspartate receptor subunit. NR1, in cultured cerebellar granule cells.","volume":"274","author":"Huh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1113\/jphysiol.2006.105510","article-title":"Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons.","volume":"572","author":"Ivanov","year":"2006","journal-title":"J. Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1523\/JNEUROSCI.5687-08.2009","article-title":"Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of huntington disease.","volume":"29","author":"Joshi","year":"2009","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"50524","DOI":"10.1074\/jbc.M404981200","article-title":"Presynaptic trafficking of synaptotagmin I is regulated by protein palmitoylation.","volume":"279","author":"Kang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/nature07605","article-title":"Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.","volume":"456","author":"Kang","year":"2008","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"3992","DOI":"10.1523\/JNEUROSCI.4129-11.2012","article-title":"Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.","volume":"32","author":"Kaufman","year":"2012","journal-title":"J. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"21939","DOI":"10.1074\/jbc.M115.657668","article-title":"Identification of a novel sequence motif recognized by the ankyrin repeat domain of zDHHC17\/13 S-acyltransferases.","volume":"290","author":"Lemonidis","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1096\/fj.08-107268","article-title":"Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.","volume":"22","author":"Leveille","year":"2008","journal-title":"FASEB J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/(SICI)1097-4547(19991115)58:4<515::AID-JNR5>3.0.CO;2-F","article-title":"Enhanced sensitivity to N-Methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington \u2019 s disease.","volume":"532","author":"Levine","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1152\/jn.00308.2004","article-title":"Enhanced striatal NR2B-containing N-Methyl-D-Aspartate receptor-mediated synaptic currents in a mouse model of huntington disease.","volume":"92","author":"Li","year":"2004","journal-title":"J. Neurophysiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide that is expanded and unstable on Huntington \u2019 s disease chromosomes.","volume":"72","author":"Lin","year":"1993","journal-title":"Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.11306","article-title":"ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.","volume":"4","author":"Lin","year":"2015","journal-title":"Elife"},{"key":"B48","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1056\/NEJM199403033300907","article-title":"Excotatory amino acids as a final common pathway for neurologic disorders.","volume":"330","author":"Lipton","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","article-title":"Neurobiology of disease NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.","volume":"27","author":"Liu","year":"2007","journal-title":"J. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.conb.2011.09.001","article-title":"New development on the role of NMDA receptors in Alzheimer\u2019s Disease.","volume":"22","author":"Malinow","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.neuron.2012.03.021","article-title":"The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.","volume":"74","author":"Martel","year":"2012","journal-title":"Neuron"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049089","article-title":"Palmitoylation at two cysteine clusters on the C-Terminus of GluN2A and GluN2B differentially control synaptic targeting of NMDA receptors.","volume":"7","author":"Mattison","year":"2012","journal-title":"PLoS One"},{"key":"B53","doi-asserted-by":"publisher","first-page":"14318","DOI":"10.1523\/JNEUROSCI.1589-10.2010","article-title":"Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.","volume":"30","author":"Metzler","year":"2010","journal-title":"J. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2010.01.008","article-title":"Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington\u2019s disease mice.","volume":"65","author":"Milnerwood","year":"2010","journal-title":"Neuron"},{"key":"B55","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.nbd.2012.05.013","article-title":"Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington\u2019s disease mice.","volume":"48","author":"Milnerwood","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"20296","DOI":"10.1073\/pnas.1222384110","article-title":"Memory and synaptic deficits in Hip14\/DHHC17 knockout mice.","volume":"110","author":"Milnerwood","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1113\/jphysiol.2007.142448","article-title":"Corticostriatal synaptic function in mouse models of Huntington\u2019s disease: early effects of huntingtin repeat length and protein load.","volume":"585","author":"Milnerwood","year":"2007","journal-title":"J. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/nm.2056","article-title":"Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.","volume":"15","author":"Okamoto","year":"2009","journal-title":"Nat. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1136\/jnnp.2009.171926","article-title":"Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease.","volume":"81","author":"Orth","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1074\/jbc.M113.513945","article-title":"Bidirectional control of Postsynaptic Density-95 (PSD-95) clustering by Huntingtin.","volume":"289","author":"Parsons","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.neuron.2014.03.030","article-title":"Extrasynaptic NMDA receptor involvement in central nervous system disorders.","volume":"82","author":"Parsons","year":"2014","journal-title":"Neuron"},{"key":"B62","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2014.05.032","article-title":"Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington\u2019s disease.","volume":"83","author":"Plotkin","year":"2014","journal-title":"Neuron"},{"key":"B63","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.08.052","article-title":"Pathophysiology of Huntington\u2019s disease: Time-dependent alterations in synaptic and receptor function.","volume":"198","author":"Raymond","year":"2011","journal-title":"Neuroscience"},{"key":"B64","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1042\/BJ20110679","article-title":"Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington\u2019s disease.","volume":"442","author":"Rush","year":"2012","journal-title":"Biochem. J."},{"key":"B65","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1042\/BST20140242","article-title":"Aberrant palmitoylation in Huntington disease.","volume":"214","author":"Sanders","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090669","article-title":"Identification of binding sites in huntingtin for the huntingtin interacting proteins HIP14 and HIP14L.","volume":"9","author":"Sanders","year":"2014","journal-title":"PLoS One"},{"key":"B67","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.neuron.2010.08.011","article-title":"Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors.","volume":"67","author":"Sanz-Clemente","year":"2010","journal-title":"Neuron"},{"key":"B68","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1177\/1073858411435129","article-title":"Diversity in NMDA receptor composition: many regulators, many consequences.","volume":"19","author":"Sanz-Clemente","year":"2013","journal-title":"Neuroscientist"},{"key":"B69","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.neuron.2012.05.024","article-title":"Network organization of the huntingtin proteomic interactome in mammalian brain.","volume":"75","author":"Shirasaki","year":"2012","journal-title":"Neuron"},{"key":"B70","doi-asserted-by":"publisher","first-page":"11322","DOI":"10.1523\/JNEUROSCI.23-36-11322.2003","article-title":"Selective activation induced cleavage of the NR2B subunit by calpain.","volume":"23","author":"Simpkins","year":"2003","journal-title":"J. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1093\/hmg\/11.23.2815","article-title":"HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.","volume":"11","author":"Singaraja","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1093\/hmg\/ddr308","article-title":"Altered palmitoylation and neuropathological deficits in mice lacking HIP14.","volume":"20","author":"Singaraja","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/hmg\/dds441","article-title":"Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.","volume":"22","author":"Sutton","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B75","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1042\/BST20120223","article-title":"Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners.","volume":"41","author":"Thomas","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"B76","doi-asserted-by":"publisher","first-page":"23954","DOI":"10.1074\/jbc.M110.137802","article-title":"Multiple palmitoyltransferases are required for palmitoylation-dependent regulation of large conductance calcium- and voltage-activated potassium channels.","volume":"285","author":"Tian","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington Disease.","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1038\/nprot.2007.225","article-title":"Palmitoylated proteins: Purification and identification.","volume":"2","author":"Wan","year":"2007","journal-title":"Nat. Protoc."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/j.chembiol.2013.09.018","article-title":"Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington\u2019s disease.","volume":"20","author":"Wan","year":"2013","journal-title":"Chem. Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"11246","DOI":"10.1523\/JNEUROSCI.2488-10.2010","article-title":"Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses.","volume":"30","author":"Xia","year":"2010","journal-title":"J. Neurosci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.nbd.2009.08.012","article-title":"Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington\u2019s disease: role in excitotoxicity.","volume":"36","author":"Xifr\u00f3","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"B82","doi-asserted-by":"publisher","first-page":"9330","DOI":"10.1523\/JNEUROSCI.2212-09.2009","article-title":"Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP.","volume":"29","author":"Xu","year":"2009","journal-title":"J. Neurosci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/nn1702","article-title":"Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.","volume":"9","author":"Yanai","year":"2006","journal-title":"Nat. Neurosci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"6431","DOI":"10.1523\/JNEUROSCI.0419-16.2016","article-title":"Identification of PSD-95 depalmitoylating enzymes.","volume":"36","author":"Yokoi","year":"2016","journal-title":"J. Neurosci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1126\/science.2841762","article-title":"NMDA receptor losses in putamen from patients with Huntington \u2019 s Disease.","volume":"241","author":"Young","year":"1988","journal-title":"Science"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036315","article-title":"Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-\/- mice.","volume":"7","author":"Young","year":"2012","journal-title":"PLoS One"},{"key":"B87","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.mcn.2003.11.014","article-title":"Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington\u2019s disease.","volume":"25","author":"Zeron","year":"2004","journal-title":"Mol. Cell. Neurosci."}],"container-title":["Frontiers in Synaptic Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnsyn.2019.00003\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T19:45:31Z","timestamp":1720986331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnsyn.2019.00003\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,21]]},"references-count":87,"alternative-id":["10.3389\/fnsyn.2019.00003"],"URL":"https:\/\/doi.org\/10.3389\/fnsyn.2019.00003","relation":{},"ISSN":["1663-3563"],"issn-type":[{"value":"1663-3563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,21]]},"article-number":"3"}}