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Synaptic Neurosci."],"abstract":"<jats:p>This review summarizes our current knowledge of human disease-relevant genetic variants within the family of voltage gated Ca<jats:sup>2+<\/jats:sup> channels. Ca<jats:sup>2+<\/jats:sup> channelopathies cover a wide spectrum of diseases including epilepsies, autism spectrum disorders, intellectual disabilities, developmental delay, cerebellar ataxias and degeneration, severe cardiac arrhythmias, sudden cardiac death, eye disease and endocrine disorders such as congential hyperinsulinism and hyperaldosteronism. A special focus will be on the rapidly increasing number of <jats:italic>de novo<\/jats:italic> missense mutations identified in the pore-forming \u03b11-subunits with next generation sequencing studies of well-defined patient cohorts. In contrast to likely gene disrupting mutations these can not only cause a channel loss-of-function but can also induce typical functional changes permitting enhanced channel activity and Ca<jats:sup>2+<\/jats:sup> signaling. Such gain-of-function mutations could represent therapeutic targets for mutation-specific therapy of Ca<jats:sup>2+<\/jats:sup>-channelopathies with existing or novel Ca<jats:sup>2+<\/jats:sup>-channel inhibitors. Moreover, many pathogenic mutations affect positive charges in the voltage sensors with the potential to form gating-pore currents through voltage sensors. If confirmed in functional studies, specific blockers of gating-pore currents could also be of therapeutic interest.<\/jats:p>","DOI":"10.3389\/fnsyn.2021.634760","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T05:02:55Z","timestamp":1614747775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Voltage-Gated Ca2+-Channel \u03b11-Subunit de novo Missense Mutations: Gain or Loss of Function \u2013 Implications for Potential Therapies"],"prefix":"10.3389","volume":"13","author":[{"given":"J\u00f6rg","family":"Striessnig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s00424-020-02420-2","article-title":"Neuronal alpha2delta proteins and brain disorders.","volume":"472","author":"Ablinger","year":"2020","journal-title":"Pflugers. 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