{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:06:43Z","timestamp":1792145203674,"version":"4.4.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Synaptic Neurosci."],"abstract":"<jats:p>The GAIP interacting protein c terminus (<jats:italic>GIPC<\/jats:italic>) genes encode a small family of proteins characterized by centrally located PDZ domains. <jats:italic>GIPC3<\/jats:italic> encodes a 312 amino acid protein. Variants of human <jats:italic>GIPC3<\/jats:italic> are associated with non-syndromic hearing loss. <jats:italic>GIPC3<\/jats:italic> is one of over a hundred different genes with variants causing human deafness. Screening for variants of <jats:italic>GIPC3<\/jats:italic> is essential for early detection of hearing loss in children and eventually treatment of deafness. Accordingly, this paper assesses the status of research developments on the role of <jats:italic>GIPC3<\/jats:italic> in hereditary deafness and the effects of pathogenic variants on the auditory system.<\/jats:p>","DOI":"10.3389\/fnsyn.2022.1101587","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T23:40:53Z","timestamp":1673048453000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["A review of the mechanisms underlying the role of the GIPC3 gene in hereditary deafness"],"prefix":"10.3389","volume":"14","author":[{"given":"Xinxin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00439-007-0418-z","article-title":"The autosomal recessive nonsyndromic deafness locus DFNB72 is located on chromosome 19p13.3.","volume":"122","author":"Ain","year":"2007","journal-title":"Hum. 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