{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:00:09Z","timestamp":1777611609033,"version":"3.51.4"},"reference-count":42,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Syst. Neurosci."],"DOI":"10.3389\/fnsys.2014.00253","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T09:27:08Z","timestamp":1421746028000},"source":"Crossref","is-referenced-by-count":12,"title":["Acoustic input and efferent activity regulate the expression of molecules involved in cochlear micromechanics"],"prefix":"10.3389","volume":"8","author":[{"given":"Veronica","family":"Lamas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Ar\u00c3\u00a9valo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00c3\u00a9 M.","family":"Juiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Merch\u00c3\u00a1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(85)90242-2","article-title":"Immunocytochemical localization of choline acetyltransferase-like immunoreactivity in the guinea pig cochlea","volume":"338","author":"Altschuler","year":"1985","journal-title":"Brain Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1111\/j.1460-9568.2004.03797.x","article-title":"Regulation of the lateral wall stiffness by acetylcholine and GABA in the outer hair cells of the guinea pig","volume":"20","author":"Batta","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e66078","DOI":"10.1371\/journal.pone.0066078","article-title":"Real time measures of prestin charge and fluorescence during plasma membrane trafficking reveal sub-tetrameric activity","volume":"8","author":"Bian","year":"2013","journal-title":"PLoS One"},{"key":"B4","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1523\/JNEUROSCI.17-06-02212.1997","article-title":"Acetylcholine, outer hair cell electromotility and the cochlear amplifier","volume":"17","author":"Dallos","year":"1997","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/s0006-8993(01)03248-6","article-title":"The cellular origin of corticofugal projections to the superior olivary complex in the rat","volume":"925","author":"Doucet","year":"2002","journal-title":"Brain Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/cne.10722","article-title":"Axonal pathways to the lateral superior olive labeled with biotinylated dextran amine injections in the dorsal cochlear nucleus of rats","volume":"461","author":"Doucet","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.heares.2009.12.028","article-title":"Prestin and the cholinergic receptor of hair cells: positively-selected proteins in mammals","volume":"273","author":"Elgoyhen","year":"2011","journal-title":"Hear. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/0092-8674(94)90555-x","article-title":"\u00ce\u00b19: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells","volume":"79","author":"Elgoyhen","year":"1994","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1073\/pnas.051622798","article-title":"\u00ce\u00b110: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells","volume":"98","author":"Elgoyhen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1046\/j.1471-4159.1995.65031348.x","article-title":"Evidence for a Glutamatergic pathway from the Guinea Pig auditory cortex to the inferior Colliculus","volume":"65","author":"Feliciano","year":"1995","journal-title":"J. Neurochem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1007\/s10529-006-9127-2","article-title":"Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR","volume":"28","author":"Fleige","year":"2006","journal-title":"Biotechnol. Lett."},{"key":"B12","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1097\/01.aud.0000240507.83072.e7","article-title":"Olivocochlear efferents: anatomy, physiology, function and the measurement of efferent effects in humans","volume":"27","author":"Guinan","year":"2006","journal-title":"Ear. Hear."},{"key":"B13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1152\/jn.00728.2011","article-title":"Prestin in HEK cells is an obligate tetramer","volume":"107","author":"Hallworth","year":"2012","journal-title":"J. Neurophysiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"8223","DOI":"10.1073\/pnas.96.14.8223","article-title":"Somatic stiffness of cochlear outer hair cells is voltage-dependent","volume":"96","author":"He","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s101620010006","article-title":"Properties of voltage-dependent somatic stiffness of cochlear outer hair cells","volume":"1","author":"He","year":"2000","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.heares.2013.12.002","article-title":"Prestin at year 14: progress and prospect","volume":"311","author":"He","year":"2014","journal-title":"Hear. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"28000","DOI":"10.1074\/jbc.M004917200","article-title":"Rho GTPases mediate the regulation of cochlear outer hair cell motility by acetylcholine","volume":"275","author":"Kalinec","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e73585","DOI":"10.1371\/journal.pone.0073585","article-title":"Long-term evolution of brainstem electrical evoked responses to sound after restricted ablation of the auditory cortex","volume":"8","author":"Lamas","year":"2013","journal-title":"PLoS One"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e36203","DOI":"10.1371\/journal.pone.0036203","article-title":"Auditory cortex basal activity modulates cochlear responses in chinchillas","volume":"7","author":"Le\u00c3\u00b3n","year":"2012","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B21","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1002\/cne.10490","article-title":"Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions and transmitter colocalization","volume":"455","author":"Maison","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"B22","doi-asserted-by":"crossref","first-page":"10838","DOI":"10.1523\/JNEUROSCI.22-24-10838.2002","article-title":"Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells","volume":"22","author":"Maison","year":"2002","journal-title":"J. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1152\/jn.00067.2007","article-title":"A novel effect of cochlear efferents: in vivo response enhancement does not require \u00ce\u00b19 cholinergic receptors","volume":"97","author":"Maison","year":"2007","journal-title":"J. Neurophysiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1111\/j.1471-4159.2004.02377.x","article-title":"N-linked glycosylation sites of the motor protein prestin: effects on membrane targeting and electrophysiological function","volume":"89","author":"Matsuda","year":"2004","journal-title":"J. Neurochem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1016\/j.bpj.2010.08.015","article-title":"Pivotal role of actin depolymerization in the regulation of cochlear outer hair cell motility","volume":"99","author":"Matsumoto","year":"2010","journal-title":"Biophys. J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.heares.2007.05.008","article-title":"Up-regulation of prestin mRNA expression in the organs of Corti of guinea pigs and rats following unilateral impulse noise exposure","volume":"231","author":"Mazurek","year":"2007","journal-title":"Hear. Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1074\/jbc.m702681200","article-title":"The motor protein prestin is a bullet-shaped molecule with inner cavities","volume":"283","author":"Mio","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/s0378-5955(00)00046-0","article-title":"Evidence for direct cortical innervation of medial olivocochlear neurones in rats","volume":"144","author":"Mulders","year":"2000","journal-title":"Hear. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"B30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.heares.2004.08.003","article-title":"Auditory cortical projections to the cochlear nucleus in guinea pigs","volume":"199","author":"Schofield","year":"2005","journal-title":"Hear. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.1152\/jn.00401.2005","article-title":"Responses of ventral cochlear nucleus neurons to contralateral sound after conductive hearing loss","volume":"94","author":"Sumner","year":"2005","journal-title":"J. Neurophysiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3109\/00016489309135818","article-title":"Acetylcholine controls the gain of the voltage-to-movement converter in isolated outer hair cells","volume":"113","author":"Sziklai","year":"1993","journal-title":"Acta Otolaryngol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0378-5955(96)00026-3","article-title":"Effect of acetylcholine and GABA on the transfer function of electromotility in isolated outer hair cells","volume":"95","author":"Sziklai","year":"1996","journal-title":"Hear. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/000164801300043280","article-title":"Phosphorylation mediates the influence of acetylcholine upon outer hair cell electromotility","volume":"121","author":"Sziklai","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/syn.890070104","article-title":"Chemically distinct rat olivocochlear neurons","volume":"7","author":"Vetter","year":"1991","journal-title":"Synapse"},{"key":"B36","doi-asserted-by":"publisher","first-page":"20594","DOI":"10.1073\/pnas.0708545105","article-title":"The \u00ce\u00b110 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system","volume":"104","author":"Vetter","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B37","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/cne.901610203","article-title":"Olivocochlear and vestibular efferent neurons of the feline brain stem: their location, morphology and number determined by retrograde axonal transport and acetylcholinesterase histochemistry","volume":"161","author":"Warr","year":"1975","journal-title":"J. Comp. Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e82602","DOI":"10.1371\/journal.pone.0082602","article-title":"Prestin regulation and function in residual outer hair cells after noise-induced hearing loss","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"B39","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1080\/14992020802327998","article-title":"Long-term administration of salicylate enhances prestin expression in rat cochlea","volume":"48","author":"Yang","year":"2009","journal-title":"Int. J. Audiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1600-0854.2010.01156.x","article-title":"Regulation of trafficking of activated TrkA is critical for NGF-mediated functions","volume":"12","author":"Yu","year":"2011","journal-title":"Traffic"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1007\/s00018-008-8195-y","article-title":"Prestin up-regulation in chronic salicylate (aspirin) administration: an implication of functional dependence of prestin expression","volume":"65","author":"Yu","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"19916","DOI":"10.1074\/jbc.m513854200","article-title":"Analysis of the oligomeric structure of the motor protein prestin","volume":"281","author":"Zheng","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Frontiers in Systems Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T18:18:26Z","timestamp":1566238706000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnsys.2014.00253\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,20]]},"references-count":42,"URL":"https:\/\/doi.org\/10.3389\/fnsys.2014.00253","relation":{},"ISSN":["1662-5137"],"issn-type":[{"value":"1662-5137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,20]]}}}