{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:39:23Z","timestamp":1778942363878,"version":"3.51.4"},"reference-count":64,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["PCIG13-GA-2013-630662"],"award-info":[{"award-number":["PCIG13-GA-2013-630662"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["154\/14"],"award-info":[{"award-number":["154\/14"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["646880-SynChI"],"award-info":[{"award-number":["646880-SynChI"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001739","name":"National Institute for Psychobiology in Israel, Hebrew University of Jerusalem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Neurosci."],"DOI":"10.3389\/fnsys.2016.00102","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T11:10:26Z","timestamp":1482145826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington\u2019s Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Asami","family":"Tanimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean Austin O.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose de Jesus","family":"Aceves Buendia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. James","family":"Surmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrd2069","article-title":"Ranolazine","volume":"5","author":"Abrams","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1523\/JNEUROSCI.4531-08.2009","article-title":"Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels","volume":"29","author":"Aman","year":"2009","journal-title":"J. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1523\/JNEUROSCI.3539-10.2011","article-title":"Differential electrophysiological changes in striatal output neurons in Huntington\u2019s disease","volume":"31","author":"Andr\u00e9","year":"2011","journal-title":"J. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1177\/107424840400900106","article-title":"Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent","volume":"9","author":"Antzelevitch","year":"2004","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"B5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.neuron.2007.03.005","article-title":"In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2","volume":"54","author":"Arenkiel","year":"2007","journal-title":"Neuron"},{"key":"B7","doi-asserted-by":"crossref","first-page":"8493","DOI":"10.1523\/JNEUROSCI.20-22-08493.2000","article-title":"Intrinsic membrane properties underlying spontaneous tonic firing in neostriatal cholinergic interneurons","volume":"20","author":"Bennett","year":"2000","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1523\/JNEUROSCI.19-13-05586.1999","article-title":"Spontaneous activity of neostriatal cholinergic interneurons in vitro","volume":"19","author":"Bennett","year":"1999","journal-title":"J. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/0306-4522(84)90165-9","article-title":"Characterization of cholinergic neurons in the rat neostriatum. A combination of choline acetyltransferase immunocytochemistry, Golgi-impregnation and electron microscopy","volume":"12","author":"Bolam","year":"1984","journal-title":"Neuroscience"},{"key":"B9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.neuron.2013.04.039","article-title":"The thalamostriatal pathway and cholinergic control of goal-directed action: interlacing new with existing learning in the striatum","volume":"79","author":"Bradfield","year":"2013","journal-title":"Neuron"},{"key":"B10","doi-asserted-by":"publisher","first-page":"7727","DOI":"10.1523\/JNEUROSCI.1197-04.2004","article-title":"Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington\u2019s disease","volume":"24","author":"Canals","year":"2004","journal-title":"J. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/35077553","article-title":"Neuromodulation of Na+ channels: an unexpected form of cellular plasticity","volume":"2","author":"Cantrell","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/s0896-6273(03)00531-2","article-title":"Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity","volume":"39","author":"Carr","year":"2003","journal-title":"Neuron"},{"key":"B13","doi-asserted-by":"publisher","first-page":"6480","DOI":"10.1073\/pnas.95.11.6480","article-title":"Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene","volume":"95","author":"Cha","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1111\/j.1460-9568.1996.tb01565.x","article-title":"The cerebral cortex and parafascicular thalamic nucleus facilitate in vivo acetylcholine release in the rat striatum through distinct glutamate receptor subtypes","volume":"8","author":"Consolo","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"11603","DOI":"10.1523\/JNEUROSCI.1840-08.2008","article-title":"Differential excitability and modulation of striatal medium spiny neuron dendrites","volume":"28","author":"Day","year":"2008","journal-title":"J. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1152\/jn.00691.2003","article-title":"Visual and saccade-related activity in macaque posterior cingulate cortex","volume":"92","author":"Dean","year":"2004","journal-title":"J. Neurophysiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/s0891-0618(04)00028-6","article-title":"Differential loss of striatal projection systems in Huntington\u2019s disease: a quantitative immunohistochemical study","volume":"27","author":"Deng","year":"2004","journal-title":"J. Chem. Neuroanat."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1002\/cne.24013","article-title":"Cholinergic interneurons in the Q140 knockin mouse model of Huntington\u2019s disease: reductions in dendritic branching and thalamostriatal input","volume":"524","author":"Deng","year":"2016","journal-title":"J. Comp. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.nbd.2013.08.009","article-title":"Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington\u2019s disease mice","volume":"60","author":"Deng","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuron.2010.06.017","article-title":"Thalamic gating of corticostriatal signaling by cholinergic interneurons","volume":"67","author":"Ding","year":"2010","journal-title":"Neuron"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1523\/JNEUROSCI.4627-13.2014","article-title":"Cortical and thalamic excitation mediate the multiphasic responses of striatal cholinergic interneurons to motivationally salient stimuli","volume":"34","author":"Doig","year":"2014","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1113\/jphysiol.2012.245233","article-title":"Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum","volume":"591","author":"Ellender","year":"2013","journal-title":"J. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/0006-8993(76)90502-3","article-title":"Alterations of brain neurotransmitter receptor binding in Huntington\u2019s chorea","volume":"116","author":"Enna","year":"1976","journal-title":"Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.expneurol.2011.08.010","article-title":"Reduced striatal acetylcholine efflux in the R6\/2 mouse model of Huntington\u2019s disease: an examination of the role of altered inhibitory and excitatory mechanisms","volume":"232","author":"Farrar","year":"2011","journal-title":"Exp. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/nn.3209","article-title":"Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson\u2019s disease","volume":"15","author":"Goldberg","year":"2012","journal-title":"Nat. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"8396","DOI":"10.1523\/JNEUROSCI.5582-08.2009","article-title":"Nonequilibrium calcium dynamics regulate the autonomous firing pattern of rat striatal cholinergic interneurons","volume":"29","author":"Goldberg","year":"2009","journal-title":"J. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"10230","DOI":"10.1523\/JNEUROSCI.2734-05.2005","article-title":"Control of spontaneous firing patterns by the selective coupling of calcium currents to calcium-activated potassium currents in striatal cholinergic interneurons","volume":"25","author":"Goldberg","year":"2005","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nature09536","article-title":"Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1","volume":"468","author":"Guzman","year":"2010","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s004010050408","article-title":"Nerve cell loss in the thalamic centromedian-parafascicular complex in patients with Huntington\u2019s disease","volume":"91","author":"Heinsen","year":"1996","journal-title":"Acta Neuropathol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.neuropharm.2014.09.028","article-title":"Modulation of direct pathway striatal projection neurons by muscarinic M4-type receptors","volume":"89","author":"Hern\u00e1ndez-Flores","year":"2015","journal-title":"Neuropharmacology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/nn.2368","article-title":"Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration","volume":"12","author":"Higley","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e0008","DOI":"10.1523\/ENEURO.0008-14.2015","article-title":"Enhanced GABAergic inputs contribute to functional alterations of cholinergic interneurons in the R6\/2 mouse model of Huntington\u2019s disease","volume":"2","author":"Holley","year":"2015","journal-title":"eNeuro"},{"key":"B33","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1093\/cercor\/bhh185","article-title":"Thalamic atrophy in Huntington\u2019s disease co-varies with cognitive performance: a morphometric MRI analysis","volume":"15","author":"Kassubek","year":"2005","journal-title":"Cereb. Cortex"},{"key":"B34","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1523\/JNEUROSCI.13-11-04908.1993","article-title":"Physiological, morphological and histochemical characterization of three classes of interneurons in rat neostriatum","volume":"13","author":"Kawaguchi","year":"1993","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1098\/rstb.1971.0103","article-title":"The synaptic organization of the caudate nucleus","volume":"262","author":"Kemp","year":"1971","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1093\/cercor\/bhw252","article-title":"Cortical control of striatal dopamine transmission via striatal cholinergic interneurons","volume":"26","author":"Kosillo","year":"2016","journal-title":"Cereb. Cortex"},{"key":"B37","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/0306-4522(92)90293-b","article-title":"Input from the frontal cortex and the nucleus to cholinergic interneurons in the dorsal of the rat","volume":"51","author":"Lapper","year":"1992","journal-title":"Neuroscience"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1523\/JNEUROSCI.1079-16.2016","article-title":"Mutant \u03b1-synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in Parkinson\u2019s disease","author":"Lasser-Katz","year":"in press","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.neuroimage.2016.04.055","article-title":"A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action","volume":"134","author":"Manza","year":"2016","journal-title":"Neuroimage"},{"key":"B40","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1152\/jn.2001.85.2.960","article-title":"Neurons in the thalamic CM-Pf complex supply striatal neurons with information about behaviorally significant sensory events","volume":"85","author":"Matsumoto","year":"2001","journal-title":"J. Neurophysiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"10289","DOI":"10.1523\/JNEUROSCI.2155-04.2004","article-title":"D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons","volume":"24","author":"Maurice","year":"2004","journal-title":"J. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/cne.10776","article-title":"Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington\u2019s disease with 140 CAG repeats","volume":"465","author":"Menalled","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.brainresbull.2008.08.013","article-title":"Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action","volume":"78","author":"Minamimoto","year":"2009","journal-title":"Brain Res. Bull."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.1152\/jn.00564.2001","article-title":"Participation of the thalamic CM-Pf complex in attentional orienting","volume":"87","author":"Minamimoto","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/s0014-2999(02)01910-6","article-title":"Muscarinic M4 receptor inhibition of dopamine D1-like receptor signalling in rat nucleus accumbens","volume":"448","author":"Onali","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.neuron.2015.12.038","article-title":"Pathway-specific remodeling of thalamostriatal synapses in parkinsonian mice","volume":"89","author":"Parker","year":"2016","journal-title":"Neuron"},{"key":"B47","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.nbd.2005.10.009","article-title":"Plastic and behavioral abnormalities in experimental Huntington\u2019s disease: a crucial role for cholinergic interneurons","volume":"22","author":"Picconi","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2014.05.032","article-title":"Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington\u2019s disease","volume":"83","author":"Plotkin","year":"2014","journal-title":"Neuron"},{"key":"B49","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pharmthera.2014.05.004","article-title":"Pharmacology and therapeutics role for the nicotinic cholinergic system in movement disorders; therapeutic implications","volume":"144","author":"Quik","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"B50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1990.70.1.165","article-title":"Quantal analysis of synaptic potentials in neurons of the central nervous system","volume":"70","author":"Redman","year":"1990","journal-title":"Physiol. Rev."},{"key":"B51","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1152\/jn.1995.74.5.2220","article-title":"Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons","volume":"74","author":"Schwindt","year":"1995","journal-title":"J. Neurophysiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.neuron.2015.10.039","article-title":"M4 muscarinic receptor signaling ameliorates striatal plasticity deficits in models of L-DOPA-induced dyskinesia","volume":"88","author":"Shen","year":"2015","journal-title":"Neuron"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/s0306-4522(98)00367-4","article-title":"Thalamic inputs to striatal interneurons in monkeys: synaptic organization and co-localization of calcium binding proteins","volume":"89","author":"Sidibe","year":"1999","journal-title":"Neuroscience"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1093\/hmg\/ddl252","article-title":"Cholinergic neuronal defect without cell loss in Huntington\u2019s disease","volume":"15","author":"Smith","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"B55","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1523\/JNEUROSCI.18-09-03124.1998","article-title":"Somatodendritic depolarization-activated potassium currents in rat neostriatal cholinergic interneurons are predominantly of the A type and attributable to coexpression of Kv4.2 and Kv4.1 subunits","volume":"18","author":"Song","year":"1998","journal-title":"J. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1085\/jgp.62.1.37","article-title":"The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine","volume":"62","author":"Strichartz","year":"1973","journal-title":"J. Gen. Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.conb.2004.10.003","article-title":"Functional diversity and specificity of neostriatal interneurons","volume":"14","author":"Tepper","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/1098-2396(20000915)37:4252::AID-SYN23.0.CO;2-A","article-title":"Cortical inputs to m2-immunoreactive striatal interneurons in rat and monkey","volume":"37","author":"Thomas","year":"2000","journal-title":"Synapse"},{"key":"B59","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neuron.2012.04.038","article-title":"Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons","volume":"75","author":"Threlfell","year":"2012","journal-title":"Neuron"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1113\/jphysiol.2014.271825","article-title":"Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice","volume":"592","author":"Wang","year":"2014","journal-title":"J. Physiol."},{"key":"B61","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0026-895X(25)13548-7","article-title":"Biochemical characterization of the muscarinic cholinergic receptor in human brain: alterations in Huntington\u2019s disease","volume":"14","author":"Wastek","year":"1978","journal-title":"Mol. Pharmacol."},{"key":"B62","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1523\/JNEUROSCI.10-02-00508.1990","article-title":"Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum","volume":"10","author":"Wilson","year":"1990","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1523\/JNEUROSCI.16-08-02592.1996","article-title":"Muscarinic (m2\/m4) receptors reduce N- and P-type Ca2+ currents in rat neostriatal cholinergic interneurons through a fast, membrane-delimited, G-protein pathway","volume":"16","author":"Yan","year":"1996","journal-title":"J. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington\u2019s disease","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol. Rev."}],"container-title":["Frontiers in Systems Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnsys.2016.00102\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T18:50:29Z","timestamp":1749840629000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnsys.2016.00102\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":64,"URL":"https:\/\/doi.org\/10.3389\/fnsys.2016.00102","relation":{},"ISSN":["1662-5137"],"issn-type":[{"value":"1662-5137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,16]]}}}