{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:55:53Z","timestamp":1791521753599,"version":"4.3.4"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Neurosci."],"DOI":"10.3389\/fnsys.2020.00015","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T04:50:21Z","timestamp":1584507021000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Brain-Wide Mapping of Afferent Inputs to Accumbens Nucleus Core Subdomains and Accumbens Nucleus Subnuclei"],"prefix":"10.3389","volume":"14","author":[{"given":"Liping","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"B520","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-x","article-title":"The functional anatomy of basal ganglia disorders","volume":"12","author":"Albin","year":"1989","journal-title":"Trends Neurosci."},{"key":"B1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.nlm.2010.05.007","article-title":"Substantia nigra, nucleus basalis magnocellularis and basolateral amygdala roles in extinction of contextual fear conditioning in the rat","volume":"94","author":"Baldi","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/cne.10783","article-title":"Overlapping distributions of orexin\/hypocretin- and dopamine-\u03b2-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress","volume":"464","author":"Baldo","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1016\/j.celrep.2017.11.062","article-title":"Nucleus accumbens dopamine signaling regulates sexual preference for females in male mice","volume":"21","author":"Beny-Shefer","year":"2017","journal-title":"Cell Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1046\/j.1471-4159.2000.0751625.x","article-title":"Serotonin 5-HT2 receptor stimulation of dopamine release in the posterior but not anterior nucleus accumbens of the rat","volume":"75","author":"Bowers","year":"2000","journal-title":"J. Neurochem."},{"key":"B4700","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/cne.903380209","article-title":"The patterns of afferent innervation of the core and shell in the \u201caccumbens\u201d part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold","volume":"338","author":"Brog","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/(sici)1098-2396(199904)32:1<13::aid-syn2>3.0.co;2-r","article-title":"Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites","volume":"32","author":"Bubser","year":"1999","journal-title":"Synapse"},{"key":"B6","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neuropharm.2008.06.075","article-title":"Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis","volume":"56","author":"Carlezon","year":"2009","journal-title":"Neuropharmacology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.neuron.2019.03.003","article-title":"A motivational and neuropeptidergic hub: anatomical and functional diversity within the nucleus accumbens shell","volume":"102","author":"Castro","year":"2019","journal-title":"Neuron"},{"key":"B5201","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1038\/npp.2016.10","article-title":"Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose \u2018Liking\u2019 and Intake but Scopolamine in Caudal Shell Shifts \u2018Liking\u2019 Toward \u2018Disgust\u2019 and \u2018Fear\u2019","volume":"41","author":"Castro","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6527","DOI":"10.1523\/JNEUROSCI.3250-16.2017","article-title":"Reduced Slc6a15 in nucleus accumbens D2-neurons underlies stress susceptibility","volume":"37","author":"Chandra","year":"2017","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1097\/j.pain.0000000000001497","article-title":"Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia","volume":"160","author":"Chang","year":"2019","journal-title":"Pain"},{"key":"B10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s0006-8993(00)03013-4","article-title":"Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata","volume":"888","author":"Chiba","year":"2001","journal-title":"Brain Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neuron.2015.06.022","article-title":"Oxytocin mediates entrainment of sensory stimuli to social cues of opposing valence","volume":"87","author":"Choe","year":"2015","journal-title":"Neuron"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e39945","DOI":"10.7554\/eLife.39945","article-title":"Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement","volume":"7","author":"Corre","year":"2018","journal-title":"Elife"},{"key":"B13","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/s0361-9230(01)00527-5","article-title":"Glial cell abnormalities in major psychiatric disorders: the evidence and implications","volume":"55","author":"Cotter","year":"2001","journal-title":"Brain Res. Bull."},{"key":"B14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/s0006-8993(98)00672-6","article-title":"Origin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat","volume":"806","author":"Delfs","year":"1998","journal-title":"Brain Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"bio043554","DOI":"10.1242\/bio.043554","article-title":"Whole-brain mapping of projection from mouse lateral septal nucleus","volume":"8","author":"Deng","year":"2019","journal-title":"Biol. Open"},{"key":"B16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fnsys.2017.00032","article-title":"The melanin-concentrating hormone as an integrative peptide driving motivated behaviors","volume":"11","author":"Diniz","year":"2017","journal-title":"Front. Syst. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature12518","article-title":"Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin","volume":"501","author":"D\u00f6len","year":"2013","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.neuron.2012.12.002","article-title":"The role of medial prefrontal cortex in memory and decision making","volume":"76","author":"Euston","year":"2012","journal-title":"Neuron"},{"key":"B19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/s0149-7634(05)80222-2","article-title":"Sexual motivation: a neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses of male rats","volume":"14","author":"Everitt","year":"1990","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1046\/j.1365-2826.2002.00819.x","article-title":"Habituation and cross-sensitization of stress-induced hypothalamic-pituitary-adrenal activity: effect of lesions in the paraventricular nucleus of the thalamus or bed nuclei of the stria terminalis","volume":"14","author":"Fernandes","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-psych-010213-115159","article-title":"The nucleus accumbens: an interface between cognition, emotion, and action","volume":"66","author":"Floresco","year":"2015","journal-title":"Annu. Rev. Psychol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.biopsych.2014.07.021","article-title":"Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress","volume":"77","author":"Francis","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/s41593-017-0027-7","article-title":"An interactive framework for whole-brain maps at cellular resolution","volume":"21","author":"F\u00fcrth","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/npp.2016.210","article-title":"Ketamine mechanism of action: separating the wheat from the chaff","volume":"42","author":"Gould","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1749-6632.1999.tb09260.x","article-title":"Convergence and segregation of ventral striatal inputs and outputs","volume":"877","author":"Groenewegen","year":"1999","journal-title":"Ann. N Y Acad. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s10571-004-6921-z","article-title":"The \u03b1-2B adrenoceptor in the paraventricular thalamic nucleus is persistently upregulated by chronic psychosocial stress","volume":"24","author":"Heilbronner","year":"2004","journal-title":"Cell. Mol. Neurobiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1176\/jnp.9.3.354","article-title":"The accumbens: beyond the core-shell dichotomy","volume":"9","author":"Heimer","year":"1997","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1073\/pnas.1719014115","article-title":"Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility","volume":"115","author":"Heshmati","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.brainresbull.2012.09.002","article-title":"Putative genes mediating the effects of orexins in the posterior paraventricular thalamus on neuroendocrine and behavioral adaptations to repeated stress","volume":"89","author":"Heydendael","year":"2012","journal-title":"Brain Res. Bull."},{"key":"B30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neuropharm.2017.09.005","article-title":"Electrical stimulation of the hippocampal fimbria facilitates neuronal nitric oxide synthase activity in the medial shell of the rat nucleus accumbens: modulation by dopamine D1 and D2 receptor activation","volume":"126","author":"Hoque","year":"2017","journal-title":"Neuropharmacology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"4462","DOI":"10.1523\/JNEUROSCI.3383-16.2017","article-title":"Regulation of alcohol extinction and cue-induced reinstatement by specific projections among medial prefrontal cortex, nucleus accumbens, and basolateral amygdala","volume":"37","author":"Keistler","year":"2017","journal-title":"J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fncir.2017.00041","article-title":"Neuroanatomical substrates of rodent social behavior: the medial prefrontal cortex and its projection patterns","volume":"11","author":"Ko","year":"2017","journal-title":"Front. Neural Circuits"},{"key":"B33","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/s0301-0082(00)00019-8","article-title":"Current concepts in neuroanatomical tracing","volume":"62","author":"K\u00f6bbert","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/nn.4068","article-title":"Coding the direct\/indirect pathways by D1 and D2 receptors is not valid for accumbens projections","volume":"18","author":"Kupchik","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/s41586-018-0772-0","article-title":"A circuit from hippocampal CA2 to lateral septum disinhibits social aggression","volume":"564","author":"Leroy","year":"2018","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fnana.2018.00084","article-title":"Cell-type-specific afferent innervation of the nucleus accumbens core and shell","volume":"12","author":"Li","year":"2018","journal-title":"Front. Neuroanat."},{"key":"B37","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.conb.2014.05.010","article-title":"Functional neuromodulation of chemosensation in vertebrates","volume":"29","author":"Linster","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1188472","article-title":"Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward","volume":"330","author":"Lobo","year":"2010","journal-title":"Science"},{"key":"B39","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fnana.2019.00044","article-title":"Whole brain mapping of long-range direct input to glutamatergic and GABAergic neurons in motor cortex","volume":"13","author":"Luo","year":"2019","journal-title":"Front. Neuroanat."},{"key":"B40","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.biopsych.2016.05.015","article-title":"Bidirectional modulation of extinction of drug seeking by deep brain stimulation of the ventral striatum","volume":"80","author":"Mart\u00ednez-Rivera","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev.psych.121208.131631","article-title":"Fear extinction as a model for translational neuroscience: ten years of progress","volume":"63","author":"Milad","year":"2012","journal-title":"Annu. Rev. Psychol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12767","article-title":"Associations between nucleus accumbens structural connectivity, brain function, and initiation of binge drinking","author":"Morales","year":"2019","journal-title":"Addict. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/npp.2017.122","article-title":"In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens","volume":"43","author":"Muir","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.biopsych.2005.09.018","article-title":"The mesolimbic dopamine reward circuit in depression","volume":"59","author":"Nestler","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3389\/fneur.2017.00399","article-title":"Subregional structural alterations in hippocampus and nucleus accumbens correlate with the clinical impairment in patients with Alzheimer\u2019s disease clinical spectrum: parallel combining volume and vertex-based approach","volume":"8","author":"Nie","year":"2017","journal-title":"Front. Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"423.e4","DOI":"10.1016\/j.neuron.2019.05.018","article-title":"Paraventricular thalamus projection neurons integrate cortical and hypothalamic signals for cue-reward processing","volume":"103","author":"Otis","year":"2019","journal-title":"Neuron"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.2147\/jpr.s138360","article-title":"Antinociceptive tolerance to NSAIDs in the agranular insular cortex is mediated by opioid mechanism","volume":"10","author":"Pirkulashvili","year":"2017","journal-title":"J. Pain Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1126\/science.aat2512","article-title":"The paraventricular thalamus is a critical thalamic area for wakefulness","volume":"362","author":"Ren","year":"2018","journal-title":"Science"},{"key":"B49","doi-asserted-by":"publisher","first-page":"8764","DOI":"10.1073\/pnas.1200782109","article-title":"Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear","volume":"109","author":"Rodriguez-Romaguera","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B50","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.bbr.2010.11.058","article-title":"The cholinergic system in aging and neuronal degeneration","volume":"221","author":"Schliebs","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.nlm.2019.05.001","article-title":"Circuit directionality for motivation: lateral accumbens-pallidum, but not pallidum-accumbens, connections regulate motivational attraction to reward cues","volume":"162","author":"Smedley","year":"2019","journal-title":"Neurobiol. Learn. Mem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.brainres.2003.10.054","article-title":"Thalamic paraventricular nucleus lesions facilitate central amygdala neuronal responses to acute psychological stress","volume":"997","author":"Spencer","year":"2004","journal-title":"Brain Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e33455","DOI":"10.1371\/journal.pone.0033455","article-title":"Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat","volume":"7","author":"van der Plasse","year":"2012","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/syn.10279","article-title":"Differential projections of the infralimbic and prelimbic cortex in the rat","volume":"51","author":"Vertes","year":"2004","journal-title":"Synapse"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1001\/archneur.64.11.1575","article-title":"Dopamine in drug abuse and addiction: results of imaging studies and treatment implications","volume":"64","author":"Volkow","year":"2007","journal-title":"Arch. Neurol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41586-018-0416-4","article-title":"5-HT release in nucleus accumbens rescues social deficits in mouse autism model","volume":"560","author":"Walsh","year":"2018","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fnana.2015.00040","article-title":"Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Neuroanat."},{"key":"B58","doi-asserted-by":"publisher","first-page":"434.e4","DOI":"10.1016\/j.neuron.2017.12.022","article-title":"Nucleus accumbens subnuclei regulate motivated behavior via direct inhibition and disinhibition of VTA dopamine subpopulations","volume":"97","author":"Yang","year":"2018","journal-title":"Neuron"},{"key":"B59","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13024-019-0334-4","article-title":"A circuit view of deep brain stimulation in Alzheimer\u2019s disease and the possible mechanisms","volume":"14","author":"Yu","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"B60","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/0306-4522(85)90302-1","article-title":"Cholecystokinin innervation of the ventral striatum: a morphological and radioimmunological study","volume":"14","author":"Z\u00e1borszky","year":"1985","journal-title":"Neuroscience"},{"key":"B61","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1749-6632.1999.tb09264.x","article-title":"Functional-anatomical implications of the nucleus accumbens core and shell subterritories","volume":"877","author":"Zahm","year":"1999","journal-title":"Ann. N Y Acad. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0149-7634(99)00065-2","article-title":"An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens","volume":"24","author":"Zahm","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B63","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/0306-4522(92)90202-d","article-title":"On the significance of subterritories in the \u201caccumbens\u201d part of the rat ventral striatum","volume":"50","author":"Zahm","year":"1992","journal-title":"Neuroscience"},{"key":"B64","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1126\/science.aat0481","article-title":"Dynamic salience processing in paraventricular thalamus gates associative learning","volume":"362","author":"Zhu","year":"2018","journal-title":"Science"}],"container-title":["Frontiers in Systems Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnsys.2020.00015\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T13:48:50Z","timestamp":1585316930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnsys.2020.00015\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":67,"alternative-id":["10.3389\/fnsys.2020.00015"],"URL":"https:\/\/doi.org\/10.3389\/fnsys.2020.00015","relation":{},"ISSN":["1662-5137"],"issn-type":[{"value":"1662-5137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"article-number":"15"}}