{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:04:40Z","timestamp":1792872280050,"version":"4.5.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To review and organize the research results on the mechanism of action of acupuncture in the treatment of subjective tinnitus over the past 30\u202fyears. This will provide a reference basis for the clinical acupuncture treatment of subjective tinnitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Computer searches of PubMed, China National Knowledge Infrastructure (CNKI), and China Science and Technology Journal Database (CCD) were conducted to collect and organize literature on the research on the mechanism of action of acupuncture in the treatment of subjective tinnitus. The searches were limited to the period from January 1, 1995 to July 31, 2024. The literature was then summarized and analyzed in terms of the blood circulation of the inner ear, immuno-inflammation, and neural cells to elaborate on the potential mechanism of action of acupuncture. The objective of this study was to describe the potential mechanism of action of acupuncture. The final results yielded 36 research papers related to subjective tinnitus and the mechanism of action of acupuncture. The identified mechanisms are as follows: the enhancement of local microcirculation in the inner ear by regulating the blood supply of the vertebrobasilar artery may improve the inner ear\u2019s blood supply obstacle. Additionally, the reduction of immuno-inflammatory factors in the inner ear may reduce the toxicity of the cochlea\u2019s hair cells and protect them. The modulation of 5-hydroxytryptamine receptors in the cochlear nucleus may serve to protect spiral ganglion neurons from damage. Additionally, the modulation of the thalamus and the functional reorganization of the auditory cortex and synaptic network may contribute to the achievement of therapeutic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While acupuncture has demonstrated clinical efficacy in the treatment of subjective tinnitus, the underlying mechanism of action remains poorly understood. In the future, there is a need to accelerate the application of modern advanced technology and multidisciplinary cross-fertilization, as well as to conduct in-depth and systematic investigations into the mechanisms of acupuncture effects. This will provide an objective basis for clinical treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnsys.2025.1523761","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:24:02Z","timestamp":1748841842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Recent advances on the mechanism of acupuncture in the treatment of subjective tinnitus"],"prefix":"10.3389","volume":"19","author":[{"given":"Feifei","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixiang","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiyu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.51507\/j.jams.2023.16.1.11","article-title":"Lipid profile response to acupuncture in obese patients with subjective tinnitus: a randomized controlled trial","volume":"16","author":"Ali","year":"2023","journal-title":"J. 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Neurosci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jams.2019.05.002","article-title":"Thermal effects of acupuncture by the infrared thermography test in patients with tinnitus","volume":"12","author":"Cai","year":"2019","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"276","DOI":"10.13703\/j.0255-2930.20230814-0001","article-title":"Combined treatment of idiopathic tinnitus with \u201cFa Meng\u201d acupuncture and electroacupuncture: a case series of 45 patients","volume":"44","author":"Cai","year":"2024","journal-title":"Chin Acupuncture Moxibustion"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"9114676","DOI":"10.1155\/2021\/9114676","article-title":"Effect of Electroacupuncture on noise-induced hearing loss in rats","volume":"2021","author":"Chang","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1001\/jamaoto.2020.2920","article-title":"Novel risk loci in tinnitus and causal inference with neuropsychiatric disorders among adults of European ancestry","volume":"146","author":"Clifford","year":"2020","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref9","first-page":"296","article-title":"The impact of Electroacupuncture intervention on expression of 5-HTR 1 B\/2 C genes in mice under radiation stimulation from Mobile phone","volume":"40","author":"Dai","year":"2015","journal-title":"Zhen Ci Yan Jiu"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/ejn.12759","article-title":"The auditory cortex and tinnitus - a review of animal and human studies","volume":"41","author":"Eggermont","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12938-024-01255-7","article-title":"Changes in temporal lobe activation during a sound stimulation task in patients with sensorineural tinnitus: a multi- channel near-infrared spectroscopy study","volume":"23","author":"Fan","year":"2024","journal-title":"Biomed. Eng. Online"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1152\/physrev.00029.2020","article-title":"What's the buzz? The neuroscience and the treatment of tinnitus","volume":"101","author":"Henton","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1001\/jamaneurol.2022.2189","article-title":"Global prevalence and incidence of tinnitus: a systematic review and Meta-analysis","volume":"79","author":"Jarach","year":"2022","journal-title":"JAMA Neurol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"579","DOI":"10.13703\/j.0255-2930.2015.06.016","article-title":"Effects of electroacupuncture on cochlea morphology and expression of aquaporins in guinea pigs with endolymphatic hydrops","volume":"35","author":"Jiang","year":"2015","journal-title":"Zhongguo Zhen Jiu"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.bbi.2021.02.003","article-title":"Lipidomics reveals that acupuncture modulates the lipid metabolism and inflammatory interaction in a mouse model of depression","volume":"94","author":"Jung","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5065","DOI":"10.1113\/jphysiol.2014.278572","article-title":"Single unit hyperactivity and bursting in the auditory thalamus of awake rats directly correlates with behavioural evidence of tinnitus","volume":"592","author":"Kalappa","year":"2014","journal-title":"J. Physiol."},{"key":"ref17","first-page":"362","article-title":"Effect of electroacupuncture on succinate dehydrogenase of gentamycin induced ototoxic cochlear hair cells in guinea pigs","volume":"18","author":"Kang","year":"1998","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1007\/s00405-024-08633-w","article-title":"Current understanding of subjective tinnitus in adults","volume":"281","author":"Kang","year":"2024","journal-title":"Eur. Arch. Otorrinolaringol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.13703\/j.0255-2930.20200925-0001","article-title":"Effect of ZHU Lian's type II inhibition on chronic migraine and serum 5-HT, VEGF, CGRP","volume":"41","author":"Ke","year":"2021","journal-title":"Zhongguo Zhen Jiu"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jfma.2022.12.013","article-title":"Objective multidisciplinary measurements of sleep disturbance and autonomic dysfunction as risk factors for chronic subjective tinnitus","volume":"122","author":"Lee","year":"2023","journal-title":"J. Formos. Med. Assoc."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"514","DOI":"10.11477\/mf.1436204944","article-title":"Basilar artery, anterior inferior cerebellar artery, superior cerebellar artery","volume":"52","author":"Matsubara","year":"2024","journal-title":"No Shinkei Geka"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2830157","DOI":"10.1155\/2016\/2830157","article-title":"Sensorineural tinnitus: its pathology and probable therapies","volume":"2016","author":"Moller","year":"2016","journal-title":"Int J Otolaryngol"},{"key":"ref23","volume-title":"Anatomy, Head and Neck, Posterior Auricular Artery","author":"Nguyen","year":"2024"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.brainres.2012.02.014","article-title":"Targeting inhibitory neurotransmission in tinnitus","volume":"1485","author":"Richardson","year":"2012","journal-title":"Brain Res."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/nrneurol.2016.12","article-title":"Maladaptive plasticity in tinnitus \u2014 triggers, mechanisms and treatment","volume":"12","author":"Shore","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e89904","DOI":"10.1371\/journal.pone.0089904","article-title":"Combining transcranial direct current stimulation and tailor-made notched music training to decrease tinnitus-related distress \u2013 a pilot study","volume":"9","author":"Teismann","year":"2014","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s11596-019-2127-y","article-title":"Influence of acupuncture on autonomic balance in adult tinnitus patients: an exploratory study","volume":"39","author":"Tu","year":"2019","journal-title":"Curr. Med. Sci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"742","DOI":"10.3109\/00016489509139396","article-title":"The influence of unilateral vertebral artery occlusion on brainstem and inner ear blood flow in rat","volume":"115","author":"Ueda","year":"1995","journal-title":"Acta Otolaryngol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fnsys.2012.00031","article-title":"The auditory and non-auditory brain areas involved in tinnitus. An emergent property of multiple parallel overlapping subnetworks","volume":"6","author":"Vanneste","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0306-4522(00)00521-2","article-title":"Capsaicin stimulation of the cochlea and electric stimulation of the trigeminal ganglion mediate vascularpermeability in cochlear and vertebro-basilar arteries: a potential cause of inner ear dysfunction in headache","volume":"103","author":"Vass","year":"2001","journal-title":"Neuroscience"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1089\/acu.2023.0077","article-title":"Networks of nerve fibers, and blood and lymphatic vessels in the mouse auricle: the structural basis of ear acupuncture","volume":"36","author":"Wang","year":"2024","journal-title":"Med. Acupunct."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"737993","DOI":"10.3389\/fnins.2021.737993","article-title":"Acupuncture treatment decreased temporal variability of dynamic functional connectivity in chronic tinnitus","volume":"15","author":"Wei","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref33","first-page":"6043","article-title":"Neuroglial activation in the auditory cortex and medial geniculate body of salicylate-induced tinnitus rats","volume":"12","author":"Xia","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref34","volume-title":"Efficacy evaluation of Electroacupuncture in treating noise-induced hearing loss with depressive symptoms and exploration of its immunological mechanisms","author":"Xiaofeng","year":"2018"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"637","DOI":"10.13703\/j.0255-2930.2019.06.018","article-title":"Effect of electrical stimulation at auricular points combined with sound masking on the expression of CREB, BDNF and TrkB in the auditory cortex of tinnitus rats","volume":"39","author":"Yang","year":"2019","journal-title":"Zhongguo Zhen Jiu"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.13702\/j.1000-0607.2015.04.007","article-title":"Acupuncture attenuates ototoxicity induced by gentamicin in mice","volume":"28","author":"Yu","year":"2022","journal-title":"Altern. Ther. Health Med."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1109\/TNSRE.2022.3231899","article-title":"Effect of acupuncture treatment on cortical activation in patients with tinnitus: a functional near-infrared spectroscopy study","volume":"31","author":"Yu","year":"2023","journal-title":"IEEE Trans. Neural. Syst. Rehabil. Eng. PP"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1373390","DOI":"10.3389\/fneur.2024.1373390","article-title":"Modulations of resting-static functional connectivity on insular by electroacupuncture in subjective tinnitus","volume":"15","author":"Zha","year":"2024","journal-title":"Front. Neurol."},{"key":"ref39","first-page":"1","article-title":"Clinical efficacy of acupuncture in treating subjective tinnitus at different stages and its impact on quality of life","volume":"11","author":"Zha","year":"2024","journal-title":"J Anhui Univ Chin Med"},{"key":"ref40","volume-title":"A study on the effect of acupuncture on the caudate nucleus functional connectivity network in patients with subjective tinnitus based on resting-state fMRI","author":"Zhang","year":"2022"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e37464","DOI":"10.1097\/MD.0000000000037464","article-title":"A randomized controlled study investigating the efficacy of electro-acupuncture and exercise-based swallowing rehabilitation for post-stroke dysphagia: impacts on brainstem auditory evoked potentials and cerebral blood flow","volume":"103","author":"Zhang","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"986805","DOI":"10.3389\/fneur.2022.986805","article-title":"Acupuncture decreases amygdala functional connectivity in subjective tinnitus","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Neurol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"12","DOI":"10.13703\/j.0255-2930.20230628-0003","article-title":"Preliminary exploration of the regulatory effect of \u201cNing Shen Tong Qiao\u201d acupuncture on the anterior cingulate cortex and whole-brain functional connectivity in patients with subjective tinnitus based on fMRI","volume":"44","author":"Zhang","year":"2024","journal-title":"Chin Acupuncture Moxibustion"},{"key":"ref44","first-page":"99","article-title":"Electroacupuncture improves VBI-induced microcirculatory disorders in the inner ear and its effect on VOR[J]","volume-title":"Chin. J. Appl. Physiol","author":"Zheng","year":"2006"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"446","DOI":"10.12659\/MSM.898535","article-title":"Protective effects of acupuncture against gentamicin-induced ototoxicity in rats: possible role of Neurotrophin-3","volume":"23","author":"Zhou","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0254-6272(09)60029-7","article-title":"The NGF point-injection for treatment of the sound-perceiving nerve deafness and tinnitus in 68 cases","volume":"29","author":"Zhou","year":"2009","journal-title":"J. Tradit. Chin. 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