{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T03:30:09Z","timestamp":1782617409520,"version":"3.54.5"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>High-altitude environments challenge cognitive function due to hypoxia, yet their specific effects on cerebral lobe functions remain unclear. This study examines the impact of high-altitude exposure on frontal, parietal, temporal, and occipital lobes in climbers in the Nepali Himalayas, aiming to enhance understanding of altitude-related cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross-sectional cohort study was conducted with 76 participants, including 46 non-selected individuals (NOSCL) and 30 selected climbers divided into Everest (EMCL, <jats:italic>n<\/jats:italic> = 12), Kanchanjanga (KMCL, <jats:italic>n<\/jats:italic> = 9), and Manaslu (MMCL, <jats:italic>n<\/jats:italic> = 9) groups. Cognitive function tests (CFT) assessed cerebral lobe function at altitudes ranging from 800 to 5,500 meters using a non-invasive neuropsychological battery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant altitude-related declines were observed in frontal lobe function, particularly in the Visual Stroop test at 800 meters (75%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) and 2,700 meters (86.1%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). Attention scores also decreased at 800 meters (94.4%, <jats:italic>p<\/jats:italic> = 0.002). No significant changes were found in parietal, temporal, or occipital lobe functions. The Manaslu climb presented greater cognitive challenges than Everest or Kanchanjanga, with reduced attention and social cognition scores at 4,800 meters (<jats:italic>p<\/jats:italic> = 0.145).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The findings indicate that frontal lobe functions are particularly vulnerable to hypoxia at high altitudes. The results support the necessity of region-specific cognitive testing for high-altitude risk assessments. Further research should explore long-term cognitive effects and mitigation strategies for climbers exposed to extreme altitude conditions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnsys.2025.1563398","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:46:55Z","timestamp":1748584015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of high-altitude exposure on cerebral lobe functions in climbers: insights from the Nepali Himalayas"],"prefix":"10.3389","volume":"19","author":[{"given":"Sunil","family":"Dhungel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavana R. 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Sports Med. Phys. Fitness"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1056\/NEJMcp1214870","article-title":"Acute high-altitude illnesses","volume":"368","author":"B\u00e4rtsch","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref3","volume-title":"Neuroanatomy through clinical cases","author":"Blumenfeld","year":""},{"key":"ref4","article-title":"Bedside frontal lobe tests","author":"Blumenfeld","year":""},{"key":"ref5","first-page":"2313","article-title":"Clinical care in extreme environments: physiology at high altitude and in space","volume-title":"Miller\u2019s anaesthesia","author":"Cumpstey","year":"2020"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1136\/jramc-157-01-17","article-title":"Changes to color vision on exposure to high altitude","volume":"157","author":"Davies","year":"2011","journal-title":"J. R. Army Med. Corps"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"670278","DOI":"10.3389\/fphys.2021.670278","article-title":"A prospective evaluation of the acute effects of high altitude on cognitive and physiological functions in lowlanders","volume":"12","author":"Falla","year":"2021","journal-title":"Front. Physiol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1111\/ene.12507","article-title":"Psychological and cognitive impairment of long-term migrators to high altitudes and the relationship to physiological and biochemical changes","volume":"22","author":"Gao","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"ref9","article-title":"Nepalese Army launches Mountain Cleanup Campaign 2022","year":"2022"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/jcbfm.1994.84","article-title":"The brain at high altitude: Hypometabolism as a defense against chronic hypoxia?","volume":"14","author":"Hochachka","year":"1994","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref11","article-title":"The Nepal Himalayas","year":""},{"key":"ref12","volume-title":"Netter\u2019s neurology","author":"Jones","year":"2012"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jshs.2020.04.004","article-title":"Does exercise have a protective effect on cognitive function under hypoxia? A systematic review with meta-analysis","volume":"9","author":"Jung","year":"2020","journal-title":"J. Sport Health Sci."},{"key":"ref14","volume-title":"Synopsis of psychiatry","author":"Kaplan","year":"2015"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1159\/000055584","article-title":"Ophthalmological effects of high altitude","volume":"32","author":"Karakucuk","year":"2000","journal-title":"Ophthalmic Res."},{"key":"ref16","volume-title":"Fundamentals of human neuropsychology","author":"Kolb","year":"2009"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1089\/ham.2010.1079","article-title":"Poor sleep quality predicts decreased cognitive function independently of chronic mountain sickness score in young soldiers with polycythemia stationed in Tibet","volume":"12","author":"Kong","year":"2011","journal-title":"High Alt. Med. Biol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"S224","DOI":"10.1002\/1520-6378(2001)26:1+<::AID-COL43>3.0.CO;2-9","article-title":"Colour vision at very high altitude","volume":"26","author":"Leid","year":"2001","journal-title":"Color Res. Appl."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1111\/ene.13334","article-title":"Migraine associated with altitude: results from a population-based study in Nepal","volume":"24","author":"Linde","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"S146","DOI":"10.1016\/j.wem.2017.03.002","article-title":"Wilderness medical society clinical practice guidelines for the prevention and treatment of acute altitude illness","volume":"28","author":"Luks","year":"2017","journal-title":"Wilderness Environ. Med."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s11916-015-0483-2","article-title":"High-altitude headache","volume":"19","author":"Marmura","year":"2015","journal-title":"Curr. Pain Headache Rep."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.neubiorev.2019.01.017","article-title":"Corrigendum to \u201cEffect of acute hypoxia on cognition: A systematic review and meta-regression analysis\u201d Neurosci. Biobehav. Rev. 74 (2017) 225-232","volume":"98","author":"McMorris","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1007\/s00421-013-2635-6","article-title":"Cognitive performance in high-altitude climbers: a comparative study of saccadic eye movements and neuropsychological tests","volume":"113","author":"Merz","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref24","year":""},{"key":"ref25","doi-asserted-by":"publisher","first-page":"16406","DOI":"10.1038\/s41598-019-52563-1","article-title":"Chronic exposure to high altitude: synaptic, astroglial, and memory changes","volume":"9","author":"Sharma","year":"2019","journal-title":"Sci. Rep."},{"key":"ref26","volume-title":"The state of forest genetic resource conservation and management in Nepal. Forest Resources Development Service Working Paper FGR\/69E","author":"Tamrakar","year":"2003"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1111\/j.1467-7687.2011.01064.x","article-title":"Changing patterns of neuropsychological functioning in children living at high altitudes above and below 4000 m: a report from the Bolivian Children Living at Altitude (BoCLA) study","volume":"14","author":"Virues-Ortega","year":"2011","journal-title":"Dev. Sci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1038\/srep04443","article-title":"Long-term exposure to high altitude affects voluntary spatial attention at early and late processing stages","volume":"4","author":"Wang","year":"2014","journal-title":"Sci. Rep."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0140-6736(86)90066-8","article-title":"Do climbs to extreme altitude cause brain damage?","volume":"328","author":"West","year":"1986","journal-title":"Lancet"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1201\/b13633","volume-title":"High altitude medicine and physiology","author":"West","year":"2012"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1474-4422(09)70014-6","article-title":"The cerebral effects of climbing to high altitudes","volume":"8","author":"Wilson","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1089\/ham.2014.1009","article-title":"Cognitive impairments at high altitudes and adaptation","volume":"15","author":"Yan","year":"2014","journal-title":"High Alt. Med. Biol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00221-010-2494-x","article-title":"Prolonged high-altitude residence impacts verbal working memory: an fMRI study","volume":"208","author":"Yan","year":"2011","journal-title":"Exp. 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