{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:08:56Z","timestamp":1753891736877,"version":"3.41.2"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Neurosci."],"abstract":"<jats:p>The mesolimbic dopamine system is a set of subcortical brain circuits that plays a key role in reward processing, reinforcement, associative learning, and behavioral responses to salient environmental events. In our previous studies of the dopaminergic response to salient visual stimuli, we observed that dopamine release in the lateral nucleus accumbens (LNAc) of mice encoded information about the rate and magnitude of rapid environmental luminance changes from darkness. Light-evoked dopamine responses were rate-dependent, robust to the time of testing or stimulus novelty, and required phototransduction by rod and cone opsins. However, it is unknown if these dopaminergic responses also involve non-visual opsins, such as melanopsin, the primary photopigment expressed by intrinsically photosensitive retinal ganglion cells (ipRGCs). In the current study, we evaluated the role of melanopsin in the dopaminergic response to light in the LNAc using the genetically encoded dopamine sensor dLight1 and fiber photometry. By measuring light-evoked dopamine responses across a broad irradiance and wavelength range in constitutive melanopsin (<jats:italic>Opn4<\/jats:italic>) knockout mice, we were able to provide new insights into the ability of non-visual opsins to regulate the mesolimbic dopamine response to visual stimuli.<\/jats:p>","DOI":"10.3389\/fnsys.2025.1568878","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T06:29:15Z","timestamp":1743575355000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Examining the role of the photopigment melanopsin in the striatal dopamine response to light"],"prefix":"10.3389","volume":"19","author":[{"given":"L. Sofia","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austen A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kassidy E.","family":"Grover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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Physiol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neuropharm.2008.06.075","article-title":"Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis","volume":"56","author":"Carlezon","year":"2009","journal-title":"Neuropharmacology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature10206","article-title":"Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs","volume":"476","author":"Chen","year":"2011","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuron.2019.08.036","article-title":"Learning from action: reconsidering movement signaling in midbrain dopamine neuron activity","volume":"104","author":"Coddington","year":"2019","journal-title":"Neuron"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/nn1113","article-title":"A direct projection from superior colliculus to substantia nigra for detecting salient visual events","volume":"6","author":"Comoli","year":"2003","journal-title":"Nat. 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Biol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nature06829","article-title":"Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision","volume":"453","author":"G\u00fcler","year":"2008","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1002\/cne.24181","article-title":"Melanopsin expressing human retinal ganglion cells: subtypes, distribution, and intraretinal connectivity","volume":"525","author":"Hannibal","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1096\/fasebj.6.6.1544542","article-title":"Rhodopsin and phototransduction: a model system for G protein-linked receptors","volume":"6","author":"Hargrave","year":"1992","journal-title":"FASEB J."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/eye.1990.127","article-title":"The influence of dopamine on spatial vision","volume":"4","author":"Harris","year":"1990","journal-title":"Eye"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/cne.20970","article-title":"Central projections of melanopsin-expressing retinal ganglion cells in the mouse","volume":"497","author":"Hattar","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1038\/s41467-021-24696-3","article-title":"The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice","volume":"12","author":"Huang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"eabq6740","DOI":"10.1126\/science.abq6740","article-title":"Mesolimbic dopamine release conveys causal associations","volume":"378","author":"Jeong","year":"2022","journal-title":"Science"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.neuron.2021.03.010","article-title":"Cell-type-specific binocular vision guides predation in mice","volume":"109","author":"Johnson","year":"2021","journal-title":"Neuron"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cbpa.2008.04.600","article-title":"Rod and cone photoreceptors: molecular basis of the difference in their physiology","volume":"150","author":"Kawamura","year":"2008","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuron.2015.08.037","article-title":"Dopamine prediction errors in reward learning and addiction: from theory to neural circuitry","volume":"88","author":"Keiflin","year":"2015","journal-title":"Neuron"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/s41593-022-01126-1","article-title":"Dopamine signaling in the nucleus accumbens core mediates latent inhibition","volume":"25","author":"Kutlu","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"8883","DOI":"10.1523\/JNEUROSCI.1060-20.2020","article-title":"Disparity sensitivity and binocular integration in mouse visual cortex areas","volume":"40","author":"La Chioma","year":"2020","journal-title":"J. Neurosci."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.neuron.2010.04.037","article-title":"Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance","volume":"66","author":"Lall","year":"2010","journal-title":"Neuron"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"114383","DOI":"10.1016\/j.celrep.2024.114383","article-title":"Alternating bilateral sensory stimulation alleviates alcohol-induced conditioned place preference via a superior colliculus-VTA circuit","volume":"43","author":"Lei","year":"2024","journal-title":"Cell Rep."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2015.07.014","article-title":"Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits","volume":"162","author":"Lerner","year":"2015","journal-title":"Cell"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"137997","DOI":"10.1016\/j.neulet.2024.137997","article-title":"The neural circuit of superior colliculus to ventral tegmental area modulates visual cue associated with rewarding behavior in optical intracranial self-stimulation in mice","volume":"842","author":"Li","year":"2024","journal-title":"Neurosci. Lett."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1002\/cne.24469","article-title":"Divergent projection patterns of M1 ipRGC subtypes","volume":"526","author":"Li","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41583-023-00788-5","article-title":"The cognitive impact of light: illuminating ipRGC circuit mechanisms","volume":"25","author":"Mahoney","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nn.4487","article-title":"Hormonal gain control of a medial preoptic area social reward circuit","volume":"20","author":"McHenry","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/178564","article-title":"Seasonal affective disorder: an overview of assessment and treatment approaches","volume":"2015","author":"Melrose","year":"2015","journal-title":"Depress. Res. Treat."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1016\/j.cub.2016.06.057","article-title":"Chemogenetic activation of Melanopsin retinal ganglion cells induces signatures of arousal and\/or anxiety in mice","volume":"26","author":"Milosavljevic","year":"2016","journal-title":"Curr. Biol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"636330","DOI":"10.3389\/fneur.2021.636330","article-title":"Intrinsically photosensitive retinal ganglion cells of the human retina","volume":"12","author":"Mure","year":"2021","journal-title":"Front. Neurol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.biopsych.2005.09.018","article-title":"The mesolimbic dopamine reward circuit in depression","volume":"59","author":"Nestler","year":"2006","journal-title":"Biol. 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Neurosci."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"eaat4422","DOI":"10.1126\/science.aat4422","article-title":"Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors","volume":"360","author":"Patriarchi","year":"2018","journal-title":"Science"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"3471","DOI":"10.1038\/s41596-019-0239-2","article-title":"Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators","volume":"14","author":"Patriarchi","year":"2019","journal-title":"Nat. Protoc."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jneumeth.2017.04.007","article-title":"Light and the laboratory mouse","volume":"300","author":"Peirson","year":"2018","journal-title":"J. Neurosci. 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Neurosci."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1088686","DOI":"10.3389\/fncir.2023.1088686","article-title":"Retinorecipient areas in the common marmoset (Callithrix jacchus): an image-forming and non-image forming circuitry","volume":"17","author":"Santana","year":"2023","journal-title":"Front. Neural Circ."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1016\/j.visres.2007.05.004","article-title":"Bloch\u2019s law and the dynamics of feature fusion","volume":"47","author":"Scharnowski","year":"2007","journal-title":"Vis. Res."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"16262","DOI":"10.1523\/JNEUROSCI.3656-10.2010","article-title":"Differential cone pathway influence on intrinsically photosensitive retinal ganglion cell subtypes","volume":"30","author":"Schmidt","year":"2010","journal-title":"J. Neurosci."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3389\/fncel.2018.00203","article-title":"The roles of rods, cones, and Melanopsin in Photoresponses of M4 intrinsically photosensitive retinal ganglion cells (ipRGCs) and optokinetic visual behavior","volume":"12","author":"Schroeder","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/jn.1998.80.1.1","article-title":"Predictive reward signal of dopamine neurons","volume":"80","author":"Schultz","year":"1998","journal-title":"J. Neurophysiol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cobeha.2015.09.006","article-title":"Phasic dopamine signals: from subjective reward value to formal economic utility","volume":"5","author":"Schultz","year":"2015","journal-title":"Curr. Opin. Behav. Sci."},{"key":"ref91","first-page":"S2","article-title":"Shiftwork as a risk factor for depression: a pilot study","volume":"3","author":"Scott","year":"1997","journal-title":"Int. J. Occup. Environ. Health"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1146785","DOI":"10.3389\/fopht.2023.1146785","article-title":"Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina","volume":"3","author":"Sladek","year":"2023","journal-title":"Front. Ophthalmol."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s41467-022-28512-4","article-title":"Superior colliculus to VTA pathway controls orienting response and influences social interaction in mice","volume":"13","author":"Soli\u00e9","year":"2022","journal-title":"Nat. Commun."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"E5734","DOI":"10.1073\/pnas.1505274112","article-title":"Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn","volume":"112","author":"Storchi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"8575","DOI":"10.1038\/s41467-024-52727-2","article-title":"Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states","volume":"15","author":"Tao","year":"2024","journal-title":"Nat. Commun."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"e828","DOI":"10.1038\/tp.2016.93","article-title":"Association between striatal dopamine D2\/D3 receptors and brain activation during visual attention: effects of sleep deprivation","volume":"6","author":"Tomasi","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"R265","DOI":"10.1016\/j.cub.2014.02.001","article-title":"Correlation between individual differences in striatal dopamine and in visual consciousness","volume":"24","author":"Van Opstal","year":"2014","journal-title":"Curr. Biol."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"e0125631","DOI":"10.1371\/journal.pone.0125631","article-title":"A comparison of some organizational characteristics of the mouse central retina and the human macula","volume":"10","author":"Volland","year":"2015","journal-title":"PLoS One"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1146\/annurev-neuro-072116-031109","article-title":"Neural circuitry of reward prediction error","volume":"40","author":"Watabe-Uchida","year":"2017","journal-title":"Annu. Rev. Neurosci."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"eabn3567","DOI":"10.1126\/sciadv.abn3567","article-title":"Daily changes in light influence mood via inhibitory networks within the thalamic perihabenular nucleus","volume":"8","author":"Weil","year":"2022","journal-title":"Sci. Adv."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"4172","DOI":"10.1016\/j.cub.2021.06.094","article-title":"Spatial modulation of dark versus bright stimulus responses in the mouse visual system","volume":"31","author":"Williams","year":"2021","journal-title":"Curr. Biol."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nrn1406","article-title":"Dopamine, learning and motivation","volume":"5","author":"Wise","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/cne.20689","article-title":"Forebrain substrates of reward and motivation","volume":"493","author":"Wise","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1113\/jphysiol.2007.133751","article-title":"Synaptic influences on rat ganglion-cell photoreceptors","volume":"582","author":"Wong","year":"2007","journal-title":"J. Physiol."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1111\/j.1460-9568.2008.06422.x","article-title":"Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks","volume":"28","author":"Yin","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.neubiorev.2005.02.004","article-title":"The role of dopamine in conditioning and latent inhibition: what, when, where and how?","volume":"29","author":"Young","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"5115","DOI":"10.1038\/s41467-021-25378-w","article-title":"The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.cub.2018.12.031","article-title":"Superior colliculus GABAergic neurons are essential for acute dark induction of wakefulness in mice","volume":"29","author":"Zhang","year":"2019","journal-title":"Curr. 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