{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T14:43:32Z","timestamp":1767019412565,"version":"3.48.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Neurosci."],"abstract":"<jats:p>Neurological disorders stem from an intermingled change to self-in-space. While many of these disorders present as spatial deficits\u2014contralateral neglect syndrome, for example\u2014they manifest from the same etiology: disruption to the brain\u2019s \u201cdefault spatial representation\u201d (DSR). DSR is a basic internally generated representation of space that delineates where the self is located in space\u2014without attentional focus from an external drive. We review how pathologic disintegration of DSR is associated with anomalous activation and connectivity within distinct large-scale brain networks (e.g., the default mode network and a comprehensive attention-networked system), leading to a heterogeneous presentation of clinically assessed outcomes. The outcomes include psychogenic paralysis of limbs, left-side neglect, rectified sense of other locations, disorders of consciousness, symptoms related to autism spectrum disorder, Alzheimer\u2019s disease, schizophrenia, and depersonalization\/derealization disorder. By consolidating evidence from neuroimaging, lesion-symptom mapping, and computational assessment, we aim to reconceptualize these disorders not as separate and independent maladies, but as manifestations of a deeper, shared etiology, supporting a network-based assessment strategy for diagnosis and treatment that seeks to restore self-in-space.<\/jats:p>","DOI":"10.3389\/fnsys.2025.1655500","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T14:40:21Z","timestamp":1767019221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The fading self in space-disruption of default spatial representation across neurological disorders"],"prefix":"10.3389","volume":"19","author":[{"given":"Ravinder","family":"Jerath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Malani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1002\/alz.13016","article-title":"2023 Alzheimer\u2019s disease facts and figures","volume":"19","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref2","first-page":"743","article-title":"The anatomical and functional neuroanatomy of spatial neglect","volume":"29","author":"Bartolomeo","year":"2016","journal-title":"Curr. Opin. Neurol."},{"key":"ref3","first-page":"1","article-title":"Anosognosia in patients with unilateral neglect","volume":"27","author":"Bisiach","year":"1991","journal-title":"Cortex"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0010-9452(78)80016-1","article-title":"Unilateral neglect of mental representations","volume":"14","author":"Bisiach","year":"1978","journal-title":"Cortex"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.tics.2008.10.003","article-title":"Full-body illusions and minimal phenomenal selfhood","volume":"13","author":"Blanke","year":"2009","journal-title":"Trends Cogn. Sci."},{"key":"ref6","first-page":"192","article-title":"Integrated information theory of consciousness: an updated account.","volume":"155","author":"Boly","year":"2017","journal-title":"Archives Italiennes de Biologie."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Annals of the New York Academy of Sciences,"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer\u2019s disease","volume":"29","author":"Buckner","year":"2009","journal-title":"The Journal of Neuroscience,"},{"key":"ref9","first-page":"3206","article-title":"The default mode network in health and disease: a review","volume":"138","author":"Bzdok","year":"2015","journal-title":"Brain"},{"key":"ref10","first-page":"770","article-title":"A diffusion tensor imaging tractography atlas for a new approach to the study of the human brain","volume":"63","author":"Catani","year":"2008","journal-title":"Ann. Neurol."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e13107","DOI":"10.1371\/journal.pone.0013107","article-title":"Functional connectivity of the posteromedial cortex","volume":"5","author":"Cauda","year":"2011","journal-title":"PLoS ONE,"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel\u2014now? The anterior insula and human awareness","volume":"10","author":"Craig","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e26373","DOI":"10.1371\/journal.pone.0026373","article-title":"Deactivation of the default mode network as a marker of impaired consciousness: an fMRI study","volume":"6","author":"Crone","year":"2011","journal-title":"PLoS ONE,"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nrn1246","article-title":"Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging","volume":"4","author":"D\u2019Esposito","year":"2003","journal-title":"Nature Reviews Neuroscience,"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/sj.npp.1300496","article-title":"The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis","volume":"29","author":"D\u2019Souza","year":"2004","journal-title":"Neuropsychopharmacology,"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrn3963","article-title":"Rethinking segregation and integration: contributions of whole-brain modelling","volume":"16","author":"Deco","year":"2015","journal-title":"Nature Reviews Neuroscience,"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.neuron.2011.03.018","article-title":"Experimental and theoretical approaches to conscious processing","volume":"70","author":"Dehaene","year":"2011","journal-title":"Neuron"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/217","article-title":"Parietal neglect and visual awareness","volume":"1","author":"Driver","year":"1998","journal-title":"Nat. Neurosci."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/nn.4656","article-title":"The cognitive map in humans: spatial navigation and beyond","volume":"20","author":"Epstein","year":"2017","journal-title":"Nature Neuroscience,"},{"key":"ref21","first-page":"675","article-title":"The default mode network and schizophrenia","volume":"36","author":"Feinberg","year":"2010","journal-title":"Schizophr. Bull."},{"key":"ref22","first-page":"13","article-title":"The bodily self in anosognosia","volume":"105","author":"Fotopoulou","year":"2017","journal-title":"Neuropsychologia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nature Reviews Neuroscience,"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.neuron.2015.09.034","article-title":"Rhythms for cognition: communication through coherence","volume":"88","author":"Fries","year":"2015","journal-title":"Neuron"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1098\/rstb.2008.0300","article-title":"Predictive coding under the free-energy principle","volume":"364","author":"Friston","year":"2009","journal-title":"Phil. Trans. R. Soc. B: Biol. Sci."},{"key":"ref26","first-page":"841","article-title":"The cognitive neuropsychology of schizophrenia","volume":"22","author":"Frith","year":"1992","journal-title":"Psychol. Med."},{"key":"ref27","first-page":"125","article-title":"The neural basis of hallucinations and delusions","volume":"7","author":"Frith","year":"2005","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1176\/ajp.2007.164.3.450","article-title":"Aberrant default mode network activity in schizophrenia","volume":"164","author":"Garrity","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/j.clinph.2011.03.022","article-title":"Determination of awareness in patients with severe brain injury using EEG power spectral analysis","volume":"122","author":"Goldfine","year":"2011","journal-title":"Clinical Neurophysiology,"},{"key":"ref30","first-page":"346","article-title":"Reorganization of cerebral networks after stroke: new insights from functional and structural connectivity","volume":"95","author":"Grefkes","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref31","first-page":"633","article-title":"Connectivity-based approaches to understand post-stroke recovery of motor function","volume":"27","author":"Grefkes","year":"2014","journal-title":"Curr. Opin. Neurol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer\u2019s disease from healthy aging","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.cub.2015.03.059","article-title":"Posterior cingulate cortex integrates the senses of self-location and body-ownership","volume":"25","author":"Guterstam","year":"2015","journal-title":"Current Biology,"},{"key":"ref34","first-page":"297","article-title":"Neglect and related disorders","volume-title":"Clinical neuropsychology","author":"Heilman","year":"2012"},{"key":"ref35","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780199682737.001.0001","volume-title":"The predictive mind","author":"Hohwy","year":"2013"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10484-015-9279-8","article-title":"Self-regulation of breathing as a primary treatment for anxiety","volume":"40","author":"Jerath","year":"2015","journal-title":"Applied Psychophysiology and Biofeedback,"},{"key":"ref37","first-page":"203","article-title":"Spatial neglect: a neurological disorder of space exploration and its rehabilitation","volume":"218","author":"Karnath","year":"2015","journal-title":"Prog. Brain Res."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/35082075","article-title":"Spatial awareness is a function of the temporal not the posterior parietal lobe","volume":"411","author":"Karnath","year":"2001","journal-title":"Nature,"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.tics.2012.10.007","article-title":"Alpha-band oscillations, attention, and controlled access to stored information","volume":"16","author":"Klimesch","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"ref1003","doi-asserted-by":"crossref","DOI":"10.1016\/S0079-6123(05)50034-7","article-title":"The locked-in syndrome: What is it like to be conscious but paralyzed and voiceless? In","author":"Laureys","year":"2005","journal-title":"Progress in Brain Research."},{"key":"ref1012","first-page":"1","article-title":"Resting-state functional connectivity in depersonalization-derealization disorder: A systematic review","volume":"78","author":"Lim","year":"2016","journal-title":"Journal of Psychiatric Research,"},{"key":"ref1007","first-page":"652","article-title":"Knowing where and knowing what: The human hippocampal formation subserving both navigation and recognition memory","volume":"8","author":"Maguire","year":"1998","journal-title":"Hippocampus,"},{"key":"ref1002","first-page":"423","article-title":"The hippocampus and new memories: A new role for a familiar structure.","volume":"5","author":"Maguire","year":"2001","journal-title":"Trends in Cognitive Sciences,"},{"key":"ref40","first-page":"3327","article-title":"Resting-state functional connectivity in the default mode network: A marker for consciousness in patients with severe brain injury","volume":"36","author":"Martini","year":"2019","journal-title":"J. Neurotrauma"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1126\/science.1117256","article-title":"Breakdown of cortical effective connectivity during sleep","volume":"309","author":"Massimini","year":"2005","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1192\/apt.11.2.92","article-title":"Understanding and treating depersonalization disorder","volume":"11","author":"Medford","year":"2005","journal-title":"Advances in Psychiatric Treatment,"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/ana.410100402","article-title":"A cortical network for directed attention and unilateral neglect","volume":"10","author":"Mesulam","year":"1981","journal-title":"Ann. Neurol."},{"key":"ref44","first-page":"148","article-title":"Spatial attention in normal and parietal neglect states: the role of the right hemisphere","volume":"3","author":"Mesulam","year":"1999","journal-title":"Trends Cogn. Sci."},{"key":"ref45","volume-title":"Neurophilosophy of free will: From libertarianism to determinism","author":"Northoff","year":"2016"},{"key":"ref1009","first-page":"590","article-title":"The default mode network and the \u201cself\u201d in psychiatric disorders: a common pathophysiological mechanism?","volume":"18","author":"Northoff","year":"2014","journal-title":"Trends Cogn. Sci."},{"key":"ref47","volume-title":"The hippocampus as a cognitive map","author":"O\u2019Keefe","year":"1978"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1126\/science.1130197","article-title":"Detecting awareness in the vegetative state","volume":"313","author":"Owen","year":"2006","journal-title":"Science"},{"key":"ref49","first-page":"1024","article-title":"Default mode network dysfunction in schizophrenia: a systematic review","volume":"46","author":"Palaniyappan","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"ref50","volume-title":"The cerebral cortex of man: a clinical study of localization of function","author":"Penfield","year":"1950"},{"key":"ref1004","first-page":"619","article-title":"Brain networks and consciousness: A review of the evidence","volume":"24","author":"Perani","year":"2011","journal-title":"Current Opinion in Neurology,"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","article-title":"The brain\u2019s default mode network","volume":"38","author":"Raichle","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nrn1521","article-title":"Using human brain lesions to infer function: a special case in imaging","volume":"5","author":"Rorden","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1093\/brain\/awr340","article-title":"Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients","volume":"135","author":"Rosanova","year":"2012","journal-title":"Brain,"},{"key":"ref1005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tins.2009.11.002","article-title":"Recovery of consciousness after brain injury: A mesocircuit hypothesis","volume":"33","author":"Schiff","year":"2010","journal-title":"Trends in Neurosciences,"},{"key":"ref1001","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","article-title":"Dissociable intrinsic connectivity networks for salience processing and executive control","volume":"27","author":"Seeley","year":"2007","journal-title":"Journal of Neuroscience,"},{"key":"ref54","first-page":"551","article-title":"Domain-general signals in the cingulo-opercular network for visuospatial attention and episodic memory","volume":"29","author":"Sestieri","year":"2017","journal-title":"Journal of Cognitive Neuroscience,"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.tics.2013.09.007","article-title":"Interoceptive inference, emotion, and the embodied self","volume":"17","author":"Seth","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"ref56","first-page":"1354","article-title":"A predictive processing theory of consciousness","volume":"5","author":"Seth","year":"2014","journal-title":"Front. Psychol."},{"key":"ref57","first-page":"859","article-title":"Interoceptive inference and the embodied self","volume":"20","author":"Seth","year":"2016","journal-title":"Trends Cogn. Sci."},{"key":"ref58","first-page":"55","article-title":"The thalamus is more than a relay","volume":"26","author":"Sherman","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref59","first-page":"165","article-title":"The phenomenological structure of depersonalization","volume":"33","author":"Sierra","year":"2000","journal-title":"Psychopathology"},{"key":"ref1011","first-page":"17","article-title":"Time as coding space in the cerebral cortex","volume":"59","author":"Singer","year":"1999","journal-title":"Acta Neurobiologiae Experimentalis,"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1126\/science.133.3466.1749","article-title":"Cerebral organization and behavior","volume":"133","author":"Sperry","year":"1961","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1080\/17470218.2016.1181768","article-title":"The multisensory basis of the self: from body to identity","volume":"70","author":"Tsakiris","year":"2017","journal-title":"Q. J. Exp. Psychol."},{"key":"ref63","first-page":"123","article-title":"Resting-state functional connectivity in spatial neglect: A meta-analysis","volume":"160","author":"Umar","year":"2023","journal-title":"Cortex"},{"key":"ref64","first-page":"180","article-title":"Anosognosia for hemiplegia: a review","volume":"108","author":"Vallar","year":"2018","journal-title":"Cortex"},{"key":"ref1010","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1152\/jn.00783.2009","article-title":"Intrinsic functional connectivity as a tool for human connectomics: Theory, properties, and optimization","volume":"103","author":"Van Dijk","year":"2010","journal-title":"Journal of Neurophysiology,"},{"key":"ref65","first-page":"792","article-title":"What does the retrosplenial cortex do?. Nature Reviews","volume":"10","author":"Vann","year":"2009","journal-title":"Neuroscience,"},{"key":"ref66","first-page":"1","article-title":"Auditory motion elicits attentional enhancement in younger and older adults","volume":"10","author":"Vercillo","year":"2020","journal-title":"Scientific Reports,"},{"key":"ref1008","first-page":"230","article-title":"Default mode network activity and connectivity in psychopathology","volume":"70","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Biological Psychiatry,"},{"key":"ref1006","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"Journal of Neurophysiology,"}],"container-title":["Frontiers in Systems Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnsys.2025.1655500\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T14:40:29Z","timestamp":1767019229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnsys.2025.1655500\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":77,"alternative-id":["10.3389\/fnsys.2025.1655500"],"URL":"https:\/\/doi.org\/10.3389\/fnsys.2025.1655500","relation":{},"ISSN":["1662-5137"],"issn-type":[{"value":"1662-5137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"article-number":"1655500"}}