{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:57:01Z","timestamp":1782961021225,"version":"3.54.5"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Neurosci."],"abstract":"<jats:p>A theory of self-organization in the central nervous system is described, proposing that additive and dissipative synaptodendritic summation leads to synchronous oscillation as the equilibrium state, thereby underpinning a primary mechanism of prediction error minimization. As a consequence, synaptic connections become arranged in mirror-symmetric paired patterns, wherein exchanges of synaptic flux within each pattern form coupled spatial eigenmodes. The mirror-reflection axis between each pair functions as a Markov blanket that maintains excitatory\u2013inhibitory equilibrium, while multiway exchanges among mirror pairs converge toward overall error minimization and mutual organization. The primary organization of this type is evident in the spinal cord. During cortical embryogenesis, connections develop in topographies interpretable as mirror reflections with broken symmetry, aligning along the radial and circumferential axes of cortical growth, as described by the Structural Model, and subsequently manifest at the millimetric scale throughout the cortex. The proposed framework integrates a diverse range of experimental data and provides an explanatory basis for how generative models with agency can emerge through both species evolution and individual learning.<\/jats:p>","DOI":"10.3389\/fnsys.2025.1683448","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T13:48:08Z","timestamp":1763732888000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Minimization of prediction errors during cerebral embryogenesis and the emergence of agency"],"prefix":"10.3389","volume":"19","author":[{"given":"James Joseph","family":"Wright","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul David","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00429-012-0475-5","article-title":"Predictions not commands: active inference in the motor system","volume":"218","author":"Adams","year":"2013","journal-title":"Brain Struct. Funct."},{"key":"B2","doi-asserted-by":"publisher","first-page":"8131","DOI":"10.1093\/cercor\/bhad104","article-title":"Comparison of the predictive power of two models of cortico-cortical connections in primates: the distance rule model and the structural model","volume":"33","author":"Aparicio-Rodriguez","year":"2023","journal-title":"Cereb. Cortex"},{"key":"B3","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/cne.902520310","article-title":"Pattern in the laminar origin of cortico-cortical connections","volume":"252","author":"Barbas","year":"1986","journal-title":"J Comp Neurol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1146\/annurev-neuro-071714-033936","article-title":"General cortical and special prefrontal connections: principles from structure to function","volume":"38","author":"Barbas","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.conb.2016.07.003","article-title":"How the prefrontal executive got its stripes","volume":"40","author":"Barbas","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.tins.2015.03.005","article-title":"Motor cortex layer 4: less is more","volume":"38","author":"Barbas","year":"2015","journal-title":"Trends Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/cercor\/7.7.635","article-title":"Cortical structure predicts the pattern of cortico-cortical connections","volume":"7","author":"Barbas","year":"1997","journal-title":"Cereb. Cortex"},{"key":"B8","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1177\/1073858406293182","article-title":"Small-world brain networks","volume":"12","author":"Bassett","year":"2006","journal-title":"Neuroscientist"},{"key":"B9","doi-asserted-by":"publisher","first-page":"31459","DOI":"10.1073\/pnas.2014868117","article-title":"Layer and rhythm specificity for predictive routing","volume":"117","author":"Bastos","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B10","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.neuron.2012.10.038","article-title":"Canonical microcircuits for predictive coding","volume":"76","author":"Bastos","year":"2012","journal-title":"Neuron"},{"key":"B11","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1113\/jphysiol.1975.sp010995","article-title":"Innate and environmental factors in the development of the kitten's visual cortex","volume":"248","author":"Blakemore","year":"1975","journal-title":"J. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.tics.2022.06.003","article-title":"Mirror neurons 30 years later: implications and applications","volume":"26","author":"Bonini","year":"2022","journal-title":"Trends Cogn. Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s002850200141","article-title":"Spatial eigenmodes and synchronous oscillation: coincidence detection in simulated cerebral cortex","volume":"45","author":"Chapman","year":"2002","journal-title":"J. Math. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1017\/S0140525X12000477","article-title":"Whatever next? Predictive brains, situated agents, and the future of cognitive science","volume":"35","author":"Clarke","year":"2013","journal-title":"Behav. Brain Sci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/00207727008920220","article-title":"Every Good Regulator of a system must be a model of that system","volume":"1","author":"Conant","year":"1970","journal-title":"Int. J. Systems Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"6947","DOI":"10.1113\/JP272787","article-title":"Central control of interlimb coordination and speed-dependent gait expression in quadrupeds","volume":"8","author":"Danner","year":"2016","journal-title":"J. Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e1002522","DOI":"10.1371\/journal.pcbi.1002522","article-title":"Emergence of a small-world functional network in cultured neurons","volume":"8","author":"Downes","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1080\/19420889.2019.1643666","article-title":"Somatic multicellularity as a satisficing solution to the prediction-error minimization problem","volume":"12","author":"Fields","year":"2019","journal-title":"Commun. Integr. Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0301-0082(02)00076-X","article-title":"Functional integration and inference in the brain","volume":"68","author":"Friston","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1098\/rstb.2005.1622","article-title":"A theory of cortical responses","volume":"360","author":"Friston","year":"2005","journal-title":"Philos. Trans. R Soc. B Biol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e1000211","DOI":"10.1371\/journal.pcbi.1000211","article-title":"Hierarchical models in the brain","volume":"4","author":"Friston","year":"2008","journal-title":"PLoS Comput. Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrn2787","article-title":"The free energy principle: a unified brain theory?","volume":"11","author":"Friston","year":"","journal-title":"Nat. Rev. Neurosci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nrn2787-c2","article-title":"Is the free-energy principle neurocentric?","volume":"11","author":"Friston","year":"","journal-title":"Nat. Rev. Neurosci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3389\/fpsyg.2012.00130","article-title":"Free energy minimization and the dark room problem","volume":"3","author":"Friston","year":"2012","journal-title":"Front. Psychol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1162\/NECO_a_00912","article-title":"Active inference: a process theory","volume":"29","author":"Friston","year":"2017","journal-title":"Neural Comput"},{"key":"B26","doi-asserted-by":"publisher","first-page":"576015","DOI":"10.3389\/fnana.2020.576015","article-title":"A protocol for cortical type analysis of the human neocortex applied on histological samples, the Atlas of Von Economo and Koskinas, and magnetic resonance imaging","volume":"14","author":"Garcia-Cabezas","year":"2020","journal-title":"Front. Neuroanat"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1111\/ejn.13706","article-title":"Mirror trends of plasticity and stability indicators in primate prefrontal cortex","volume":"46","author":"Garcia-Cabezas","year":"2017","journal-title":"Eur. J. Neurosci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00429-019-01841-9","article-title":"The structural model: a theory linking connections, plasticity, pathology, development and evolution of the cerebral cortex","volume":"224","author":"Garcia-Cabezas","year":"2019","journal-title":"Brain Struct. Funct."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e3000362","DOI":"10.1371\/journal.pbio.3000362","article-title":"Human visual cortex is organized along two genetically opposed hierarchical gradients with unique developmental and evolutionary origins","volume":"17","author":"Gomez","year":"2019","journal-title":"PLoS Biol"},{"key":"B30","volume-title":"The Organization of Behaviour","author":"Hebb","year":"1949"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1093\/cercor\/bhm165","article-title":"Activity dependent regulation of neuronal apoptosis in neonatal mouse cerebral cortex","volume":"18","author":"Heck","year":"2008","journal-title":"Cereb. Cortex"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1126\/science.7761831","article-title":"The \u201cwake-sleep\u201d algorithm for unsupervised neural networks","volume":"268","author":"Hinton","year":"1995","journal-title":"Science"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1162\/neco.2006.18.7.1527","article-title":"A fast learning algorithm for deep belief nets","volume":"18","author":"Hinton","year":"2006","journal-title":"Neural Comput."},{"key":"B34","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/nous.12062","article-title":"The self-evidencing","volume":"50","author":"Hohwy","year":"2016","journal-title":"Brain"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1111\/febs.14970","article-title":"Apoptotic cell death regulation in neurons","volume":"286","author":"Hollville","year":"2019","journal-title":"FEBS J"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1073\/pnas.79.8.2554","article-title":"Neural networks and physical systems with emergent collective computational abilities","volume":"79","author":"Hopfield","year":"1982","journal-title":"Proc. Nat. Acad. Sci. U. S. A."},{"key":"B37","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1098\/rstb.2005.1623","article-title":"The cortical column: a structure without a function","volume":"360","author":"Horton","year":"2005","journal-title":"Philos. Trans. R. Soc."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1162\/089976603321891783","article-title":"Relating STDP to BCM","volume":"15","author":"Izhikevich","year":"2003","journal-title":"Neural Comput."},{"key":"B39","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3390\/e27050459","article-title":"Thoughtseeds: a hierarchical and agentic framework for investigating though dynamics in meditative states","volume":"27","author":"Kavi","year":"2025","journal-title":"Entropy"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1098\/rstb.2016.0158","article-title":"Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions","volume":"327","author":"Keck","year":"2017","journal-title":"Philosoph. Trans. R. Soc. B."},{"key":"B41","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3389\/fnsys.2011.00080","article-title":"Free energy and dendritic self-organization","volume":"5","author":"Kiebel","year":"2011","journal-title":"Front. Syst. Neurosci"},{"key":"B42","doi-asserted-by":"publisher","first-page":"20170792","DOI":"10.1098\/rsif.2017.0792","article-title":"The Markov blankets of life: autonomy, active inference and the free energy principle","volume":"15","author":"Kirchhoff","year":"2018","journal-title":"J. R. Soc. Interface"},{"key":"B43","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s42113-019-00032-3","article-title":"Computation resource demands of a predictive Bayesian brain","volume":"3","author":"Kwisthout","year":"2020","journal-title":"Comput. Brain Behav."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.3389\/fpsyg.2019.02688","article-title":"The computational boundary of a \u201cself\u201d: developmental bioelectricity drives multicellularity and scale-free cognition","volume":"10","author":"Levin","year":"2019","journal-title":"Front. Psychol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e22439","DOI":"10.1002\/dev.22439","article-title":"Continuity and change in neural plasticity through embryonic morphogenesis, fetal activity-dependent synaptogenesis and infant memory consolidation","volume":"65","author":"Luu","year":"2023","journal-title":"Dev. Psychobiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"bhad458","DOI":"10.1093\/cercor\/bhad458","article-title":"From active affordance to active inference: vertical integration of cognition in the cerebral cortex through dual subcortical control systems","volume":"34","author":"Luu","year":"2024","journal-title":"Cereb. Cortex"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1007\/s00421-025-05855-6","article-title":"The myth of the Bayesian brain","volume":"125","author":"Mangalam","year":"2025","journal-title":"Eur. J. Appl. Physiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1093\/cercor\/bhq201","article-title":"Weight consistency specifies regularities of macaque cortical networks","volume":"21","author":"Markov","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B49","doi-asserted-by":"publisher","first-page":"55252","DOI":"10.1038\/ncomms6252","article-title":"Superficial layer pyramidal cells communicate heterogeneously between multiple functional domains of cat primary visual cortex","volume":"5","author":"Martin","year":"2014","journal-title":"Nat. Commun."},{"key":"B50","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1126\/science.1205737","article-title":"Comment on \u201cUniversality in the evolution of orientation columns in the visual cortex","volume":"336","author":"Meng","year":"2012","journal-title":"Science"},{"key":"B51","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0896-6273(00)80169-5","article-title":"Synaptic economics : competition and cooperation in synaptic plasticity","volume":"17","author":"Miller","year":"1996","journal-title":"Neuron"},{"key":"B52","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1007\/s12565-025-00877-8","article-title":"Complicated architecture of cortical microcircuit: a comprehensive review","volume":"100","author":"Miyashita","year":"2025","journal-title":"Anat. Sci. Int"},{"key":"B53","first-page":"109","article-title":"\u201cCortical columns,\u201d","volume-title":"Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Brain","author":"Molnar","year":"2020"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1093\/cercor\/bhq290","article-title":"Embedding of cortical representations by the superficial patch system","volume":"21","author":"Muir","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1093\/cercor\/bhq184","article-title":"From neural arbours to daisies","volume":"21","author":"Muir","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B56","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.1523\/JNEUROSCI.13-10-04114.1993","article-title":"Geometry of orientation and ocular dominance columns in monkey striate cortex","volume":"13","author":"Obermayer","year":"1993","journal-title":"J. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0303-2647(99)00084-2","article-title":"A model for molecular mechanisms of synaptic competition for a finite resource","volume":"55","author":"Okamoto","year":"2000","journal-title":"BioSystems."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e25647","DOI":"10.1002\/cne.25647","article-title":"genoarchitectural definition of the adult mouse mesocortical ring: a contribution to cortical ring theory","volume":"532","author":"Puelles","year":"2024","journal-title":"J. Comp. Neurol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1002\/cne.24650","article-title":"Concentric ring topology of mammalian cortical sectors and relevance for patterning studies","volume":"527","author":"Puelles","year":"2019","journal-title":"J. Comp. Neurol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nrn700","article-title":"Neurogenesis in adult primate neocortex: an evaluation of the evidence","volume":"3","author":"Rakic","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.brainresrev.2007.02.010","article-title":"The radial edifice of cortical architecture: from neuronal silhouttes to genetic engineering","volume":"55","author":"Rakic","year":"2007","journal-title":"Brain Res. Rev."},{"key":"B62","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.neubiorev.2020.11.024","article-title":"Neural and phenotypic representation under the free energy principle","volume":"120","author":"Ramstead","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B63","doi-asserted-by":"publisher","first-page":"20220029","DOI":"10.1098\/rsfs.2022.0029","article-title":"On Bayesian mechanics: a physics of and by beliefs","volume":"13","author":"Ramstead","year":"2022","journal-title":"Interf. Focus"},{"key":"B64","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00422-002-0310-9","article-title":"Unified neurophysical model of EEG spectra and evoked potentials","volume":"86","author":"Rennie","year":"2002","journal-title":"Biol. Cybern."},{"key":"B65","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1006\/jtbi.2000.2040","article-title":"Mechanisms of cortical electrical activity and emergence of gamma rhythm","volume":"205","author":"Rennie","year":"2000","journal-title":"J. Theor. Biol."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.56.826","article-title":"Propagation and stability of waves of electrical activity in the cerebral cortex","author":"Robinson","year":"1997","journal-title":"Phys. Rev. E"},{"key":"B67","doi-asserted-by":"publisher","first-page":"021930","DOI":"10.1103\/PhysRevE.63.021903","article-title":"Prediction of electroencephalographic spectra from neurophysiology","volume":"63","author":"Robinson","year":"2001","journal-title":"Phys. Rev. E"},{"key":"B68","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/323533a0","article-title":"Learning representations by backpropagating errors","volume":"323","author":"Rumelhart","year":"1986","journal-title":"Propag. Nat."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1187280","DOI":"10.3389\/fnana.2023.1187280","article-title":"Cortical type: a conceptual tool for meaningful biological interpretation of high-throughput gene expression data in the human cerebral cortex","volume":"17","author":"Sancha-Velasco","year":"2023","journal-title":"Front. Neuroanat"},{"key":"B70","doi-asserted-by":"publisher","first-page":"6575","DOI":"10.3390\/ijms22126575","article-title":"Optogenetically controlled activity pattern determines survival rate of developing neocortical neurons","volume":"22","author":"Sang","year":"2021","journal-title":"Int. J. Mol. Sci"},{"key":"B71","first-page":"1","article-title":"Architectonics of the human frontal lobe of the brain. With a demonstration of the principles of its formation as a reflection of phylogenetic differentiation of the cerebral cortex","volume":"98","author":"Sanides","year":"1962","journal-title":"Monogr. Gesamtgeb. Neurol. Psychiatr"},{"key":"B72","first-page":"269","article-title":"The cyto-myeloarchitecture of the human frontal lobe and its relation to phylogenetic differentiation of the cerebral cortex","volume":"47","author":"Sanides","year":"1964","journal-title":"J. Hirnforsch"},{"key":"B73","first-page":"137","article-title":"\u201cFunctional architecture of motor and sensory cortices in primates in the light of a new concept of neocortex evolution,\u201d","volume-title":"The Primate Brain: Advances in Primatology","author":"Sanides","year":"1970"},{"key":"B74","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1152\/jn.1976.39.1.63","article-title":"Quantitative study of cortical orientation selectivity in visually inexperienced kitten","volume":"39","author":"Sherk","year":"1976","journal-title":"J. Neurophysiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"R443","DOI":"10.1016\/j.cub.2007.03.044","article-title":"Structure and function of the cerebral cortex","volume":"17","author":"Shipp","year":"2007","journal-title":"Curr. Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1093\/med\/9780197676158.003.0041","article-title":"\u201cPredictive coding: forward and backward connectivity,\u201d","author":"Shipp","year":"2022","journal-title":"The Cerebral Cortex and the Thalamus"},{"key":"B77","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1146\/annurev.ph.55.030193.002025","article-title":"Synchronization of cortical activity and its putative role in information processing and learning","volume":"55","author":"Singer","year":"1993","journal-title":"Annu. Rev. Physiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"802606","DOI":"10.3389\/fpsyt.2022.802606","article-title":"The brain is adaptive, not triune; how the brain responds to threat, challenge, and change","volume":"13","author":"Steffen","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B79","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.tics.2020.02.006","article-title":"The dark room problem","volume":"24","author":"Sun","year":"2020","journal-title":"Trends Cogn. Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41586-025-08790-w","article-title":"Functional connectomics spanning multiple areas of mouse visual cortex","volume":"640","year":"2025","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.newideapsych.2006.09.002","article-title":"Intentionality in non-equilibrium systems? The functional aspects of self-organised pattern formation","volume":"25","author":"Tschacher","year":"2007","journal-title":"New Ideas Psychol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.neubiorev.2021.05.029","article-title":"Motive control of unconscious inference: the limbic basis of adaptive Bayes","volume":"128","author":"Tucker","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"7870","DOI":"10.1093\/cercor\/bhad085","article-title":"Adaptive control of functional connectivity: dorsal and ventral limbic divisions regulate the dorsal and ventral neocortical networks","volume":"33","author":"Tucker","year":"2023","journal-title":"Cereb. Cortex"},{"key":"B84","doi-asserted-by":"publisher","first-page":"bhaf122","DOI":"10.1093\/cercor\/bhaf122","article-title":"Adaptive consolidation of active inference: excitatory and inhibitory mechanisms for organizing feedforward and feedback memory systems in sleep","volume":"35","author":"Tucker","year":"2025","journal-title":"Cereb. Cortex"},{"key":"B85","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1152\/jn.00328.2022","article-title":"Neurophysiological mechanisms of implicit and explicit memory in the process of consciousness","volume":"128","author":"Tucker","year":"2022","journal-title":"J. Neurophysiol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"e25623","DOI":"10.1002\/cne.25623","article-title":"Hyperphosphorylated tau in Alzheimer's disease disseminates along pathways predicted by the Structural model for cortico-cortical connections","volume":"532","author":"Uceda-Heras","year":"2024","journal-title":"J. Comp. Neurol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3389\/fncom.2019.00049","article-title":"The energy homeostasis principle: neuronal energy regulation drives local network dynamics generating behavior","volume":"10","author":"Vergara","year":"2019","journal-title":"Front. Comp. Neurosci"},{"key":"B88","doi-asserted-by":"publisher","first-page":"117479","DOI":"10.1016\/j.neuroimage.2020.117479","article-title":"Cortical hierarchy, dual counterstream architecture and the importance of top-down generative networks","volume":"225","author":"Vezoli","year":"2021","journal-title":"Neuroimage"},{"key":"B89","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/cne.901580306","article-title":"Ordered arrangement of orientation columns in monkeys lacking visual experience","volume":"158","author":"Wiesel","year":"1974","journal-title":"J. Comp. Neurol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/978-3-642-74557-7_16","article-title":"\u201cLinearity and nonlinearity in electrocortical waves and their elementary statistical dynamics,\u201d","author":"Wright","year":"1989","journal-title":"Brain Dynamics"},{"key":"B91","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fncom.2013.00004","article-title":"On the dynamics of cortical development: synchrony and synaptic self-organization","volume":"7","author":"Wright","year":"2013","journal-title":"Front. Comp. Neurosci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3389\/fncom.2016.00127","article-title":"Further work on the shaping of cortical development and function by synchrony and metabolic competition","volume":"10","author":"Wright","year":"2016","journal-title":"Front. Comp. Neurosci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"869268","DOI":"10.3389\/fncom.2022.869268","article-title":"Unification of free energy minimization, spatio-temporal energy, and dimension reduction models of V1 organization:postnatal learning on an antenatal scaffold","volume":"16","author":"Wright","year":"2022","journal-title":"Front. Comput. Neurosci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1169772","DOI":"10.3389\/fncom.2023.1169772","article-title":"The mesoanatomy of the cortex, minimization of free energy, and generative cognition","volume":"12","author":"Wright","year":"2023","journal-title":"Front. Comput. Neurosci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/e26040287","article-title":"Markov blankets and mirror symmetries. Free energy minimization and mesocortical anatomy","volume":"26","author":"Wright","year":"","journal-title":"Entropy"},{"key":"B96","doi-asserted-by":"publisher","first-page":"bhae416","DOI":"10.1093\/cercor\/bhae416","article-title":"Cortical development in the structural model and free energy minimization","volume":"34","author":"Wright","year":"","journal-title":"Cereb. Cortex"},{"key":"B97","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s004220000155","article-title":"Synchronous oscillation in the cerebral cortex and object coherence: simulation of basic electrophysiological findings","volume":"83","author":"Wright","year":"2000","journal-title":"Biol. Cybern."},{"key":"B98","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3389\/fnana.2014.00119","article-title":"Mobius-strip-like columnar functional connections are revealed in somato-sensory receptive field centroids","volume":"8","author":"Wright","year":"2014","journal-title":"Front. Neuroanat."},{"key":"B99","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/BF00202790","article-title":"Simulation of electrocortical waves","volume":"72","author":"Wright","year":"1995","journal-title":"Biol. Cybern."},{"key":"B100","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1017\/S0140525X00042679","article-title":"Dynamics of the brain at global and microscopic scales: neural networks and the EEG","volume":"19","author":"Wright","year":"1996","journal-title":"Behav. Brain Sci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1162\/089976603762552988","article-title":"Equivalence of backpropagation and contrastive Hebbian learning in a layered network","volume":"15","author":"Xie","year":"2003","journal-title":"Neural Comput."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J. Neurophysiol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3390\/e21030308","article-title":"The understanding capacity and information dynamics in the human brain","volume":"21","author":"Yufik","year":"2019","journal-title":"Entropy"},{"key":"B104","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fnsys.2016.00098","article-title":"Life and understanding: the origins of \u201cunderstanding\u201d in self-organizing nervous systems","volume":"10","author":"Yufik","year":"2016","journal-title":"Front. Syst. Neurosci."}],"container-title":["Frontiers in Systems Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnsys.2025.1683448\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T13:48:09Z","timestamp":1763732889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnsys.2025.1683448\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":104,"alternative-id":["10.3389\/fnsys.2025.1683448"],"URL":"https:\/\/doi.org\/10.3389\/fnsys.2025.1683448","relation":{},"ISSN":["1662-5137"],"issn-type":[{"value":"1662-5137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"article-number":"1683448"}}